Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the antiadipogenic effects of tumor necrosis factor-α

Molecular Endocrinology

Volumn 10, Issue 11, 1996, Pages 1457-1466

  Zhang, Bei ^a   Berger, Joel ^a   Hu, Erding ^b   Szalkowski, Deborah ^a   White Carrington, Sylvia ^a   Spiegelman, Bruce M ^b   Moller, David E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; DNA BINDING PROTEIN; FATTY ACID BINDING PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; GENE EXPRESSION; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; ADIPOCYTES; ANIMALS; CARRIER PROTEINS; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; COMPLEMENT FACTOR D; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FATTY ACID-BINDING PROTEINS; GENE EXPRESSION REGULATION; MICE; MYELIN P2 PROTEIN; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SERINE ENDOPEPTIDASES; SUPPRESSION, GENETIC; TIME FACTORS; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0030458404     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.10.11.1457     Document Type: Article

References (60)

1. Beutler B, Cerami A 1988 Cachectin (tumor necrosis factor): a macrophage hormone governing cellular metabolism and inflammatory response. Endocr Rev 9:57-66
2. Price SR, Olivecrona T, Pekala PH 1986 Regulation of lipoprotein lipase synthesis in 3T3-L1 adipocytes by cachectin. Biochem J 240:601-604
3. Kawakami M, Murase T, Ogawa H, Ishibashi S, Mori N, Takaku F, Shibata S 1987 Human recombinant TNF suppresses lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells. J Biochem 101:331-338
4. Cornelius P, Enerback S, Bjursell G, Olivecrona T, Pekala PH 1988 Regulation of lipoprotein lipase mRNA content in 3T3-L1 cells by tumour necrosis factor. Biochem J 249:765-769
5. Mackay AG, Oliver JD, Rogers MP 1990 Regulation of lipoprotein lipase activity and mRNA content in rat epididymal adipose tissue in vitro by recombinant tumour necrosis factor. Biochem J 269:123-126
6. Fried SK, Zechner R 1989 Cachectin/tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis, and activity. J Lipid Res 30:1917-1923
7. Torti FM, Dieckmann B, Beutler B, Cerami A, Ringold GM 1985 A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science 229:867-869
8. Dobson DE, Groves DL, Spiegelman BM 1987 Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation. J Biol Chem 262: 1804-1809
9. Pape ME, Kim K-H 1988 Effect of tumor necrosis factor on acetyl-coenzyme A carboxylase gene expression and preadipocyte differentiation. Mol Endocrinol 2:395-403
10. Pape ME, Kim K-H 1989 Transcriptional regulation of acetyl coenzyme A carboxylase gene expression by tumor necrosis factor in 30A-5 preadipocytes. Mol Cell Biol 9:974-982
11. Green A, Dobias SB, Walters DJA, Brasier AR 1994 Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase. Endocrinology 134:2581-2588
12. Ogawa H, Nielsen S, Kawakami M 1989 Cachetin/tumor necrosis factor and interleukin-1 show different modes of combined effect on lipoprotein lipase activity and intracellular lipolysis in 3T3-L1 cells. Biochim Biophys Acta 1003:131-135
13. Patton JS, Shepard HM, Wilking H, Lewis G, Aggarwal BB, Eessalu TE, Gavin LA, Grunfeld C 1986 Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. Proc Natl Acad Sci USA 83:8313-8317
14. Marshall M, Doerrler W, Feingold KR, Grunfeld C 1994 Leukemia inhibitory factor induces changes in metabolism in cultured adipocytes. Endocrinology 135:141-147
15. Ron D, Brasier AD, McGehee REJ, Habener JF 1992 Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3 L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). J Clin Invest 89:223-233
16. Szalkowski D, White-Carrington S, Berger J, Zhang B 1995 Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-α on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells. Endocrinology 136:1474-1481
17. Petruschke TH, Hauner H 1993 Tumor necrosis factor-α prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells. J Clin Endocrinol Metab 76:742-747
18. Stephens JM, Pekala PH 1991 Transcriptional repression of the GLUT4 and c/EBP genes in 3T3-L1 cells by tumor necrosis factor-alpha. J Biol Chem 266:21839-21845
19. Hauner H, Petruschke T, Russ M, Rohrig K, Eckel J 1995 Effects of tumour necrosis factor alpha on glucose transport and lipid metabolism of newly-differentiated human fat cells in culture. Diabetologia 38:764-771
20. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM 1994 Tumor necrosis factor a inhibits signaling from the insulin receptor. Proc Natl Acad Sci USA 91:4854-4858
21. Spiegelman BM, Hotamisligil GS 1993 Through thick and thin: wasting, obesity, and TNFα. Cell 73:625-627
22. Stephens JM, Butts M, Stone R, Pekala PH, Bernlohr DA 1993 Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by antagonists of adipogenesis. Mol Cell Biochem 123:63-71
23. Ninomiya-Tsuji J, Torti FM, Ringold GM 1993 Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation. Proc Natl Acad Sci USA 90:9611-9615
24. Freytag SO, Paielli DL, Gilbert JD 1994 Ectopic expression of the CCAAT/enhancer-binding protein a promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev 8:1654-1663
25. Cornelius P, MacDougald OA, Lane MD 1994 Regulation of adipocyte development. Annu Rev Nutr 14:99-129
26. Tontonoz P, Hu E, Spiegelman BM 1995 Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor γ. Curr Biol 5:571-576
27. Chawla A, Schwarz E, Dimaculangan D, Lazar M 1994 Peroxisome proliferator activated receptor (PPAR) γ. adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135:798-800
28. Tontonoz P, Hu E, Graves R, Budavari A, Spiegelman B 1994 mPPARgamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8:1224-1234
29. Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D, Sambasiva Rao M, Reddy JK 1995 Structural organization of mouse peroxisome proliferator-activated receptor γ (m PPAR γ) gene: alternative promoter use and different splicing yield two m PPAR γ isoforms. Proc Natl Acad Sci USA 92:7921-7925
30. Vidal-Puig A, Jimenez-Linan M, Hamann A, Lowell BB, Hu E, Spiegelman BM, Flier JS, Moller DE 1996 Regulation of PPARγ gene expression in vivo by nutrition and obesity. J Clin Invest 97:2553-2561
31. Tontonoz P, Hu E, Spiegelman BM 1994 Stimulation of adipogenesis in fibroblasts by PPAR γ 2, a lipid activated transcription factor. Cell 79:1147-1156
32. Hu E, Tontonoz P, Spiegelman BM 1995 Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα. Proc Natl Acad Sci USA 92:9856-9860
33. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM 1995 15-deoxy-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812
34. Kliewer SA, Lenhard JM, Willson RM, Patel I, Morris DC, Lehmann JM 1995 A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83:813-819
35. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA 1995 An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ. J Biol Chem 270: 12953-12956
36. Berger J, Bailey P, Biswas C, Cullinan C, Hayes NS, Smith RG, Leibowitz MD, Thiazolidinediones produce conformational changes in PPARγ: binding and activation correlate with antidiabetic actions in db/db mice. In: Keystone Symposium on Steroid/Thyroid/Retinoic Acid Gene Family, Lake Tahoe, CA, 1996, p. 49
37. Kletzien RF, Clarke SD, Ulrich RG 1991 Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol Pharmacol 41:393-398
38. Green H, Mauth M 1974 An established pre-adipose cell line and its differentiation in culture. Cell 3:127-133
39. Green H, Kehinde O 1975 An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion. Cell 5:19-26
40. Torti FM, Torti SV, Larrick JW, Ringold GM 1989 Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta. J Cell Biol 108:1105-1113
41. Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P 1993 Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem 268:6823-6826
42. Chen F, Law SW, O'Malley BW 1993 Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun 196:671-677
43. Zhu Y, Alvares K, Huang Q, Sambasiva Rao M, Reddy J 1993 cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J Biol Chem 236:26817-26820
44. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W 1996 Differential expression of peroxisome proliferator-activated Receptor (PPARs): tissue distribution of PPAR-α, -β, and γ in the adult rat. Endocrinology 137:354-366
45. Christy RJ, Yang VW, Ntambi JM, DEG, Landschulz WH, Friedman AD, Nakabeppu Y, Kelly TJ, Lane MD 1989 Differentiation-induced gene expression in 3T3-L1 pre-adipocytes: CCAAT/enhancer binding protein interacts with and activates the promoter of two adipocyte-specific gene. Genes Dev 3:1323-1335
46. Samuelsson L, Stromberg K, Vikman K, Bjursell G, Enerback S 1991 The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J 10:3787-3793
47. Umek RM, Friedman AD, McKnight SL 1991 CCAAT-Enhancer binding protein: a component of a differentiation switch. Science 251:288-292
48. Wang N, Finegold MJ, Bradley A, Ching NO, Abdelsayed SV, Wilde MD, Taylor R, Wilson DR, Darlington GJ 1995 Impaired energy homeostasis in C/EBPα Knockout mice. Science 269:1108-1112
49. Williams PM, Chang DJ, Danesch U, Ringold RM, Heller RA 1992 CCAAT/Enhancer binding protein expression is rapidly extinguished in TA1 adipocytes cells treated with tumor necrosis factor. Mol Endocrinol 6:1135-1141
50. Issemann I, Green S 1990 Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-649
51. Schmidt A, Endo N, Rutledge S, Vogel R, Shinar D, Rodan G 1992 Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acid. Mol Endocrinol :1634-1641
52. Amri E-Z, Bonino F, Ailhaud G, Abumrad NA, Grimaldi PA 1995 Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. J Biol Chem 270:2367-2371
53. Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM 1996 Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev 10:974-984
54. Ohsumi J, Sakakibara S, Yamaguchi J, Miyadai K, Yoshioka S, Fujiwara T, Horikoshi H, Serizawa N 1994 Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells. Endocrinology 135:2279-2281
55. Norman RA, Bogardus C, Ravussin E 1995 Linkage between obesity and a marker near the tumor necrosis-α locus in Pima Indians. J Clin Invest 96:158-162
56. Hotamisligil GS, Shargill NS, Spiegelman BM 1993 Adipose tissue expression of tumor necrosis factor alpha: direct role in obesity-linked insulin resistance. Science 259:87-90
57. Kohanski RA, Frost SC, Lane MD 1986 Insulin-dependent phosphorylation of the insulin receptor-protein kinase and activation of glucose transport in 3T3-I1 adipocytes. J Biol Chem 261:12272-12281
58. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
59. Ausubel FM, Brent R, Kingston RE 1987 Current Protocols in Molecular Biology. John Wiley & Sons, New York
60. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans RM 1994 Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 91:7355-7359