-
1
-
-
3042857903
-
Alzheimer's disease
-
Cummings JL. Alzheimer's disease. N Engl J Med 2004; 351: 56-67
-
(2004)
N Engl J Med
, vol.351
, pp. 56-67
-
-
Cummings, J.L.1
-
2
-
-
0037417238
-
Memantine in moderate-to-severe Alzheimer's disease
-
Reisberg B, Doody R, Stoffler A, et al. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med 2003; 348: 1333-41
-
(2003)
N Engl J Med
, vol.348
, pp. 1333-1341
-
-
Reisberg, B.1
Doody, R.2
Stoffler, A.3
-
3
-
-
0345872128
-
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
-
Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 2004; 291: 317-24
-
(2004)
JAMA
, vol.291
, pp. 317-324
-
-
Tariot, P.N.1
Farlow, M.R.2
Grossberg, G.T.3
-
4
-
-
0034516988
-
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
-
Selkoe DJ. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 2000; 924: 17-25
-
(2000)
Ann N Y Acad Sci
, vol.924
, pp. 17-25
-
-
Selkoe, D.J.1
-
5
-
-
0037168655
-
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR
-
U S A
-
Petkova AT, Ishii Y, Balbach JJ, et al. A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A 2002; 99: 16742-7
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 16742-16747
-
-
Petkova, A.T.1
Ishii, Y.2
Balbach, J.J.3
-
6
-
-
9144238052
-
Alzheimer neurofibrillary degeneration: Therapeutic targets and high-throughput assays
-
Iqbal K, Alonso Adel C, El-Akkad E, et al. Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays. J Mol Neurosci 2003; 20: 425-9
-
(2003)
J Mol Neurosci
, vol.20
, pp. 425-429
-
-
Iqbal, K.1
Alonso Adel, C.2
El-Akkad, E.3
-
7
-
-
0028132966
-
Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia
-
Samuel W, Terry RD, DeTeresa R, et al. Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia. Arch Neurol 1994; 51: 772-8
-
(1994)
Arch Neurol
, vol.51
, pp. 772-778
-
-
Samuel, W.1
Terry, R.D.2
DeTeresa, R.3
-
8
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Naslund J, Haroutunian V, Mohs R, et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 2000; 283: 1571-7
-
(2000)
JAMA
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Mohs, R.3
-
9
-
-
0035864113
-
Alzheimer's disease: New insights into its cause lead to new drug strategies
-
Nash JM. Alzheimer's disease: new insights into its cause lead to new drug strategies. Time 2001; 157: 80-81, 85
-
(2001)
Time
, vol.157
, pp. 80-81
-
-
Nash, J.M.1
-
10
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001; 81: 741-66
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
11
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-6
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
12
-
-
9044239670
-
Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a final common pathway
-
Lippa CF, Saunders AM, Smith TW, et al. Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway. Neurology 1996; 46: 406-12
-
(1996)
Neurology
, vol.46
, pp. 406-412
-
-
Lippa, C.F.1
Saunders, A.M.2
Smith, T.W.3
-
13
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996; 2: 864-70
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
14
-
-
18244365872
-
Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: The chickens or the eggs?
-
Smith MA, Drew KL, Nunomura A, et al. Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochem Int 2002; 40: 527-31
-
(2002)
Neurochem Int
, vol.40
, pp. 527-531
-
-
Smith, M.A.1
Drew, K.L.2
Nunomura, A.3
-
15
-
-
0034509448
-
A very incomplete comprehensive theory of Alzheimer's disease
-
Davies P. A very incomplete comprehensive theory of Alzheimer's disease. Ann N Y Acad Sci 2000; 924: 8-16
-
(2000)
Ann N Y Acad Sci
, vol.924
, pp. 8-16
-
-
Davies, P.1
-
16
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
Oddo S, Billings L, Kesslak JP, et al. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 2004; 43: 321-32
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
-
17
-
-
2942530513
-
Neurogenic effect of beta-amyloid peptide in the development of neural stem cells
-
Lopez-Toledano MA, Shelanski ML. Neurogenic effect of beta-amyloid peptide in the development of neural stem cells. J Neurosci 2004; 24: 5439-44
-
(2004)
J Neurosci
, vol.24
, pp. 5439-5444
-
-
Lopez-Toledano, M.A.1
Shelanski, M.L.2
-
18
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi N, Tomita T, Hayashi I, et al. The role of presenilin cofactors in the gamma-secretase complex. Nature 2003; 422: 438-41
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
-
19
-
-
4344580888
-
Strategies for disease modification in Alzheimer's disease
-
Citron M. Strategies for disease modification in Alzheimer's disease. Nat Rev Neurosci 2004; 5: 677-85
-
(2004)
Nat Rev Neurosci
, vol.5
, pp. 677-685
-
-
Citron, M.1
-
20
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaert W, Cupers P, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 1999; 398: 518-22
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
-
21
-
-
8444247084
-
Modulation of Notch Processing by {gamma}-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
-
Milano J, McKay J, Dagenais C, et al. Modulation of Notch Processing by {gamma}-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol Sci 2004; 82: 341-58
-
(2004)
Toxicol Sci
, vol.82
, pp. 341-358
-
-
Milano, J.1
McKay, J.2
Dagenais, C.3
-
22
-
-
6344233805
-
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site: Evidence for an allosteric mechanism
-
Beher D, Clarke EE, Wrigley JD, et al. Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site: evidence for an allosteric mechanism. J Biol Chem 2004; 279: 43419-26
-
(2004)
J Biol Chem
, vol.279
, pp. 43419-43426
-
-
Beher, D.1
Clarke, E.E.2
Wrigley, J.D.3
-
23
-
-
0142059785
-
Gleevec inhibits beta-amyloid production but not Notch cleavage
-
U S A
-
Netzer WJ, Dou F, Cai D, et al. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci U S A 2003; 100: 12444-9
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 12444-12449
-
-
Netzer, W.J.1
Dou, F.2
Cai, D.3
-
24
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 2001; 414: 212-6
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
-
25
-
-
19944430290
-
Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor
-
Feb
-
Barten DM, Guss VL, Corsa JA, et al. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor. J Pharmacol Exp Ther 2005 Feb; 312 (2): 635-43
-
(2005)
J Pharmacol Exp Ther
, vol.312
, Issue.2
, pp. 635-643
-
-
Barten, D.M.1
Guss, V.L.2
Corsa, J.A.3
-
26
-
-
21544458621
-
Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitors in volunteers
-
Siemers E, Skinner M, Dean RA, et al. Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitors in volunteers. Clin Neuropharmacol 2005; 28: 126-32
-
(2005)
Clin Neuropharmacol
, vol.28
, pp. 126-132
-
-
Siemers, E.1
Skinner, M.2
Dean, R.A.3
-
27
-
-
85099487990
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 1999; 402: 33-7
-
(1999)
Nature
, vol.402
, pp. 33-37
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
-
28
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, et al. beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286: 735-41
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
-
29
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 1999; 402: 537-40
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
-
30
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as beta-secretase
-
Hussain I, Powell D, Howlett DR, et al. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 1999; 14: 419-27
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
-
31
-
-
0034613320
-
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
-
Hong L, Koelsch G, Lin X, et al. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science 2000; 290: 150-3
-
(2000)
Science
, vol.290
, pp. 150-153
-
-
Hong, L.1
Koelsch, G.2
Lin, X.3
-
32
-
-
17344388652
-
BACE knockout mice are healthy despite lacking the primary beta- secretase activity in brain: Implications for Alzheimer's disease therapeutics
-
Roberds SL, Anderson J, Basi G, et al. BACE knockout mice are healthy despite lacking the primary beta- secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet 2001; 10: 1317-24
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1317-1324
-
-
Roberds, S.L.1
Anderson, J.2
Basi, G.3
-
33
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
-
Luo Y, Bolon B, Kahn S, et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci 2001; 4: 231-2
-
(2001)
Nat Neurosci
, vol.4
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
-
34
-
-
3042658599
-
In vivo inhibition of A beta production by memopsin 2 (beta-secretase) inhibitors
-
Chang WP, Koelsch G, Wong S, et al. In vivo inhibition of A beta production by memopsin 2 (beta-secretase) inhibitors. J Neurochem 2004; 89: 1409-16
-
(2004)
J Neurochem
, vol.89
, pp. 1409-1416
-
-
Chang, W.P.1
Koelsch, G.2
Wong, S.3
-
35
-
-
10644249886
-
Structure-based design of potent and selective ceel-permeable inhibitors of human beta-secretase (BACE-1)
-
Stachel SJ, Coburn CA, Steele TG, et al. Structure-based design of potent and selective ceel-permeable inhibitors of human beta-secretase (BACE-1). J Med Chem 2004; 47: 6447-50
-
(2004)
J Med Chem
, vol.47
, pp. 6447-6450
-
-
Stachel, S.J.1
Coburn, C.A.2
Steele, T.G.3
-
36
-
-
0023880172
-
Protein kinase C as the receptor for the phorbol ester tumor promoters
-
Blumberg PM. Protein kinase C as the receptor for the phorbol ester tumor promoters. Cancer Res 1988; 48: 1-8
-
(1988)
Cancer Res
, vol.48
, pp. 1-8
-
-
Blumberg, P.M.1
-
37
-
-
3342934646
-
Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice
-
U S A
-
Etcheberrigaray R, Tan M, Dewachter I, et al. Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proc Natl Acad Sci U S A 2004; 101: 11141-6
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 11141-11146
-
-
Etcheberrigaray, R.1
Tan, M.2
Dewachter, I.3
-
38
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999; 400: 173-7
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
-
39
-
-
0037452779
-
Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology
-
U S A
-
Bard F, Barbour R, Cannon C, et al. Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci U S A 2003; 100: 2023-8
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 2023-2028
-
-
Bard, F.1
Barbour, R.2
Cannon, C.3
-
40
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo JM, Gilman S, Dartigues JF, et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 2003; 61: 46-54
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
-
41
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Nicoll JA, Wilkinson D, Holmes C, et al. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 2003; 9: 448-52
-
(2003)
Nat Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
-
42
-
-
20944448555
-
Clinical effects of A beta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S, Koller M, Black RS, et al. Clinical effects of A beta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 2005; 10: 1553-62
-
(2005)
Neurology
, vol.10
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
-
43
-
-
0037107177
-
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
-
Bacskai BJ, Kajdasz ST, McLellan ME, et al. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci 2002; 22: 7873-8
-
(2002)
J Neurosci
, vol.22
, pp. 7873-7878
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
McLellan, M.E.3
-
44
-
-
0037155581
-
Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummins DJ, et al. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 2002; 295: 2264-7
-
(2002)
Science
, vol.295
, pp. 2264-2267
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
-
45
-
-
0041332884
-
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice
-
Lemere CA, Spooner ET, LaFrancois J, et al. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiol Dis 2003; 14: 10-8
-
(2003)
Neurobiol Dis
, vol.14
, pp. 10-18
-
-
Lemere, C.A.1
Spooner, E.T.2
LaFrancois, J.3
-
46
-
-
0037223101
-
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid
-
Matsuoka Y, Saito M, LaFrancois J, et al. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci 2003; 23: 29-33
-
(2003)
J Neurosci
, vol.23
, pp. 29-33
-
-
Matsuoka, Y.1
Saito, M.2
LaFrancois, J.3
-
47
-
-
3543060658
-
Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation
-
Ye C, Walsh DM, Selkoe DJ, et al. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neurosci Lett 2004; 366: 320-5
-
(2004)
Neurosci Lett
, vol.366
, pp. 320-325
-
-
Ye, C.1
Walsh, D.M.2
Selkoe, D.J.3
-
48
-
-
0036669881
-
Amyloid-beta oligomers: Their production, toxicity and therapeutic inhibition
-
Walsh DM, Klyubin I, Fadeeva JV, et al. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans 2002; 30: 552-7
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 552-557
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
-
49
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416: 535-9
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
-
50
-
-
0034213718
-
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
-
Mucke L, Masliah E, Yu GQ, et al. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 2000; 20: 4050-8
-
(2000)
J Neurosci
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.Q.3
-
51
-
-
13544255842
-
Clinical data on Alzhemed after 12 months of treatment in patients with mild to moderate Alzheimer's disease
-
Aisen PS, Mehran M, Poole R, et al. Clinical data on Alzhemed after 12 months of treatment in patients with mild to moderate Alzheimer's disease [abstract]. Neurobiol Aging 2004; 25: 20
-
(2004)
Neurobiol Aging
, vol.25
, pp. 20
-
-
Aisen, P.S.1
Mehran, M.2
Poole, R.3
-
52
-
-
0037386086
-
The metallobiology of Alzheimer's disease
-
Bush AI. The metallobiology of Alzheimer's disease. Trends Neurosci 2003; 26: 207-14
-
(2003)
Trends Neurosci
, vol.26
, pp. 207-214
-
-
Bush, A.I.1
-
53
-
-
18144374793
-
Metal ion-dependent effects of clioquinol on the fibril growth of an anyloid beta peptide
-
Raman B, Ban T, Yamaguchi K, et al. Metal ion-dependent effects of clioquinol on the fibril growth of an anyloid beta peptide. J Biol Chem 2005; 280: 16157-62
-
(2005)
J Biol Chem
, vol.280
, pp. 16157-16162
-
-
Raman, B.1
Ban, T.2
Yamaguchi, K.3
-
54
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny RA, Atwood CS, Xilinas ME, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 2001; 30: 665-76
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
-
55
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
Ritchie CW, Bush AI, Mackinnon A, et al. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 2003; 60: 1685-91
-
(2003)
Arch Neurol
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
Mackinnon, A.3
-
56
-
-
0033781375
-
Subacute myelo-optico-neuropathy: Clioquinol intoxication in humans and animals
-
Tateishi J. Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals. Neuropathology 2000; 20 Suppl.: S20-4
-
(2000)
Neuropathology
, vol.20
, Issue.SUPPL.
-
-
Tateishi, J.1
-
57
-
-
0034820554
-
Glycosaminoglycan mimetics: A therapeutic approach to cerebral amyloid angiopathy
-
Gervais F, Chalifour R, Garceau D, et al. Glycosaminoglycan mimetics: a therapeutic approach to cerebral amyloid angiopathy. Amyloid 2001; 8 Suppl. 1: 28-35
-
(2001)
Amyloid
, vol.8
, Issue.1 SUPPL.
, pp. 28-35
-
-
Gervais, F.1
Chalifour, R.2
Garceau, D.3
-
58
-
-
28844467064
-
GAG mimetics: Potential to modify underlying disease process in AD
-
Gervais F. GAG mimetics: potential to modify underlying disease process in AD. Neurobiol Aging 2004; 25: S11-2
-
(2004)
Neurobiol Aging
, vol.25
-
-
Gervais, F.1
-
59
-
-
0026619343
-
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides
-
Hilbich C, Kisters-Woike B, Reed J, et al. Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J Mol Biol 1992; 228: 460-73
-
(1992)
J Mol Biol
, vol.228
, pp. 460-473
-
-
Hilbich, C.1
Kisters-Woike, B.2
Reed, J.3
-
60
-
-
0036547110
-
Peptide inhibitors of beta amyloid aggregation
-
Findeis MA. Peptide inhibitors of beta amyloid aggregation. Curr Top Med Chem 2002; 2: 417-23
-
(2002)
Curr Top Med Chem
, vol.2
, pp. 417-423
-
-
Findeis, M.A.1
-
61
-
-
0032500717
-
Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells
-
Klunk WE, Debnath ML, Koros AM, et al. Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci 1998; 63: 1807-14
-
(1998)
Life Sci
, vol.63
, pp. 1807-1814
-
-
Klunk, W.E.1
Debnath, M.L.2
Koros, A.M.3
-
62
-
-
0034718206
-
Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization
-
Findeis MA. Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization. Biochim Biophys Acta 2000; 1502: 76-84
-
(2000)
Biochim Biophys Acta
, vol.1502
, pp. 76-84
-
-
Findeis, M.A.1
-
63
-
-
27144504825
-
Benefits of atorvastatin in subjects with ALzheimer's disease
-
11017
-
Sparks DL, Sabbagh MN, Connor DJ, et al. Benefits of atorvastatin in subjects with ALzheimer's disease. Circulation 2004; 11017: III-813
-
(2004)
Circulation
-
-
Sparks, D.L.1
Sabbagh, M.N.2
Connor, D.J.3
-
64
-
-
5144227934
-
The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease
-
Hutter-Paier B, Huttunen HJ, Puglielli L, et al. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron 2004; 44: 227-38
-
(2004)
Neuron
, vol.44
, pp. 227-238
-
-
Hutter-Paier, B.1
Huttunen, H.J.2
Puglielli, L.3
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