Insulin resistance due to lipid-induced signaling defects could be prevented by mahanine

Molecular and Cellular Biochemistry

Volumn 336, Issue 1-2, 2010, Pages 97-107

  Biswas, Anindita ^a   Bhattacharya, Sushmita ^a   Dasgupta, Suman ^a   Kundu, Rakesh ^a   Roy, Sib Sankar ^b   Pal, Bikas C ^b   Bhattacharya, Samir ^a  

^a VISVA BHARATI UNIVERSITY   (India)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Free fatty acids; Insulin resistance; Insulin signaling; Mahanine; NF B; PKC

Indexed keywords

ALKALOID; CARBAZOLE DERIVATIVE; HIGH MOBILITY GROUP A PROTEIN; I KAPPA B KINASE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR; LIPID; MAHANINE; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; TRANSCRIPTION FACTOR; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL NUCLEUS; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSOL; ENZYME PHOSPHORYLATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; ISOLATION PROCEDURE; MURRAYA KOENEGII; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT LEAF; RECEPTOR GENE; RUTACEAE; SIGNAL TRANSDUCTION; SYRIAN HAMSTER;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; CARBAZOLES; CRICETINAE; DEOXYGLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FATTY ACIDS, NONESTERIFIED; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; MESOCRICETUS; MURRAYA; MUSCLE FIBERS, SKELETAL; NF-KAPPA B; PHOSPHORYLATION; PLANT LEAVES; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA; MESOCRICETUS AURATUS; MURRAYA;

EID: 77649235210     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0257-4     Document Type: Conference Paper

References (54)

1. DE Kelley M Mokan JA Simoneau LJ Mandarino 1993 Interaction between glucose and free fatty acid metabolism in human skeletal muscle J Clin Invest 92 91 98 10.1172/JCI116603 1:CAS:528:DyaK3sXlslCnurk%3D 8326021
2. G Boden X Chen J Ruiz JV White L Rossetti 1994 Mechanisms of fatty acid-induced inhibition of glucose uptake J Clin Invest 93 2438 2446 10.1172/JCI117252 1:CAS:528:DyaK2cXlsFCksL8%3D 8200979
3. GI Shulman 2000 Cellular mechanisms of insulin resistance J Clin Invest 106 171 176 10.1172/JCI10583 1:CAS:528:DC%2BD3cXkvFWhu7k%3D 10903330
4. PG Kopelman 2000 Obesity as a medical problem Nature 404 635 643 1:CAS:528:DC%2BD3cXis1Grtb8%3D 10766250
5. C Yu Y Chen GW Cline D Zhang H Zong Y Wang R Bergeron JK Kim SW Cushman GJ Cooney B Atcheson MF White EW Kraegen GI Shulman 2002 Mechanisms by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle J Biol Chem 27 50230 50236 10.1074/jbc.M200958200 (Pubitemid 36042170)
6. GA Boden 1997 Role of fatty acids in the pathogenesis of insulin resistance and NIDDM Diabetes 46 3 10 10.2337/diabetes.46.1.3 1:CAS:528:DyaK2sXks1aj 8971073
7. G Boden GI Shulman 2002 Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction Eur J Clin Invest 32 Suppl 3 14 23 10.1046/j.1365-2362.32.s3.3.x 1:CAS:528:DC%2BD38XlslCksb8%3D 12028371 (Pubitemid 41704996)
8. DE Moller 2001 New drug targets for type 2 diabetes and the metabolic syndrome Nature 414 821 827 10.1038/414821a 1:CAS:528:DC%2BD38Xhtlyltw%3D%3D 11742415 (Pubitemid 34000786)
9. AT Santomauro G Boden ME Silva DM Rocha RF Santos MJ Ursich PG Strassmann BL Wajchenburg 1999 Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects Diabetes 48 1836 1841 10.2337/diabetes.48.9.1836 1:CAS:528:DyaK1MXmtVaitb0%3D 10480616 (Pubitemid 29415205)
10. A Dresner D Laurent M Marcucci ME Griffin S Dufour GW Cline LA Slezak DK Andersen RS Hundal DL Rothman KF Petersen GI Shulman 1999 Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity J Clin Invest 103 253 259 10.1172/JCI5001 1:CAS:528: DyaK1MXltFequw%3D%3D 9916137
11. AD Kohn SA Summers MJ Birnbaum RA Roth 1996 Expression of a constitutively active Akt Ser/Thr kinase in 3T3 L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation J Biol Chem 271 31372 31378 10.1074/jbc.271.49.31372 1:CAS:528:DyaK28Xns1aitLs%3D 8940145 (Pubitemid 26408588)
12. Q Wang R Somwar PJ Bilan Z Liu J Jin JR Woodgett A Klip 1999 Protein kinase B/Akt participitates in Glut4 translocation by insulin in L6 myoblasts Mol Cell Biol 19 4008 4018 1:CAS:528:DyaK1MXjt1yjtb8%3D 10330141
13. SI Itani NB Ruderman S Frank G Boden 2002 Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, Protein kinase C, and IκBα Diabetes 51 2005 2011 10.2337/diabetes.51.7.2005 1:CAS:528:DC%2BD38Xlt1Wls7c%3D 12086926
14. ME Griffin MJ Marcucci GW Cline K Bell N Barucci D Lee LJ Goodyear EW Kraegen MF White GI Shulman 1999 Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin-signaling cascade Diabetes 48 1270 1274 10.2337/diabetes.48.6.1270 1:CAS:528:DyaK1MXjsFSgtr8%3D 10342815 (Pubitemid 29241025)
15. SE Shoelson J Lee AB Goldfine 2006 Inflammation and insulin resistance J Clin Invest 116 1793 1801 10.1172/JCI29069 1:CAS:528:DC%2BD28XmvV2ltLo%3D 16823477
16. S Chung JM Brown JN Provo R Hopkins MK Mclntosh 2005 Conjugated linoleic acid promotes human adipocyte insulin resistance through NFκB-dependent cytokine production J Biol Chem 280 38445 38456 10.1074/jbc.M508159200 1:CAS:528:DC%2BD2MXht1SktL3I 16155293 (Pubitemid 43853742)
17. D Cai M Yuan DF Frantz PA Melendez L Hansen J Lee SE Shoelson 2005 Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB Nat Med 11 183 190 10.1038/nm1166 1:CAS:528: DC%2BD2MXpvF2ntQ%3D%3D 15685173 (Pubitemid 40321354)
18. M Jove A Planavila JC Laguna M Vazquez-Carrera 2005 Palmitate-induced interleukin 6 production is mediated by protein kinase C and Nuclear-factor κB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells Endocrinology 146 3087 3095 10.1210/en.2004-1560 1:CAS:528:DC%2BD2MXlslGhtr4%3D 15802498 (Pubitemid 41002818)
19. D Dey M Mukherjee D Basu M Datta SS Roy A Bandyopadhyay S Bhattacharya 2005 Inhibition of insulin receptor gene expression and insulin signaling by fatty acid: interplay of PKC isoforms therein Cell Physiol Biochem 16 217 228 10.1159/000089847 1:CAS:528:DC%2BD2MXht1agsbfL 16301821 (Pubitemid 41643021)
20. D Dey D Basu SS Roy A Bandyopadhyay S Bhattacharya 2006 Involvement of PKC isoforms in FFA induced defects in insulin signaling Mol Cell Endocrinol 246 60 64 10.1016/j.mce.2005.12.014 1:CAS:528:DC%2BD28XhsF2gtLk%3D 16448741 (Pubitemid 43238397)
21. D Dey A Bhattacharya SS Roy S Bhattacharya 2007 Fatty acid represses insulin receptor gene expression by impairing HMGA1 through protein kinase Cε Biochem Biophys Res Commun 357 474 479 10.1016/j.bbrc.2007.03.183 1:CAS:528:DC%2BD2sXksFeiu70%3D 17434141 (Pubitemid 46628902)
22. P Barma S Bhattacharya A Bhattacharya R Kundu S Dasgupta A Biswas S Bhattacharya SS Roy S Bhattacharya 2009 Lipid induced overexpression of NF-κB in skeletal muscle cells is linked to insulin resistance Biochim Biophys Acta 1792 190 200 1:CAS:528:DC%2BD1MXivVGrs7Y%3D 19111928
23. JM Lehmann LB Moore TA Smith-Oliver WO Wilkison TM Willson SA Kliewer 1995 An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ) J Biol Chem 270 12953 12956 10.1074/jbc.270.50.30221 1:CAS:528:DyaK2MXmtV2itr0%3D 7768881 (Pubitemid 26001700)
24. P Tontonoz E Hu BM Spiegelman 1994 Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor Cell 79 1147 1156 10.1016/0092-8674(94)90006-X 1:STN:280:DyaK2M%2FpsVaqsg%3D%3D 8001151
25. M Lehrke MA Lazar 2005 The many faces of PPARgamma Cell 123 993 999 10.1016/j.cell.2005.11.026 1:CAS:528:DC%2BD28XptVOj 16360030 (Pubitemid 41785415)
26. JP Berger TE Akiyama PT Meinke 2005 PPARs: therapeutic targets for metabolic disease Trends Pharmacol Sci 26 244 251 10.1016/j.tips.2005.03.003 1:CAS:528:DC%2BD2MXjslKhsL8%3D 15860371 (Pubitemid 40603072)
27. RW Nesto D Bell RO Bonow V Fonseca SM Grundy ES Horton M Le Winter D Porte CF Semenkovich S Smith LH Young R Kahn 2003 Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association Circulation 108 2941 2948 10.1161/01.CIR.0000103683.99399.7E 14662691 (Pubitemid 37517824)
28. F Tremblay C Lavigne H Jacques A Marette 2001 Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities Diabetes 50 1901 1910 10.2337/diabetes.50.8.1901 1:CAS:528:DC%2BD3MXlslKmsrk%3D 11473054
29. OH Lowry NJ Rosenbrough AE Farr RJ Randall 1951 Protein measurement with Folin Phenol reagent J Biol Chem 193 265 275 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
30. JD Dignam RM Lebovitz RG Roeder 1983 Accurate transcription initiation by RNA polymerase D in a soluble extract from isolated mammalian nuclei Nucleic Acids Res 11 475 1489
31. GK Toscani EM Chaves FL Cervi MB Tavares IS Silva HE Corleta E Capp 2004 Gene expression and tyrosine kinase activity of insulin receptor in uterine leiomyoma and matched myometrium Arch Gynecol Obstet 270 170 173 10.1007/s00404-003-0534-5 1:CAS:528:DC%2BD2cXptl2hu7o%3D 12937923 (Pubitemid 40394488)
32. F Paonessa D Foti V Costa E Chiefari G Brunetti F Leone F Luciano F Wu AS Lee E Gulletta A Fusco A Brunetti 2006 Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer Cancer Res 66 5085 5093 10.1158/0008-5472.CAN-05-3678 1:CAS:528:DC%2BD28XksF2isr8%3D 16707431 (Pubitemid 43844930)
33. MN Ghazzi JE Perez TK Antonucci JH Driscoll SM Huang BW Faja RW Whitcomb 1997 Cardiac and glycemic benefits of troglitazone treatment in NIDDM: the troglitazone study group Diabetes 46 433 439 10.2337/diabetes.46.3.433 1:CAS:528:DyaK2sXhsVGlur0%3D 9032099
34. DG Maggs TA Buchanan CF Burant G Cline B Gumbiner WA Hsueh S Inzucchi D Kelley J Nolan JM Olefsky KS Polonsky D Silver TR Valiquett GI Shulman 1998 Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus: a randomized, double-blind, placebocontrolled trial Ann Intern Med 128 176 185 1:CAS:528:DyaK1cXhtVahsL8%3D 9454525 (Pubitemid 28078198)
35. AB Mayerson RS Hundal S Dufour V Lebon D Befroy GW Cline S Enocksson SE Inzucchi GI Shulman KF Petersen 2002 The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes Diabetes 51 797 802 10.2337/diabetes.51.3.797 1:CAS:528:DC%2BD38XitFSgsbk%3D 11872682
36. M Stumvoll HU Haring 2002 Glitazones: Clinical effects and molecular mechanisms Ann Med 34 217 224 1:CAS:528:DC%2BD38XmvVahtb0%3D 12173692
37. TM Willson JE Cobb DJ Cowan RW Wiethe ID Correa SR Prakash KD Beck LB Moore SA Kliewer JM Lehmann 1996 The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones J Med Chem 39 665 668 10.1021/jm950395a 1:CAS:528:DyaK28Xjt1Ortw%3D%3D 8576907 (Pubitemid 26065821)
38. P Tontonoz E Hu RA Graves AI Budavari BM Spiegelman 1994 mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer Genes Dev 8 1224 1234 10.1101/gad.8.10.1224 1:CAS:528:DyaK2cXlsFSgsbc%3D 7926726
39. G Martin K Schoonjans AM Lefebvre B Staels J Auwerx 1997 Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPAR-α and PPAR-γ activators J Biol Chem 272 28210 28217 10.1074/jbc.272.45.28210 1:CAS:528:DyaK2sXntlCrsbY%3D 9353271 (Pubitemid 27517759)
40. L Nagy P Tontonoz JG Alvarez H Chen RM Evans 1998 Oxidized LDL regulates macrophage gene expression through activation of PPAR-γ Cell 93 229 240 10.1016/S0092-8674(00)81574-3 1:CAS:528:DyaK1cXivVygt74%3D 9568715 (Pubitemid 28180856)
41. HP Guan Y Li MV Jensen CB Newgard CM Steppan MA Lazar 2002 A futile metabolic cycle activated in adipocytes by antidiabetic agents Nat Med 8 1122 1127 10.1038/nm780 1:CAS:528:DC%2BD38XnsVGrtLY%3D 12357248 (Pubitemid 35175967)
42. AY Cheng IG Fantus 2004 Thiazolidinedione induced congestive heart failure Ann Pharmacother 38 817 820 10.1345/aph.1D400 15039476 (Pubitemid 38509060)
43. A Kermani A Garg 2003 Thiazolidinedione associated congestive heart failure and pulmonary edema Mayo Clin Proc 78 1088 1091 10.4065/78.9.1088 1:CAS:528:DC%2BD3sXns1ertLw%3D 12962163
44. S Aronoff S Rosenblatt S Braithwaite JW Egan AL Mathisen RL Schneider 2000 Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study: the Pioglitazone 001 Study Group Diabetes Care 23 1605 1611 10.2337/diacare.23.11.1605 1:CAS:528: DC%2BD3cXot1ahsrw%3D 11092281
45. LS Phillips G Grunberger E Miller R Patwardhan EB Rappaport A Salzman 2001 Once- and twice-daily dosing with rosiglitazone improves glycemic control in patients with type 2 diabetes Diabetes Care 24 308 315 10.2337/diacare.24.2. 308 1:CAS:528:DC%2BD3MXhtlKhu7o%3D 11213884
46. Y Ikeda GS Olsen E Ziv LL Hansen AK Busch BoF Hansen E Shafrir SL Mostaf 2001 Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus Diabetes 50 584 592 10.2337/diabetes.50.3.584 1:CAS:528: DC%2BD3MXhslGgsrc%3D 11246878
47. K Seedorf M Shearman A Ullrich 1995 Rapid and long term effects of protein kinase C on receptor tyrosine kinase phosphorylation and degradation J Biol Chem 270 18953 18960 10.1074/jbc.270.32.18953 1:CAS:528:DyaK2MXnsVOjurc%3D 7642554
48. VT Samuel ZX Liu A Wang SA Beddow JG Geisler M Kahn X Zhang BP Monia S Bhanot GI Shulman 2007 Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease J Clin Invest 117 739 745 10.1172/JCI30400 1:CAS:528:DC%2BD2sXis12htLo%3D 17318260 (Pubitemid 46348532)
49. D Accili J Drago EJ Lee MD Johnson MH Cool P Salvatore LD Asico PA Jose SI Taylor H Westphal 1996 Early neonatal death in mice homozygous for a null allele of the insulin receptor gene Nat Genet 12 106 109 10.1038/ng0196-106 1:CAS:528:DyaK28XhsV2gtg%3D%3D 8528241 (Pubitemid 26013160)
50. RL Joshi B Lamothe N Cordonnier K Mesbah E Monthioux J Jami D Bucchini 1996 Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality EMBO J 15 1542 1547 1:CAS:528:DyaK28XisVOmtL0%3D 8612577
51. D Foti E Chiefari M Fedele R Iuliano L Brunetti F Paonessa G Manfioletti F Barbetti A Brunetti CM Croce A Fusco A Brunetti 2005 Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice Nat Med 11 765 773 10.1038/nm1254 1:CAS:528:DC%2BD2MXmt1ajurs%3D 15924147 (Pubitemid 41021209)
52. S Sinha G Perdomo NF Brown RM O'Doherty 2004 Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of Nuclear Factor-κB J Biol Chem 279 41294 41301 10.1074/jbc.M406514200 1:CAS:528:DC%2BD2cXnvFWhsb4%3D 15252018 (Pubitemid 39313568)
53. RC Li P Ping J Zhang WB Wead X Cao J Gao Y Zheng S Huang J Han R Bolli 2000 PKCε modulates NF-κB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes Am J Physiol Heart Circ Physiol 279 H1679 H1689 1:CAS:528:DC%2BD3cXns1ehu7k%3D 11009455
54. A Satoh AS Gukovskaya JR Reeve T Shimosegawa SJ Pandol 2006 Ethanol sensitizes NF-κB in pancreatic acinar cells through effects on protein kinase C-ε Am J Physiol Gastrointest Liver Physiol 291 G432 G438 10.1152/ajpgi.00579.2005 1:CAS:528:DC%2BD28XhtVSlu7fL 16574982 (Pubitemid 44330163)