Gene expression and tyrosine kinase activity of insulin receptor in uterine leiomyoma and matched myometrium

Archives of Gynecology and Obstetrics

Volumn 270, Issue 3, 2004, Pages 170-173

  Toscani, Guilherme Kirjner ^a   Chaves, Eunice Martin ^a   Cervi, Fabíola Lara ^a   Tavares, Marcelo Belmonte ^a   Brum Da Silva, Lima Simoni ^a   Von Eye Corleta, Helena ^a,b   Capp, Edison ^a,b,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Clin Gerar Fertilizacao Assistida   (Brazil)

^c NONE   (Brazil)

Author keywords

Insulin receptor; Leiomyoma; Myometrium; Tyrosine kinase

Indexed keywords

INSULIN; INSULIN RECEPTOR; MESSENGER RNA; PROTEIN TYROSINE KINASE; PRIMER DNA;

ARTICLE; AUTOPHOSPHORYLATION; CELL MEMBRANE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; DENSITOMETRY; ENZYME ACTIVITY; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; HYSTERECTOMY; INCUBATION TIME; INFRARED RADIATION; MEDICAL RESEARCH; MYOMETRIUM; OPTICAL DENSITY; OUTCOMES RESEARCH; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; UTERUS MYOMA; WESTERN BLOTTING; CASE CONTROL STUDY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LEIOMYOMA; METABOLISM; PHOSPHORYLATION; UTERUS CANCER;

BLOTTING, WESTERN; CASE-CONTROL STUDIES; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEIOMYOMA; MYOMETRIUM; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTOR, INSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UTERINE NEOPLASMS;

EID: 15444365353     PISSN: 09320067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00404-003-0534-5     Document Type: Article

References (24)

1. Capp E, Brandelli A, Monego H, Ribeiro MF, de Freitas MS, Pureur R, Tortorela H (1996) Binding and tyrosine kinase activity of insulin receptor in human normal and neoplastic endometrium. Med Sci Res 24:621-623
2. Chandrasekhar Y, Heiner J, Osuamkpe C, Nagamani M (1992) Insulin-like growth factor I and II binding in human myometrium and leiomyomas. Am J Obstet Gynecol 166:64-69
3. Cheatham B, Kahn CR (1995) Insulin action and the insulin signaling network. Endocr Rev 16:117-142
4. Corleta HE, Capp E, Corleta OC (1996) Insulin receptor tyrosine kinase activity in colon carcinoma. Braz J Med Biol Res 29:1593-1597
5. De Leo V, la Marca A, Morgante G, Severi FM, Petraglia F (2001) Administration of somatostatin analogue reduces uterine and myoma volume in women with uterine leiomyomata. Fertil Steril 75:632-633
6. Dupont J, LeRoith D (2001) Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction. Horm Res 55 [Suppl 2]:22-26
7. Englund K, Lindblom B, Carlstrom K, Gustavsson I, Sjoblom P, Blanck A (2000) Gene expression and tissue concentrations of IGF-I in human myometrium and fibroids under different hormonal conditions. Mol Hum Reprod 6:915-920
8. Fayed YM, Tsibris JC, Langenberg PW, Robertson AL (1989) Human uterine leiomyoma cells: binding and growth responses to epidermal growth factor, platelet-derived growth factor, and insulin. Lab Invest 60:30-37
9. Giudice LC, Irwin JC, Dsupin BA, Pannier EM, Jin IH, Vu TH (1993) Insulin-like growth factor (IGF), IGF binding protein (IGFBP), and IGF receptor gene expression and IGFBP synthesis in human uterine leiomyomata. Hum Reprod 8:1796-1806
10. Harrison-Woolrych ML, Charnock-Jones DS, Smith SK (1994) Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction. J Clin Endocrinol Metab 78:1179-1184
11. Kellerer M, von Eye Corleta H, Muhlhofer A, Capp E, Mosthaf L, Bock S et al (1995) Insulin- and insulin-like growth-factor-I receptor tyrosine-kinase activities in human renal carcinoma. Int J Cancer 62:501-507
12. Kurachi O, Matsuo H, Samoto T, Maruo T (2001) Tumor necrosis factor-alpha expression in human uterine leiomyoma and its down-regulation by progesterone. J Clin Endocrinol Metab 86:2275-2280
13. Liu HC, He ZY, Tang YX (1997) Simultaneous detection of multiple gene expression in mouse and human individual preimplantation embryos. Fertil Steril 67:733-741
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with folic phenol reagent. J Biol Chem 193:265-275
15. Maruo T, Matsuo H, Samoto T, Shimomura Y, Kurachi O, Gao Z et al (2001) Effects of progesterone on uterine leiomyoma growth and apoptosis. Steroids 65:585-592
16. Moran C, Huerta R, Conway-Myers BA, Hines GA, Azziz R (2001) Altered autophosphorylation of the insulin receptor in the ovary of a woman with polycystic ovary syndrome. Fertil Steril 75:625-628
17. Nagamani M, Stuart CA (1992) Specific binding sites for insulin in the human myometrium and leiomyomas of the uterus. Fertil Steril 58:120-123
18. Pandini G, Vigneri R, Costantino A, Frasca F, Ippolito A, Fujita-Yamaguchi Y et al (1999) Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 5:1935-1944
19. Sale EM, Atkinson PP, Arnott CH, Chad JE, Sale GJ (1999) Role of ERK1/ERK2 and p70S6 K pathway in insulin signalling of protein synthesis. FEBS Lett 446:122-126
20. Seedorf K (1995) Intracellular signaling by growth factors. Metabolism 44:24-32
21. Silva IS, Morsch DM, Urnauer L, Spritzer PM (2001) Androgen-induced cell growth and c-myc expression in human non-transformed epithelial prostatic cells in primary culture. Endocr Res 27:153-169
22. Stewart EA (2001) Uterine fibroids. Lancet 357:293-298
23. Taplin ME, Bubley GJ, Shuster TD, Frantz ME, Spooner AE, Ogata GK et al (1995) Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 332:1393-1398
24. Vollenhoven BJ, Herington AC, Healy DL (1995) Epidermal growth factor and transforming growth factor-beta in uterine fibroids and myometrium. Gynecol Obstet Invest 40:120-124