Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

Nature Medicine

Volumn 11, Issue 7, 2005, Pages 765-773

  Foti, Daniela ^a   Chiefari, Eusebio ^a   Fedele, Monica ^b   Iuliano, Rodolfo ^a   Brunetti, Leonardo ^a   Paonessa, Francesco ^a   Manfioletti, Guidalberto ^c   Barbetti, Fabrizio ^d   Brunetti, Arturo ^b   Croce, Carlo M ^e   Fusco, Alfredo ^b   Brunetti, Antonio ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

^d BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^e THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 4; HIGH MOBILITY GROUP A1 PROTEIN; INSULIN RECEPTOR; NUCLEIC ACID BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASE REPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; GENE MUTATION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GLUCOSE HOMEOSTASIS; HUMAN; IN VITRO STUDY; INSULIN BINDING; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PEDIGREE; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; SIGNAL TRANSDUCTION; WILD TYPE;

3' UNTRANSLATED REGIONS; ADOLESCENT; ADULT; ANIMALS; ANTIGENS, CD; CELLS, CULTURED; CHILD; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HMGA1A PROTEIN; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MALE; MICE; MICE, MUTANT STRAINS; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUTATION; PANCREAS; PEDIGREE; POSITRON-EMISSION TOMOGRAPHY; PREGNANCY PROTEINS; RECEPTOR, INSULIN; RNA STABILITY; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 22544482628     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1254     Document Type: Article

References (33)

1. Kahn, C.R. Insulin action, diabetogenes, and the cause of type II diabetes (Banting Lecture). Diabetes 43, 1066-1084 (1994).
2. Polonsky, K.S., Sturis, J. & Bell G.I. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance. N. Engl. J. Med. 334, 777-783 (1996).
3. Taylor, S.I. Insulin resistance or insulin deficiency: which is the primary cause of NIDDM? Diabetes 43, 735-740 (1994).
4. Goldfine, I.D. The insulin receptor: molecular biology and transmembrane signalling. Endocr. Rev. 8, 235-255 (1987).
5. Taylor, S.I. et al. Mutations in the insulin receptor gene. Endocr. Rev. 13, 566-595 (1992).
6. Bustin, M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol. Cell. Biol. 19, 5237-5246 (1999).
7. Reeves, R., Beckerbauer, L. HMGI/Y proteins: flexible regulators of transcription and chromatin structure. Biochim. Biophys. Acta. 1519, 13-29 (2001).
8. Thanos, D., & Maniatis, T. The high mobility group protein HMG I(Y) is required for NF-kB-dependent virus induction of the human IFN-β gene. Cell 71, 777-789 (1992).
9. Brunetti, A., Manfioletti, G., Chiefari, E., Goldfine, I.D. & Foti, D. Transcriptional regulation of human insulin receptor gene by the high-mobility-group protein HMGI-Y. FASEB J. 15, 492-500 (2001).
10. Foti, D., Iuliano, R., Chiefari, E. & Brunetti, A. A nucleoprotein complex containing Sp1, C/EBPβ, and HMGI-Y controls human insulin receptor gene transcription. Mol. Cell. Biol. 23, 2720-2732 (2003).
11. Brunetti, A., Brunetti, L., Foti, D., Accili, D. & Goldfine, I.D. Human diabetes associated with defects in regulatory proteins for the insulin receptor gene. J. Clin. Invest. 97, 258-262 (1996).
12. Holth, L.T., Thorlacius, A.E. & Reeves, R. Effect of epidermal growth factor and estrogen on the regulation of the HMGI/Y gene in human mammary epithelial cell lines. DNA Cell Biol. 16, 1299-1309 (1997).
13. Borrmann, L., Wilkening, S. & Bullerdiek, J. The expression of HMGA genes is regulated by their 3'UTR. Oncogene 20, 4537-4541 (2001).
14. Kahn, C.R. et al. The syndromes of insulin resistance and acanthosis nigricans. N. Engl. J. Med. 294, 739-745 (1976).
15. Fidanza, V. et al. Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro. Cancer. Res. 56, 1179-1183 (1996).
16. White, M.F. The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem. 182, 3-11 (1998).
17. Saltiel, A.R. & Pessin, J.E. Insulin signaling pathways in time and space. Trends Cell Biol. 12, 65-71 (2002).
18. Cho, H. et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292, 1728-1731 (2001).
19. Bruning, J.C. et al. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 nullalleles. Cell 88, 561-572 (1997).
20. Kulkarni, R.N. et al. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329-339 (1999).
21. Kitamura, T., Kahn, C.R. & Accili, D. Insulin receptor knockout mice. Annu. Rev. Physiol. 65, 313-332 (2003).
22. Shimomura, I. et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell. 6, 77-86 (2000).
23. Rane, S.G. et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia. Nat. Genet. 22, 44-52 (1999).
24. Belke, D.D., Larsen, T.S., Gibbs, E.M., & Severson, D.L. Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter. Am. J. Physiol. Endocrinol. Metab. 280, E420-E427 (2001).
25. Bilan, P.J., Ramlal, T., & Klip, A. IGF-1 mediated recruitment of glucose transporters from intracellular membranes to plasma membranes in L6 muscle cells. Adv. Exp. Med. Biol. 293, 273-288 (1991).
26. Weiland, M. et al. The signaling potential of the receptors for insulin and insulin-like growth factor I (IGF-1) in 3T3-L1 adipocytes: comparison of glucose transport activity, induction of oncogene c-fos, glucose transporter mRNA, and DNA-synthesis. J. Cell. Physiol. 149, 428-435 (1991).
27. Sandhu, M.S. et al. Circulating concentrations of insulin-like growth factor-1 and development of glucose intolerance: a prospective observational study. Lancet. 359, 1740-1745 (2002).
28. Allander, S.V. et al. Hepatic nuclear factor 3 and high mobility group I/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter. Endocrinology. 138, 4291-4300 (1997).
29. Di Cola, G., Cool, M.H., & Accili, D. Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors. J. Clin. Invest. 99, 2538-2544 (1997).
30. Ohneda, K., Mirmira, R.G., Wang, J., Johnson, J.D. & German, M.S. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol. Cell. Biol. 20, 900-911 (2000).
31. Taylor, S.I. Deconstructing type 2 diabetes. Cell 97, 9-12 (1999).
32. Kim, S.K., & Hebrok, M. Intercellular signals regulating pancreas development and function. Genes & Dev. 15, 111-127 (2001).
33. Eizirik, D.L. et al. Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proc. Natl. Acad. Sci. USA. 91, 9253-9256 (1994).