Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer

Cancer Research

Volumn 66, Issue 10, 2006, Pages 5085-5093

  Paonessa, Francesco ^a   Foti, Daniela ^a   Costa, Vanessa ^a   Chiefari, Eusebio ^a   Brunetti, Giuseppe ^c   Leone, Francesco ^b   Luciano, Francesco ^a   Wu, Frank ^d   Lee, Amy S ^d   Gulletta, Elio ^a   Fusco, Alfredo ^e   Brunetti, Antonio ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b PUGLIESE CIACCIO HOSPITAL   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HIGH MOBILITY GROUP A PROTEIN; INSULIN RECEPTOR; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SP1;

ARTICLE; BREAST CANCER; DNA BINDING; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

BREAST NEOPLASMS; CELL LINE, TUMOR; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HMGA1A PROTEIN; HUMANS; PROMOTER REGIONS (GENETICS); RECEPTOR, INSULIN; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP-2;

EID: 33744909111     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3678     Document Type: Article

References (42)

1. Goldfine ID. The insulin receptor: molecular biology and transmembrane signalling. Endocr Rev 1987;8:235-55.
2. Ullrich A, Bell JR, Chen EY, et al. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 1985;313:756-61.
3. White MF, Kahn CR. The insulin signaling system. J Biol Chem 1994;269:1-4.
4. Baserga R. The insulin-like growth factor I receptor: a key to tumor growth. Cancer Res 1995;55:249-52.
5. Yarden Y, Ullrich A. Growth factor receptor tyrosine kinases. Annu Rev Biochem 1988;57:443-78.
6. Massague J, Blinderman LA, Czech MP. The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells. J Biol Chem 1982;257:13958-63.
7. Milazzo G, Giorgino F, Damante G, et al. Insulin receptor expression and function in human breast cancer cell lines. Cancer Res 1992;52:3924-30.
8. Osborne CK, Monaco ME, Lippman ME, Kahn CR. Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture. Cancer Res 1978;38:94-102.
9. Strauss DS. Growth-stimulatory actions of insulin in vitro and in vivo. Endocr Rev 1984;5:356-69.
10. Giorgino F, Belfiore A, Milazzo G, et al. Overexpression of insulin receptor in fibroblast and ovary cells induces a ligand-mediated transformed phenotype. Mol Endocrinol 1991;5:452-9.
11. Brunetti A, Manfioletti G, Chiefari E, Goldfine ID, Foti D. Transcriptional regulation of human insulin receptor gene by the high-mobility-group protein HMG1-Y. FASEB J 2001;15:492-500.
12. Foti D, Iuliano R, Chiefari E, Brunetti A. A nucleo-protein complex containing Sp1, C/EBPβ, and HMG1-Y controls human insulin receptor gene transcription. Mol Cell Biol 2003;23:2720-32.
13. Foti D, Chiefari E, Fedele M, et al. Lack of the architectural factor HMGA1 causes severe insulin resistance and diabetes in humans and mice. Nat Med 2005;11:765-73.
14. Bustin M, Reeves R. High-mobility group proteins: architectural components that facilitates chromatin function. Prog Nucleic Acids Res 1996;54:35-100.
15. Bustin M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol Cell Biol 1999;19:5237-46.
16. Reeves R, Beckerbauer L. HMG1/Y proteins: flexible regulators of transcription and chromatin structure. Biochim Biophys Acta 2001;1519:13-29.
17. Merika M, Thanos D. Enhanceosomes. Curr Opin Genet Dev 2001;11:205-8.
18. Mitchell PJ, Wang C, Tjian R. Positive and negative regulation of transcription in vitro: enhancer binding protein AP-2 is inhibited by SV40 T antigen. Cell 1987;50:847-61.
19. Imagawa M, Chiu R, Karin M. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 1987;51:251-60.
20. Schorle H, Meier P, Buchert M, Jaenisch R, Mitchell PJ. Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature 1996;381:235-8.
21. Nyormoi O, Wang Z, Doan D, Ruiz M, Mcconkey D, Bar-Eli M. Transcription factor AP-2α is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells. Mol Cell Biol 2001;21:4856-67.
22. Turner BC, Zhang J, Gumbs AA, et al. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Res 1998;58:5466-72.
23. Bosher JM, Williams T, Hurst HC. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc Natl Acad Sci U S A 1995;92:744-7.
24. Brunetti A, Foti D, Goldfine ID. Identification of unique nuclear regulatory proteins for the insulin receptor gene, which appear during myocyte and adypocyte differentiation. J Clin Invest 1993;92:1288-95.
25. Wu F, Lee AS. YY1 as a regulator of replication-dependent hamster histone H3.2 promoter and an interactive partner of AP-2. J Biol Chem 2001;276:28-34.
26. Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 1989;77:51-9.
27. Yie J, Merika M, Munshi N, Chen G, Thanos D. The role of HMG1-Y in the assembly and function of the IFN-β enhanceosome. EMBO J 1999;18:3074-89.
28. Papa V, Pezzino V, Costantino A, et al. Elevated insulin receptor content in human breast cancer. J Clin Invest 1990;86:1503-10.
29. Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene 2001;277:63-81.
30. Thanos D, Maniatis T. The high mobility group protein HMG1-Y is required for NF-kappa B-dependent virus induction of the human IFN-β gene. Cell 1992;71:777-89.
31. Lai JS, Herr W. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. Proc Natl Acad Sci U S A 1992;89:6958-62.
32. Benson LQ, Coon MR, Krueger LM, Han GC, Sarnaik AA, Wechsler DS. Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2. J Biol Chem 1999;274:28794-802.
33. Pena P, Reutens AT, Albanese C, et al. Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA. Mol Endocrinol 1999;13:1402-16.
34. Reeves R, Edberg DD, Li Y. Architectural transcription factor HMG1-Y promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol 2001;21:575-94.
35. Liu Y, Zhong X, Li W, Brattain MG, Banerji SS. The role of Sp1 in the differential expression of transforming growth factor-β receptor type II in human breast adenocarcinoma MCF-7 cells. J Biol Chem 2000;275:12231-6.
36. Morishita R, Sugimoto T, Aoki M, et al. In vivo transfection of cis element "decoy" against nuclear factor-kappa B binding site prevents myocardial infarction. Nat Med 1997;3:894-9.
37. Williams T, Tjian R. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev 1991;5:670-82.
38. Gaubatz S, Imhof A, Dosch R, et al. Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J 1995;14:1508-19.
39. Somasundarum K, Jayaraman G, Williams T, Moran E, Frisch S, Thimmapaya B. Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2. Proc Natl Acad Sci U S A 1996;93:3088-93.
40. Seipel K, Georgiev O, Schaffner W. Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions. EMBO J 1992;11:4961-8.
41. Carvalho I, Milanezi F, Martins A, Reis RM, Schmitt F. Overexpression of platelet-derived growth factor receptor α in breast cancer is associated with tumour progression. Breast Cancer Res 2005;7:R788-95.
42. Blanchi ME, Agresti A. HMG proteins: dynamic players in gene regulation and differentiation. Curr Opin Genet Dev 2005;15:496-506.