Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through reactive oxygen species-mediated damage

Molecular Cancer Therapeutics

Volumn 6, Issue 8, 2007, Pages 2178-2187

  Oh, Se Yeong ^a   Sohn, Young Woo ^a   Park, Jong Whi ^a   Park, Hyo Jung ^a   Jeon, Hye Min ^a   Kim, Tae Kyung ^a   Lee, Joong Seob ^a   Jung, Ji Eun ^a   Jin, Xun ^a   Yong, Gu Chung ^b   Choi, Young Ki ^c   You, Seungkwon ^a   Lee, Jang Bo ^b   Kim, Hyunggee ^a  

^a Korea University   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Chungbuk National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; PEPSTATIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CANCER; CANCER CELL; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY TEST; DOSE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; ASTROCYTES; BRAIN NEOPLASMS; CELL DEATH; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOPOSIDE; MICE; MICE, NUDE; ONCOGENE PROTEIN V-AKT; PEPSTATINS; REACTIVE OXYGEN SPECIES; TIME FACTORS; TRANSDUCTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34548101114     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0111     Document Type: Article

References (25)

1. Maher EA, Furnari FB, Bachoo RM, et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001;15:1311-33.
2. Bachoo RM, Maher EA, Ligon KL, et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002;1:269-77.
3. Capdeville R, Buchdunger E, Zimmermann J, Matter A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat Rev Drug Discov 2002;1:493-502.
4. Mokbel K, Hassanally D. From HER2 to Herceptin. Curr Med Res Opin 2001;17:51-9.
5. Shawver LK, Slamon D, Ullrich A. Smart drugs: tyrosine kinase inhibitors in cancer therapy. Cancer Cell 2002;1:117-23.
6. McCarthy KD, de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 1980;85:890-902.
7. Trachootham D, Zhou Y, Zhang H, et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate. Cancer Cell 2006;10:241-52.
8. Ishii N, Maier D, Merlo A, et al. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 1999;9:469-79.
9. Russo T, Zambrano N, Esposito F, et al. A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress. J Biol Chem 1995;270:29386-91.
10. Nohl H, Gille L. Lysosomal ROS formation. Redox Rep 2005;10:199-205.
11. Raymond MA, Mollica L, Vigneault N, et al. Blockade of the apoptotic machinery by cyclosporin A redirects cell death toward necrosis in arterial endothelial cells: regulation by reactive oxygen species and cathepsin D. FASEB J 2003;17:515-7.
12. Demarchi F, Schneider C. The calpain system as a modulator of stress/damage response. Cell Cycle 2007;6:136-8.
13. Hahn WC, Weinberg RA. Modeling the molecular circuitry of cancer. Nat Rev Cancer 2002;2:331-41.
14. Behin A, Hoang-Xuan K, Carpentier AF, Delattre JY. Primary brain tumors in adults. Lancet 2003;361:323-31.
15. Nishikawa R, Furnari FB, Lin H, et al. Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res 1995;55:1941-5.
16. Holland EC. Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2001;2:120-9.
17. Maehama T, Dixon JE. PTEN: a tumour suppressor that functions as a phospholipids phosphatase. Trends Cell Biol 1999;9:125-8.
18. Shimizu S, Kanaseki T, Mizushima N, et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004;6:1221-8.
19. Kim R, Emi M, Tanabe K. Caspase-dependent and -independent cell death pathways after DNA damage. Oncol Rep 2005;14:595-9.
20. Crighton D, Wilkinson S, O'Prey J, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006;126:121-34.
21. Nicotera P, Melino G. Regulation of the apoptosis-necrosis switch. Oncogene 2004;23:2757-65.
22. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996;85:27-37.
23. Downward J. PI3-kinase, Akt, and cell survival. Semin Cell Dev Biol 2004;15:177-82.
24. Irani K, Xia Y, Zweier JL, et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 1997;275:1649-52.
25. 2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem 1998;332:43-50.