메뉴 건너뛰기




Volumn 452, Issue 7187, 2008, Pages 564-570

Enabling personalized cancer medicine through analysis of gene-expression patterns

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

EID: 41649114164     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06915     Document Type: Review
Times cited : (452)

References (50)
  • 1
    • 0032547564 scopus 로고    scopus 로고
    • Polychemotherapy for early breast cancer: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group
    • Early Breast Cancer Trialists' Collaborative Group. Polychemotherapy for early breast cancer: an overview of the randomised trials. Lancet 352, 930-942 (1998).
    • (1998) Lancet , vol.352 , pp. 930-942
  • 2
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene expression patterns with a complementary DNA microarray
    • Schena, M., Shalon, D., Davis, R. W. & Brown, P. O. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270, 467-470 (1995).
    • (1995) Science , vol.270 , pp. 467-470
    • Schena, M.1    Shalon, D.2    Davis, R.W.3    Brown, P.O.4
  • 3
    • 0026108692 scopus 로고
    • Light-directed, spatially addressable parallel chemical synthesis
    • Fodor, S. P., Read, J. L., Pirrung, M. C., Lu, A. T. & Solas, D. Light-directed, spatially addressable parallel chemical synthesis. Science 251, 767-773 (1991).
    • (1991) Science , vol.251 , pp. 767-773
    • Fodor, S.P.1    Read, J.L.2    Pirrung, M.C.3    Lu, A.T.4    Solas, D.5
  • 4
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van 't Veer, L. J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002).
    • (2002) Nature , vol.415 , pp. 530-536
    • van 't Veer, L.J.1
  • 5
    • 20144386127 scopus 로고    scopus 로고
    • Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
    • Chang, H. Y. et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc. Natl Acad. Sci. USA 102, 3738-3743 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 3738-3743
    • Chang, H.Y.1
  • 6
    • 33748093767 scopus 로고    scopus 로고
    • Linking oncogenic pathways with therapeutic opportunities
    • Bild, A. H., Potti, A. & Nevins, J. R. Linking oncogenic pathways with therapeutic opportunities. Nature Rev. Cancer 6, 735-741 (2006).
    • (2006) Nature Rev. Cancer , vol.6 , pp. 735-741
    • Bild, A.H.1    Potti, A.2    Nevins, J.R.3
  • 7
    • 31144459985 scopus 로고    scopus 로고
    • Bild, A. H. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006). This paper shows that the activation status of oncogenic pathways is associated with a characteristic gene-expression signature and that these signatures can be used both to determine a patient's prognosis and to predict his or her response to particular drugs.
    • Bild, A. H. et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439, 353-357 (2006). This paper shows that the activation status of oncogenic pathways is associated with a characteristic gene-expression signature and that these signatures can be used both to determine a patient's prognosis and to predict his or her response to particular drugs.
  • 8
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik, S. et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351, 2817-2826 (2004).
    • (2004) N. Engl. J. Med , vol.351 , pp. 2817-2826
    • Paik, S.1
  • 9
    • 0035375137 scopus 로고    scopus 로고
    • Computational analysis of microarray data
    • Quackenbush, J. Computational analysis of microarray data. Nature Rev. Genet. 2, 418-427 (2001).
    • (2001) Nature Rev. Genet , vol.2 , pp. 418-427
    • Quackenbush, J.1
  • 10
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou, C. M. et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2000).
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 11
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie, T. et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA 98, 10869-10874 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 10869-10874
    • Sorlie, T.1
  • 12
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie, T. et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl Acad. Sci. USA 100, 8418-8423 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8418-8423
    • Sorlie, T.1
  • 13
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • This study shows that previously undetected and clinically significant subtypes of cancer can be identified by molecular classification of tumours on the basis of gene expression
    • Alizadeh, A. A. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503-511 (2000). This study shows that previously undetected and clinically significant subtypes of cancer can be identified by molecular classification of tumours on the basis of gene expression.
    • (2000) Nature , vol.403 , pp. 503-511
    • Alizadeh, A.A.1
  • 14
    • 13844310310 scopus 로고    scopus 로고
    • Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    • Wang, Y. et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365, 671-679 (2005).
    • (2005) Lancet , vol.365 , pp. 671-679
    • Wang, Y.1
  • 15
    • 33645825183 scopus 로고    scopus 로고
    • Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer
    • Ein-Dor, L., Zuk, O. & Domany, E. Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer. Proc. Natl Acad. Sci. USA 103, 5923-5928 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 5923-5928
    • Ein-Dor, L.1    Zuk, O.2    Domany, E.3
  • 16
    • 34250652449 scopus 로고    scopus 로고
    • Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series
    • Desmedt, C. et al. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin. Cancer Res. 13, 3207-3214 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 3207-3214
    • Desmedt, C.1
  • 17
    • 33748693297 scopus 로고    scopus 로고
    • Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer
    • Buyse, M. et al. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J. Natl Cancer Inst. 98, 1183-1192 (2006).
    • (2006) J. Natl Cancer Inst , vol.98 , pp. 1183-1192
    • Buyse, M.1
  • 18
    • 33746910265 scopus 로고    scopus 로고
    • Concordance among gene-expression-based predictors for breast cancer
    • Fan, C. et al. Concordance among gene-expression-based predictors for breast cancer. N. Engl. J. Med. 355, 560-569 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 560-569
    • Fan, C.1
  • 19
    • 36148981192 scopus 로고    scopus 로고
    • Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer
    • doi:10.1186/1471-2407-7-182
    • Yu, J. X. et al. Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer. BMC Cancer 7, 182, doi:10.1186/1471-2407-7-182 (2007).
    • (2007) BMC Cancer , vol.7 , pp. 182
    • Yu, J.X.1
  • 20
    • 33746875641 scopus 로고    scopus 로고
    • A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer
    • Potti, A. et al. A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N. Engl. J. Med. 355, 570-580 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 570-580
    • Potti, A.1
  • 21
    • 33750598939 scopus 로고    scopus 로고
    • The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer
    • Ma, X.-J. et al. The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. J. Clin. Oncol. 24, 4611-4619 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 4611-4619
    • Ma, X.-J.1
  • 22
    • 33947246109 scopus 로고    scopus 로고
    • Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer
    • Harris, L. N. et al. Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin. Cancer Res. 13, 1198-1207 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 1198-1207
    • Harris, L.N.1
  • 23
    • 32944476048 scopus 로고    scopus 로고
    • Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy
    • Dressman, H. K. et al. Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clin. Cancer Res. 12, 819-826 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 819-826
    • Dressman, H.K.1
  • 24
    • 33750727368 scopus 로고    scopus 로고
    • Genomic signatures to guide the use of chemotherapeutics
    • Potti, A. et al. Genomic signatures to guide the use of chemotherapeutics. Nature Med. 12, 1294-1300 (2006).
    • (2006) Nature Med , vol.12 , pp. 1294-1300
    • Potti, A.1
  • 25
    • 0035845531 scopus 로고    scopus 로고
    • Chemosensitivity prediction by transcriptional profiling
    • Staunton, J. E. et al. Chemosensitivity prediction by transcriptional profiling. Proc. Natl Acad. Sci. USA 98, 10787-10792 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 10787-10792
    • Staunton, J.E.1
  • 26
    • 34548799629 scopus 로고    scopus 로고
    • A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
    • Lee, J. K. et al. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc. Natl Acad. Sci. USA 104, 13086-13091 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 13086-13091
    • Lee, J.K.1
  • 27
  • 28
    • 36549068221 scopus 로고    scopus 로고
    • Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: A substudy of the EORTC 10994/BIG 00-01 clinical trial
    • Bonnefoi, H. et al. Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial. Lancet Oncol. 8, 1071-1078 (2007).
    • (2007) Lancet Oncol , vol.8 , pp. 1071-1078
    • Bonnefoi, H.1
  • 29
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Neve, R. M. et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10, 515-527 (2006).
    • (2006) Cancer Cell , vol.10 , pp. 515-527
    • Neve, R.M.1
  • 30
    • 0037941536 scopus 로고    scopus 로고
    • Gene expression phenotypic models that predict the activity of oncogenic pathways
    • Huang, E. et al. Gene expression phenotypic models that predict the activity of oncogenic pathways. Nature Genet. 34, 226-230 (2003).
    • (2003) Nature Genet , vol.34 , pp. 226-230
    • Huang, E.1
  • 31
    • 34250687198 scopus 로고    scopus 로고
    • Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
    • Saal, L. H. et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc. Natl Acad. Sci. USA 104, 7564-7569 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 7564-7569
    • Saal, L.H.1
  • 32
    • 0034616930 scopus 로고    scopus 로고
    • Functional discovery via a compendium of expression profiles
    • Hughes, T. R. et al. Functional discovery via a compendium of expression profiles. Cell 102, 109-126 (2000).
    • (2000) Cell , vol.102 , pp. 109-126
    • Hughes, T.R.1
  • 33
    • 33749335282 scopus 로고    scopus 로고
    • The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease
    • In this study, a compendium of gene-expression profiles of cells subjected to known perturbations was used to find connections among small molecules that share a mechanism of action, between chemicals and physiological processes, and between drugs and diseases
    • Lamb, J. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935 (2006). In this study, a compendium of gene-expression profiles of cells subjected to known perturbations was used to find connections among small molecules that share a mechanism of action, between chemicals and physiological processes, and between drugs and diseases.
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1
  • 34
    • 33749433916 scopus 로고    scopus 로고
    • Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
    • Hieronymus, H. et al. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell 10, 321-330 (2006).
    • (2006) Cancer Cell , vol.10 , pp. 321-330
    • Hieronymus, H.1
  • 35
    • 33749443714 scopus 로고    scopus 로고
    • Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
    • Wei, G. et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell 10, 331-342 (2006).
    • (2006) Cancer Cell , vol.10 , pp. 331-342
    • Wei, G.1
  • 36
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel, C. L. et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J. Clin. Oncol. 20, 719-726 (2002).
    • (2002) J. Clin. Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1
  • 37
    • 35148885729 scopus 로고    scopus 로고
    • Berns, K. et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12, 395-402 (2007). This study used large-scale RNA-interference screens to identify oncogenic pathways that cause resistance to anticancer drugs in the clinic.
    • Berns, K. et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12, 395-402 (2007). This study used large-scale RNA-interference screens to identify oncogenic pathways that cause resistance to anticancer drugs in the clinic.
  • 38
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata, Y. et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6, 117-127 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1
  • 39
    • 34249828179 scopus 로고    scopus 로고
    • Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
    • Swanton, C. et al. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 11, 498-512 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 498-512
    • Swanton, C.1
  • 40
    • 34147198467 scopus 로고    scopus 로고
    • Synthetic lethal screen identification of chemosensitizer loci in cancer cells
    • Whitehurst, A. W. et al. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 446, 815-819 (2007).
    • (2007) Nature , vol.446 , pp. 815-819
    • Whitehurst, A.W.1
  • 41
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921 (2005).
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1
  • 42
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913-917 (2005).
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1
  • 43
    • 33748491517 scopus 로고    scopus 로고
    • The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
    • Shi, L. et al. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nature Biotechnol. 24, 1151-1161 (2006).
    • (2006) Nature Biotechnol , vol.24 , pp. 1151-1161
    • Shi, L.1
  • 44
    • 33750895236 scopus 로고    scopus 로고
    • TAILORx: Trial assigning individualized options for treatment (Rx)
    • Sparano, J. A. TAILORx: trial assigning individualized options for treatment (Rx). Clin. Breast Cancer 7, 347-350 (2006).
    • (2006) Clin. Breast Cancer , vol.7 , pp. 347-350
    • Sparano, J.A.1
  • 45
    • 34249311296 scopus 로고    scopus 로고
    • Individualization of therapy using MammaPrint: From development to the MINDACT Trial
    • Mook, S. et al. Individualization of therapy using MammaPrint: from development to the MINDACT Trial. Cancer Genomics Proteomics 4, 147-155 (2007).
    • (2007) Cancer Genomics Proteomics , vol.4 , pp. 147-155
    • Mook, S.1
  • 46
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver, M. J. et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999-2009 (2002).
    • (2002) N. Engl. J. Med , vol.347 , pp. 1999-2009
    • van de Vijver, M.J.1
  • 47
    • 36849069347 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
    • Harris, L. et al. American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J. Clin. Oncol. 25, 5287-5312 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 5287-5312
    • Harris, L.1
  • 48
    • 0033959550 scopus 로고    scopus 로고
    • Reliability of immunohistochemical demonstration of oestrogen receptors in routine practice: Interlaboratory variance in the sensitivity of detection and evaluation of scoring systems
    • Rhodes, A. et al. Reliability of immunohistochemical demonstration of oestrogen receptors in routine practice: interlaboratory variance in the sensitivity of detection and evaluation of scoring systems. J. Clin. Pathol. 53, 125-130 (2000).
    • (2000) J. Clin. Pathol , vol.53 , pp. 125-130
    • Rhodes, A.1
  • 49
    • 34347395753 scopus 로고    scopus 로고
    • Robust interlaboratory reproducibility of a gene expression signature measurement consistent with the needs of a new generation of diagnostic tools
    • doi:10.1186/1471-2164-8- 148
    • Ach, R. A. et al. Robust interlaboratory reproducibility of a gene expression signature measurement consistent with the needs of a new generation of diagnostic tools. BMC Genomics 8, 148, doi:10.1186/1471-2164-8- 148 (2007).
    • (2007) BMC Genomics , vol.8 , pp. 148
    • Ach, R.A.1
  • 50
    • 18444374426 scopus 로고    scopus 로고
    • Economic analysis of targeting chemotherapy using a 21-gene RT-PCR assay in lymph-node-negative, estrogen-receptor-positive, early-stage breast cancer
    • Hornberger, J., Cosler, L. E. & Lyman, G. H. Economic analysis of targeting chemotherapy using a 21-gene RT-PCR assay in lymph-node-negative, estrogen-receptor-positive, early-stage breast cancer. Am. J. Manag. Care 11, 313-324 (2005).
    • (2005) Am. J. Manag. Care , vol.11 , pp. 313-324
    • Hornberger, J.1    Cosler, L.E.2    Lyman, G.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.