Pharamacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissuse

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 38, 2005, Pages 13604-13609

  Chen, Qi ^a,d   Espey, Michael Graham ^b   Krishna, Murali C ^b   Mitchell, James B ^b   Corpe, Christopher P ^a   Buettner, Garry R ^c   Shaded, Emily ^d   Levine, Mark ^a,e  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Ascorbate radical; Cell death

Indexed keywords

ASCORBIC ACID; HYDROGEN PEROXIDE; METAL CHELATE; PRODRUG; RADICAL; ANTIOXIDANT; FREE RADICAL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER; CANCER CELL CULTURE; CELL DEATH; CELL KILLING; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; INFECTION; LYMPHOMA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM; DOSE RESPONSE; LYMPHOMA; METABOLISM; OXIDATION REDUCTION REACTION; TUMOR CELL LINE;

ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICALS; HUMANS; HYDROGEN PEROXIDE; LYMPHOMA; OXIDATION-REDUCTION; PRODRUGS;

EID: 26444521256     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0506390102     Document Type: Article

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