메뉴 건너뛰기




Volumn 9, Issue 5, 2009, Pages 517-525

Role of oxygen in cancer: Looking beyond hypoxia

Author keywords

Carcinogenesis; Cell proliferation; Glycolysis; HIF 1; Hydrogen peroxide; Metastasis; Reactive oxygen species; Tumor growth

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; REACTIVE OXYGEN METABOLITE;

EID: 67651083751     PISSN: 18715206     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152009788451806     Document Type: Review
Times cited : (26)

References (110)
  • 1
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein, B.; Kinzler, K.W. Cancer genes and the pathways they control. Nat. Med., 2004, 10(8), 789-799.
    • (2004) Nat. Med , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 3
    • 34547135687 scopus 로고    scopus 로고
    • Hypoxia and cancer
    • Semenza, G.L. Hypoxia and cancer. Cancer Metastasis Rev., 2007, 26(2), 223-224.
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.2 , pp. 223-224
    • Semenza, G.L.1
  • 5
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer, 2003, 3(10), 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 6
    • 10644270846 scopus 로고    scopus 로고
    • Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response
    • Vaupel, P.; Harrison, L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist, 2004, 9(5), 4-9.
    • (2004) Oncologist , vol.9 , Issue.5 , pp. 4-9
    • Vaupel, P.1    Harrison, L.2
  • 7
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • Vaupel, P.; Mayer, A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev., 2007, 26(2), 225-239.
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.2 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 8
    • 34447506424 scopus 로고    scopus 로고
    • Detection and characterization of tumor hypoxia using pO2 histography
    • Vaupel, P.; Hockel, M.; Mayer, A. Detection and characterization of tumor hypoxia using pO2 histography. Antioxid. Redox. Signal., 2007, 9(8), 1221-1235.
    • (2007) Antioxid. Redox. Signal , vol.9 , Issue.8 , pp. 1221-1235
    • Vaupel, P.1    Hockel, M.2    Mayer, A.3
  • 9
    • 35148888161 scopus 로고    scopus 로고
    • Life with oxygen
    • Semenza, G.L. Life with oxygen. Science, 2007, 318(5847), 62-64.
    • (2007) Science , vol.318 , Issue.5847 , pp. 62-64
    • Semenza, G.L.1
  • 10
    • 35048875691 scopus 로고    scopus 로고
    • Evaluation of HIF-1 inhibitors as anticancer agents
    • Semenza, G.L. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov. Today, 2007, 12(19-20), 853-859.
    • (2007) Drug Discov. Today , vol.12 , Issue.19-20 , pp. 853-859
    • Semenza, G.L.1
  • 11
    • 33645786505 scopus 로고    scopus 로고
    • Development of novel therapeutic strategies that target HIF-1
    • Semenza, G.L. Development of novel therapeutic strategies that target HIF-1. Expert. Opin. Ther. Targets, 2006, 10(2), 267-280.
    • (2006) Expert. Opin. Ther. Targets , vol.10 , Issue.2 , pp. 267-280
    • Semenza, G.L.1
  • 12
    • 33845984533 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention
    • Lopez-Lazaro, M. Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention. Cancer Epidemiol. Biomarkers Prev., 2006, 15(12), 2332-2335.
    • (2006) Cancer Epidemiol. Biomarkers Prev , vol.15 , Issue.12 , pp. 2332-2335
    • Lopez-Lazaro, M.1
  • 13
    • 34547125574 scopus 로고    scopus 로고
    • Hypoxia, gene expression, and metastasis
    • Chan, D.A.; Giaccia, A.J. Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev., 2007, 26(2), 333-339.
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.2 , pp. 333-339
    • Chan, D.A.1    Giaccia, A.J.2
  • 15
    • 0029859510 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
    • Jiang, B.H.; Semenza, G.L.; Bauer, C.; Marti, H.H. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am. J Physiol., 1996, 271(4), C1172-C1180.
    • (1996) Am. J Physiol , vol.271 , Issue.4
    • Jiang, B.H.1    Semenza, G.L.2    Bauer, C.3    Marti, H.H.4
  • 17
    • 19944429962 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: Correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix
    • Hutchison, G.J.; Valentine, H.R.; Loncaster, J.A.; Davidson, S.E.; Hunter, R.D.; Roberts, S.A.; Harris, A.L.; Stratford, I.J.; Price, P.M.; West, C.M. Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix. Clin. Cancer Res., 2004, 10(24), 8405-8412.
    • (2004) Clin. Cancer Res , vol.10 , Issue.24 , pp. 8405-8412
    • Hutchison, G.J.1    Valentine, H.R.2    Loncaster, J.A.3    Davidson, S.E.4    Hunter, R.D.5    Roberts, S.A.6    Harris, A.L.7    Stratford, I.J.8    Price, P.M.9    West, C.M.10
  • 18
    • 4143118037 scopus 로고    scopus 로고
    • Lack of correlation between expression of HIF-1alpha protein and oxygenation status in identical tissue areas of squamous cell carcinomas of the uterine cervix
    • Mayer, A.; Wree, A.; Hockel, M.; Leo, C.; Pilch, H.; Vaupel, P. Lack of correlation between expression of HIF-1alpha protein and oxygenation status in identical tissue areas of squamous cell carcinomas of the uterine cervix. Cancer Res., 2004, 64(16), 5876-5881.
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5876-5881
    • Mayer, A.1    Wree, A.2    Hockel, M.3    Leo, C.4    Pilch, H.5    Vaupel, P.6
  • 19
    • 17644425583 scopus 로고    scopus 로고
    • Microregional expression of glucose transporter-1 and oxygenation status: Lack of correlation in locally advanced cervical cancers
    • Mayer, A.; Hockel, M.; Wree, A.; Vaupel, P. Microregional expression of glucose transporter-1 and oxygenation status: lack of correlation in locally advanced cervical cancers. Clin. Cancer Res., 2005, 11(7), 2768-2773.
    • (2005) Clin. Cancer Res , vol.11 , Issue.7 , pp. 2768-2773
    • Mayer, A.1    Hockel, M.2    Wree, A.3    Vaupel, P.4
  • 20
    • 27144451824 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix
    • Mayer, A.; Hockel, M.; Vaupel, P. Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix. Clin. Cancer Res., 2005, 11(20), 7220-7225.
    • (2005) Clin. Cancer Res , vol.11 , Issue.20 , pp. 7220-7225
    • Mayer, A.1    Hockel, M.2    Vaupel, P.3
  • 21
    • 84934436127 scopus 로고    scopus 로고
    • Endogenous hypoxia markers: Case not proven
    • Mayer, A.; Hockel, M.; Vaupel, P. Endogenous hypoxia markers: case not proven. Adv. Exp. Med. Biol., 2008, 614(4), 127-136.
    • (2008) Adv. Exp. Med. Biol , vol.614 , Issue.4 , pp. 127-136
    • Mayer, A.1    Hockel, M.2    Vaupel, P.3
  • 22
    • 0037178551 scopus 로고    scopus 로고
    • Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions
    • Zhong, H.; Mabjeesh, N.; Willard, M.; Simons, J. Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions. Cancer Lett., 2002, 181(2), 233-238.
    • (2002) Cancer Lett , vol.181 , Issue.2 , pp. 233-238
    • Zhong, H.1    Mabjeesh, N.2    Willard, M.3    Simons, J.4
  • 23
    • 0035860375 scopus 로고    scopus 로고
    • A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha
    • Haddad, J.J.; Land, S.C. A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. FEBS Lett., 2001, 505(2), 269-274.
    • (2001) FEBS Lett , vol.505 , Issue.2 , pp. 269-274
    • Haddad, J.J.1    Land, S.C.2
  • 24
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Lu, H.; Forbes, R.A.; Verma, A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J. Biol. Chem., 2002, 277(26), 23111-23115.
    • (2002) J. Biol. Chem , vol.277 , Issue.26 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 27
    • 2642542967 scopus 로고    scopus 로고
    • Endogenous 2-oxoacids differentially regulate expression of oxygen sensors
    • Dalgard, C.L.; Lu, H.; Mohyeldin, A.; Verma, A. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem. J., 2004, 380(2), 419-424.
    • (2004) Biochem. J , vol.380 , Issue.2 , pp. 419-424
    • Dalgard, C.L.1    Lu, H.2    Mohyeldin, A.3    Verma, A.4
  • 28
    • 29644442625 scopus 로고    scopus 로고
    • Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
    • Lu, H.; Dalgard, C.; Mohyeldin, A.; McFate, T.; Tait, A.S.; Verma, A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J. Biol. Chem., 2005, 280(51), 41928-41939.
    • (2005) J. Biol. Chem , vol.280 , Issue.51 , pp. 41928-41939
    • Lu, H.1    Dalgard, C.2    Mohyeldin, A.3    McFate, T.4    Tait, A.S.5    Verma, A.6
  • 30
    • 33645080666 scopus 로고    scopus 로고
    • Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: Effect of natural resistance-associated macrophage protein 1
    • Knowles, H.J.; Mole, D.R.; Ratcliffe, P.J.; Harris, A.L. Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. Cancer Res., 2006, 66(5), 2600-2607.
    • (2006) Cancer Res , vol.66 , Issue.5 , pp. 2600-2607
    • Knowles, H.J.1    Mole, D.R.2    Ratcliffe, P.J.3    Harris, A.L.4
  • 31
    • 0026021362 scopus 로고
    • Production of large amounts of hydrogen peroxide by human tumor cells
    • Szatrowski, T.P.; Nathan, C.F. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res., 1991, 51(3), 794-798.
    • (1991) Cancer Res , vol.51 , Issue.3 , pp. 794-798
    • Szatrowski, T.P.1    Nathan, C.F.2
  • 32
    • 34248396033 scopus 로고    scopus 로고
    • Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy
    • Lopez-Lazaro, M. Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy. Cancer Lett., 2007, 252(1), 1-8.
    • (2007) Cancer Lett , vol.252 , Issue.1 , pp. 1-8
    • Lopez-Lazaro, M.1
  • 33
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby, R.A.; Gillies, R.J. Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer, 2004, 4(11), 891-899.
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 34
    • 43549121719 scopus 로고    scopus 로고
    • Lopez-Lazaro, M. The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med. Chem., 2008, 8(3), 305-312.
    • Lopez-Lazaro, M. The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med. Chem., 2008, 8(3), 305-312.
  • 35
    • 34447504549 scopus 로고    scopus 로고
    • Oxygen, a source of life and stress
    • Brahimi-Horn, M.C.; Pouyssegur, J. Oxygen, a source of life and stress. FEBS Lett., 2007, 581(19), 3582-3591.
    • (2007) FEBS Lett , vol.581 , Issue.19 , pp. 3582-3591
    • Brahimi-Horn, M.C.1    Pouyssegur, J.2
  • 37
    • 34547883821 scopus 로고    scopus 로고
    • Lack of correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in non-small cell lung cancer assessed by 18F-Fluoromisonidazole and 18F-FDG PET
    • Cherk, M.H.; Foo, S.S.; Poon, A.M.; Knight, S.R.; Murone, C.; Papenfuss, A.T.; Sachinidis, J.I.; Saunder, T.H.; O'Keefe, G.J.; Scott, A.M. Lack of correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in non-small cell lung cancer assessed by 18F-Fluoromisonidazole and 18F-FDG PET. J. Nucl. Med., 2006, 47(12), 1921-1926.
    • (2006) J. Nucl. Med , vol.47 , Issue.12 , pp. 1921-1926
    • Cherk, M.H.1    Foo, S.S.2    Poon, A.M.3    Knight, S.R.4    Murone, C.5    Papenfuss, A.T.6    Sachinidis, J.I.7    Saunder, T.H.8    O'Keefe, G.J.9    Scott, A.M.10
  • 38
    • 33845609726 scopus 로고    scopus 로고
    • Does hypoxia really control tumor growth?
    • Lopez-Lazaro, M. Does hypoxia really control tumor growth? Cell Oncol., 2006, 28(5-6), 327-329.
    • (2006) Cell Oncol , vol.28 , Issue.5-6 , pp. 327-329
    • Lopez-Lazaro, M.1
  • 40
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • Deberardinis, R.J.; Lum, J.J.; Hatzivassiliou, G.; Thompson, C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab., 2008, 7(1), 11-20.
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 41
    • 0034798178 scopus 로고    scopus 로고
    • Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation
    • Evans, S.M.; Hahn, S.M.; Magarelli, D.P.; Koch, C.J. Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation. Am. J. Clin. Oncol., 2001, 24(5), 467-472.
    • (2001) Am. J. Clin. Oncol , vol.24 , Issue.5 , pp. 467-472
    • Evans, S.M.1    Hahn, S.M.2    Magarelli, D.P.3    Koch, C.J.4
  • 42
    • 0032541838 scopus 로고    scopus 로고
    • ABC of oxygen: Oxygen at high altitude
    • Peacock, A.J. ABC of oxygen: oxygen at high altitude. BMJ, 1998, 317(7165), 1063-1066.
    • (1998) BMJ , vol.317 , Issue.7165 , pp. 1063-1066
    • Peacock, A.J.1
  • 43
    • 0016298348 scopus 로고
    • Correlation of leukemia mortality rates with altitude in the United States
    • Eckhoff, N.D.; Shultis, J.K.; Clack, R.W.; Ramer, E.R. Correlation of leukemia mortality rates with altitude in the United States. Health Phys., 1974, 27(4), 377-380.
    • (1974) Health Phys , vol.27 , Issue.4 , pp. 377-380
    • Eckhoff, N.D.1    Shultis, J.K.2    Clack, R.W.3    Ramer, E.R.4
  • 44
    • 0016680885 scopus 로고
    • Cancer and altitude. Does intracellular pH regulate cell division?
    • Burton, A.C. Cancer and altitude. Does intracellular pH regulate cell division? Eur. J. Cancer, 1975, 11(5), 365-371.
    • (1975) Eur. J. Cancer , vol.11 , Issue.5 , pp. 365-371
    • Burton, A.C.1
  • 45
    • 0020321872 scopus 로고
    • Relationship of site-specific cancer mortality rates to altitude
    • Amsel, J.; Waterbor, J.W.; Oler, J.; Rosenwaike, I.; Marshall, K. Relationship of site-specific cancer mortality rates to altitude. Carcinogenesis, 1982, 3(5), 461-465.
    • (1982) Carcinogenesis , vol.3 , Issue.5 , pp. 461-465
    • Amsel, J.1    Waterbor, J.W.2    Oler, J.3    Rosenwaike, I.4    Marshall, K.5
  • 46
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge, W. Free radicals in the physiological control of cell function. Physiol. Rev., 2002, 82(1), 47-95.
    • (2002) Physiol. Rev , vol.82 , Issue.1 , pp. 47-95
    • Droge, W.1
  • 47
    • 28844473846 scopus 로고    scopus 로고
    • Radical medicine: Treating ageing to cure disease
    • Finkel, T. Radical medicine: treating ageing to cure disease. Nat. Rev. Mol. Cell Biol., 2005, 6(12), 971-976.
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , Issue.12 , pp. 971-976
    • Finkel, T.1
  • 48
    • 0035025124 scopus 로고    scopus 로고
    • Mechanisms of carcinogenesis: Focus on oxidative stress and electron transfer
    • Kovacic, P.; Jacintho, J.D. Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Curr. Med. Chem., 2001, 8(7), 773-796.
    • (2001) Curr. Med. Chem , vol.8 , Issue.7 , pp. 773-796
    • Kovacic, P.1    Jacintho, J.D.2
  • 49
    • 0021964203 scopus 로고
    • Prooxidant states and tumor promotion
    • Cerutti, P.A. Prooxidant states and tumor promotion. Science, 1985, 227(4685), 375-381.
    • (1985) Science , vol.227 , Issue.4685 , pp. 375-381
    • Cerutti, P.A.1
  • 50
    • 0028900690 scopus 로고
    • Persistent oxidative stress in cancer
    • Toyokuni, S.; Okamoto, K.; Yodoi, J.; Hiai, H. Persistent oxidative stress in cancer. FEBS Lett., 1995, 358(1), 1-3.
    • (1995) FEBS Lett , vol.358 , Issue.1 , pp. 1-3
    • Toyokuni, S.1    Okamoto, K.2    Yodoi, J.3    Hiai, H.4
  • 53
    • 32444433202 scopus 로고    scopus 로고
    • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    • Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic, M.; Mazur, M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact., 2006, 160(1), 1-40.
    • (2006) Chem. Biol. Interact , vol.160 , Issue.1 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Izakovic, M.4    Mazur, M.5
  • 54
    • 33846987527 scopus 로고    scopus 로고
    • Excessive superoxide anion generation plays a key role in carcinogenesis
    • Lopez-Lazaro, M. Excessive superoxide anion generation plays a key role in carcinogenesis. Int. J. Cancer, 2007, 120(6), 1378-1380.
    • (2007) Int. J. Cancer , vol.120 , Issue.6 , pp. 1378-1380
    • Lopez-Lazaro, M.1
  • 55
    • 33846331650 scopus 로고    scopus 로고
    • Oxidative stress and cancer: Have we moved forward?
    • Halliwell, B. Oxidative stress and cancer: have we moved forward? Biochem. J., 2007, 401(1), 1-11.
    • (2007) Biochem. J , vol.401 , Issue.1 , pp. 1-11
    • Halliwell, B.1
  • 56
    • 0037376674 scopus 로고    scopus 로고
    • Oxidant signals and oxidative stress
    • Finkel, T. Oxidant signals and oxidative stress. Curr. Opin. Cell Biol., 2003, 15(2), 247-254.
    • (2003) Curr. Opin. Cell Biol , vol.15 , Issue.2 , pp. 247-254
    • Finkel, T.1
  • 58
    • 9944230966 scopus 로고    scopus 로고
    • Cell type-specific effects of asbestos on intracellular ROS levels, DNA oxidation and G1 cell cycle checkpoint
    • Kopnin, P.B.; Kravchenko, I.V.; Furalyov, V.A.; Pylev, L.N.; Kopnin, B.P. Cell type-specific effects of asbestos on intracellular ROS levels, DNA oxidation and G1 cell cycle checkpoint. Oncogene, 2004, 23(54), 8834-8840.
    • (2004) Oncogene , vol.23 , Issue.54 , pp. 8834-8840
    • Kopnin, P.B.1    Kravchenko, I.V.2    Furalyov, V.A.3    Pylev, L.N.4    Kopnin, B.P.5
  • 59
    • 1842585519 scopus 로고    scopus 로고
    • Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells
    • Chou, W.C.; Jie, C.; Kenedy, A.A.; Jones, R.J.; Trush, M.A.; Dang, C.V. Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc. Natl. Acad. Sci. USA, 2004, 101(13), 4578-4583.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.13 , pp. 4578-4583
    • Chou, W.C.1    Jie, C.2    Kenedy, A.A.3    Jones, R.J.4    Trush, M.A.5    Dang, C.V.6
  • 61
    • 0036489192 scopus 로고    scopus 로고
    • UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism
    • Phillipson, R.P.; Tobi, S.E.; Morris, J.A.; McMillan, T.J. UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism. Free Radic. Biol. Med., 2002, 32(5), 474-480.
    • (2002) Free Radic. Biol. Med , vol.32 , Issue.5 , pp. 474-480
    • Phillipson, R.P.1    Tobi, S.E.2    Morris, J.A.3    McMillan, T.J.4
  • 62
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong, G.; Waris, G.; Tanveer, R.; Siddiqui, A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc. Natl. Acad. Sci. USA, 2001, 98(17), 9599-9604.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.17 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 63
    • 6444242588 scopus 로고    scopus 로고
    • Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage
    • Hsieh, Y.H.; Su, I.J.; Wang, H.C.; Chang, W.W.; Lei, H.Y.; Lai, M.D.; Chang, W.T.; Huang, W. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis, 2004, 25(10), 2023-2032.
    • (2004) Carcinogenesis , vol.25 , Issue.10 , pp. 2023-2032
    • Hsieh, Y.H.1    Su, I.J.2    Wang, H.C.3    Chang, W.W.4    Lei, H.Y.5    Lai, M.D.6    Chang, W.T.7    Huang, W.8
  • 64
    • 0029886717 scopus 로고    scopus 로고
    • Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts
    • Yan, T.; Oberley, L.W.; Zhong, W.; St Clair, D.K. Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts. Cancer Res., 1996, 56(12), 2864-2871.
    • (1996) Cancer Res , vol.56 , Issue.12 , pp. 2864-2871
    • Yan, T.1    Oberley, L.W.2    Zhong, W.3    St Clair, D.K.4
  • 65
    • 44449120173 scopus 로고    scopus 로고
    • Epstein-Barr virus induces an oxidative stress during the early stages of infection in B lymphocytes, epithelial, and lymphoblastoid cell lines
    • Lassoued, S.; Ben Ameur, R.; Ayadi, W.; Gargouri, B.; Ben Mansour, R.; Attia, H. Epstein-Barr virus induces an oxidative stress during the early stages of infection in B lymphocytes, epithelial, and lymphoblastoid cell lines. Mol. Cell Biochem., 2008, 313(1-2), 179-186.
    • (2008) Mol. Cell Biochem , vol.313 , Issue.1-2 , pp. 179-186
    • Lassoued, S.1    Ben Ameur, R.2    Ayadi, W.3    Gargouri, B.4    Ben Mansour, R.5    Attia, H.6
  • 66
    • 0036667550 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress
    • Naito, Y.; Yoshikawa, T. Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic. Biol. Med., 2002, 33(3), 323-336.
    • (2002) Free Radic. Biol. Med , vol.33 , Issue.3 , pp. 323-336
    • Naito, Y.1    Yoshikawa, T.2
  • 67
    • 23144461217 scopus 로고    scopus 로고
    • Alcohol, iron-associated oxidative stress, and cancer
    • Petersen, D.R. Alcohol, iron-associated oxidative stress, and cancer. Alcohol, 2005, 35(3), 243-249.
    • (2005) Alcohol , vol.35 , Issue.3 , pp. 243-249
    • Petersen, D.R.1
  • 68
    • 0037093693 scopus 로고    scopus 로고
    • Spin trapping evidence for alcohol-associated oxidative stress
    • Reinke, L.A. Spin trapping evidence for alcohol-associated oxidative stress. Free Radic. Biol. Med., 2002, 32(10), 953-957.
    • (2002) Free Radic. Biol. Med , vol.32 , Issue.10 , pp. 953-957
    • Reinke, L.A.1
  • 70
    • 16844382360 scopus 로고    scopus 로고
    • Increased oxidative stress in children exposed to passive smoking
    • Kosecik, M.; Erel, O.; Sevinc, E.; Selek, S. Increased oxidative stress in children exposed to passive smoking. Int. J. Cardiol., 2005, 100(1), 61-64.
    • (2005) Int. J. Cardiol , vol.100 , Issue.1 , pp. 61-64
    • Kosecik, M.1    Erel, O.2    Sevinc, E.3    Selek, S.4
  • 73
    • 0034626769 scopus 로고    scopus 로고
    • The age of cancer
    • DePinho, R.A. The age of cancer. Nature, 2000, 408(6809), 248-254.
    • (2000) Nature , vol.408 , Issue.6809 , pp. 248-254
    • DePinho, R.A.1
  • 74
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal, R.S.; Weindruch, R. Oxidative stress, caloric restriction, and aging. Science, 1996, 273(5271), 59-63.
    • (1996) Science , vol.273 , Issue.5271 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 76
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. On the origin of cancer cells. Science, 1956, 123(3191), 309-314.
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 78
    • 10744221423 scopus 로고    scopus 로고
    • Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
    • Isidoro, A.; Martinez, M.; Fernandez, P.L.; Ortega, A.D.; Santamaria, G.; Chamorro, M.; Reed, J.C.; Cuezva, J.M. Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer. Biochem. J., 2004, 378(1), 17-20.
    • (2004) Biochem. J , vol.378 , Issue.1 , pp. 17-20
    • Isidoro, A.1    Martinez, M.2    Fernandez, P.L.3    Ortega, A.D.4    Santamaria, G.5    Chamorro, M.6    Reed, J.C.7    Cuezva, J.M.8
  • 80
    • 35448961939 scopus 로고    scopus 로고
    • The Warburg effect and its cancer therapeutic implications
    • Chen, Z.; Lu, W.; Garcia-Prieto, C.; Huang, P. The Warburg effect and its cancer therapeutic implications. J. Bioenerg. Biomembr., 2007, 39(3), 267-274.
    • (2007) J. Bioenerg. Biomembr , vol.39 , Issue.3 , pp. 267-274
    • Chen, Z.1    Lu, W.2    Garcia-Prieto, C.3    Huang, P.4
  • 81
    • 33744457297 scopus 로고    scopus 로고
    • HIF-1: Hypoxia-inducible factor or dysoxia-inducible factor?
    • Lopez-Lazaro, M. HIF-1: Hypoxia-inducible factor or dysoxia-inducible factor? FASEB J., 2006, 20(5), 828-832.
    • (2006) FASEB J , vol.20 , Issue.5 , pp. 828-832
    • Lopez-Lazaro, M.1
  • 82
    • 34247383169 scopus 로고    scopus 로고
    • Why do tumors metastasize?
    • Lopez-Lazaro, M. Why do tumors metastasize? Cancer Biol. Ther., 2007, 6(2), 141-144.
    • (2007) Cancer Biol. Ther , vol.6 , Issue.2 , pp. 141-144
    • Lopez-Lazaro, M.1
  • 83
    • 0034682786 scopus 로고    scopus 로고
    • Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
    • Chandel, N.S.; McClintock, D.S.; Feliciano, C.E.; Wood, T.M.; Melendez, J.A.; Rodriguez, A.M.; Schumacker, P.T. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J. Biol. Chem., 2000, 275(33), 25130-25138.
    • (2000) J. Biol. Chem , vol.275 , Issue.33 , pp. 25130-25138
    • Chandel, N.S.1    McClintock, D.S.2    Feliciano, C.E.3    Wood, T.M.4    Melendez, J.A.5    Rodriguez, A.M.6    Schumacker, P.T.7
  • 86
    • 24144447915 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
    • Mansfield, K.D.; Guzy, R.D.; Pan, Y.; Young, R.M.; Cash, T.P.; Schumacker, P.T.; Simon, M.C. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab., 2005, 1(6), 393-399.
    • (2005) Cell Metab , vol.1 , Issue.6 , pp. 393-399
    • Mansfield, K.D.1    Guzy, R.D.2    Pan, Y.3    Young, R.M.4    Cash, T.P.5    Schumacker, P.T.6    Simon, M.C.7
  • 87
    • 35248871643 scopus 로고    scopus 로고
    • Mitochondrial oxygen sensing: Regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species
    • Bell, E.L.; Chandel, N.S. Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species. Essays Biochem., 2007, 43, 17-27.
    • (2007) Essays Biochem , vol.43 , pp. 17-27
    • Bell, E.L.1    Chandel, N.S.2
  • 90
    • 9344221090 scopus 로고    scopus 로고
    • Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: Quantitative analysis with firefly luciferase-expressing melanoma cells
    • Hyoudou, K.; Nishikawa, M.; Umeyama, Y.; Kobayashi, Y.; Yamashita, F.; Hashida, M. Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: quantitative analysis with firefly luciferase-expressing melanoma cells. Clin. Cancer Res., 2004, 10(22), 7685-7691.
    • (2004) Clin. Cancer Res , vol.10 , Issue.22 , pp. 7685-7691
    • Hyoudou, K.1    Nishikawa, M.2    Umeyama, Y.3    Kobayashi, Y.4    Yamashita, F.5    Hashida, M.6
  • 92
    • 33646843717 scopus 로고    scopus 로고
    • Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes
    • Nishikawa, M.; Hashida, M. Inhibition of tumour metastasis by targeted delivery of antioxidant enzymes. Expert. Opin. Drug Deliv., 2006, 3(3), 355-369.
    • (2006) Expert. Opin. Drug Deliv , vol.3 , Issue.3 , pp. 355-369
    • Nishikawa, M.1    Hashida, M.2
  • 93
    • 0034646080 scopus 로고    scopus 로고
    • Microsatellite instability induced by hydrogen peroxide in Escherichia coli
    • Jackson, A.L.; Loeb, L.A. Microsatellite instability induced by hydrogen peroxide in Escherichia coli. Mutat. Res., 2000, 447(2), 187-198.
    • (2000) Mutat. Res , vol.447 , Issue.2 , pp. 187-198
    • Jackson, A.L.1    Loeb, L.A.2
  • 94
    • 21544465580 scopus 로고    scopus 로고
    • Substantial DNA damage from sub-micromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli
    • Park, S.; You, X.; Imlay, J.A. Substantial DNA damage from sub-micromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli. Proc. Natl. Acad. Sci. USA, 2005, 102(26), 9317-9322.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.26 , pp. 9317-9322
    • Park, S.1    You, X.2    Imlay, J.A.3
  • 97
    • 0029837398 scopus 로고    scopus 로고
    • Transformation in vitro of a nontumorigenic rat urothelial cell line by hydrogen peroxide
    • Okamoto, M.; Kawai, K.; Reznikoff, C.A.; Oyasu, R. Transformation in vitro of a nontumorigenic rat urothelial cell line by hydrogen peroxide. Cancer Res., 1996, 56(20), 4649-4653.
    • (1996) Cancer Res , vol.56 , Issue.20 , pp. 4649-4653
    • Okamoto, M.1    Kawai, K.2    Reznikoff, C.A.3    Oyasu, R.4
  • 98
    • 0030963342 scopus 로고    scopus 로고
    • Tumorigenic conversion of a non-tumorigenic rat urothelial cell line by overexpression of H2O2-generating peroxisomal fatty acyl-CoA oxidase
    • Okamoto, M.; Reddy, J.K.; Oyasu, R. Tumorigenic conversion of a non-tumorigenic rat urothelial cell line by overexpression of H2O2-generating peroxisomal fatty acyl-CoA oxidase. Int. J. Cancer, 1997, 70(6), 716-721.
    • (1997) Int. J. Cancer , vol.70 , Issue.6 , pp. 716-721
    • Okamoto, M.1    Reddy, J.K.2    Oyasu, R.3
  • 99
    • 41749114288 scopus 로고    scopus 로고
    • Autophagy: Basic principles and relevance to disease
    • Kundu, M.; Thompson, C.B. Autophagy: basic principles and relevance to disease. Annu. Rev. Pathol., 2008, 3, 427-455.
    • (2008) Annu. Rev. Pathol , vol.3 , pp. 427-455
    • Kundu, M.1    Thompson, C.B.2
  • 100
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine, B.; Kroemer, G. Autophagy in the pathogenesis of disease. Cell, 2008, 132(1), 27-42.
    • (2008) Cell , vol.132 , Issue.1 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 101
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima, N.; Levine, B.; Cuervo, A.M.; Klionsky, D.J. Autophagy fights disease through cellular self-digestion. Nature, 2008, 451(7182), 1069-1075.
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 103
    • 35248828654 scopus 로고    scopus 로고
    • Hypoxia in cancer cell metabolism and pH regulation
    • Brahimi-Horn, M.C.; Pouyssegur, J. Hypoxia in cancer cell metabolism and pH regulation. Essays Biochem., 2007, 43, 165-178.
    • (2007) Essays Biochem , vol.43 , pp. 165-178
    • Brahimi-Horn, M.C.1    Pouyssegur, J.2
  • 104
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout, J.A.; Patel, S.A.; Simon, M.C. The impact of O2 availability on human cancer. Nat. Rev. Cancer, 2008, 8(12), 967-975.
    • (2008) Nat. Rev. Cancer , vol.8 , Issue.12 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 105
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown, J.M.; Wilson, W.R. Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer, 2004, 4(6), 437-447.
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.6 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 106
    • 26444521256 scopus 로고    scopus 로고
    • Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a prodrug to deliver hydrogen peroxide to tissues
    • Chen, Q.; Espey, M.G.; Krishna, M.C.; Mitchell, J.B.; Corpe, C.P.; Buettner, G.R.; Shacter, E.; Levine, M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a prodrug to deliver hydrogen peroxide to tissues. Proc. Natl. Acad. Sci. USA, 2005, 102(38), 13604-13609.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.38 , pp. 13604-13609
    • Chen, Q.1    Espey, M.G.2    Krishna, M.C.3    Mitchell, J.B.4    Corpe, C.P.5    Buettner, G.R.6    Shacter, E.7    Levine, M.8
  • 107
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • Pelicano, H.; Martin, D.S.; Xu, R.H.; Huang, P. Glycolysis inhibition for anticancer treatment. Oncogene, 2006, 25(34), 4633-4646.
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 108
    • 34547754022 scopus 로고    scopus 로고
    • Digitoxin as an anticancer agent with selectivity for cancer cells: Possible mechanisms involved
    • Lopez-Lazaro, M. Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved. Expert. Opin. Ther. Targets, 2007, 11(8), 1043-1053.
    • (2007) Expert. Opin. Ther. Targets , vol.11 , Issue.8 , pp. 1043-1053
    • Lopez-Lazaro, M.1
  • 110
    • 35248824187 scopus 로고    scopus 로고
    • Oxygen sensing and hypoxia-induced responses
    • Coleman, M.L.; Ratcliffe, P.J. Oxygen sensing and hypoxia-induced responses. Essays Biochem., 2007, 43, 1-15.
    • (2007) Essays Biochem , vol.43 , pp. 1-15
    • Coleman, M.L.1    Ratcliffe, P.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.