메뉴 건너뛰기




Volumn 252, Issue 1, 2007, Pages 1-8

Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy

Author keywords

Antioxidant; Apoptosis; Carcinogenesis; Hypoxia inducible factor; Prooxidant; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1;

EID: 34248396033     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2006.10.029     Document Type: Review
Times cited : (614)

References (104)
  • 1
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82 (2002) 47-95
    • (2002) Physiol. Rev. , vol.82 , pp. 47-95
    • Droge, W.1
  • 2
    • 0028918334 scopus 로고
    • Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
    • Burdon R.H. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med. 18 (1995) 775-794
    • (1995) Free Radic. Biol. Med. , vol.18 , pp. 775-794
    • Burdon, R.H.1
  • 3
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban R.S., Nemoto S., and Finkel T. Mitochondria, oxidants, and aging. Cell 120 (2005) 483-495
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 4
    • 0036911138 scopus 로고    scopus 로고
    • Hydrogen peroxide as second messenger in lymphocyte activation
    • Reth M. Hydrogen peroxide as second messenger in lymphocyte activation. Nat. Immunol. 3 (2002) 1129-1134
    • (2002) Nat. Immunol. , vol.3 , pp. 1129-1134
    • Reth, M.1
  • 5
    • 33744457297 scopus 로고    scopus 로고
    • HIF-1: Hypoxia-inducible factor or Dysoxia-inducible factor?
    • Lopez-Lazaro M. HIF-1: Hypoxia-inducible factor or Dysoxia-inducible factor?. FASEB J. 20 (2006) 828-832
    • (2006) FASEB J. , vol.20 , pp. 828-832
    • Lopez-Lazaro, M.1
  • 8
    • 0027931870 scopus 로고
    • Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase
    • Safford S.E., Oberley T.D., Urano M., and St Clair D.K. Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. Cancer Res. 54 (1994) 4261-4265
    • (1994) Cancer Res. , vol.54 , pp. 4261-4265
    • Safford, S.E.1    Oberley, T.D.2    Urano, M.3    St Clair, D.K.4
  • 9
    • 0029886717 scopus 로고    scopus 로고
    • Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts
    • Yan T., Oberley L.W., Zhong W., and St Clair D.K. Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts. Cancer Res. 56 (1996) 2864-2871
    • (1996) Cancer Res. , vol.56 , pp. 2864-2871
    • Yan, T.1    Oberley, L.W.2    Zhong, W.3    St Clair, D.K.4
  • 10
    • 0036170568 scopus 로고    scopus 로고
    • Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth
    • Zhang Y., Zhao W., Zhang H.J., Domann F.E., and Oberley L.W. Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. Cancer Res. 62 (2002) 1205-1212
    • (2002) Cancer Res. , vol.62 , pp. 1205-1212
    • Zhang, Y.1    Zhao, W.2    Zhang, H.J.3    Domann, F.E.4    Oberley, L.W.5
  • 11
    • 3743050370 scopus 로고    scopus 로고
    • Inhibition of AP-1 and NF-kappaB by manganese-containing superoxide dismutase in human breast cancer cells
    • Li J.J., Oberley L.W., Fan M., and Colburn N.H. Inhibition of AP-1 and NF-kappaB by manganese-containing superoxide dismutase in human breast cancer cells. FASEB J. 12 (1998) 1713-1723
    • (1998) FASEB J. , vol.12 , pp. 1713-1723
    • Li, J.J.1    Oberley, L.W.2    Fan, M.3    Colburn, N.H.4
  • 12
    • 0033572554 scopus 로고    scopus 로고
    • Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype
    • Zhang H.J., Yan T., Oberley T.D., and Oberley L.W. Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res. 59 (1999) 6276-6283
    • (1999) Cancer Res. , vol.59 , pp. 6276-6283
    • Zhang, H.J.1    Yan, T.2    Oberley, T.D.3    Oberley, L.W.4
  • 14
    • 0034660880 scopus 로고    scopus 로고
    • The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase
    • Li S., Yan T., Yang J.Q., Oberley T.D., and Oberley L.W. The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res. 60 (2000) 3927-3939
    • (2000) Cancer Res. , vol.60 , pp. 3927-3939
    • Li, S.1    Yan, T.2    Yang, J.Q.3    Oberley, T.D.4    Oberley, L.W.5
  • 15
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat. Med. 10 (2004) 789-799
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 17
    • 7044264244 scopus 로고    scopus 로고
    • The somatic mutation theory of cancer: growing problems with the paradigm?
    • Soto A.M., and Sonnenschein C. The somatic mutation theory of cancer: growing problems with the paradigm?. Bioessays 26 (2004) 1097-1107
    • (2004) Bioessays , vol.26 , pp. 1097-1107
    • Soto, A.M.1    Sonnenschein, C.2
  • 18
    • 0037805151 scopus 로고    scopus 로고
    • Untangling the roots of cancer
    • Gibbs W.W. Untangling the roots of cancer. Sci. Am. 289 (2003) 56-65
    • (2003) Sci. Am. , vol.289 , pp. 56-65
    • Gibbs, W.W.1
  • 19
    • 0347379799 scopus 로고    scopus 로고
    • Epigenetic theories of cancer initiation
    • Jaffe L.F. Epigenetic theories of cancer initiation. Adv. Cancer Res. 90 (2003) 209-230
    • (2003) Adv. Cancer Res. , vol.90 , pp. 209-230
    • Jaffe, L.F.1
  • 20
    • 0028172057 scopus 로고
    • Cancers beget mutations versus mutations beget cancers
    • Prehn R.T. Cancers beget mutations versus mutations beget cancers. Cancer Res. 54 (1994) 5296-5300
    • (1994) Cancer Res. , vol.54 , pp. 5296-5300
    • Prehn, R.T.1
  • 22
    • 11844262086 scopus 로고    scopus 로고
    • Does aneuploidy or mutation start cancer?
    • Duesberg P. Does aneuploidy or mutation start cancer?. Science 307 (2005) 41
    • (2005) Science , vol.307 , pp. 41
    • Duesberg, P.1
  • 23
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 123 (1956) 309-314
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 24
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 25
    • 0037079003 scopus 로고    scopus 로고
    • Rules for making human tumor cells
    • Hahn W.C., and Weinberg R.A. Rules for making human tumor cells. N. Engl. J. Med. 347 (2002) 1593-1603
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1593-1603
    • Hahn, W.C.1    Weinberg, R.A.2
  • 26
    • 21544465580 scopus 로고    scopus 로고
    • Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli
    • Park S., You X., and Imlay J.A. Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli. Proc. Natl. Acad. Sci. USA 102 (2005) 9317-9322
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 9317-9322
    • Park, S.1    You, X.2    Imlay, J.A.3
  • 27
    • 0032170014 scopus 로고    scopus 로고
    • Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress
    • Hunt C.R., Sim J.E., Sullivan S.J., Featherstone T., Golden W., Kapp-Herr C., et al. Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Res. 58 (1998) 3986-3992
    • (1998) Cancer Res. , vol.58 , pp. 3986-3992
    • Hunt, C.R.1    Sim, J.E.2    Sullivan, S.J.3    Featherstone, T.4    Golden, W.5    Kapp-Herr, C.6
  • 28
    • 0034646080 scopus 로고    scopus 로고
    • Microsatellite instability induced by hydrogen peroxide in Escherichia coli
    • Jackson A.L., and Loeb L.A. Microsatellite instability induced by hydrogen peroxide in Escherichia coli. Mutat. Res. 447 (2000) 187-198
    • (2000) Mutat. Res. , vol.447 , pp. 187-198
    • Jackson, A.L.1    Loeb, L.A.2
  • 29
    • 0036334551 scopus 로고    scopus 로고
    • Short-sequence tandem and nontandem DNA repeats and endogenous hydrogen peroxide production contribute to genetic instability of Streptococcus pneumoniae
    • Pericone C.D., Bae D., Shchepetov M., McCool T., and Weiser J.N. Short-sequence tandem and nontandem DNA repeats and endogenous hydrogen peroxide production contribute to genetic instability of Streptococcus pneumoniae. J. Bacteriol. 184 (2002) 4392-4399
    • (2002) J. Bacteriol. , vol.184 , pp. 4392-4399
    • Pericone, C.D.1    Bae, D.2    Shchepetov, M.3    McCool, T.4    Weiser, J.N.5
  • 30
    • 0030797051 scopus 로고    scopus 로고
    • Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide
    • Henle E.S., and Linn S. Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide. J. Biol. Chem. 272 (1997) 19095-19098
    • (1997) J. Biol. Chem. , vol.272 , pp. 19095-19098
    • Henle, E.S.1    Linn, S.2
  • 31
    • 0023886170 scopus 로고
    • DNA damage and oxygen radical toxicity
    • Imlay J.A., and Linn S. DNA damage and oxygen radical toxicity. Science 240 (1988) 1302-1309
    • (1988) Science , vol.240 , pp. 1302-1309
    • Imlay, J.A.1    Linn, S.2
  • 32
    • 0036889886 scopus 로고    scopus 로고
    • Adenoviral-mediated overexpression of catalase inhibits endothelial cell proliferation
    • Zanetti M., Katusic Z.S., and O'Brien T. Adenoviral-mediated overexpression of catalase inhibits endothelial cell proliferation. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H2620-H2626
    • (2002) Am. J. Physiol. Heart Circ. Physiol. , vol.283
    • Zanetti, M.1    Katusic, Z.S.2    O'Brien, T.3
  • 33
    • 28844472313 scopus 로고    scopus 로고
    • Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene
    • Polytarchou C., Hatziapostolou M., and Papadimitriou E. Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene. J. Biol. Chem. 280 (2005) 40428-40435
    • (2005) J. Biol. Chem. , vol.280 , pp. 40428-40435
    • Polytarchou, C.1    Hatziapostolou, M.2    Papadimitriou, E.3
  • 34
    • 0033578905 scopus 로고    scopus 로고
    • Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells
    • Brown M.R., Miller Jr. F.J., Li W.G., Ellingson A.N., Mozena J.D., Chatterjee P., et al. Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells. Circ. Res. 85 (1999) 524-533
    • (1999) Circ. Res. , vol.85 , pp. 524-533
    • Brown, M.R.1    Miller Jr., F.J.2    Li, W.G.3    Ellingson, A.N.4    Mozena, J.D.5    Chatterjee, P.6
  • 35
    • 0032905740 scopus 로고    scopus 로고
    • Hydrogen peroxide produced during gamma-glutamyl transpeptidase activity is involved in prevention of apoptosis and maintainance of proliferation in U937 cells
    • del Bello B., Paolicchi A., Comporti M., Pompella A., and Maellaro E. Hydrogen peroxide produced during gamma-glutamyl transpeptidase activity is involved in prevention of apoptosis and maintainance of proliferation in U937 cells. FASEB J. 13 (1999) 69-79
    • (1999) FASEB J. , vol.13 , pp. 69-79
    • del Bello, B.1    Paolicchi, A.2    Comporti, M.3    Pompella, A.4    Maellaro, E.5
  • 36
    • 0038182533 scopus 로고    scopus 로고
    • Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis
    • Qian Y., Luo J., Leonard S.S., Harris G.K., Millecchia L., Flynn D.C., and Shi X. Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis. J. Biol. Chem. 278 (2003) 16189-16197
    • (2003) J. Biol. Chem. , vol.278 , pp. 16189-16197
    • Qian, Y.1    Luo, J.2    Leonard, S.S.3    Harris, G.K.4    Millecchia, L.5    Flynn, D.C.6    Shi, X.7
  • 38
    • 0042849142 scopus 로고    scopus 로고
    • Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis
    • Nelson K.K., Ranganathan A.C., Mansouri J., Rodriguez A.M., Providence K.M., Rutter J.L., et al. Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis. Clin. Cancer Res. 9 (2003) 424-432
    • (2003) Clin. Cancer Res. , vol.9 , pp. 424-432
    • Nelson, K.K.1    Ranganathan, A.C.2    Mansouri, J.3    Rodriguez, A.M.4    Providence, K.M.5    Rutter, J.L.6
  • 40
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 41
    • 33645786505 scopus 로고    scopus 로고
    • Development of novel therapeutic strategies that target HIF-1
    • Semenza G.L. Development of novel therapeutic strategies that target HIF-1. Expert. Opin. Ther. Targets 10 (2006) 267-280
    • (2006) Expert. Opin. Ther. Targets , vol.10 , pp. 267-280
    • Semenza, G.L.1
  • 42
    • 2942709631 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT)
    • Nishi H., Nakada T., Kyo S., Inoue M., Shay J.W., and Isaka K. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol. Cell Biol. 24 (2004) 6076-6083
    • (2004) Mol. Cell Biol. , vol.24 , pp. 6076-6083
    • Nishi, H.1    Nakada, T.2    Kyo, S.3    Inoue, M.4    Shay, J.W.5    Isaka, K.6
  • 43
    • 2442688089 scopus 로고    scopus 로고
    • HIF-1-mediated activation of telomerase in cervical cancer cells
    • Yatabe N., Kyo S., Maida Y., Nishi H., Nakamura M., Kanaya T., et al. HIF-1-mediated activation of telomerase in cervical cancer cells. Oncogene 23 (2004) 3708-3715
    • (2004) Oncogene , vol.23 , pp. 3708-3715
    • Yatabe, N.1    Kyo, S.2    Maida, Y.3    Nishi, H.4    Nakamura, M.5    Kanaya, T.6
  • 44
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59 (1999) 5830-5835
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3    Lim, M.4    Hilton, D.A.5    Zagzag, D.6
  • 46
    • 0035860375 scopus 로고    scopus 로고
    • A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha
    • Haddad J.J., and Land S.C. A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. FEBS Lett. 505 (2001) 269-274
    • (2001) FEBS Lett. , vol.505 , pp. 269-274
    • Haddad, J.J.1    Land, S.C.2
  • 48
    • 24144493814 scopus 로고    scopus 로고
    • Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    • Guzy R.D., Hoyos B., Robin E., Chen H., Liu L., Mansfield K.D., et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 1 (2005) 401-408
    • (2005) Cell Metab. , vol.1 , pp. 401-408
    • Guzy, R.D.1    Hoyos, B.2    Robin, E.3    Chen, H.4    Liu, L.5    Mansfield, K.D.6
  • 49
    • 24144447915 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
    • Mansfield K.D., Guzy R.D., Pan Y., Young R.M., Cash T.P., Schumacker P.T., and Simon M.C. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab. 1 (2005) 393-399
    • (2005) Cell Metab. , vol.1 , pp. 393-399
    • Mansfield, K.D.1    Guzy, R.D.2    Pan, Y.3    Young, R.M.4    Cash, T.P.5    Schumacker, P.T.6    Simon, M.C.7
  • 50
    • 0026021362 scopus 로고
    • Production of large amounts of hydrogen peroxide by human tumor cells
    • Szatrowski T.P., and Nathan C.F. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51 (1991) 794-798
    • (1991) Cancer Res. , vol.51 , pp. 794-798
    • Szatrowski, T.P.1    Nathan, C.F.2
  • 51
    • 0033856835 scopus 로고    scopus 로고
    • Comparison of hydrogen peroxide generation and the content of lipid peroxidation products in lung cancer tissue and pulmonary parenchyma
    • Zieba M., Suwalski M., Kwiatkowska S., Piasecka G., Grzelewska-Rzymowska I., Stolarek R., and Nowak D. Comparison of hydrogen peroxide generation and the content of lipid peroxidation products in lung cancer tissue and pulmonary parenchyma. Respir. Med. 94 (2000) 800-805
    • (2000) Respir. Med. , vol.94 , pp. 800-805
    • Zieba, M.1    Suwalski, M.2    Kwiatkowska, S.3    Piasecka, G.4    Grzelewska-Rzymowska, I.5    Stolarek, R.6    Nowak, D.7
  • 53
    • 0029837398 scopus 로고    scopus 로고
    • Transformation in vitro of a nontumorigenic rat urothelial cell line by hydrogen peroxide
    • Okamoto M., Kawai K., Reznikoff C.A., and Oyasu R. Transformation in vitro of a nontumorigenic rat urothelial cell line by hydrogen peroxide. Cancer Res. 56 (1996) 4649-4653
    • (1996) Cancer Res. , vol.56 , pp. 4649-4653
    • Okamoto, M.1    Kawai, K.2    Reznikoff, C.A.3    Oyasu, R.4
  • 54
    • 0033517275 scopus 로고    scopus 로고
    • Cell transformation by the superoxide-generating oxidase Mox1
    • Suh Y.A., Arnold R.S., Lassegue B., Shi J., Xu X., Sorescu D., et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401 (1999) 79-82
    • (1999) Nature , vol.401 , pp. 79-82
    • Suh, Y.A.1    Arnold, R.S.2    Lassegue, B.3    Shi, J.4    Xu, X.5    Sorescu, D.6
  • 55
    • 0035826733 scopus 로고    scopus 로고
    • Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
    • Arnold R.S., Shi J., Murad E., Whalen A.M., Sun C.Q., Polavarapu R., et al. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc. Natl. Acad. Sci. USA 98 (2001) 5550-5555
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5550-5555
    • Arnold, R.S.1    Shi, J.2    Murad, E.3    Whalen, A.M.4    Sun, C.Q.5    Polavarapu, R.6
  • 57
    • 0842282482 scopus 로고    scopus 로고
    • Imbalance of antioxidant enzymes in tumor cells and inhibition of proliferation and malignant features by scavenging hydrogen peroxide
    • Policastro L., Molinari B., Larcher F., Blanco P., Podhajcer O.L., Costa C.S., et al. Imbalance of antioxidant enzymes in tumor cells and inhibition of proliferation and malignant features by scavenging hydrogen peroxide. Mol. Carcinog. 39 (2004) 103-113
    • (2004) Mol. Carcinog. , vol.39 , pp. 103-113
    • Policastro, L.1    Molinari, B.2    Larcher, F.3    Blanco, P.4    Podhajcer, O.L.5    Costa, C.S.6
  • 59
    • 7444223594 scopus 로고    scopus 로고
    • Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells
    • Ahmad K.A., Iskandar K.B., Hirpara J.L., Clement M.V., and Pervaiz S. Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells. Cancer Res. 64 (2004) 7867-7878
    • (2004) Cancer Res. , vol.64 , pp. 7867-7878
    • Ahmad, K.A.1    Iskandar, K.B.2    Hirpara, J.L.3    Clement, M.V.4    Pervaiz, S.5
  • 60
    • 0035808388 scopus 로고    scopus 로고
    • Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells
    • Hirpara J.L., Clement M.V., and Pervaiz S. Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J. Biol. Chem. 276 (2001) 514-521
    • (2001) J. Biol. Chem. , vol.276 , pp. 514-521
    • Hirpara, J.L.1    Clement, M.V.2    Pervaiz, S.3
  • 61
    • 0242524405 scopus 로고    scopus 로고
    • Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria
    • Clement M.V., Hirpara J.L., and Pervaiz S. Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria. Cell Death Differ. 10 (2003) 1273-1285
    • (2003) Cell Death Differ. , vol.10 , pp. 1273-1285
    • Clement, M.V.1    Hirpara, J.L.2    Pervaiz, S.3
  • 63
    • 0033568238 scopus 로고    scopus 로고
    • Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
    • Jing Y., Dai J., Chalmers-Redman R.M., Tatton W.G., and Waxman S. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 94 (1999) 2102-2111
    • (1999) Blood , vol.94 , pp. 2102-2111
    • Jing, Y.1    Dai, J.2    Chalmers-Redman, R.M.3    Tatton, W.G.4    Waxman, S.5
  • 64
    • 12844275026 scopus 로고    scopus 로고
    • Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
    • Mizutani H., Tada-Oikawa S., Hiraku Y., Kojima M., and Kawanishi S. Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide. Life Sci. 76 (2005) 1439-1453
    • (2005) Life Sci. , vol.76 , pp. 1439-1453
    • Mizutani, H.1    Tada-Oikawa, S.2    Hiraku, Y.3    Kojima, M.4    Kawanishi, S.5
  • 66
    • 33646517942 scopus 로고    scopus 로고
    • Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo
    • Alexandre J., Batteux F., Nicco C., Chereau C., Laurent A., Guillevin L., et al. Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int. J. Cancer 119 (2006) 41-48
    • (2006) Int. J. Cancer , vol.119 , pp. 41-48
    • Alexandre, J.1    Batteux, F.2    Nicco, C.3    Chereau, C.4    Laurent, A.5    Guillevin, L.6
  • 67
    • 0037334443 scopus 로고    scopus 로고
    • Differential effects of catalase on apoptosis induction in human promonocytic cells. Relationships with heat-shock protein expression
    • Sancho P., Troyano A., Fernandez C., De Blas E., and Aller P. Differential effects of catalase on apoptosis induction in human promonocytic cells. Relationships with heat-shock protein expression. Mol. Pharmacol. 63 (2003) 581-589
    • (2003) Mol. Pharmacol. , vol.63 , pp. 581-589
    • Sancho, P.1    Troyano, A.2    Fernandez, C.3    De Blas, E.4    Aller, P.5
  • 68
    • 0035088082 scopus 로고    scopus 로고
    • Hydrogen peroxide and hydroxyl radical involvement in the activation of caspase-3 in chemically induced apoptosis of HL-60 cells
    • Kajiwara K., Ikeda K., Kuroi R., Hashimoto R., Tokumaru S., and Kojo S. Hydrogen peroxide and hydroxyl radical involvement in the activation of caspase-3 in chemically induced apoptosis of HL-60 cells. Cell Mol. Life Sci. 58 (2001) 485-491
    • (2001) Cell Mol. Life Sci. , vol.58 , pp. 485-491
    • Kajiwara, K.1    Ikeda, K.2    Kuroi, R.3    Hashimoto, R.4    Tokumaru, S.5    Kojo, S.6
  • 69
    • 0032906669 scopus 로고    scopus 로고
    • Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells
    • Ikeda K., Kajiwara K., Tanabe E., Tokumaru S., Kishida E., Masuzawa Y., and Kojo S. Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells. Biochem. Pharmacol. 57 (1999) 1361-1365
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 1361-1365
    • Ikeda, K.1    Kajiwara, K.2    Tanabe, E.3    Tokumaru, S.4    Kishida, E.5    Masuzawa, Y.6    Kojo, S.7
  • 70
    • 0032500543 scopus 로고    scopus 로고
    • Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs
    • Simizu S., Takada M., Umezawa K., and Imoto M. Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs. J. Biol. Chem. 273 (1998) 26900-26907
    • (1998) J. Biol. Chem. , vol.273 , pp. 26900-26907
    • Simizu, S.1    Takada, M.2    Umezawa, K.3    Imoto, M.4
  • 71
    • 0031027794 scopus 로고    scopus 로고
    • Role of peroxide and superoxide anion during tumour cell apoptosis
    • Gorman A., McGowan A., and Cotter T.G. Role of peroxide and superoxide anion during tumour cell apoptosis. FEBS Lett. 404 (1997) 27-33
    • (1997) FEBS Lett. , vol.404 , pp. 27-33
    • Gorman, A.1    McGowan, A.2    Cotter, T.G.3
  • 72
    • 0033778727 scopus 로고    scopus 로고
    • Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells
    • Lee Y.S., Kang Y.S., Lee S.H., and Kim J.A. Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells. Cell Death Differ. 7 (2000) 925-932
    • (2000) Cell Death Differ. , vol.7 , pp. 925-932
    • Lee, Y.S.1    Kang, Y.S.2    Lee, S.H.3    Kim, J.A.4
  • 73
    • 3543084996 scopus 로고    scopus 로고
    • Effective treatment of advanced solid tumors by the combination of arsenic trioxide and l-buthionine-sulfoximine
    • Maeda H., Hori S., Ohizumi H., Segawa T., Kakehi Y., Ogawa O., and Kakizuka A. Effective treatment of advanced solid tumors by the combination of arsenic trioxide and l-buthionine-sulfoximine. Cell Death Differ. 11 (2004) 737-746
    • (2004) Cell Death Differ. , vol.11 , pp. 737-746
    • Maeda, H.1    Hori, S.2    Ohizumi, H.3    Segawa, T.4    Kakehi, Y.5    Ogawa, O.6    Kakizuka, A.7
  • 74
    • 26444521256 scopus 로고    scopus 로고
    • Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues
    • Chen Q., Espey M.G., Krishna M.C., Mitchell J.B., Corpe C.P., Buettner G.R., et al. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc. Natl. Acad. Sci. USA 102 (2005) 13604-13609
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 13604-13609
    • Chen, Q.1    Espey, M.G.2    Krishna, M.C.3    Mitchell, J.B.4    Corpe, C.P.5    Buettner, G.R.6
  • 75
    • 0038531029 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production
    • Djavaheri-Mergny M., Wietzerbin J., and Besancon F. 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. Oncogene 22 (2003) 2558-2567
    • (2003) Oncogene , vol.22 , pp. 2558-2567
    • Djavaheri-Mergny, M.1    Wietzerbin, J.2    Besancon, F.3
  • 76
    • 12844283848 scopus 로고    scopus 로고
    • Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells
    • Evens A.M., Lecane P., Magda D., Prachand S., Singhal S., Nelson J., Miller R.A., et al. Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells. Blood 105 (2005) 1265-1273
    • (2005) Blood , vol.105 , pp. 1265-1273
    • Evens, A.M.1    Lecane, P.2    Magda, D.3    Prachand, S.4    Singhal, S.5    Nelson, J.6    Miller, R.A.7
  • 77
    • 18044364401 scopus 로고    scopus 로고
    • Differential modulation of normal and tumor cell proliferation by reactive oxygen species
    • Nicco C., Laurent A., Chereau C., Weill B., and Batteux F. Differential modulation of normal and tumor cell proliferation by reactive oxygen species. Biomed. Pharmacother. 59 (2005) 169-174
    • (2005) Biomed. Pharmacother. , vol.59 , pp. 169-174
    • Nicco, C.1    Laurent, A.2    Chereau, C.3    Weill, B.4    Batteux, F.5
  • 78
    • 9344232306 scopus 로고
    • A method of destroying a malignant rat tumour in vivo
    • Holman R.A. A method of destroying a malignant rat tumour in vivo. Nature 179 (1957) 1033
    • (1957) Nature , vol.179 , pp. 1033
    • Holman, R.A.1
  • 79
    • 34248347130 scopus 로고
    • Hydrogen peroxide and cancer
    • Jeffree G.M. Hydrogen peroxide and cancer. Nature 182 (1958) 892
    • (1958) Nature , vol.182 , pp. 892
    • Jeffree, G.M.1
  • 80
    • 0019789553 scopus 로고
    • Antitumor effects of hydrogen peroxide in vivo
    • Nathan C.F., and Cohn Z.A. Antitumor effects of hydrogen peroxide in vivo. J. Exp. Med. 154 (1981) 1539-1553
    • (1981) J. Exp. Med. , vol.154 , pp. 1539-1553
    • Nathan, C.F.1    Cohn, Z.A.2
  • 81
    • 0027354826 scopus 로고    scopus 로고
    • Questionable methods of cancer management: hydrogen peroxide and other 'hyperoxygenation' therapies, CA Cancer J. Clin. 43 (1993) 47-56.
  • 83
    • 22244478639 scopus 로고    scopus 로고
    • LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway
    • Poh T.W., and Pervaiz S. LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway. Cancer Res. 65 (2005) 6264-6274
    • (2005) Cancer Res. , vol.65 , pp. 6264-6274
    • Poh, T.W.1    Pervaiz, S.2
  • 86
    • 0036637235 scopus 로고    scopus 로고
    • Chemoprevention: an essential approach to controlling cancer
    • Sporn M.B., and Suh N. Chemoprevention: an essential approach to controlling cancer. Nat. Rev. Cancer 2 (2002) 537-543
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 537-543
    • Sporn, M.B.1    Suh, N.2
  • 87
    • 27644477094 scopus 로고    scopus 로고
    • Cancer chemoprevention: scientific promise, clinical uncertainty
    • Sporn M.B., and Liby K.T. Cancer chemoprevention: scientific promise, clinical uncertainty. Nat. Clin. Pract. Oncol. 2 (2005) 518-525
    • (2005) Nat. Clin. Pract. Oncol. , vol.2 , pp. 518-525
    • Sporn, M.B.1    Liby, K.T.2
  • 88
    • 28844448258 scopus 로고    scopus 로고
    • Evaluation for safety of antioxidant chemopreventive agents
    • Kawanishi S., Oikawa S., and Murata M. Evaluation for safety of antioxidant chemopreventive agents. Antioxid. Redox Signal 7 (2005) 1728-1739
    • (2005) Antioxid. Redox Signal , vol.7 , pp. 1728-1739
    • Kawanishi, S.1    Oikawa, S.2    Murata, M.3
  • 89
    • 0035106035 scopus 로고    scopus 로고
    • Antioxidant and prooxidant roles for beta-carotene, alpha-tocopherol and ascorbic acid in human lung cells
    • Zhang P., and Omaye S.T. Antioxidant and prooxidant roles for beta-carotene, alpha-tocopherol and ascorbic acid in human lung cells. Toxicol. In Vitro 15 (2001) 13-24
    • (2001) Toxicol. In Vitro , vol.15 , pp. 13-24
    • Zhang, P.1    Omaye, S.T.2
  • 91
    • 4744375335 scopus 로고    scopus 로고
    • Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2′-deoxyguanosine in DNA and induction of apoptotic cell death
    • Yoshino M., Haneda M., Naruse M., Htay H.H., Tsubouchi R., Qiao S.L., et al. Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2′-deoxyguanosine in DNA and induction of apoptotic cell death. Toxicol. In Vitro 18 (2004) 783-789
    • (2004) Toxicol. In Vitro , vol.18 , pp. 783-789
    • Yoshino, M.1    Haneda, M.2    Naruse, M.3    Htay, H.H.4    Tsubouchi, R.5    Qiao, S.L.6
  • 92
    • 27944494853 scopus 로고    scopus 로고
    • Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells
    • Yeh C.T., and Yen G.C. Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells. Carcinogenesis 26 (2005) 2138-2148
    • (2005) Carcinogenesis , vol.26 , pp. 2138-2148
    • Yeh, C.T.1    Yen, G.C.2
  • 93
    • 27744511607 scopus 로고    scopus 로고
    • Use of cancer chemopreventive phytochemicals as antineoplastic agents
    • D'Incalci M., Steward W.P., and Gescher A.J. Use of cancer chemopreventive phytochemicals as antineoplastic agents. Lancet Oncol. 6 (2005) 899-904
    • (2005) Lancet Oncol. , vol.6 , pp. 899-904
    • D'Incalci, M.1    Steward, W.P.2    Gescher, A.J.3
  • 95
    • 0842304283 scopus 로고    scopus 로고
    • Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species
    • Ito K., Nakazato T., Yamato K., Miyakawa Y., Yamada T., Hozumi N., et al. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res. 64 (2004) 1071-1078
    • (2004) Cancer Res. , vol.64 , pp. 1071-1078
    • Ito, K.1    Nakazato, T.2    Yamato, K.3    Miyakawa, Y.4    Yamada, T.5    Hozumi, N.6
  • 96
    • 0642276600 scopus 로고    scopus 로고
    • vitamin C and cancer chemoprevention: reappraisal
    • Lee K.W., Lee H.J., Surh Y.J., and Lee C.Y. vitamin C and cancer chemoprevention: reappraisal. Am. J. Clin. Nutr. 78 (2003) 1074-1078
    • (2003) Am. J. Clin. Nutr. , vol.78 , pp. 1074-1078
    • Lee, K.W.1    Lee, H.J.2    Surh, Y.J.3    Lee, C.Y.4
  • 97
    • 33845472110 scopus 로고    scopus 로고
    • Preventive effects of vitamin C on carcinogenesis
    • Lee K.W., Lee H.J., Kang K.S., and Lee C.Y. Preventive effects of vitamin C on carcinogenesis. Lancet 359 (2002) 172
    • (2002) Lancet , vol.359 , pp. 172
    • Lee, K.W.1    Lee, H.J.2    Kang, K.S.3    Lee, C.Y.4
  • 98
    • 0035874967 scopus 로고    scopus 로고
    • vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins
    • Lee S.H., Oe T., and Blair I.A. vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 292 (2001) 2083-2086
    • (2001) Science , vol.292 , pp. 2083-2086
    • Lee, S.H.1    Oe, T.2    Blair, I.A.3
  • 99
    • 0032586401 scopus 로고    scopus 로고
    • What can randomized controlled trials tell us about nutrition and cancer prevention?
    • Byers T. What can randomized controlled trials tell us about nutrition and cancer prevention?. CA Cancer J. Clin. 49 (1999) 353-361
    • (1999) CA Cancer J. Clin. , vol.49 , pp. 353-361
    • Byers, T.1
  • 100
    • 10644263516 scopus 로고    scopus 로고
    • The beta-carotene and retinol efficacy trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements
    • Goodman G.E., Thornquist M.D., Balmes J., Cullen M.R., Meyskens Jr. F.L., Omenn G.S., et al. The beta-carotene and retinol efficacy trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J. Natl. Cancer Inst. 96 (2004) 1743-1750
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 1743-1750
    • Goodman, G.E.1    Thornquist, M.D.2    Balmes, J.3    Cullen, M.R.4    Meyskens Jr., F.L.5    Omenn, G.S.6
  • 101
    • 0036215297 scopus 로고    scopus 로고
    • Selenium and vitamin E supplements for prostate cancer: evidence or embellishment?
    • Moyad M.A. Selenium and vitamin E supplements for prostate cancer: evidence or embellishment?. Urology 59 (2002) 9-19
    • (2002) Urology , vol.59 , pp. 9-19
    • Moyad, M.A.1
  • 102
    • 27144537231 scopus 로고    scopus 로고
    • Prooxidant and antioxidant activity of vitamin E analogues and troglitazone
    • Tafazoli S., Wright J.S., and O'Brien P.J. Prooxidant and antioxidant activity of vitamin E analogues and troglitazone. Chem. Res. Toxicol. 18 (2005) 1567-1574
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1567-1574
    • Tafazoli, S.1    Wright, J.S.2    O'Brien, P.J.3
  • 104
    • 0034697654 scopus 로고    scopus 로고
    • EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups
    • van Zandwijk N., Dalesio O., Pastorino U., de Vries N., and van Tinteren H. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. J. Natl. Cancer Inst. 92 (2000) 977-986
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 977-986
    • van Zandwijk, N.1    Dalesio, O.2    Pastorino, U.3    de Vries, N.4    van Tinteren, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.