Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction

EMBO Journal

Volumn 29, Issue 1, 2010, Pages 158-170

  Kozak, Marina L ^a   Chavez, Alejandro ^a   Dang, Weiwei ^b   Berger, Shelley L ^b   Ashok, Annie ^a   Guo, Xiaoge ^a   Johnson, F Brad ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

Chromatin; SAS2; Senescence; Sir complex; Telomere

Indexed keywords

ARGININE; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE SAS2; HISTONE H4; SILENT INFORMATION REGULATOR PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; SILENT INFORMATION REGULATOR PROTEIN 3; SILENT INFORMATION REGULATOR PROTEIN 4; UNCLASSIFIED DRUG; HISTONE; MULTIPROTEIN COMPLEX; SACCHAROMYCES CEREVISIAE PROTEIN; SAS2 PROTEIN, S CEREVISIAE; SIR2 PROTEIN, S CEREVISIAE; SIR3 PROTEIN, S CEREVISIAE; SIR4 PROTEIN, S CEREVISIAE; SIRTUIN 2; TELOMERASE;

ARTICLE; CELL AGING; CONTROLLED STUDY; ENZYME INACTIVATION; EUCHROMATIN; FUNGAL CELL; FUNGUS MUTATION; GENE DELETION; HETEROCHROMATIN; HISTONE ACETYLATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TELOMERE; TELOMERE SHORTENING; ACETYLATION; BIOLOGICAL MODEL; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; FUNGAL GENE; GENETIC EPISTASIS; GENETIC RECOMBINATION; GENETICS; METABOLISM; MUTATION;

ACETYLATION; EPISTASIS, GENETIC; GENE DELETION; GENES, FUNGAL; HISTONE ACETYLTRANSFERASES; HISTONES; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; MUTATION; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUIN 2; TELOMERASE; TELOMERE;

EID: 75649086193     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2009.314     Document Type: Article

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