MYST opportunities for growth control: Yeast genes illuminate human cancer gene functions

Oncogene

Volumn 26, Issue 37, 2007, Pages 5373-5384

  Lafon, A ^a   Chang, C S ^a   Scott, E M ^a   Jacobson, S J ^a   Pillus, L ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Chromatin; Saccharomyces cerevisiae; Silencing; Transcription

Indexed keywords

HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; NUCLEAR PROTEIN;

CHROMATIN; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; ENZYME SUBUNIT; EPIGENETICS; FUNGAL GENE; GENE CONTROL; GENE FUNCTION; GENE SILENCING; GENE TARGETING; GENETIC ANALYSIS; GENETIC CORRELATION; GENETIC LINKAGE; GENETIC TRANSCRIPTION; GENOMICS; GROWTH REGULATION; HETEROCHROMATIN; HUMAN; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEOMICS; REVIEW; TRANSCRIPTION INITIATION; TUMOR GENE; TUMOR GROWTH; YEAST;

GENES, FUNGAL; GENES, NEOPLASM; HETEROCHROMATIN; HISTONE ACETYLTRANSFERASES; HUMANS; NEOPLASMS; PROTEOMICS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 34547861703     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210606     Document Type: Review

References (119)

1. Akhtar A, Zink D, Becker PB. (2000). Chromodomains are protein-RNA interaction modules. Nature 407: 405-409.
2. Allard S, Utley RT, Savard J, Clarke A, Grant P, Brandl CJ et al. (1999). NuA4, an essential transcription adaptor/ histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J 18: 5108-5119.
3. Altaf M, Saksouk N, Côté J. (2007). Histone modifications in response to DNA damage. Mutat Res 618: 81-90.
4. Anafi M, Yang YF, Barlev NA, Govindan MV, Berger SL, Butt TR et al. (2000). GCN5 and ADA adaptor proteins regulate triiodothyronine/GRIP1 and SRC-1 coactivator-dependent gene activation by the human thyroid hormone receptor. Mol Endocrinol 14: 718-732.
5. Avvakumov N, Côté J. (2007). The MYST family of histone acetyltransferases and their intimate links to cancer. Oncogene 26: 5395-5407.
6. Babiarz JE, Halley JE, Rine J. (2006). Telomeric heterochromatin boundaries require NuA4-dependent acetylation of histone variant H2A.Z in Saccharomyces cerevisiae. Genes Dev 20: 700-710.
7. Baker SP, Grant PA. (2007). The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene 26: 5329-5340.
8. Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA. (2001). Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci USA 98: 15113-15118.
9. Bird AW, Yu DY, Pray-Grant MG, Qiu Q, Harmon KE, Megee PC et al. (2002). Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Nature 419: 411-415.
10. Bittner CB, Zeisig DT, Zeisig BB, Slany RK. (2004). Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p. Eukaryot Cell 3: 976-983.
11. Borrow J, Shearman AM, Stanton Jr VP, Becher R, Collins T, Williams AJ et al. (1996). The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98and class I homeoprotein HOXA9. Nat Genet 12: 159-167.
12. Boudreault AA, Cronier D, Selleck W, Lacoste N, Utley RT, Allard S et al. (2003). Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev 17: 1415-1428.
13. Brachmann RK, Vidal M, Boeke JD. (1996). Dominantnegative p53 mutations selected in yeast hit cancer hot spots. Proc Natl Acad Sci USA 93: 4091-4095.
14. Brown CE, Howe L, Sousa K, Alley SC, Carrozza MJ, Tan S et al. (2001). Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292: 2333-2337.
15. Brown K, Chen Y, Underhill TM, Mymryk JS, Torchia J. (2003). The coactivator p/CIP/SRC-3 facilitates retinoic acid receptor signaling via recruitment of GCN5. J Biol Chem 278: 39402-39412.
16. Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY et al. (1996). Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84: 843-851.
17. Burke TW, Cook JG, Asano M, Nevins JR. (2001). Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. J Biol Chem 276: 15397-15408.
18. Cairns BR, Henry NL, Kornberg RD. (1996). TFG/TAF30/ ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9. Mol Cell Biol 16: 3308-3316.
19. Carrozza MJ, Li B, Florens L, Suganuma T, Swanson SK, Lee KK et al. (2005). Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123: 581-592.
20. Choy JS, Kron SJ. (2002). NuA4 subunit Yng2 function in intra-S-phase DNA damage response. Mol Cell Biol 22: 8215-8225.
21. Choy JS, Tobe BT, Huh JH, Kron SJ. (2001). Yng2p-dependent NuA4 histone H4 acetylation activity is required for mitotic and meiotic progression. J Biol Chem 276: 43653-43662.
22. Clarke AS, Lowell JE, Jacobson SJ, Pillus L. (1999). Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol 19: 2515-2526.
23. Clarke AS, Samal E, Pillus L. (2006). Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Mol Biol Cell 17: 1744-1757.
24. Daniel JA, Pray-Grant MG, Grant PA. (2005). Effector proteins for methylated histones: an expanding family. Cell Cycle 4: 919-926.
25. Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR et al. (2002). The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/ SNF complex. Blood 99: 275-281.
26. Downs JA, Allard S, Jobin-Robitaille O, Javaheri A, Auger A, Bouchard N et al. (2004). Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol Cell 16: 979-990.
27. Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W et al. (2006). ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell 21: 51-64.
28. Doyon Y, Selleck W, Lane WS, Tan S, Côté J. (2004). Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol 24: 1884-1896.
29. Dziak R, Leishman D, Radovic M, Tye BK, Yankulov K. (2003). Evidence for a role of MCM (mini-chromosome maintenance)5 in transcriptional repression of sub-telomeric and Ty-proximal genes in Saccharomyces cerevisiae. J Biol Chem 278: 27372-27381.
30. Ehrenhofer-Murray AE, Rivier DH, Rine J. (1997). The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function. Genetics 145: 923-934.
31. Eisen A, Utley RT, Nourani A, Allard S, Schmidt P, Lane WS et al. (2001). The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. J Biol Chem 276: 3484-3491.
32. Galarneau L, Nourani A, Boudreault AA, Zhang Y, Heliot L, Allard S et al. (2000). Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5: 927-937.
33. Georgiakaki M, Chabbert-Buffet N, Dasen B, Meduri G, Wenk S, Rajhi L et al. (2006). Ligand-controlled interaction of histone acetyltransferase binding to ORC-1 (HBO1) with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription. Mol Endocrinol 20: 2122-2140.
34. Gómez EB, Espinosa JM, Forsburg SL. (2005). Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing. Mol Cell Biol 25: 8887-8903.
35. Grant PA, Schieltz D, Pray-Grant MG, Yates III JR, Workman JL. (1998). The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2: 863-867.
36. Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. (2001). Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276: 38837-38843.
37. Grunstein M. (1990). Histone function in transcription. Annu Rev Cell Biol 6: 643-678.
38. Gupta A, Sharma GG, Young CS, Agarwal M, Smith ER, Paull TT et al. (2005). Involvement of human MOF in ATM function. Mol Cell Biol 25: 5292-5305.
39. Hilfiker A, Hilfiker-Kleiner D, Pannuti A, Lucchesi JC. (1997). mof, A putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J 16: 2054-2060.
40. Howe L, Auston D, Grant P, John S, Cook RG, Workman JL et al. (2001). Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes Dev 15: 3144-3154.
41. Howe L, Kusch T, Muster N, Chaterji R, Yates III JR, Workman JL. (2002). Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 histone acetyltransferase complex. Mol Cell Biol 22: 5047-5053.
42. Iizuka M, Matsui T, Takisawa H, Smith MM. (2006). Regulation of replication licensing by acetyltransferase Hbo1. Mol Cell Biol 26: 1098-1108.
43. Iizuka M, Stillman B. (1999). Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. J Biol Chem 274: 23027-23034.
44. Jacobson S, Pillus L. (2004). Molecular requirements for gene expression mediated by targeted histone acetyltransferases. Mol Cell Biol 24: 6029-6039.
45. John S, Howe L, Tafrov ST, Grant PA, Sternglanz R, Workman JL. (2000). The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev 14: 1196-1208.
46. Kabani M, Michot K, Boschiero C, Werner M. (2005). Anc1 interacts with the catalytic subunits of the general transcription factors TFIID and TFIIF, the chromatin remodeling complexes RSC and INO80, and the histone acetyltransferase complex NuA3. Biochem Biophys Res Commun 332: 398-403.
47. Kamine J, Elangovan B, Subramanian T, Coleman D, Chinnadurai G. (1996). Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 216: 357-366.
48. Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR et al. (2005). Cotranscriptional Set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123: 593-605.
49. Keogh MC, Mennella TA, Sawa C, Berthelet S, Krogan NJ, Wolek A et al. (2006). The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4. Genes Dev 20: 660-665.
50. Kimura A, Umehara T, Horikoshi M. (2002). Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nat Genet 32: 370-377.
51. Kirchmaier AL, Rine J. (2001). DNA replication-independent silencing in S. cerevisiae. Science 291: 646-650.
52. Kleff S, Andrulis ED, Anderson CW, Sternglanz R. (1995). Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem 270: 24674-24677.
53. Kobor MS, Venkatasubrahmanyam S, Meneghini MD, Gin JW, Jennings JL, Link AJ et al. (2004). A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin. PLoS Biol 2: E131.
54. Krogan NJ, Baetz K, Keogh MC, Datta N, Sawa C, Kwok TC et al. (2004). Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci USA 101: 13513-13518.
55. Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A et al. (2006). Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440: 637-643.
56. Krogan NJ, Keogh MC, Datta N, Sawa C, Ryan OW, Ding H et al. (2003). A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12: 1565-1576.
57. Le Masson I, Yu DY, Jensen K, Chevalier A, Courbeyrette R, Boulard Y et al. (2003). Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. Mol Cell Biol 23: 6086-6102.
58. Legube G, Linares LK, Tyteca S, Caron C, Scheffner M, Chevillard-Briet M et al. (2004). Role of the histone acetyl transferase Tip60 in the p53 pathway. J Biol Chem 279: 44825-44833.
59. Li YC, Cheng TH, Gartenberg MR. (2001). Establishment of transcriptional silencing in the absence of DNA replication. Science 291: 650-653.
60. Liu Y, Vidanes G, Lin YC, Mori S, Siede W. (2000). Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNAdamage-induced M-phase arrest. Mol Gen Genet 262: 1132-1146.
61. Lonard DM, O'Malley BW. (2006). The expanding cosmos of nuclear receptor coactivators. Cell 125: 411-414.
62. Martin DG, Grimes DE, Baetz K, Howe L. (2006). Methylation of histone H3 mediates the association of the NuA3 histone acetyltransferase with chromatin. Mol Cell Biol 26: 3018-3028.
63. McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD. (1998). The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94: 363-374.
64. Meijsing SH, Ehrenhofer-Murray AE. (2001). The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae. Genes Dev 15: 3169-3182.
65. Millar CB, Xu F, Zhang K, Grunstein M. (2006). Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast. Genes Dev 20: 711-722.
66. Murr R, Vaissière T, Sawan C, Shukla V, Herceg Z. (2007). Orchestration of chromatin-based processes: mind the TRRAP. Oncogene 26: 5358-5372.
67. Nishikawa J, Saito K, Goto J, Dakeyama F, Matsuo M, Nishihara T. (1999). New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator. Toxicol Appl Pharmacol 154: 76-83.
68. Nourani A, Doyon Y, Utley RT, Allard S, Lane WS, Côté J. (2001). Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol Cell Biol 21: 7629-7640.
69. Nourani A, Howe L, Pray-Grant MG, Workman JL, Grant PA, Côté J. (2003). Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem 278: 19171-19175.
70. Nourani A, Utley RT, Allard S, Côté J. (2004). Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation. EMBO J 23: 2597-2607.
71. Ogryzko VV. (2001). Mammalian histone acetyltransferases and their complexes. Cell Mol Life Sci 58: 683-692.
72. Olaharski AJ, Rine J, Marshall BL, Babiarz J, Zhang L, Verdin E et al. (2005). The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet 1: e77.
73. Ooi SL, Pan X, Peyser BD, Ye P, Meluh PB, Yuan DS et al. (2006). Global synthetic-lethality analysis and yeast functional profiling. Trends Genet 22: 56-63.
74. Osada S, Sutton A, Muster N, Brown CE, Yates III JR, Sternglanz R et al. (2001). The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Genes Dev 15: 3155-3168.
75. Panchenko MV, Zhou MI, Cohen HT. (2004). von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity. J Biol Chem 279: 56032-56041.
76. Parthun MR, Widom J, Gottschling DE. (1996). The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87: 85-94.
77. Pokholok DK, Harbison CT, Levine S, Cole M, Hannett NM, Lee TI et al. (2005). Genome-wide map of nucleosome acetylation and methylation in yeast. Cell 122: 517-527.
78. Pray-Grant MG, Schieltz D, McMahon SJ, Wood JM, Kennedy EL, Cook RG et al. (2002). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway. Mol Cell Biol 22: 8774-8786.
79. Rea S, Xouri G, Akhtar A. (2007). Males absent on the first (MOF): from flies to humans. Oncogene 26: 5385-5394.
80. Reid JL, Iyer VR, Brown PO, Struhl K. (2000). Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol Cell 6: 1297-1307.
81. Reifsnyder C, Lowell J, Clarke A, Pillus L. (1996). Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet 14: 42-49.
82. Robert F, Pokholok DK, Hannett NM, Rinaldi NJ, Chandy M, Rolfe A et al. (2004). Global position and recruitment of HATs and HDACs in the yeast genome. Mol Cell 16: 199-209.
83. Saleh A, Schieltz D, Ting N, McMahon SB, Litchfield DW, Yates III JR et al. (1998). Tra1p is a component of the yeast Ada. Spt transcriptional regulatory complexes. J Biol Chem 273: 26559-26565.
84. Schreiner SA, Garcia-Cuellar MP, Fey GH, Slany RK. (1999). The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator. Leukemia 13: 1525-1533.
85. Selleck W, Fortin I, Sermwittayawong D, Côté J, Tan S. (2005). The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the Enhancer of Polycomb A domain and chromodomain to acetylate nucleosomes. Mol Cell Biol 25: 5535-5542.
86. Sharma M, Zarnegar M, Li X, Lim B, Sun Z. (2000). Androgen receptor interacts with a novel MYST protein, HBO1. J Biol Chem 275: 35200-35208.
87. Shen X, Xiao H, Ranallo R, Wu WH, Wu C. (2003). Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. Science 299: 112-114.
88. Shia WJ, Li B, Workman JL. (2006). SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae. Genes Dev 20: 2507-2512.
89. Shia WJ, Osada S, Florens L, Swanson SK, Washburn MP, Workman JL. (2005). Characterization of the yeast trimeric-SAS acetyltransferase complex. J Biol Chem 280: 11987-11994.
90. Slany RK, Lavau C, Cleary ML. (1998). The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. Mol Cell Biol 18: 122-129.
91. Smith ER, Eisen A, Gu W, Sattah M, Pannuti A, Zhou J et al. (1998a). ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc Natl Acad Sci USA 95: 3561-3565.
92. Smith ER, Pannuti A, Gu W, Steurnagel A, Cook RG, Allis CD et al. (2000). The Drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation. Mol Cell Biol 20: 312-318.
93. Smith JS, Brachmann CB, Pillus L, Boeke JD. (1998b). Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics 149: 1205-1219.
94. Sterner DE, Belotserkovskaya R, Berger SL. (2002). SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription. Proc Natl Acad Sci USA 99: 11622-11627.
95. Sterner DE, Berger SL. (2000). Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev 64: 435-459.
96. Suka N, Luo K, Grunstein M. (2002). Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nat Genet 32: 378-383.
97. Suka N, Suka Y, Carmen AA, Wu J, Grunstein M. (2001). Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin. Mol Cell 8: 473-479.
98. Sutton A, Shia WJ, Band D, Kaufman PD, Osada S, Workman JL et al. (2003). Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex. J Biol Chem 278: 16887-16892.
99. Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS et al. (2006). Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 24: 841-851.
100. Takechi S, Nakayama T. (1999). Sas3 is a histone acetyltransferase and requires a zinc finger motif. Biochem Biophys Res Commun 266: 405-410.
101. Tamburini BA, Tyler JK. (2005). Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair. Mol Cell Biol 25: 4903-4913.
102. Tang Y, Luo J, Zhang W, Gu W. (2006). Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell 24: 827-839.
103. Taverna SD, Ilin S, Rogers RS, Tanny JC, Lavender H, Li H et al. (2006). Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 24: 785-796.
104. Timmermann S, Lehrmann H, Polesskaya A, Harel-Bellan A. (2001). Histone acetylation and disease. Cell Mol Life Sci 58: 728-736.
105. Tong AH, Evangelista M, Parsons AB, Xu H, Bader GD, Page N et al. (2001). Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294: 2364-2368.
106. Troke PJ, Kindle KB, Collins HM, Heery DM. (2006). MOZ fusion proteins in acute myeloid leukaemia. Biochem Soc Symp 73: 23-39.
107. Utley RT, Côté J. (2003). The MYST family of histone acetyltransferases. Curr Top Microbiol Immunol 274: 203-236.
108. Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J et al. (1998). The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol Cell 2: 869-875.
109. Vogelauer M, Wu J, Suka N, Grunstein M. (2000). Global histone acetylation and deacetylation in yeast. Nature 408: 495-498.
110. Xu EY, Kim S, Replogle K, Rine J, Rivier DH. (1999a). Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae. Genetics 153: 13-23.
111. Xu EY, Kim S, Rivier DH. (1999b). SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae. Genetics 153: 25-33.
112. Yan Y, Barlev NA, Haley RH, Berger SL, Marmorstein R. (2000). Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases. Mol Cell 6: 1195-1205.
113. Yang XJ. (2004). The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res 32: 959-976.
114. Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U et al. (2004). Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol 24: 617-628.
115. Zhang H, Richardson DO, Roberts DN, Utley R, Erdjument-Bromage H, Tempst P et al. (2004). The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24: 9424-9436.
116. Zhang W, Xia X, Reisenauer MR, Hemenway CS, Kone BC. (2006). Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. J Biol Chem 281: 18059-18068.
117. Zhang Y, Rowley JD. (2006). Chromatin structural elements and chromosomal translocations in leukemia. DNA Repair (Amst) 5: 1282-1297.
118. Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT. (2002). The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. J Biol Chem 277: 39887-39898.
119. Zong H, Li Z, Liu L, Hong Y, Yun X, Jiang J et al. (2005). Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity. FEBS Lett 579: 3579-3588.