MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae

Molecular Biology of the Cell

Volumn 13, Issue 8, 2002, Pages 2626-2638

  Enomoto, Shinichiro ^a   Glowczewski, Lynn ^a   Berman, Judith ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN DDC2; PROTEIN MEC1; PROTEIN MEC3; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL AGING; CELL CYCLE; CELL CYCLE G2 PHASE; CELL GROWTH; DNA DAMAGE; FUNGAL GENE; FUNGAL GENETICS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TELOMERE;

CELL CYCLE; CELL CYCLE PROTEINS; DNA DAMAGE; FUNGAL PROTEINS; GENES, CDC; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERASE; TELOMERE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036677405     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.02-02-0012     Document Type: Article

References (58)

1. Switching and signaling at the telomere
2. Telomere states and cell fates
3. Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
4. Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events
5. Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae
6. Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae
7. The yeast Xrs2 complex functions in S phase checkpoint regulation
8. Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere
9. Turning telomeres off and on
10. Mutations in SPK1/RAD53 that specifically abolish checkpoint but not growth-related functions
11. RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast
12. Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex
13. A family of cyclin homologs that control the G1 phase in yeast
14. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
15. PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae
16. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
17. Block in anaphase chromosome separation caused by a telomerase template mutation
18. Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
19. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
20. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
21. Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
22. DNA damage checkpoint in budding yeast
23. An alternative pathway for yeast telomere maintenance rescues est1- senescence
24. A mutant with a defect in telomere elongation leads to senescence in yeast
25. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase
26. Progressive cis-inhibition of telomerase upon telomere elongation
27. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
28. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
29. Role of calcineurin and Mpk 1 in regulating the onset of mitosis in budding yeast
30. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
31. Telomerase catalytic subunit homologs from fission yeast and human
32. The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mecl and is regulated by Mec1-dependent phosphorylation in budding yeast
33. Meclp is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
34. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
35. Varying the number of telomere-bound proteins does not alter telomere length in tel1Δ cells
36. The selection of S. cerevisiae mutants defective in the start event of cell division
37. An essential G1 function for cyclin-like proteins in yeast
38. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC 1 in regulating telomere length in the yeast Saccharomyces cerevisiae
39. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast
40. LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signaling pathway in Saccharomyces cerevisiae
41. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
42. Getting started with yeast
43. Micromanipulation and dissection of asci
44. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
45. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
46. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
47. The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres
48. A DNA damage response pathway controlled by Tell and the Mre11 complex
49. Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span of human diploid fibroblasts. A review
50. Pie1, a protein interacting with Mecl, controls cell growth and checkpoint responses in Saccharomyces cerevisiae
51. Dual cell cycle checkpoints sensitive to chromosome replication and DNA damage in the budding yeast Saccharomyces cerevisiae
52. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
53. 1-3 tails occur sequentially in late S phase on a yeast linear plasmid
54. 1-3 tails late in S phase
55. Clinical significance of telomerase activation and telomeric restriction fragment (TRF) in cervical cancer
56. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
57. The DNA damage response: Putting checkpoints in perspective