Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase

Science

Volumn 322, Issue 5901, 2008, Pages 597-602

  Nagai, Shigeki ^a,b   Dubrana, Karine ^b,e,f   Tsai Pflugfelder, Monika ^a   Davidson, Marta B ^c   Roberts, Tania M ^c   Brown, Grant W ^c   Varela, Elisa ^a   Hediger, Florence ^b   Gasser, Susan M ^a,b   Krogan, Nevan J ^d  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b Frontiers in Genetics National Center for Competence in Research   (Switzerland)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e INSTITUT CURIE   (France)

^f INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MEC1 KINASE; NUCLEOPORIN; PHOSPHOTRANSFERASE; PROTEIN NUP84; SLX8 ENZYME; TEL1 KINASE; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

CYTOLOGY; DAMAGE; DNA; ENZYME ACTIVITY; GENE EXPRESSION; REAL TIME;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; GENE CONVERSION; GENE TARGETING; GENETIC EPISTASIS; NONHUMAN; NUCLEAR PORE COMPLEX; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

CHROMATIN IMMUNOPRECIPITATION; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA, FUNGAL; DNA-BINDING PROTEINS; GENE CONVERSION; GENES, FUNGAL; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; UBIQUITIN-PROTEIN LIGASES; ZINC FINGERS;

EID: 54949093203     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1162790     Document Type: Article

References (34)

1. R. Schneider, R. Grosschedl, Genes Dev. 21, 3027 (2007).
2. A. Akhtar, S. M. Gasser, Nat. Rev. Genet. 8, 507 (2007).
3. P. Therizols et al., J. Cell Biol. 172, 189 (2006).
4. C. B. Bennett et al., Nat. Genet. 29, 426 (2001).
5. S. Loeillet et al., DNA Repair 4, 459 (2005).
6. X. Pan et al., Cell 124, 1069 (2006).
7. B. Palancade et al., Mol. Biol. Cell 18, 2912 (2007).
8. X. Zhao, C. Y. Wu, G. Blobel, J. Cell Biol. 167, 605 (2004).
9. K. Stade et al., J. Biol. Chem. 277, 49554 (2002).
10. Materials and methods are available as supporting material on Science Online.
11. S. E. Lee et al., Cell 94, 399 (1998).
12. F. Hediger, A. Taddei, F. R. Neumann, S. M. Gasser, Methods Enzymol. 375, 345 (2004).
13. K. Dubrana, H. van Attikum, F. Hediger, S. M. Gasser, J. Cell Sci. 120, 4209 (2007).
14. P. Heun, T. Laroche, K. Shimada, P. Furrer, S. M. Gasser, Science 294, 2181 (2001).
15. X. H. Wang, J. E. Haber, PLoS Biol. 2, E21 (2004).
16. M. Lisby, U. H. Mortensen, R. Rothstein, Nat. Cell Biol. 5, 572 (2003).
17. J. A. Tercero, J. F. Diffley, Nature 412, 553 (2001).
18. J. A. Cobb et al., Genes Dev. 19, 3055 (2005).
19. V. Doye, R. Wepf, E. C. Hurt, EMBO J. 13, 6062 (1994).
20. M. Schuldiner et al., Cell 123, 507 (2005).
21. S. R. Collins et al., Nature 446, 806 (2007).
22. J. R. Mullen, V. Kaliraman, S. S. Ibrahim, S. J. Brill, Genetics 157, 103 (2001).
23. Y. Xie et al., J. Biol. Chem. 282, 34176 (2007).
24. R. C. Burgess, S. Rahman, M. Lisby, R. Rothstein, X. Zhao, Mol. Cell. Biol. 27, 6153 (2007).
25. C. Zhang, T. M. Roberts, J. Yang, R. Desai, G. W. Brown, DNA Repair 5, 336 (2006).
26. Z. Wang, G. M. Jones, G. Prelich, Genetics 172, 1499 (2006).
27. L. Yang, J. R. Mullen, S. J. Brill, Nucleic Acids Res. 34, 5541 (2006).
28. J. Prudden et al., EMBO J. 26, 4089 (2007).
29. C. Soustelle et al., Mol. Cell. Biol. 24, 5130 (2004).
30. J. A. Freedman, S. Jinks-Robertson, Genetics 162, 15 (2002).
31. S. R. Collins et al., Mol. Cell. Proteomics 6, 439 (2007).
32. C. Enenkel, A. Lehmann, P. M. Kloetzel, Mol. Biol. Rep. 26, 131 (1999).
33. N. Krogan et al., Mol. Cell 16, 1027 (2004).
34. We thank J. E. Haber, M. Lisby, S. Jinks-Robertson, R. Kolodner, and R. Rothstein for generously providing strains; M. Shales for artwork; K. Saeturn and V. Kalck for technical help; and C. J. Ingles, J. E. Haber, and our laboratories for discussions. We acknowledge the Novartis Research Foundation, Swiss Cancer League, Swiss National Science Foundation, Sandler Family Foundation, NIH, National Cancer Institute of Canada, and Canadian Cancer Society for support.