Evidence for silencing compartments within the yeast nucleus: A role for telomere proximity and Sir protein concentration in silencer-mediated repression

Genes and Development

Volumn 10, Issue 14, 1996, Pages 1796-1811

  Maillet, Laurent ^a   Boscheron, Cécile ^a   Gotta, Monica ^b   Marcand, Stéphane ^a   Gilson, Eric ^a   Gasser, Susan M ^b  

^a UNIVERSITÉ DE LYON   (France)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

Silencing; SIR; subnuclear organization; telomere position effect; yeast mating type

Indexed keywords

NUCLEOPLASMIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CHROMATIN; DNA FLANKING REGION; DNA TRANSCRIPTION; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCATION; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REPRESSOR GENE; SILENCER GENE; TELOMERE; YEAST;

ANIMALIA;

EID: 0029746494     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.14.1796     Document Type: Article

References (68)

1. Aparicio, O.M., B.L. Billington, and D.E. Gottschling. 1991. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell66: 1279-1287.
2. Bell, S.P., R. Kobayashi, and B. Stillman. 1993. Yeast Origin Recognition Complex functions in transcription silencing and DNA replication. Science 262:1844-1848.
3. Bilaud, T., C.E. Koering, E. Binet-Brasselet, K. Anselin, A. Pollice, S.M. Gasser, and E. Gilson. 1996. The Telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. Nucleic Acids Res. 24:1294-1303.
4. Boscheron, C., L. Maillet, S. Marcand, M. Tsai-Pflugfelder, S.M. Gasser, and E. Gilson. 1996. Cooperation at a distance between silencers and proto-silencers at the yeast HML locus. EMBO J.15: 2184-2195.
5. Brand, A.H., L. Breeden, J. Abraham, R. Sternglanz, and K. Nasmyth. 1985. Characterization of a "Silencer" in yeast: A DNA sequence with properties opposite to those of a transcriptional enhancer. Cell 41:41-48.
6. Brand, A.H., G. Micklem, and K. Nasmyth. 1987. A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation. Cell 51:709-719.
7. Buchman, A.R., W.J. Kimmerly, J. Rine, and R.D. Kornberg. 1988. Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences and telomeres in S. cerevisiae. Mol. Cell. Biol. 8:210-225.
8. Buck, S.W. and D. Shore. 1995. Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast. Genes & Dev. 9:370-384.
9. Butner, K. and C.W. Lo. 1986. Modulation of tk expression in mouse pericentromeric heterochromatin. Mol. Cell. Biol. 6:4440-4449.
10. Carlson, M., J.L. Celenza, and F.J. Eng. 1985. Evolution of the dispersed SUC gene family of S. cerevisiae by rearrangements of chromosome telomeres. Mol. Cell. Biol.5: 2894-2902.
11. Chien, C., P.L. Bartel, R. Strernglanz, and S. Fields. 1991. The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. 88:9578-9582.
12. Chien, C., S. Buck, R. Sternglanz, and D. Shore. 1993. Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast. Cell 75:531-541.
13. Chong, L., B. van Steensel, D. Broccoli, L. Erdjument-Bromage, J. Hanish, P. Tempst, and T. de Lange. 1995. A human telomeric protein. Science 270:1663-1667.
14. Cockell, M., F. Palladino, T. Laroche, G. Kyrion, C. Liu, A.J. Lustig, and S.M. Gasser. 1995. The C-termini of Sir4 and Rap1 affect Sir3 localization in yeast cells: Evidence for a multicomponent complex required for telomeric silencing. J. Cell Biol. 129:909-924.
15. Cremer, T.A., R. Kurz, S. Zirbel, B. Dietzel, E. Rinke, M.R. Schröck, U. Speicher, A. Mathieu, P. Jauch, H. Emmerich, T. Sherthan, C. Ried, C. Cremer, and P. Lichter. 1993. The role of chromosome territories in the functional compartmentalization of the cell nucleus. Cold Spring Harbor Symp. Quant. Biol. 58:777-792.
16. Diller, J.D. and M.K. Raghuraman. 1994. Eukaryotic replication origins: Control in space and time. Trends Biochem. Sci. 19:320-325.
17. Ferguson, B.M. and W.L. Fangman. 1992. A position effect on the timing of replication origin replication in yeast. Cell 68:333-339.
18. Fleig, U.N., R.D. Pridmore, and P. Philippsen. 1986. Construction of LYS2 cartridges for use in genetic manipulations of Saccharomyces cerevisiae. Gene 46:237-245.
19. Funabiki, H., I. Hagan, S. Uzawa, and M. Yanagida. 1993. Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. J. Cell Biol. 121:961-976.
20. Gasser, S.M. and U.K. Laemmli. 1987. A glimpse at chromosomal order. Trends Genet. 3:16-22.
21. Gilson, E. and S.M. Gasser. 1995. Represser Activator Protein 1 and its ligands: Organising chromatin domains. Nucleic Acids Mol. Biol.9: 308-327.
22. Gilson, E., T. Laroche, and S.M. Gasser. 1993. Telomeres and the functional architecture of the nucleus. Trends Cell Biol. 3:128-134.
23. Gotta, M., T. Laroche, A. Formenton, L. Maillet, H. Shertan, and S.M. Gasser. 1996. Cytological evidence for the clustering of telomeres and their colocalization with Rap1, Sir3 and Sir4 proteins in wild-type S. cerevisiae. J. Cell Biol. (in press).
24. Gottschling, D.E., O.M. Aparicio, B.L Billington, and V.A. Zakian. 1990. Position effect at S. cerevisiae telomeres: Reversible represssion of Pol II transcription. Cell63: 751-762.
25. Hecht, A., T. Laroche, S. Strahl-Bolsinger, S.M. Gasser, and M. Grunstein. 1995. Histone H3 and H4 N termini interact with the Silent Information Regulators Sir3 and Sir4 in vitro: A molecular model for the formation of heterochromatin in yeast. Cell 80:583-592.
26. Heitz, E. 1934. Uber α und β Heterochromatin, sowie Konstanz und Bau der Chromomeren bei Drosophila. Biol. Zentralblatt 45:588-609.
27. Ivy, J.M., A.J.S. Klar, and J.B. Hicks. 1986. Cloning and characterization of four SIR genes of S. cerevisiae. Mol. Cell. Biol. 6:688-702.
28. Karpen, G.H. 1994. Position-effect variegation and the new biology of heterochromatin. Curr. Opin. Gen. Dev. 4:281-291.
29. Kennedy, B.K., N.R. Austriaco, J. Zhang, and L. Guarente. 1995. Mutation in the Silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80:485-496.
30. Kimmerly, W. and J. Rine. 1987. Replication and segregation of plasmids containing cis-acting regulatory sites of silent mating type genes in S. cerevisiae are controlled by the SIR genes. Mol Cell. Biol.7: 4225-4237.
31. Klar, A.J.S, J.N. Strathern, J.R. Broach, and J.B. Hicks. 1981. Regulation of transcription in expressed and unexpressed mating type cassettes of yeast. Nature 289:239-244.
32. Klein, F., T. Laroche, M.E. Cardenas, J.F.X. Hofmann, D. Schweizer, and S. M. Gasser. 1992. Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast. J. Cell Biol. 117:935-948.
33. Kyrion, G., C. Liu, and A.J. Lustig. 1993. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes & Dev. 7:1146-1159.
34. Laurenson, P. and J. Rine. 1992. Silencers, silencing and heritable transcriptional states. Microbiol Rev. 56:543-560.
35. Liu, C., X. Mao, and A.J. Lustig. 1994. Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in S. cerevisiae. Genetics 138:1025-1040.
36. Louis, E.J., E.S. Naumova, A. Lee, G. Naumov, and J.E. Haber. 1994. The chromosome end in yeast: Its mosaic nature and influence on recombination dynamics. Genetics 136:789-802.
37. Lustig, A.J., C. Liu, C. Zhang, and J.P. Hanish. 1996. Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:2483-2495.
38. Mahoney, D.J. and J. Broach. 1989. The HML mating type cassette of S. cerevisiae is regulated by two functionally equivalent silencers. Mol. Cell. Biol.9: 4621-4630.
39. Mahoney, D.J., R. Marquardt, G.J. Shei, A.B. Rose, and J.R. Broach. 1991. Mutations in the HML-E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression. Genes & Dev. 5:605-615.
40. Marcand, S., S.W. Buck, P. Moretti, E. Gilson, and D. Shore. 1996. Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein. Genes & Dev. 10:1297-1309.
41. Marshall, M., D. Mahoney, A. Rose, J.B. Hicks, and J.R. Broach. 1987. Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae. Mol Cell. Biol 7:4441-4452.
42. Mathog, D., M. Hochstrasser, Y. Gruenbaum, H. Saumweber, and J. Sedat. 1984. Characteristic folding pattern of polytene chromosomes in Drosophila salivary gland nuclei. Nature 308:414-421.
43. McNally, F.J. and J. Rine. 1991. A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:5648-5659.
44. Micklem, G., A. Rowley, J. Harwood, K. Nasmyth, and J.F.X. Diffley. 1993. Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature 366:87-89.
45. Moretti, P., K. Freeman, L. Goodly, and D. Shore. 1994. Evidence that a complex of SIR proteins interacts with the silencer and telomere binding protein RAP1. Genes & Dev. 8:2257-2269.
46. Nasmyth, K.A., K. Tatchell, B.D. Hall, C. Astell, and M. Smith. 1981. A position effect in the control of transcription at yeast mating type loci. Nature 289:244-250.
47. Palladino, F. and S.M. Gasser. 1994. Telomere maintenance and gene repression: A common end? Curr. Opin. Cell Biol. 6:373-380.
48. Palladino, F., T. Laroche, E. Gilson, A. Axelrod, L. Pillus, and S.M. Gasser. 1993. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 75:543-555.
49. Paro, R. 1993. Mechanisms of heritable gene repression during development of Drosophila. Curr. Opin. Cell Biol. 5:999-1005.
50. Pillus, L. and J. Rine. 1989. Epigenetic inheritance of transcriptional states in S. cerevisiae. Cell 59:637-647.
51. Rae, P.M.M. and W.W. Franke. 1972. The interphase distribution of satellite DNA-containing heterochromatin in mouse nuclei. Chromosoma 39:443-456.
52. Renauld, H., O.M. Aparicio, P.D. Zierath, B.L. Billington, S.K. Chhablani, and D.E. Gottschling. 1993. Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes & Dev.7: 1133-1145.
53. Rose, M.D., F. Winston, and P. Hieter. 1990. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
54. Sambrook, J., E.F. Fritsh, and T. Maniatis. 1989. Molecular cloning: A laboratory manual Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
55. Shei, G.J. and J.R. Broach. 1995. Yeast silencers can act as orientation-dependent gene inactivation centers that respond to environmental signals. Mol. Cell. Biol. 15:3496-3506.
56. Shore, D. and K. Nasmyth. 1987. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51:727-732.
57. Sikorski, R.S. and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in S. cerevisiae. Genetics 122:19-27.
58. Singer, M.S. and D.E. Gottschling. 1994. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science 266:404-409.
59. Stavenhagen, J.B. and V.A. Zakian. 1994. Internal tracts of telomeric DNA act as silencers in Saccharomyces cerevisiae. Genes & Dev. 8:1411-1422.
60. Stone, E.M., M.J. Swanson, A.M. Romeo, J.B. Hicks, and R. Sternglanz. 1991. The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants. Mol Cell. Biol. 11:2253-2262.
61. Sussel, L. and D. Shore. 1991. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: Isolation of viable mutants affecting both silencing and telomere length. Proc. Natl, Acad. Sci. 88:7749-7753.
62. Thompson, J.S., L.M. Johnson, and M. Grunstein. 1994. Specific repression of the yeast silent mating type locus HMR by an adjacent telomere. Mol. Cell. Biol. 14:446-455.
63. Tornow, J., X. Zeng, W. Gao, and G.M. Santangelo. 1993. GCR1, a transcriptional activator in S. cerevisiae, complexes with RAP1 and can function without its DNA binding domain. EMBO J. 12: 2431-2437.
64. Triolo, T. and R. Sternglanz. 1996. Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. Nature 381:251-253.
65. Verdier, J.M., M. Stalder, M. Roberge, B. Amati, A. Sentenac, and S.M. Gasser. 1990. Preparation and characterization of yeast nuclear extracts for efficient RNA polymerase B (II)-dependent transcription in vitro. Nucleic Acids Res. 18:7033-7039.
66. Vourc'h, C., D. Taruscio, A.L. Boyle, and D.C. Ward. 1993. Cell cycle-dependent distribution of telomeres, centromeres, and chromosome-specific subsatellite domains in the interphase nucleus of mouse lymphocytes. Exp. Cell Res. 205:142-151.
67. Wright, W.E. and J.W. Shay. 1995. Time, telomeres and tumours: Is cellular senescence more than an anticancer mechanism? Trends Cell Biol. 5:293-297.
68. Zuckerkandl, E. and R. Villet. 1988. Generation of high specificity of effect through low-specificity binding of proteins to DNA. FEBS Lett. 231:291-298.