메뉴 건너뛰기




Volumn 10, Issue , 2009, Pages

Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ACTIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; F ACTIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE INHIBITOR; RHO FACTOR; RHO KINASE; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ZEB; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; HOMEODOMAIN PROTEIN; KRUPPEL LIKE FACTOR; PROTEIN KINASE INHIBITOR; SIGNAL PEPTIDE; SNIP1 PROTEIN, MOUSE; ZEB1 PROTEIN, MOUSE;

EID: 74549154452     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-10-94     Document Type: Article
Times cited : (93)

References (85)
  • 1
    • 0034798707 scopus 로고    scopus 로고
    • Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition
    • 10.1002/bies.1132, 11598958
    • Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 2001, 23:912-23. 10.1002/bies.1132, 11598958.
    • (2001) Bioessays , vol.23 , pp. 912-923
    • Savagner, P.1
  • 2
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • 10.1016/j.ceb.2003.10.006, 14644200
    • Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003, 15:740-6. 10.1016/j.ceb.2003.10.006, 14644200.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 3
    • 36248929390 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis
    • 2184838, 18631853
    • Bedi S, Vidyasagar A, Djamali A. Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis. Transplant Rev (Orlando) 2008, 22:1-5. 2184838, 18631853.
    • (2008) Transplant Rev (Orlando) , vol.22 , pp. 1-5
    • Bedi, S.1    Vidyasagar, A.2    Djamali, A.3
  • 4
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • 10.1111/j.1349-7006.2007.00550.x, 17645776
    • Moustakas A, Heldin CH. Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 2007, 98:1512-20. 10.1111/j.1349-7006.2007.00550.x, 17645776.
    • (2007) Cancer Sci , vol.98 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 5
    • 0036233040 scopus 로고    scopus 로고
    • Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    • 10.1046/j.1523-1755.2002.00333.x, 11967021
    • Strutz F, Zeisberg M, Ziyadeh FN, Yang CQ, Kalluri R, Muller GA, Neilson EG. Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 2002, 61:1714-28. 10.1046/j.1523-1755.2002.00333.x, 11967021.
    • (2002) Kidney Int , vol.61 , pp. 1714-1728
    • Strutz, F.1    Zeisberg, M.2    Ziyadeh, F.N.3    Yang, C.Q.4    Kalluri, R.5    Muller, G.A.6    Neilson, E.G.7
  • 6
    • 34447272058 scopus 로고    scopus 로고
    • Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment
    • 10.1002/jcb.21215, 17243120
    • Tse JC, Kalluri R. Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment. J Cell Biochem 2007, 101:816-29. 10.1002/jcb.21215, 17243120.
    • (2007) J Cell Biochem , vol.101 , pp. 816-829
    • Tse, J.C.1    Kalluri, R.2
  • 7
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • 10.1016/j.cell.2008.07.001, 18662538
    • Massagu J. TGFbeta in Cancer. Cell 2008, 134:215-30. 10.1016/j.cell.2008.07.001, 18662538.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagu, J.1
  • 8
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
    • 10.1126/science.1105718, 15761148
    • Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005, 307:1603-9. 10.1126/science.1105718, 15761148.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 9
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • 10.1038/nature02006, 14534577
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425:577-84. 10.1038/nature02006, 14534577.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 10
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signalling
    • 10.1016/j.tibs.2004.03.008, 15130563
    • ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends Biochem Sci 2004, 29:265-73. 10.1016/j.tibs.2004.03.008, 15130563.
    • (2004) Trends Biochem Sci , vol.29 , pp. 265-273
    • ten Dijke, P.1    Hill, C.S.2
  • 11
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • 10.1038/35000034, 10655587
    • Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000, 2:84-9. 10.1038/35000034, 10655587.
    • (2000) Nat Cell Biol , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3    Dominguez, D.4    Monfar, M.5    Baulida, J.6    Garcia De Herreros, A.7
  • 12
    • 33750358078 scopus 로고    scopus 로고
    • Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition
    • 10.1158/0008-5472.CAN-06-0479, 17018611
    • Moreno-Bueno G, Cubillo E, Sarrio D, Peinado H, Rodriguez-Pinilla SM, Villa S, Bolos V, Jorda M, Fabra A, Portillo F, et al. Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res 2006, 66:9543-56. 10.1158/0008-5472.CAN-06-0479, 17018611.
    • (2006) Cancer Res , vol.66 , pp. 9543-9556
    • Moreno-Bueno, G.1    Cubillo, E.2    Sarrio, D.3    Peinado, H.4    Rodriguez-Pinilla, S.M.5    Villa, S.6    Bolos, V.7    Jorda, M.8    Fabra, A.9    Portillo, F.10
  • 13
    • 34548496683 scopus 로고    scopus 로고
    • Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta
    • 10.1091/mbc.E07-03-0249, 1951739, 17615296
    • Shirakihara T, Saitoh M, Miyazono K. Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta. Mol Biol Cell 2007, 18:3533-44. 10.1091/mbc.E07-03-0249, 1951739, 17615296.
    • (2007) Mol Biol Cell , vol.18 , pp. 3533-3544
    • Shirakihara, T.1    Saitoh, M.2    Miyazono, K.3
  • 15
    • 54949147234 scopus 로고    scopus 로고
    • Expression of the ZEB1 (deltaEF1) transcription factor in human: additional insights
    • 10.1007/s11010-008-9860-z, 18622689
    • Hurt EM, Saykally JN, Anose BM, Kalli KR, Sanders MM. Expression of the ZEB1 (deltaEF1) transcription factor in human: additional insights. Mol Cell Biochem 2008, 318:89-99. 10.1007/s11010-008-9860-z, 18622689.
    • (2008) Mol Cell Biochem , vol.318 , pp. 89-99
    • Hurt, E.M.1    Saykally, J.N.2    Anose, B.M.3    Kalli, K.R.4    Sanders, M.M.5
  • 16
  • 17
    • 20144388095 scopus 로고    scopus 로고
    • DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    • 10.1038/sj.onc.1208429, 15674322
    • Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 2005, 24:2375-85. 10.1038/sj.onc.1208429, 15674322.
    • (2005) Oncogene , vol.24 , pp. 2375-2385
    • Eger, A.1    Aigner, K.2    Sonderegger, S.3    Dampier, B.4    Oehler, S.5    Schreiber, M.6    Berx, G.7    Cano, A.8    Beug, H.9    Foisner, R.10
  • 18
  • 19
    • 35548974844 scopus 로고    scopus 로고
    • The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    • 10.1038/sj.onc.1210508, 17486063
    • Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M, Mikulits W, Brabletz T, Strand D, Obrist P, et al. The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 2007, 26:6979-88. 10.1038/sj.onc.1210508, 17486063.
    • (2007) Oncogene , vol.26 , pp. 6979-6988
    • Aigner, K.1    Dampier, B.2    Descovich, L.3    Mikula, M.4    Sultan, A.5    Schreiber, M.6    Mikulits, W.7    Brabletz, T.8    Strand, D.9    Obrist, P.10
  • 20
    • 41649109459 scopus 로고    scopus 로고
    • Zeb1 links epithelial-mesenchymal transition and cellular senescence
    • 10.1242/dev.007047, 2507753, 18192284
    • Liu Y, El-Naggar S, Darling DS, Higashi Y, Dean DC. Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development 2008, 135:579-88. 10.1242/dev.007047, 2507753, 18192284.
    • (2008) Development , vol.135 , pp. 579-588
    • Liu, Y.1    El-Naggar, S.2    Darling, D.S.3    Higashi, Y.4    Dean, D.C.5
  • 21
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • 10.1038/ncb807, 12105419
    • Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002, 4:487-94. 10.1038/ncb807, 12105419.
    • (2002) Nat Cell Biol , vol.4 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 22
    • 0035861541 scopus 로고    scopus 로고
    • Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38 MAPK and epithelial plasticity
    • 10.1074/jbc.M106176200, 11590169
    • Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38 MAPK and epithelial plasticity. J Biol Chem 2001, 276:46707-13. 10.1074/jbc.M106176200, 11590169.
    • (2001) J Biol Chem , vol.276 , pp. 46707-46713
    • Bhowmick, N.A.1    Zent, R.2    Ghiassi, M.3    McDonnell, M.4    Moses, H.L.5
  • 23
    • 0141720342 scopus 로고    scopus 로고
    • Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
    • 171389, 12925691
    • Li Y, Yang J, Dai C, Wu C, Liu Y. Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 2003, 112:503-16. 171389, 12925691.
    • (2003) J Clin Invest , vol.112 , pp. 503-516
    • Li, Y.1    Yang, J.2    Dai, C.3    Wu, C.4    Liu, Y.5
  • 24
    • 0036674213 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
    • Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL. p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 2002, 115:3193-206.
    • (2002) J Cell Sci , vol.115 , pp. 3193-3206
    • Bakin, A.V.1    Rinehart, C.2    Tomlinson, A.K.3    Arteaga, C.L.4
  • 25
    • 0035185853 scopus 로고    scopus 로고
    • Transforming Growth Factor-beta1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism
    • 30565, 11160820
    • Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL. Transforming Growth Factor-beta1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism. Mol Biol Cell 2001, 12:27-36. 30565, 11160820.
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3    Aakre, M.4    Lundquist, C.A.5    Engel, M.E.6    Arteaga, C.L.7    Moses, H.L.8
  • 26
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
    • 10.1074/jbc.M005912200, 10969078
    • Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 2000, 275:36803-10. 10.1074/jbc.M005912200, 10969078.
    • (2000) J Biol Chem , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 27
    • 1842524153 scopus 로고    scopus 로고
    • Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
    • 10.1038/sj.emboj.7600069, 380966, 14976548
    • Zavadil J, Cermak L, Soto-Nieves N, Bottinger EP. Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. Embo J 2004, 23:1155-65. 10.1038/sj.emboj.7600069, 380966, 14976548.
    • (2004) Embo J , vol.23 , pp. 1155-1165
    • Zavadil, J.1    Cermak, L.2    Soto-Nieves, N.3    Bottinger, E.P.4
  • 28
    • 33748305561 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA
    • 10.1091/mbc.E05-10-0990, 1556379, 16775010
    • Zhao BM, Hoffmann FM. Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA. Mol Biol Cell 2006, 17:3819-31. 10.1091/mbc.E05-10-0990, 1556379, 16775010.
    • (2006) Mol Biol Cell , vol.17 , pp. 3819-3831
    • Zhao, B.M.1    Hoffmann, F.M.2
  • 29
    • 4344612243 scopus 로고    scopus 로고
    • NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • 503772, 15314694
    • Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, Pehamberger H, Kraut N, Beug H, Wirth T. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004, 114:569-81. 503772, 15314694.
    • (2004) J Clin Invest , vol.114 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3    Grunert, S.4    Sommer, A.5    Pehamberger, H.6    Kraut, N.7    Beug, H.8    Wirth, T.9
  • 30
    • 33644871234 scopus 로고    scopus 로고
    • Regulation of Par6 by extracellular signals
    • 10.1016/j.ceb.2006.02.005, 16490351
    • Bose R, Wrana JL. Regulation of Par6 by extracellular signals. Curr Opin Cell Biol 2006, 18:206-12. 10.1016/j.ceb.2006.02.005, 16490351.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 206-212
    • Bose, R.1    Wrana, J.L.2
  • 31
    • 6944248910 scopus 로고    scopus 로고
    • Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro
    • 10.1593/neo.04241, 1531665, 15548370
    • Xie L, Law BK, Chytil AM, Brown KA, Aakre ME, Moses HL. Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro. Neoplasia 2004, 6:603-10. 10.1593/neo.04241, 1531665, 15548370.
    • (2004) Neoplasia , vol.6 , pp. 603-610
    • Xie, L.1    Law, B.K.2    Chytil, A.M.3    Brown, K.A.4    Aakre, M.E.5    Moses, H.L.6
  • 32
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • 10.1158/0008-5472.CAN-08-4312, 19276344
    • Wang Z, Li Y, Kong D, Banerjee S, Ahmad A, Azmi AS, Ali S, Abbruzzese JL, Gallick GE, Sarkar FH. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 2009, 69:2400-7. 10.1158/0008-5472.CAN-08-4312, 19276344.
    • (2009) Cancer Res , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 33
    • 57749114754 scopus 로고    scopus 로고
    • HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    • 10.1074/jbc.M802016200, 2662269, 18832382
    • Thuault S, Tan EJ, Peinado H, Cano A, Heldin CH, Moustakas A. HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J Biol Chem 2008, 283:33437-46. 10.1074/jbc.M802016200, 2662269, 18832382.
    • (2008) J Biol Chem , vol.283 , pp. 33437-33446
    • Thuault, S.1    Tan, E.J.2    Peinado, H.3    Cano, A.4    Heldin, C.H.5    Moustakas, A.6
  • 35
    • 0026769228 scopus 로고
    • Tubulointerstitial changes as a major determinant in the progression of renal damage
    • Nat KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 1992, 20:1-17.
    • (1992) Am J Kidney Dis , vol.20 , pp. 1-17
    • Nat, K.A.1
  • 36
    • 0242413065 scopus 로고    scopus 로고
    • Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development
    • 10.1016/j.mod.2003.06.005, 14623443
    • Shook D, Keller R. Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev 2003, 120:1351-83. 10.1016/j.mod.2003.06.005, 14623443.
    • (2003) Mech Dev , vol.120 , pp. 1351-1383
    • Shook, D.1    Keller, R.2
  • 37
    • 4644265701 scopus 로고    scopus 로고
    • Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney
    • 10.1016/j.ydbio.2004.07.022, 15464572
    • Meyer TN, Schwesinger C, Bush KT, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam SK. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Dev Biol 2004, 275:44-67. 10.1016/j.ydbio.2004.07.022, 15464572.
    • (2004) Dev Biol , vol.275 , pp. 44-67
    • Meyer, T.N.1    Schwesinger, C.2    Bush, K.T.3    Stuart, R.O.4    Rose, D.W.5    Shah, M.M.6    Vaughn, D.A.7    Steer, D.L.8    Nigam, S.K.9
  • 38
    • 23144457890 scopus 로고    scopus 로고
    • Conditional gene targeting in the kidney
    • 10.2174/1566524054553522, 16101481
    • Gawlik A, Quaggin SE. Conditional gene targeting in the kidney. Curr Mol Med 2005, 5:527-36. 10.2174/1566524054553522, 16101481.
    • (2005) Curr Mol Med , vol.5 , pp. 527-536
    • Gawlik, A.1    Quaggin, S.E.2
  • 39
    • 0036088906 scopus 로고    scopus 로고
    • Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells
    • 1850832, 12057905
    • Zeisberg M, Maeshima Y, Mosterman B, Kalluri R. Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Am J Pathol 2002, 160:2001-8. 1850832, 12057905.
    • (2002) Am J Pathol , vol.160 , pp. 2001-2008
    • Zeisberg, M.1    Maeshima, Y.2    Mosterman, B.3    Kalluri, R.4
  • 41
    • 33646537449 scopus 로고    scopus 로고
    • Matrix metalloproteinases and cellular motility in development and disease
    • 10.1002/bdrc.20061, 16622849
    • VanSaun MN, Matrisian LM. Matrix metalloproteinases and cellular motility in development and disease. Birth Defects Res C Embryo Today 2006, 78:69-79. 10.1002/bdrc.20061, 16622849.
    • (2006) Birth Defects Res C Embryo Today , vol.78 , pp. 69-79
    • VanSaun, M.N.1    Matrisian, L.M.2
  • 42
    • 3442898055 scopus 로고    scopus 로고
    • Linking TGF-beta-mediated Cdc25A inhibition and cytoskeletal regulation through RhoA/p160(ROCK) signaling
    • Brown K, Bhowmick NA. Linking TGF-beta-mediated Cdc25A inhibition and cytoskeletal regulation through RhoA/p160(ROCK) signaling. Cell Cycle 2004, 3:408-10.
    • (2004) Cell Cycle , vol.3 , pp. 408-410
    • Brown, K.1    Bhowmick, N.A.2
  • 43
    • 16344378397 scopus 로고    scopus 로고
    • TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    • 10.1091/mbc.E04-08-0658, 1073677, 15689496
    • Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A. TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 2005, 16:1987-2002. 10.1091/mbc.E04-08-0658, 1073677, 15689496.
    • (2005) Mol Biol Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.H.4    Moustakas, A.5
  • 44
    • 20344385003 scopus 로고    scopus 로고
    • A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers
    • 10.1593/neo.04640, 1501161, 15967103
    • Halder SK, Beauchamp RD, Datta PK. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 2005, 7:509-21. 10.1593/neo.04640, 1501161, 15967103.
    • (2005) Neoplasia , vol.7 , pp. 509-521
    • Halder, S.K.1    Beauchamp, R.D.2    Datta, P.K.3
  • 45
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • 10.1124/mol.62.1.65, 12065756
    • Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002, 62:65-74. 10.1124/mol.62.1.65, 12065756.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6    Laping, N.J.7    Hill, C.S.8
  • 46
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • 10.1042/0264-6021:3510095, 1221339, 10998351
    • Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000, 351:95-105. 10.1042/0264-6021:3510095, 1221339, 10998351.
    • (2000) Biochem J , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 47
    • 0023337921 scopus 로고
    • Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts
    • 553930, 3111844
    • Lund LR, Riccio A, Andreasen PA, Nielsen LS, Kristensen P, Laiho M, Saksela O, Blasi F, Dano K. Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts. Embo J 1987, 6:1281-6. 553930, 3111844.
    • (1987) Embo J , vol.6 , pp. 1281-1286
    • Lund, L.R.1    Riccio, A.2    Andreasen, P.A.3    Nielsen, L.S.4    Kristensen, P.5    Laiho, M.6    Saksela, O.7    Blasi, F.8    Dano, K.9
  • 48
    • 0036082554 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542
    • 10.1124/mol.62.1.58, 12065755
    • Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol 2002, 62:58-64. 10.1124/mol.62.1.58, 12065755.
    • (2002) Mol Pharmacol , vol.62 , pp. 58-64
    • Laping, N.J.1    Grygielko, E.2    Mathur, A.3    Butter, S.4    Bomberger, J.5    Tweed, C.6    Martin, W.7    Fornwald, J.8    Lehr, R.9    Harling, J.10
  • 49
    • 0034612270 scopus 로고    scopus 로고
    • Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors
    • 10.1073/pnas.97.12.6391, 18613, 10841546
    • Postigo AA, Dean DC. Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors. Proc Natl Acad Sci USA 2000, 97:6391-6. 10.1073/pnas.97.12.6391, 18613, 10841546.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6391-6396
    • Postigo, A.A.1    Dean, D.C.2
  • 50
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • 10.1158/0008-5472.CAN-08-1942, 18829540
    • Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, Goodall GJ. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 2008, 68:7846-54. 10.1158/0008-5472.CAN-08-1942, 18829540.
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 51
    • 63049101157 scopus 로고    scopus 로고
    • The role of the ZEB family of transcription factors in development and disease
    • 10.1007/s00018-008-8465-8, 19011757
    • Vandewalle C, Van Roy F, Berx G. The role of the ZEB family of transcription factors in development and disease. Cell Mol Life Sci 2009, 66:773-87. 10.1007/s00018-008-8465-8, 19011757.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 773-787
    • Vandewalle, C.1    Van Roy, F.2    Berx, G.3
  • 52
    • 56749095797 scopus 로고    scopus 로고
    • Transcriptional regulation of cell polarity in EMT and cancer
    • 10.1038/onc.2008.346, 19029937
    • Moreno-Bueno G, Portillo F, Cano A. Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 2008, 27:6958-69. 10.1038/onc.2008.346, 19029937.
    • (2008) Oncogene , vol.27 , pp. 6958-6969
    • Moreno-Bueno, G.1    Portillo, F.2    Cano, A.3
  • 54
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    • 10.1038/nrc2131, 17508028
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat Rev Cancer 2007, 7:415-28. 10.1038/nrc2131, 17508028.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 55
    • 85011936092 scopus 로고    scopus 로고
    • The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis
    • Korpal M, Kang Y. The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol 2008, 5:115-9.
    • (2008) RNA Biol , vol.5 , pp. 115-119
    • Korpal, M.1    Kang, Y.2
  • 56
    • 54049089608 scopus 로고    scopus 로고
    • MicroRNAs as regulators of epithelial-mesenchymal transition
    • Gregory PA, Bracken CP, Bert AG, Goodall GJ. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 2008, 7:3112-8.
    • (2008) Cell Cycle , vol.7 , pp. 3112-3118
    • Gregory, P.A.1    Bracken, C.P.2    Bert, A.G.3    Goodall, G.J.4
  • 57
    • 67650686848 scopus 로고    scopus 로고
    • The role of microRNAs in metastasis and epithelial-mesenchymal transition
    • 10.1007/s00018-009-8750-1, 19153653
    • Bracken CP, Gregory PA, Khew-Goodall Y, Goodall GJ. The role of microRNAs in metastasis and epithelial-mesenchymal transition. Cell Mol Life Sci 2009, 66:1682-99. 10.1007/s00018-009-8750-1, 19153653.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1682-1699
    • Bracken, C.P.1    Gregory, P.A.2    Khew-Goodall, Y.3    Goodall, G.J.4
  • 58
    • 0037131409 scopus 로고    scopus 로고
    • Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression
    • 10.1074/jbc.M206400200, 12161443
    • Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 2002, 277:39209-16. 10.1074/jbc.M206400200, 12161443.
    • (2002) J Biol Chem , vol.277 , pp. 39209-39216
    • Guaita, S.1    Puig, I.2    Franci, C.3    Garrido, M.4    Dominguez, D.5    Batlle, E.6    Sancho, E.7    Dedhar, S.8    De Herreros, A.G.9    Baulida, J.10
  • 59
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • 10.1074/jbc.C800074200, 18411277
    • Korpal M, Lee ES, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008, 283:14910-4. 10.1074/jbc.C800074200, 18411277.
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 60
    • 67650686848 scopus 로고    scopus 로고
    • The role of microRNAs in metastasis and epithelial-mesenchymal transition
    • 10.1007/s00018-009-8750-1, 19153653
    • Bracken CP, Gregory PA, Khew-Goodall Y, Goodall GJ. The role of microRNAs in metastasis and epithelial-mesenchymal transition. Cell Mol Life Sci 2009, 66(10):1682-99. 10.1007/s00018-009-8750-1, 19153653.
    • (2009) Cell Mol Life Sci , vol.66 , Issue.10 , pp. 1682-1699
    • Bracken, C.P.1    Gregory, P.A.2    Khew-Goodall, Y.3    Goodall, G.J.4
  • 61
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • 10.1158/0008-5472.CAN-09-1298, 19654291
    • Li Y, Boom TG, Kon D, Wan Z, Al S, Phili PA, Sarka FH. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res 2009, 69:6704-12. 10.1158/0008-5472.CAN-09-1298, 19654291.
    • (2009) Cancer Res , vol.69 , pp. 6704-6712
    • Li, Y.1    Boom, T.G.2    Kon, D.3    Wan, Z.4    Al, S.5    Phili, P.A.6    Sarka, F.H.7
  • 63
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • 10.1101/gad.1640608, 2279201, 18381893
    • Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008, 22:894-907. 10.1101/gad.1640608, 2279201, 18381893.
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 64
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    • 10.1007/s10555-008-9179-y, 19153669
    • Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 2009, 28:151-66. 10.1007/s10555-008-9179-y, 19153669.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 65
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • 10.1016/j.ydbio.2003.06.003, 14697350
    • Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004, 265:23-32. 10.1016/j.ydbio.2003.06.003, 14697350.
    • (2004) Dev Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 66
    • 15744394838 scopus 로고    scopus 로고
    • LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta
    • 10.1074/jbc.M402651200, 15647284
    • Vardouli L, Moustakas A, Stournaras C. LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta. J Biol Chem 2005, 280:11448-57. 10.1074/jbc.M402651200, 15647284.
    • (2005) J Biol Chem , vol.280 , pp. 11448-11457
    • Vardouli, L.1    Moustakas, A.2    Stournaras, C.3
  • 67
    • 9944251987 scopus 로고    scopus 로고
    • Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation
    • Benitah SA, Valeron PF, van Aelst L, Marshall CJ, Lacal JC. Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim Biophys Acta 2004, 1705:121-32.
    • (2004) Biochim Biophys Acta , vol.1705 , pp. 121-132
    • Benitah, S.A.1    Valeron, P.F.2    van Aelst, L.3    Marshall, C.J.4    Lacal, J.C.5
  • 68
    • 2342643464 scopus 로고    scopus 로고
    • Beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition
    • 10.1038/sj.onc.1207416, 14755243
    • Eger A, Stockinger A, Park J, Langkopf E, Mikula M, Gotzmann J, Mikulits W, Beug H, Foisner R. beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition. Oncogene 2004, 23:2672-2680. 10.1038/sj.onc.1207416, 14755243.
    • (2004) Oncogene , vol.23 , pp. 2672-2680
    • Eger, A.1    Stockinger, A.2    Park, J.3    Langkopf, E.4    Mikula, M.5    Gotzmann, J.6    Mikulits, W.7    Beug, H.8    Foisner, R.9
  • 69
    • 39749157093 scopus 로고    scopus 로고
    • Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis
    • 10.1038/sj.onc.1210741, 17724470
    • Gal A, Sjoblom T, Fedorova L, Imreh S, Beug H, Moustakas A. Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene 2008, 27:1218-30. 10.1038/sj.onc.1210741, 17724470.
    • (2008) Oncogene , vol.27 , pp. 1218-1230
    • Gal, A.1    Sjoblom, T.2    Fedorova, L.3    Imreh, S.4    Beug, H.5    Moustakas, A.6
  • 70
    • 32944460413 scopus 로고    scopus 로고
    • Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition
    • 10.1158/0008-5472.CAN-05-2328, 16452224
    • Lacher MD, Tiirikainen MI, Saunier EF, Christian C, Anders M, Oft M, Balmain A, Akhurst RJ, Korn WM. Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition. Cancer Res 2006, 66:1648-57. 10.1158/0008-5472.CAN-05-2328, 16452224.
    • (2006) Cancer Res , vol.66 , pp. 1648-1657
    • Lacher, M.D.1    Tiirikainen, M.I.2    Saunier, E.F.3    Christian, C.4    Anders, M.5    Oft, M.6    Balmain, A.7    Akhurst, R.J.8    Korn, W.M.9
  • 71
    • 0038548187 scopus 로고    scopus 로고
    • Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest
    • 10.1038/sj.onc.1206420, 12802277
    • Nicolas FJ, Hill CS. Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest. Oncogene 2003, 22:3698-711. 10.1038/sj.onc.1206420, 12802277.
    • (2003) Oncogene , vol.22 , pp. 3698-3711
    • Nicolas, F.J.1    Hill, C.S.2
  • 72
    • 66349096392 scopus 로고    scopus 로고
    • Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase
    • 10.1128/MCB.01391-08, 2682043, 19289495
    • Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL. Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol 2009, 29:2748-61. 10.1128/MCB.01391-08, 2682043, 19289495.
    • (2009) Mol Cell Biol , vol.29 , pp. 2748-2761
    • Abell, A.N.1    Granger, D.A.2    Johnson, N.L.3    Vincent-Jordan, N.4    Dibble, C.F.5    Johnson, G.L.6
  • 73
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
    • 10.1242/jcs.00224, 12508111
    • Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003, 116:499-511. 10.1242/jcs.00224, 12508111.
    • (2003) J Cell Sci , vol.116 , pp. 499-511
    • Bolos, V.1    Peinado, H.2    Perez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 75
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-beta signalling inhibitors for cancer therapy
    • 10.1038/nrd1580, 15573100
    • Yingling JM, Blanchard KL, Sawyer JS. Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov 2004, 3:1011-22. 10.1038/nrd1580, 15573100.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 76
    • 33746034613 scopus 로고    scopus 로고
    • Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition
    • 10.1083/jcb.200512110, 2064178, 16831886
    • Thuault S, Valcourt U, Petersen M, Manfioletti G, Heldin CH, Moustakas A. Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol 2006, 174:175-83. 10.1083/jcb.200512110, 2064178, 16831886.
    • (2006) J Cell Biol , vol.174 , pp. 175-183
    • Thuault, S.1    Valcourt, U.2    Petersen, M.3    Manfioletti, G.4    Heldin, C.H.5    Moustakas, A.6
  • 77
    • 59449092007 scopus 로고    scopus 로고
    • Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines
    • 10.1158/1078-0432.CCR-08-1733, 19147758
    • Haddad Y, Choi W, McConkey DJ. Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines. Clin Cancer Res 2009, 15:532-42. 10.1158/1078-0432.CCR-08-1733, 19147758.
    • (2009) Clin Cancer Res , vol.15 , pp. 532-542
    • Haddad, Y.1    Choi, W.2    McConkey, D.J.3
  • 78
    • 47749136233 scopus 로고    scopus 로고
    • Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease
    • 10.1007/s00467-008-0818-x, 18446379
    • Zeisberg M, Kalluri R. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. Pediatr Nephrol 2008, 23:1395-8. 10.1007/s00467-008-0818-x, 18446379.
    • (2008) Pediatr Nephrol , vol.23 , pp. 1395-1398
    • Zeisberg, M.1    Kalluri, R.2
  • 80
    • 33751047033 scopus 로고    scopus 로고
    • Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma
    • 10.1038/sj.cgt.7700975, 16826191
    • Fakhrai H, Mantil JC, Liu L, Nicholson GL, Murphy-Satter CS, Ruppert J, Shawler DL. Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma. Cancer Gene Ther 2006, 13:1052-60. 10.1038/sj.cgt.7700975, 16826191.
    • (2006) Cancer Gene Ther , vol.13 , pp. 1052-1060
    • Fakhrai, H.1    Mantil, J.C.2    Liu, L.3    Nicholson, G.L.4    Murphy-Satter, C.S.5    Ruppert, J.6    Shawler, D.L.7
  • 81
    • 33644756429 scopus 로고    scopus 로고
    • Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial
    • 10.1016/j.cgh.2005.11.013, 16527696
    • Schreiber S, Feagan B, D'Haens G, Colombel JF, Geboes K, Yurcov M, Isakov V, Golovenko O, Bernstein CN, Ludwig D, et al. Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2006, 4:325-34. 10.1016/j.cgh.2005.11.013, 16527696.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 325-334
    • Schreiber, S.1    Feagan, B.2    D'Haens, G.3    Colombel, J.F.4    Geboes, K.5    Yurcov, M.6    Isakov, V.7    Golovenko, O.8    Bernstein, C.N.9    Ludwig, D.10
  • 82
    • 40849130917 scopus 로고    scopus 로고
    • Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers
    • 10.1001/archophthalmol.2007.76, 18332309
    • Tanihara H, Inatani M, Honjo M, Tokushige H, Azuma J, Araie M. Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers. Arch Ophthalmol 2008, 126:309-15. 10.1001/archophthalmol.2007.76, 18332309.
    • (2008) Arch Ophthalmol , vol.126 , pp. 309-315
    • Tanihara, H.1    Inatani, M.2    Honjo, M.3    Tokushige, H.4    Azuma, J.5    Araie, M.6
  • 83
    • 42949162045 scopus 로고    scopus 로고
    • The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy
    • 10.1038/sj.onc.1210946, 18037963
    • Lee DY, Sugden B. The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy. Oncogene 2008, 27:2833-42. 10.1038/sj.onc.1210946, 18037963.
    • (2008) Oncogene , vol.27 , pp. 2833-2842
    • Lee, D.Y.1    Sugden, B.2
  • 84
    • 70249109717 scopus 로고    scopus 로고
    • Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter
    • 10.1128/MCB.00383-09, 19620290
    • Ellison-Zelski SJ, Solodin NM, Alarig ET. Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter. Mol Cell Biol 2009, 29:4949-58. 10.1128/MCB.00383-09, 19620290.
    • (2009) Mol Cell Biol , vol.29 , pp. 4949-4958
    • Ellison-Zelski, S.J.1    Solodin, N.M.2    Alarig, E.T.3
  • 85
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • 10.1006/meth.2001.1262, 11846609
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-8. 10.1006/meth.2001.1262, 11846609.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.