Regulation of Par6 by extracellular signals

Current Opinion in Cell Biology

Volumn 18, Issue 2, 2006, Pages 206-212

  Bose, Rohit ^a,b   Wrana, Jeffrey L ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; INTEGRIN; PROTEIN PAR 6; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

CELL DIVISION; CELL JUNCTION; CELL MIGRATION; CELL MOTILITY; EPITHELIUM CELL; METASTASIS; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL;

ANIMALS; CELL MOVEMENT; CELL POLARITY; EPITHELIAL CELLS; HUMANS; MODELS, BIOLOGICAL; PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33644871234     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2006.02.005     Document Type: Review

References (52)

1. M.H. Roh, and B. Margolis Composition and function of PDZ protein complexes during cell polarization Am J Physiol Renal Physiol 285 2003 F377 F387
2. D. Henrique, and F. Schweisguth Cell polarity: the ups and downs of the Par6/aPKC complex Curr Opin Genet Dev 13 2003 341 350
3. I.G. Macara Parsing the polarity code Nat Rev Mol Cell Biol 5 2004 220 231
4. S. Etienne-Manneville, and A. Hall Cell polarity: Par6, aPKC and cytoskeletal crosstalk Curr Opin Cell Biol 15 2003 67 72
5. B. Margolis, and J.P. Borg Apicobasal polarity complexes J Cell Sci 118 2005 5157 5159
6. J.L. Watts, B. Etemad-Moghadam, S. Guo, L. Boyd, B.W. Draper, C.C. Mello, J.R. Priess, and K.J. Kemphues Par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3 Development 122 1996 3133 3140
7. L. Gao, and I.G. Macara Isoforms of the polarity protein par6 have distinct functions J Biol Chem 279 2004 41557 41562
8. D. Lin, A.S. Edwards, J.P. Fawcett, G. Mbamalu, J.D. Scott, and T. Pawson A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity Nat Cell Biol 2 2000 540 547
9. G. Joberty, C. Petersen, L. Gao, and I.G. Macara The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 Nat Cell Biol 2 2000 531 539
10. M. Brajenovic, G. Joberty, B. Kuster, T. Bouwmeester, and G. Drewes Comprehensive proteomic analysis of human par protein complexes reveals an interconnected protein network J Biol Chem 279 2004 12804 12811 The authors used tandem affinity purification of the Par proteins to identify interacting proteins. The data reveal that Par6 belongs to an extensively interconnected network of protein-protein interactions. This was one of the first proteomic studies of polarity proteins.
11. Y. Cai, L.J. Stafford, B.A. Bryan, D. Mitchell, and M. Liu G-protein-activated phospholipase C-β, new partners for cell polarity proteins par3 and par6 Oncogene 24 2005 4293 4300
12. M. Kanzaki, S. Mora, J.B. Hwang, A.R. Saltiel, and J.E. Pessin Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways J Cell Biol 164 2004 279 290
13. T. Lamark, M. Perander, H. Outzen, K. Kristiansen, A. Overvatn, E. Michaelsen, G. Bjorkoy, and T. Johansen Interaction codes within the family of mammalian phox and bem1p domain-containing proteins J Biol Chem 278 2003 34568 34581
14. E.R. Gomes, S. Jani, and G.G. Gundersen Nuclear movement regulated by cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells Cell 121 2005 451 463 Here, the authors examine the mechanism of MTOC reorientation during cell migration and make two important findings. Firstly, during MTOC reorientation, it is not the MTOC that moves per se; rather, the nucleus moves in a retrograde fashion to position itself behind the MTOC. Secondly, Par6 functions to 'hold' the MTOC in a fixed position while the nucleus is moving.
15. S. Etienne-Manneville, and A. Hall Integrin-mediated activation of cdc42 controls cell polarity in migrating astrocytes through PKCζ Cell 106 2001 489 498
16. J.S. Lee, M.I. Chang, Y. Tseng, and D. Wirtz Cdc42 mediates nucleus movement and MTOC polarization in swiss 3T3 fibroblasts under mechanical shear stress Mol Biol Cell 16 2005 871 880
17. D.J. Solecki, L. Model, J. Gaetz, T.M. Kapoor, and M.E. Hatten Par6alpha signaling controls glial-guided neuronal migration Nat Neurosci 7 2004 1195 1203
18. W. Guo, and F.G. Giancotti Integrin signalling during tumour progression Nat Rev Mol Cell Biol 5 2004 816 826
19. T. Yamanaka, Y. Horikoshi, A. Suzuki, Y. Sugiyama, K. Kitamura, R. Maniwa, Y. Nagai, A. Yamashita, T. Hirose, and H. Ishikawa PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex Genes Cells 6 2001 721 731
20. T.J. Hung, and K.J. Kemphues PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos Development 126 1999 127 135
21. A. Hutterer, J. Betschinger, M. Petronczki, and J.A. Knoblich Sequential roles of cdc42, par-6, aPKC, and lgl in the establishment of epithelial polarity during Drosophila embryogenesis Dev Cell 6 2004 845 854 Using a Drosophila embryo epithelial system, the authors examined the functional relationships between members of the Par6 polarity complex. This was one of the first genetic studies to elucidate a hierarchy and sequence of functioning among Cdc42, Par6 and aPKC. Furthermore, this paper demonstrated that the antagonism between the Par6 polarity complex and Lgl is actually mutual.
22. S. Etienne-Manneville, and A. Hall Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity Nature 421 2003 753 756
23. S. Etienne-Manneville, J.B. Manneville, S. Nicholls, M.A. Ferenczi, and A. Hall Cdc42 and par6-PKCζ regulate the spatially localized association of dlg1 and APC to control cell polarization J Cell Biol 170 2005 895 901 In this paper, the authors investigated the role of the Par6 polarity complex during polarized cell movement. They discovered that the polarity complex regulates the interaction between APC and Dlg. This finding may underlie the mechanism by which MTOC reorientation occurs in relation to extracellular cues.
24. K. Burridge, and K. Wennerberg Rho and rac take center stage Cell 116 2004 167 179
25. A.J. Ridley, M.A. Schwartz, K. Burridge, R.A. Firtel, M.H. Ginsberg, G. Borisy, J.T. Parsons, and A.R. Horwitz Cell migration: integrating signals from front to back Science 302 2003 1704 1709
26. L. Kjoller, and A. Hall Signaling to rho GTPases Exp Cell Res 253 1999 166 179
27. H.R. Wang, Y. Zhang, B. Ozdamar, A.A. Ogunjimi, E. Alexandrova, G.H. Thomsen, and J.L. Wrana Regulation of cell polarity and protrusion formation by targeting rhoA for degradation Science 302 2003 1775 1779
28. K. Matter, and M.S. Balda Signalling to and from tight junctions Nat Rev Mol Cell Biol 4 2003 225 236
29. L. Gao, G. Joberty, and I.G. Macara Assembly of epithelial tight junctions is negatively regulated by par6 Curr Biol 12 2002 221 225
30. A.E. Mertens, T.P. Rygiel, C. Olivo, R. van der Kammen, and J.G. Collard The Rac activator tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the par polarity complex J Cell Biol 170 2005 1029 1037
31. S.C. Nam, and K.W. Choi Interaction of par-6 and crumbs complexes is essential for photoreceptor morphogenesis in Drosophila Development 130 2003 4363 4372
32. T.W. Hurd, L. Gao, M.H. Roh, I.G. Macara, and B. Margolis Direct interaction of two polarity complexes implicated in epithelial tight junction assembly Nat Cell Biol 5 2003 137 142
33. C. Lemmers, D. Michel, L. Lane-Guermonprez, M.H. Delgrossi, E. Medina, J.P. Arsanto, and A. Le Bivic CRB3 binds directly to par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells Mol Biol Cell 15 2004 1324 1333
34. P.J. Plant, J.P. Fawcett, D.C. Lin, A.D. Holdorf, K. Binns, S. Kulkarni, and T. Pawson A polarity complex of mpar-6 and atypical PKC binds, phosphorylates and regulates mammalian lgl Nat Cell Biol 5 2003 301 308
35. J. Betschinger, K. Mechtler, and J.A. Knoblich The par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein lgl Nature 422 2003 326 330
36. J.P. Thiery Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 2002 442 454
37. P.M. Siegel, and J. Massague Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer Nat Rev Cancer 3 2003 807 821
38. L. Levy, and C.S. Hill Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses Mol Cell Biol 25 2005 8108 8125
39. •].
40. M. Barrios-Rodiles, K.R. Brown, B. Ozdamar, R. Bose, Z. Liu, R.S. Donovan, F. Shinjo, Y. Liu, J. Dembowy, and I.W. Taylor High-throughput mapping of a dynamic signaling network in mammalian cells Science 307 2005 1621 1625 Using a high-throughput screen, the authors identify extensive connectivity between the TGFβ pathway and the Pak and polarity networks. This led to the elucidation of the TGFβ-Par6 pathway, which controls the TGFβ-dependent dissolution of tight junctions in an epithelial cell line.
41. D.R. Warner, M.M. Pisano, E.A. Roberts, and R.M. Greene Identification of three novel smad binding proteins involved in cell polarity FEBS Lett 539 2003 167 173
42. A. Vaezi, C. Bauer, V. Vasioukhin, and E. Fuchs Actin cable dynamics and rho/rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium Dev Cell 3 2002 367 381
43. E. Sahai, and C.J. Marshall ROCK and dia have opposing effects on adherens junctions downstream of rho Nat Cell Biol 4 2002 408 415
44. W.Y. Lui, and W.M. Lee CAMP perturbs inter-sertoli tight junction permeability barrier in vitro via its effect on proteasome-sensitive ubiquitination of occludin J Cell Physiol 203 2005 564 572
45. S. Edlund, M. Landstrom, C.H. Heldin, and P. Aspenstrom Smad7 is required for TGF-β-induced activation of the small GTPase cdc42 J Cell Sci 117 2004 1835 1847
46. X.F. Liu, H. Ishida, R. Raziuddin, and T. Miki Nucleotide exchange factor ECT2 interacts with the polarity protein complex par6/par3/protein kinase cζ (PKCζ) and regulates PKCζ activity Mol Cell Biol 24 2004 6665 6675
47. M.C. Wilkes, S.J. Murphy, N. Garamszegi, and E.B. Leof Cell-type-specific activation of PAK2 by transforming growth factor β independent of smad2 and smad3 Mol Cell Biol 23 2003 8878 8889
48. D. Matenia, B. Griesshaber, X.Y. Li, A. Thiessen, C. Johne, J. Jiao, E. Mandelkow, and E.M. Mandelkow PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin Mol Biol Cell 16 2005 4410 4422
49. P. Labhart, S. Karmakar, E.M. Salicru, B.S. Egan, V. Alexiadis, B.W. O'Malley, and C.L. Smith Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator Proc Natl Acad Sci USA 102 2005 1339 1344
50. R.P. Regala, C. Weems, L. Jamieson, A. Khoor, E.S. Edell, C.M. Lohse, and A.P. Fields Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer Cancer Res 65 2005 8905 8911
51. M. Hoshino, T. Yoshimori, and S. Nakamura Small GTPase proteins rin and rit bind to PAR6 GTP-dependently and regulate cell transformation J Biol Chem 280 2005 22868 22874
52. M. Kusakabe, and E. Nishida The polarity-inducing kinase par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC EMBO J 23 2004 4190 4201 In this paper, the authors study the role of Par proteins during vertebrate development, a poorly understood area. Using the Xenopus model system, they find that Par6, aPKC and other polarity proteins are required for gastrulation to occur.