The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition

TheScientificWorldJournal

Volumn 8, Issue , 2008, Pages 901-904

  Paterson, Emily L ^a   Kolesnikoff, Natasha ^a   Gregory, Philip A ^a,b   Bert, Andrew G ^a   Khew Goodall, Yeesim ^a,c   Goodall, Gregory J ^a,b  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Epithelial to mesenchymal transition; miR 200; SIP1; ZEB1

Indexed keywords

MESSENGER RNA; MICRORNA; MICRORNA 200; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; APOPTOSIS; BINDING SITE; CELL ACTIVITY; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CELL MATURATION; CELL METABOLISM; CELL PROLIFERATION; CELL STRAIN; DOG; DOWN REGULATION; EMBRYO DEVELOPMENT; EPITHELIAL TO MESENCHYMAL TRANSITION; EPITHELIUM CELL; GENE OVEREXPRESSION; GENE TARGETING; IN VIVO STUDY; MESENCHYME CELL; METASTASIS; MICROARRAY ANALYSIS; MOLECULAR RECOGNITION; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVIEW;

ANIMALS; CELL LINE; DOGS; EPITHELIUM; HOMEODOMAIN PROTEINS; HUMANS; MESODERM; MICRORNAS; NEOPLASM METASTASIS; NEOPLASMS; NERVE TISSUE PROTEINS; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 52249100806     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2008.115     Document Type: Review

References (32)

1. Christofori, G. (2006) New signals from the invasive front. Nature 441, 444-450.
2. Sporn, M.B. (1996) The war on cancer. Lancet 347, 1377-1381.
3. Huber, M.A., Kraut, N., and Beug, H. (2005) Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17, 548-558.
4. Vleminckx, K., Vakaet, L., Mareel, M., Fiers, W., and Vanroy, F. (1991) Genetic manipulation of E-cadherin expression by epithelial tumor-cells reveals an invasion suppressor role. Cell 66, 107-119.
5. Yu, Z.B., Jian, Z.F., Shen, S.H., Purisima, E., and Wang, E. (2007) Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. Nucleic Acids Res. 35, 152-164.
6. Zhao, Y., Samal, E., and Srivastava, D. (2005) Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436, 214-220.
7. Cheng, A.M., Byrom, M.W., Shelton, J., and Ford, L.P. (2005) Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res. 33, 1290-1297.
8. Lee, Y.S., Kim, H.K., Chung, S.M., Kim, K.S., and Dutta, A. (2005) Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the downregulation of putative targets during differentiation. J. Biol. Chem. 280, 16635-16641.
9. Chen, C.Z., Li, L., Lodish, H.F., and Bartel, D.P. (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83-86.
10. Chan, J.A., Krichevsky, A.M., and Kosik, K.S. (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 65, 6029-6033.
11. Cimmino, A., Calin, G.A., Fabbri, M., Iorio, M.V., Ferracin, M., Shimizu, M., Wojcik, S.E., Aqeilan, R.I., Zupo, S., Dono, M., Rassenti, L., Alder, H., Volinia, S., Liu, C.G., Kipps, T.J., Negrini, M., and Croce, C.M. (2005) miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. U. S. A. 102, 13944-13949.
12. Xu, P.Z., Vernooy, S.Y., Guo, M., and Hay, B.A. (2003) The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism. Curr. Biol. 13, 790-795.
13. Lee, R.C., Feinbaum, R.L., and Ambros, V. (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854.
14. Johnston, R.J., Chang, S., Etchberger, J.F., Ortiz, C.O., and Hobert, O. (2005) MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision. Proc. Natl. Acad. Sci. U. S. A. 102, 12449-12454.
15. Johnston, R.J. and Hobert, O. (2003) A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Nature 426, 845-849.
16. Wienholds, E., Koudijs, M.J., van Eeden, F.J.M., Cuppen, E., and Plasterk, R.H.A. (2003) The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat. Genet. 35, 217-218.
17. Calin, G.A. and Croce, C.M. (2006) MicroRNA signatures in human cancers. Nat. Rev. Cancer 6, 857-866.
18. Tavazoie, S.F., Alarcon, C., Oskarsson, T., Padua, D., Wang, Q.Q., Bos, P.D., Gerald, W.L., and Massague, J. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451, 147-152.
19. Huang, Q.H., Gumireddy, K., Schrier, M., le Sage, C., Nagel, R., Nair, S., Egan, D.A., Li, A.P., Huang, G.H., Klein-Szanto, A.J., Gimotty, P.A., Katsaros, D., Coukos, G., Zhang, L., Pure, E., and Agami, R. (2008) The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat. Cell Biol. 10, 202-210.
20. Asangani, I.A., Rasheed, S.A.K., Nikolova, D.A., Leupold, J.H., Colburn, N.H., Post, S., and Allgayer, H. (2008) MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27, 2128-2136.
21. Ma, L., Teruya-Feldstein, J., and Weinberg, R.A. (2007) Tumour invasion and metastasis initiated by microRNA 10b in breast cancer. Nature 449, 682-688.
22. Sengupta, S., den Boon, J.A., Chen, I.H., Newton, M.A., Stanhope, S.A., Cheng, Y.J., Chen, C.J., Hildesheim, A., Sugden, B., and Ahlquist, P. (2008) MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc. Natl. Acad. Sci. U. S. A. 105, 5874-5878.
23. Peinado, H., Quintanilla, M., and Cano, A. (2003) Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines - mechanisms for epithelial mesenchymal transitions. J. Biol. Chem. 278, 21113-21123.
24. Peinado, H., Olmeda, D., and Cano, A. (2007) Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7, 415-428.
25. Hurteau, G.J., Carlson, J.A., Spivack, S.D., and Brock, G.J. (2007) Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. Cancer Res. 67, 7972-7976.
26. Christoffersen, N.R., Silahtaroglu, A., Orom, U.A., Kauppinen, S., and Lund, A.H. (2007) miR-200b mediates posttranscriptional repression of ZFHX1B. RNA 13, 1172-1178.
27. Wyatt, L., Wadham, C., Crocker, L.A., Lardelli, M., and Khew-Goodall, Y. (2007) The protein tyrosine phosphatase Pez regulates TGF beta, epithelial-mesenchymal transition, and organ development. J. Cell Biol. 178, 1223-1235.
28. Gregory, P.A., Bert, A.G., Paterson, E.L., Barry, S.C., Tsykin, A., Farshid, G., Vadas, M.A., Khew-Goodall, Y., and Goodall, G.J. (2008) The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 10, 593-601.
29. Lewis, B.P., Burge, C.B., and Bartel, D.P. (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20.
30. Park, S.M., Gaur, A.B., Lengyel, E., and Peter, M.E. (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 22, 894-907.
31. Korpal, M., Lee, E.S., Hu, G.H., and Kang, Y.B. (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J. Biol. Chem. 283, 14910-14914.
32. Burk, U., Schubert, J., Wellner, U., Schmalhofer, O., Vincan, E., Spaderna, S., and Brabletz, T. (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 9, 582-589.