Mutant N143P reveals how Na+ activates thrombin

Journal of Biological Chemistry

Volumn 284, Issue 52, 2009, Pages 36175-36185

  Niu, Weiling ^a   Chen, Zhiwei ^a   Bush Pelc, Leslie A ^a   Bah, Alaji ^a   Gandhi, Prafull S ^a   Di Cera, Enrico ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[CARBONYL; ENHANCED CATALYTIC ACTIVITY; MOLECULAR MECHANISM; OXYANION HOLE; PEPTIDE BONDS; WILD TYPES;

PEPTIDES;

POSITIVE IONS;

GLUTAMIC ACID; GLYCINE; PROLINE; SODIUM ION; THROMBIN;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; HYDROGEN BOND; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STEADY STATE;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; HYDROGEN BONDING; KINETICS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SODIUM; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 73649114244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.069500     Document Type: Article

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