Rational engineering of activity and specificity in a serine protease

Nature Biotechnology

Volumn 15, Issue 2, 1997, Pages 146-149

  Dang, Quoc D ^a   Guinto, Enriqueta R ^a   Di Cera, Enrico ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood coagulation; Protein engineering; Thrombin

Indexed keywords

SERINE PROTEINASE; THROMBIN;

ARTICLE; BINDING AFFINITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME REGULATION; ENZYME SPECIFICITY; GENETIC ENGINEERING; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTICOAGULANTS; BINDING SITES; COAGULANTS; FIBRINOGEN; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN C; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SODIUM; SUBSTRATE SPECIFICITY; THROMBIN; THROMBOMODULIN;

EID: 0031052393     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0297-146     Document Type: Article

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