-
1
-
-
73649152457
-
Allosteric proteins and cellular control systems
-
Monod J, Changeux JP, Jacob F (1963) Allosteric proteins and cellular control systems. J Mol Biol 6:306-329.
-
(1963)
J Mol Biol
, vol.6
, pp. 306-329
-
-
Monod, J.1
Changeux, J.P.2
Jacob, F.3
-
2
-
-
78651189765
-
On the nature of allosteric transitions: A plausible model
-
Monod J, Wyman J, Changeux JP (1965) On the nature of allosteric transitions: A plausible model. J Mol Biol 12:88-118.
-
(1965)
J Mol Biol
, vol.12
, pp. 88-118
-
-
Monod, J.1
Wyman, J.2
Changeux, J.P.3
-
3
-
-
41149163708
-
-
Wyman J, Gill SJ (1990) Binding and Linkage (Univ Science Books, Mill Valley, CA).
-
Wyman J, Gill SJ (1990) Binding and Linkage (Univ Science Books, Mill Valley, CA).
-
-
-
-
4
-
-
0014958182
-
Stereochemistry of cooperative effects in haemoglobin
-
Perutz MF (1970) Stereochemistry of cooperative effects in haemoglobin. Nature 228:726-739.
-
(1970)
Nature
, vol.228
, pp. 726-739
-
-
Perutz, M.F.1
-
5
-
-
20344370764
-
Allosteric mechanisms of signal transduction
-
Changeux JP, Edelstein SJ (2006) Allosteric mechanisms of signal transduction. Science 308:1424-1428.
-
(2006)
Science
, vol.308
, pp. 1424-1428
-
-
Changeux, J.P.1
Edelstein, S.J.2
-
6
-
-
33644686444
-
A structural perspective on enzymes activated by monovalent cations
-
Di Cera E (2006) A structural perspective on enzymes activated by monovalent cations. J Biol Chem 281:1305-1308.
-
(2006)
J Biol Chem
, vol.281
, pp. 1305-1308
-
-
Di Cera, E.1
-
7
-
-
0025058563
-
Escherichia coli aspartate transcarbamylase: The molecular basis for a concerted allosteric transition
-
Kantrowicz ER, Lipscomb WM (1990) Escherichia coli aspartate transcarbamylase: the molecular basis for a concerted allosteric transition. Trends Biochem Sci 15:53-59.
-
(1990)
Trends Biochem Sci
, vol.15
, pp. 53-59
-
-
Kantrowicz, E.R.1
Lipscomb, W.M.2
-
8
-
-
33751539464
-
Protein-protein interactions in the allosteric regulation of protein kinases
-
Pellicena P, Kuriyan J (2006) Protein-protein interactions in the allosteric regulation of protein kinases. Curr Opin Struct Biol 16:702-709.
-
(2006)
Curr Opin Struct Biol
, vol.16
, pp. 702-709
-
-
Pellicena, P.1
Kuriyan, J.2
-
9
-
-
0030870719
-
The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex
-
Xu Z, Horwich AL, Sigler PB (1997) The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex. Nature 388:741-750.
-
(1997)
Nature
, vol.388
, pp. 741-750
-
-
Xu, Z.1
Horwich, A.L.2
Sigler, P.B.3
-
10
-
-
6344219895
-
Is allostery an intrinsic property of all dynamic proteins?
-
Gunasekaran K, Ma B, Nussinov R (2004) Is allostery an intrinsic property of all dynamic proteins? Prot Struct Funct Genet 57:433-443.
-
(2004)
Prot Struct Funct Genet
, vol.57
, pp. 433-443
-
-
Gunasekaran, K.1
Ma, B.2
Nussinov, R.3
-
11
-
-
32344434479
-
The changing landscape of protein allostery
-
Swain JF, Gierasch LM (2006) The changing landscape of protein allostery. Curr Opin Struct Biol 16:102-108.
-
(2006)
Curr Opin Struct Biol
, vol.16
, pp. 102-108
-
-
Swain, J.F.1
Gierasch, L.M.2
-
12
-
-
33947255551
-
Thrombin allostery
-
Di Cera E, Page MJ, Bah A, Bush-Pelc LA, Garvey LC (2007) Thrombin allostery. Phys Chem Chem Phys 9:1292-1306.
-
(2007)
Phys Chem Chem Phys
, vol.9
, pp. 1292-1306
-
-
Di Cera, E.1
Page, M.J.2
Bah, A.3
Bush-Pelc, L.A.4
Garvey, L.C.5
-
13
-
-
0035859857
-
Propagating conformational changes over long (and short) distances in proteins
-
Yu EW, Koshland DE, Jr (2001) Propagating conformational changes over long (and short) distances in proteins. Proc Natl Acad Sci USA 98:9517-9520.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9517-9520
-
-
Yu, E.W.1
Koshland Jr, D.E.2
-
14
-
-
0037219686
-
Evolutionarily conserved networks of residues mediate allosteric communication in proteins
-
Süel GM, Lockless SW, Wall MA, Ranganathan R (2003) Evolutionarily conserved networks of residues mediate allosteric communication in proteins. Nat Struct Biol 10:59-69.
-
(2003)
Nat Struct Biol
, vol.10
, pp. 59-69
-
-
Süel, G.M.1
Lockless, S.W.2
Wall, M.A.3
Ranganathan, R.4
-
15
-
-
22444450449
-
Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion
-
Ota N, Agard DA (2007) Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion. J Mol Biol 351:345-354.
-
(2007)
J Mol Biol
, vol.351
, pp. 345-354
-
-
Ota, N.1
Agard, D.A.2
-
16
-
-
33645353328
-
Structure and interaction modes of thrombin
-
Bode W (2006) Structure and interaction modes of thrombin. Blood Cells Mol Dis 36:122-130.
-
(2006)
Blood Cells Mol Dis
, vol.36
, pp. 122-130
-
-
Bode, W.1
-
17
-
-
33646470969
-
An overview of the structure and function of thrombin
-
Davie EW, Kulman JD (2006) An overview of the structure and function of thrombin. Semin Thromb Hemost 32(Suppl 1):3-15.
-
(2006)
Semin Thromb Hemost
, vol.32
, Issue.SUPPL. 1
, pp. 3-15
-
-
Davie, E.W.1
Kulman, J.D.2
-
18
-
-
0029014036
-
An allosteric switch controls the procoagulant and anticoagulant activities of thrombin
-
Dang OD, Vindigni A, Di Cera E (1995) An allosteric switch controls the procoagulant and anticoagulant activities of thrombin. Proc Natl Acad Sci USA 92:5977-5981.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5977-5981
-
-
Dang, O.D.1
Vindigni, A.2
Di Cera, E.3
-
20
-
-
0029090336
-
+ binding site of thrombin
-
+ binding site of thrombin. J Biol Chem 270:22089-22092.
-
(1995)
J Biol Chem
, vol.270
, pp. 22089-22092
-
-
Di Cera, E.1
-
21
-
-
3843133006
-
+ binding to thrombin
-
+ binding to thrombin. J Biol Chem 279:31842-31853.
-
(2004)
J Biol Chem
, vol.279
, pp. 31842-31853
-
-
Pineda, A.O.1
-
22
-
-
0031052393
-
Rational engineering of activity and specificity in a serine protease
-
Dang QD, Guinto ER, Di Cera E (1997) Rational engineering of activity and specificity in a serine protease. Nat Biotechnol 15:146-149.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 146-149
-
-
Dang, Q.D.1
Guinto, E.R.2
Di Cera, E.3
-
23
-
-
22844449689
-
Hirudin binding reveals key determinants of thrombin allostery
-
Mengwasser KE, Bush LA, Shih P, Cantwell AM, Di Cera E (2005) Hirudin binding reveals key determinants of thrombin allostery. J Biol Chem 280:23997-27003.
-
(2005)
J Biol Chem
, vol.280
, pp. 23997-27003
-
-
Mengwasser, K.E.1
Bush, L.A.2
Shih, P.3
Cantwell, A.M.4
Di Cera, E.5
-
24
-
-
0026003287
-
The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity
-
Liu LW, Vu TK, Esmon CT, Coughlin SR (1991) The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem 266:16977-16980.
-
(1991)
J Biol Chem
, vol.266
, pp. 16977-16980
-
-
Liu, L.W.1
Vu, T.K.2
Esmon, C.T.3
Coughlin, S.R.4
-
25
-
-
0032512433
-
Thrombomodulin increases the rate of thrombin inhibition by BPTI
-
Rezaie AR, He X, Esmon CT (1998) Thrombomodulin increases the rate of thrombin inhibition by BPTI. Biochemistry 37:693-699.
-
(1998)
Biochemistry
, vol.37
, pp. 693-699
-
-
Rezaie, A.R.1
He, X.2
Esmon, C.T.3
-
26
-
-
0142091399
-
Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin
-
Rezaie AR, Yang L (2003) Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin. Proc Natl Acad Sci USA 100:12051-12056.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12051-12056
-
-
Rezaie, A.R.1
Yang, L.2
-
28
-
-
0028084791
-
Molecular recognition by thrombin. Role of the slow→fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components
-
Ayala Y, Di Cera E (1994) Molecular recognition by thrombin. Role of the slow→fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components. J Mol Biol 235:733-746.
-
(1994)
J Mol Biol
, vol.235
, pp. 733-746
-
-
Ayala, Y.1
Di Cera, E.2
-
29
-
-
0027050807
-
The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships
-
Bode W, Turk D, Karshikov A (1992) The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci 1:426-471.
-
(1992)
Protein Sci
, vol.1
, pp. 426-471
-
-
Bode, W.1
Turk, D.2
Karshikov, A.3
-
30
-
-
0034732094
-
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
-
Fuentes-Prior P, et al. (2000) Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex. Nature 404:518-525.
-
(2000)
Nature
, vol.404
, pp. 518-525
-
-
Fuentes-Prior, P.1
-
31
-
-
0028586082
-
The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: Changes accompanying activation and exosite binding to thrombin
-
Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A (1994) The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Protein Sci 3:2254-2271.
-
(1994)
Protein Sci
, vol.3
, pp. 2254-2271
-
-
Vijayalakshmi, J.1
Padmanabhan, K.P.2
Mann, K.G.3
Tulinsky, A.4
-
32
-
-
34547466613
-
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4
-
Bah A, Chen Z, Bush-Pelc LA, Mathews FS, Di Cera E (2007) Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc Natl Acad Sci USA 104:11603-11608.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 11603-11608
-
-
Bah, A.1
Chen, Z.2
Bush-Pelc, L.A.3
Mathews, F.S.4
Di Cera, E.5
-
33
-
-
0034648757
-
Thrombin signalling and protease-activated receptors
-
Coughlin SR (2000) Thrombin signalling and protease-activated receptors. Nature 407:258-264.
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
34
-
-
28344436780
-
Protease-activated receptors in hemostasis, thrombosis and vascular biology
-
Coughlin SR (2005) Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3:1800-1814.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 1800-1814
-
-
Coughlin, S.R.1
-
35
-
-
0034611727
-
PAR3 is a cofactor for PAR4 activation by thrombin
-
Nakanishi-Matsui M, et al. (2000) PAR3 is a cofactor for PAR4 activation by thrombin. Nature 404:609-613.
-
(2000)
Nature
, vol.404
, pp. 609-613
-
-
Nakanishi-Matsui, M.1
-
36
-
-
0029112841
-
Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface
-
Esmon CT (1995) Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J 9:946-955.
-
(1995)
FASEB J
, vol.9
, pp. 946-955
-
-
Esmon, C.T.1
-
37
-
-
0141819138
-
The protein C pathway
-
Esmon CT (2003) The protein C pathway. Chest 124:26S-32S.
-
(2003)
Chest
, vol.124
-
-
Esmon, C.T.1
-
38
-
-
0026072517
-
Domains specifying thrombin-receptor interaction
-
Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR (1991) Domains specifying thrombin-receptor interaction. Nature 353:674-677.
-
(1991)
Nature
, vol.353
, pp. 674-677
-
-
Vu, T.K.1
Wheaton, V.I.2
Hung, D.T.3
Charo, I.4
Coughlin, S.R.5
-
39
-
-
0344668870
-
Structural basis for thrombin activation of a protease-activated receptor: Inhibition of intramolecular liganding
-
Seeley S, Covic L, Jacques SL, Sudmeier J, Baleja JD, Kuliopulos A (2003) Structural basis for thrombin activation of a protease-activated receptor: Inhibition of intramolecular liganding. Chem Biol 10:1033-1041.
-
(2003)
Chem Biol
, vol.10
, pp. 1033-1041
-
-
Seeley, S.1
Covic, L.2
Jacques, S.L.3
Sudmeier, J.4
Baleja, J.D.5
Kuliopulos, A.6
-
40
-
-
0035501805
-
Molecular mapping of thrombin-receptor interactions
-
Ayala YM, Cantwell AM, Rose T, Bush LA, Arosio D, Di Cera E (2001) Molecular mapping of thrombin-receptor interactions. Proteins 45:107-116.
-
(2001)
Proteins
, vol.45
, pp. 107-116
-
-
Ayala, Y.M.1
Cantwell, A.M.2
Rose, T.3
Bush, L.A.4
Arosio, D.5
Di Cera, E.6
-
41
-
-
0028209977
-
Crystallographic structures of thrombin complexed with thrombin receptor peptides: Existence of expected and novel binding modes
-
Mathews II, et al. (1994) Crystallographic structures of thrombin complexed with thrombin receptor peptides: Existence of expected and novel binding modes. Biochemistry 33: 3266-3279.
-
(1994)
Biochemistry
, vol.33
, pp. 3266-3279
-
-
Mathews II1
-
42
-
-
33845939797
-
Crystal structure of thrombin in a self-inhibited conformation
-
Pineda AO, Chen ZW, Bah A, Garvey LC, Mathews FS, Di Cera E (2006) Crystal structure of thrombin in a self-inhibited conformation. J Biol Chem 281:32922-32928.
-
(2006)
J Biol Chem
, vol.281
, pp. 32922-32928
-
-
Pineda, A.O.1
Chen, Z.W.2
Bah, A.3
Garvey, L.C.4
Mathews, F.S.5
Di Cera, E.6
-
43
-
-
0026476381
-
Thrombin is a Na(+)-activated enzyme
-
Wells CM, Di Cera E (1992) Thrombin is a Na(+)-activated enzyme. Biochemistry 31:11721-11730.
-
(1992)
Biochemistry
, vol.31
, pp. 11721-11730
-
-
Wells, C.M.1
Di Cera, E.2
-
44
-
-
0141484541
-
Thrombin interactions
-
Di Cera E (2003) Thrombin interactions. Chest 124:11S-17S.
-
(2003)
Chest
, vol.124
-
-
Di Cera, E.1
-
45
-
-
0031733334
-
Switching serine protease specificity
-
Esmon CT, Mather T (1998) Switching serine protease specificity. Nat Struct Biol 5:933-937.
-
(1998)
Nat Struct Biol
, vol.5
, pp. 933-937
-
-
Esmon, C.T.1
Mather, T.2
-
46
-
-
34447499926
-
Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation
-
Kroh HK, Tans G, Nicolaes GAF, Rosing J, Bock PE (2007) Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation. J Biol Chem 282:16095-16104.
-
(2007)
J Biol Chem
, vol.282
, pp. 16095-16104
-
-
Kroh, H.K.1
Tans, G.2
Nicolaes, G.A.F.3
Rosing, J.4
Bock, P.E.5
-
47
-
-
0030810220
-
Kinetic pathway for the slow to fast transition of thrombin: Evidence of linked ligand binding at structurally distinct domains
-
Lai MT, Di Cera E, Shafer JA (1997) Kinetic pathway for the slow to fast transition of thrombin: Evidence of linked ligand binding at structurally distinct domains. J Biol Chem 272:30275-30282.
-
(1997)
J Biol Chem
, vol.272
, pp. 30275-30282
-
-
Lai, M.T.1
Di Cera, E.2
Shafer, J.A.3
-
48
-
-
0027516679
-
Evidence for common structural changes in thrombin induced by active-site or exosite binding
-
Parry MA, Stone SR, Hofsteenge J, Jackman MP (1993) Evidence for common structural changes in thrombin induced by active-site or exosite binding. Biochem J 290(Pt 3):665-670.
-
(1993)
Biochem J
, vol.290
, Issue.PART 3
, pp. 665-670
-
-
Parry, M.A.1
Stone, S.R.2
Hofsteenge, J.3
Jackman, M.P.4
-
49
-
-
14844331743
-
Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C
-
Xu H, Bush LA, Pineda AO, Caccia S, Di Cera E (2005) Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C. J Biol Chem 280:7956-7961.
-
(2005)
J Biol Chem
, vol.280
, pp. 7956-7961
-
-
Xu, H.1
Bush, L.A.2
Pineda, A.O.3
Caccia, S.4
Di Cera, E.5
-
50
-
-
0021099422
-
Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C
-
Esmon NL, DeBault LE, Esmon CT (1983) Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C. J Biol Chem 258:5548-5553.
-
(1983)
J Biol Chem
, vol.258
, pp. 5548-5553
-
-
Esmon, N.L.1
DeBault, L.E.2
Esmon, C.T.3
-
55
-
-
33748781457
-
The dynamic energy landscape of dihydrofolate reductase catalysis
-
Boehr DD, McElheny D, Dyson HJ, Wright PE (2006) The dynamic energy landscape of dihydrofolate reductase catalysis. Science 313:1638-1642.
-
(2006)
Science
, vol.313
, pp. 1638-1642
-
-
Boehr, D.D.1
McElheny, D.2
Dyson, H.J.3
Wright, P.E.4
-
56
-
-
9944263528
-
Searching for new allosteric sites in enzymes
-
Hardy JA, Wells JA (2004) Searching for new allosteric sites in enzymes. Curr Opin Struct Biol 14:706-715.
-
(2004)
Curr Opin Struct Biol
, vol.14
, pp. 706-715
-
-
Hardy, J.A.1
Wells, J.A.2
-
57
-
-
0034704118
-
Rational design of a potent anticoagulant thrombin
-
Cantwell AM, Di Cera E (2000) Rational design of a potent anticoagulant thrombin. J Biol Chem 275:39827-39830.
-
(2000)
J Biol Chem
, vol.275
, pp. 39827-39830
-
-
Cantwell, A.M.1
Di Cera, E.2
-
58
-
-
0037008668
-
The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo
-
Gruber A, Cantwell AM, Di Cera E, Hanson SR (2002) The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo. J Biol Chem 277:27581-27584.
-
(2002)
J Biol Chem
, vol.277
, pp. 27581-27584
-
-
Gruber, A.1
Cantwell, A.M.2
Di Cera, E.3
Hanson, S.R.4
-
59
-
-
34247379463
-
Relative antithrombotic and antihemostatic effects of protein C activator versus low molecular weight heparin in primates
-
Gruber A, et al. (2007) Relative antithrombotic and antihemostatic effects of protein C activator versus low molecular weight heparin in primates. Blood 109:3733-3740.
-
(2007)
Blood
, vol.109
, pp. 3733-3740
-
-
Gruber, A.1
-
60
-
-
4544312894
-
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket
-
Pineda AO, et al. (2004) The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem 279:39824-39828.
-
(2004)
J Biol Chem
, vol.279
, pp. 39824-39828
-
-
Pineda, A.O.1
-
61
-
-
0031059866
-
Processing of x-ray diffraction data collected by oscillation methods
-
Otwinowski Z, Minor W (1997) Processing of x-ray diffraction data collected by oscillation methods. Methods Enzymol 276:307-326.
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
62
-
-
0028103275
-
The CCP4 suite. Programs for protein crystallography
-
Bailey S (1994) The CCP4 suite. Programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50:760-763.
-
(1994)
Acta Crystallogr D Biol Crystallogr
, vol.50
, pp. 760-763
-
-
Bailey, S.1
-
63
-
-
3543012707
-
Crystallography and NMR system: A new software suite for macromolecular structure determination
-
Brunger AT, et al. (1998) Crystallography and NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr 54(Pt 5):905-921.
-
(1998)
Acta Crystallogr D Biol Crystallogr
, vol.54
, Issue.PART 5
, pp. 905-921
-
-
Brunger, A.T.1
|