Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site

Journal of Biological Chemistry

Volumn 277, Issue 40, 2002, Pages 37863-37870

  Camire, Rodney M ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; SUBSTITUTION REACTIONS;

MUTANTS;

ENZYMES;

BLOOD CLOTTING FACTOR 10A; ENZYME PRECURSOR; SODIUM;

ALLOSTERISM; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME KINETICS; GENE MUTATION; HUMAN; HUMAN CELL; MEMBRANE BINDING; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; BINDING SITES; CATALYSIS; CELL LINE; CHROMATOGRAPHY, AFFINITY; FACTOR XA; HUMANS; KINETICS; MODELS, THEORETICAL; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SODIUM; THROMBOPLASTIN; TRANSFECTION;

EID: 0037020083     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203692200     Document Type: Article

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