Stabilization of the E* form turns thrombin into an anticoagulant

Journal of Biological Chemistry

Volumn 284, Issue 30, 2009, Pages 20034-20040

  Bah, Alaji ^a   Carrell, Christopher J ^a   Chen, Zhiwei ^a   Gandhi, Prafull S ^a   Di Cera, Enrico ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AUTOLYSIS LOOP; E-FORMS; FREEFORMS; MOLECULAR ORIGINS; OXYANION HOLE; PEPTIDE BONDS; ROOT MEAN SQUARE DEVIATIONS; SIDE CHAINS; THROMBOMODULIN; X RAY CRYSTAL STRUCTURES;

AMINES; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES; CONFORMATIONS; GLYCOPROTEINS; STABILIZATION;

CRYSTAL STRUCTURE;

ANTICOAGULANT AGENT; THROMBIN; ARGATROBAN; MUTANT PROTEIN; PIPECOLIC ACID DERIVATIVE; PROTEIN C; THROMBOMODULIN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; MOLECULAR MECHANICS; MUTATION; PRIORITY JOURNAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; GENETICS; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANTICOAGULANTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PIPECOLIC ACIDS; PROTEIN BINDING; PROTEIN C; PROTEIN CONFORMATION; THROMBIN; THROMBOMODULIN;

EID: 67749099787     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.012344     Document Type: Article

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