Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase

Journal of Molecular Biology

Volumn 384, Issue 1, 2008, Pages 151-164

  Marciano, David C ^a   Pennington, Jeanine M ^a   Wang, Xiaohu ^a   Wang, Jian ^a   Chen, Yu ^b   Thomas, Veena L ^b   Shoichet, Brian K ^b   Palzkill, Timothy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antibiotic resistance; enzyme structure; global suppressor; protein stability; random mutation

Indexed keywords

BETA LACTAMASE TEM 1; PROLINE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME KINETICS; ENZYME STABILITY; GENETIC SELECTION; GENETIC VARIABILITY; IN VITRO STUDY; L201P GENE; NONHUMAN; PENICILLIN RESISTANCE; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS; SUPPRESSOR GENE; X RAY;

BACTERIA (MICROORGANISMS);

EID: 54249109407     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.09.009     Document Type: Article

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