Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain

Journal of Biological Chemistry

Volumn 280, Issue 18, 2005, Pages 18476-18487

  Nogami, Keiji ^a   Zhou, Qian ^a   Myles, Timothy ^b   Leung, Lawrence L K ^b   Wakabayashi, Hironao ^a   Fay, Philip J ^a,c  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BINDING ENERGY; CATALYSIS; ENERGY TRANSFER; FLUORESCENCE;

EXOSITE-INTERACTIVE REGIONS; FLUORESCENCE ENERGY TRANSFER; PROTEOLYTIC ACTIVATION; THROMBIN BINDING;

ENZYMES;

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; BLOOD CLOTTING FACTOR 7; HEPARIN; HIRUDIN; THROMBIN; BLOOD CLOTTING FACTOR 8; PEPTIDE FRAGMENT; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEAVY CHAIN; HEMOPHILIA; LIGHT CHAIN; MUTANT; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; STEADY STATE; WESTERN BLOTTING; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; HUMAN; HYDROLYSIS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

CATALYSIS; FACTOR VIII; HUMANS; HYDROLYSIS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; THROMBIN;

EID: 22844450455     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412778200     Document Type: Article

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