Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

Biochemistry

Volumn 35, Issue 51, 1996, Pages 16449-16457

  Tsiang, M ^a   Paborsky, L R ^a   Li, W X ^a   Jain, A K ^a   Mao, C T ^a   Dunn, K E ^a   Lee, D W ^a   Matsumura, S Y ^a   Matteucci, M D ^a   Coutre S E ^a,b   Leung, L L K ^a,b   Gibbs, C S ^a  

^a GILEAD SCIENCES   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; THROMBIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTICOAGULATION; ARTICLE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENETIC ENGINEERING; MONKEY; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; DRUG EVALUATION, PRECLINICAL; FIBRINOGEN; HALF-LIFE; HUMANS; KINETICS; MACACA FASCICULARIS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PLATELET ACTIVATION; PROTEIN C; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY; THROMBIN;

ANIMALIA; MACACA FASCICULARIS;

EID: 12644264319     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9616108     Document Type: Article

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