Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an α/β C-terminal extension and alternate conformations of the oxyanion hole

Journal of Biological Chemistry

Volumn 277, Issue 42, 2002, Pages 39960-39966

  Barrette Ng, Isabelle H ^a   Ng, Kenneth K S ^a   Mark, Brian L ^a   Van Aken, Danny ^b   Cherney, Maia M ^a   Garen, Craig ^a   Kolodenko, Yuliya ^a   Gorbalenya, Alexander E ^b   Snijder, Eric J ^b   James, Michael N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; PROTEINS;

PATHOGENS;

VIRUSES;

ANION; CHYMOTRYPSIN; OXYANION; POLYPROTEIN; PROTEIN; PROTEIN NSP4; PROTEINASE; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

AMINO ACID SEQUENCE; ARTERIVIRUS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME CONFORMATION; ENZYME PURIFICATION; EQUINE VIRAL ARTERITIS VIRUS; HYDROGEN BOND; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RNA VIRUS; VIRUS MORPHOLOGY;

AMINO ACID SEQUENCE; ANIONS; ARTERIVIRUS; ASPARTIC ACID; BINDING SITES; CATALYTIC DOMAIN; CHYMOTRYPSIN; CRYSTALLOGRAPHY, X-RAY; HISTIDINE; MODELS, GENETIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SERINE ENDOPEPTIDASES;

ARTERIVIRUS; EQUIDAE; EQUINE ARTERITIS VIRUS; EQUUS CABALLUS; RNA VIRUSES; SUS SCROFA;

EID: 0037131373     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206978200     Document Type: Article

References (38)

1. Wensvoort, G., Terpstra, C., Pol, J. M., ter Laak, E. A., Bloemraad, M., de Kluyver, E. P., Kragten, C., van Buiten, L., den Besten, A., and Wagenaar, F. (1991) Vet. Q, 13, 121-130
2. Doll, E. R., Bryans, J. T., McCollum, W. H. M., and Wallace, M. E. (1957) Cornell Vet. 47, 3-41
3. Timoney, P. J. (2002) in Equine Respiratory Diseases (Lekeux, P., ed), International Veterinary Information Service, Ithaca, NY
4. Botner, A., Strandbygaard, B., Sorensen, K. J., Have, P., Madsen, K. G., Madsen, E. S., and Alexandersen, S. (1997) Vet. Rec. 141, 497-499
5. Snijder, E. J., and Meulenberg, J. J. M. (2001) in Fields Virology (Knipe, D. M., and Howley, P. M., eds) Vol. 1, 4th Ed., pp. 1205-1220, 2 vols., Lippincott Williams and Wilkins, Philadelphia, PA
6. Snijder, E. J., and Meulenberg, J. J. (1998) J. Gen. Virol. 79, 961-979
7. Ziebuhr, J., Snijder, E. J., and Gorbalenya, A. E. (2000) J. Gen. Virol. 81, 853-879
8. Pasternak, A. O., van den Born, E., Spaan, W. J., and Snijder, E. J. (2001) EMBO J. 20, 7220-7228
9. den Boon, J. A., Snijder, E. J., Chirnside, E. D., de Vries, A. A., Horzinek, M. C., and Spaan, W. J. (1991) J. Virol. 65, 2910-2920
10. Snijder, E. J., Wassenaar, A. L., and Spaan, W. J. (1994) J. Virol. 68, 5755-5764
11. Pedersen, K. W., van der Meer, Y., Roos, N., and Snijder, E. J. (1999) J. Virol. 73, 2016-2026
12. Snijder, E. J., Wassenaar, A. L., van Dinten, L. C., Spaan, W. J., and Gorbalenya, A. E. (1996) J. Biol. Chem. 271, 4864-4871
13. Wassenaar, A. L., Spaan, W. J. M., Gorbalenya, A. E., and Snijder, E. J. (1997) J. Virol. 71, 9313-9322
14. van Dinten, L. C., Rensen, S., Gorbalenya, A. E., and Snijder, E. J. (1999) J. Virol. 73, 2027-2037
15. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
16. Terwilliger, T. C., and Berendzen, J. (1999) Acta Crystallogr. D Biol. Crystallogr. 55, 849-861
17. Terwilliger, T. C. (2001) Acta Crystallogr. D Biol. Crystallogr. 57, 1755-1762
18. Perrakis, A., Morris, R., and Lamzin, V. S. (1999) Nat. Struct. Biol. 6, 458-463
19. McRee, D. E. (1999) J. Struct. Biol. 125, 156-165
20. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol. Crystallogr. 54, 905-921
21. Winn, M. D., Isupov, M. N., and Murshudov, G. N. (2001) Acta Crystallogr, D Biol. Crystallogr. 57, 122-133
22. Morris, A. L., MacArthur, M. W., Hutchinson, E. G., and Thornton, J. M. (1992) Proteins 12, 345-364
23. Hooft, R. W., Vriend, G., Sander, C., and Abola, E. E. (1996) Nature 381, 272
24. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
25. Esnouf, R. M. (1997) J. Mol. Graph. Model. 15, 132-134
26. Merritt, E. A., and Bacon, M. (1997) Methods Enzymol. 277, 505-524
27. Tong, L., Wengler, G., and Rossmann, M. G. (1993) J. Mol. Biol. 230, 228-247
28. Choi, H. K., Lu, G., Lee, S., Wengler, G., and Rossmann, M. G. (1997) Proteins 27, 345-359
29. Hayward, S., and Berendsen, H. J. (1998) Proteins 30, 144-154
30. Matthews, D. A., Dragovich, P. S., Webber, S. E., Fuhrman, S. A., Patick, A. K., Zalman, L. S., Hendrickson, T. F., Love, R. A., Prins, T. J., Marakovits, J. T., Zhou, R., Tikhe, J., Ford, C. E., Meador, J. W., Ferre, R. A., Brown, E. L., Binford, S. L., Brothers, M. A., DeLisle, D. M., and Worland, S. T. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11000-11007
31. Nienaber, V. L., Breddam, K., and Birktoft, J. J. (1993) Biochemistry 32, 11469-11475
32. Anand, K., Palm, G. J., Mesters, J. R., Siddell, S. G., Ziebuhr, J., and Hilgenfeld, R. (2002) EMBO J. 21, 3213-3224
33. Hayward, S. (2001) Protein Sci 10, 2219-2227
34. Gunasekaran, K., Gomathi, L., Ramakrishnan, C., Chandrasekhar, J., and Balaram, P. (1998) J. Mol. Biol. 284, 1505-1516
35. Allaire, M., Chernaia, M. M., Malcolm, B. A., and James, M. N. (1994) Nature 369, 72-76
36. Stennicke, H. R., Birktoft, J. J., and Breddam, K. (1996) Protein Sci. 5, 2266-2275
37. Petersen, J. F., Cherney, M. M., Liebig, H. D., Skern, T., Kuechler, E., and James, M. N. (1999) EMBO J. 18, 5463-5475
38. DeLano, W. L. (2002), DeLano Scientific, San Carlos, CA