Vitamin-regulated cytokines and growth factors in the CNS and elsewhere

Journal of Neurochemistry

Volumn 111, Issue 6, 2009, Pages 1309-1326

  Scalabrino, Giuseppe ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Central nervous system; Cobalamin; Cytokines; Growth factors; Immune system; Nuclear factor B; Vitamin deficiency induced diseases; Vitamins

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CYANOCOBALAMIN; CYTOKINE; EPIDERMAL GROWTH FACTOR; FARNOQUINONE; FIBROBLAST GROWTH FACTOR 23; GAMMA INTERFERON; GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; NERVE GROWTH FACTOR; NICOTINAMIDE; PANTOTHENIC ACID; PHYTOMENADIONE; RETINOL; RIBOFLAVIN; THIAMINE; TRACE ELEMENT; TUMOR NECROSIS FACTOR ALPHA; VITAMIN; VITAMIN D; VITAMIN K GROUP;

BLOOD BRAIN BARRIER; CELL DIFFERENTIATION; CELL STRUCTURE; CENTRAL NERVOUS SYSTEM; CYANOCOBALAMIN DEFICIENCY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPIGENETICS; HUMAN; IMMUNOMODULATION; IN VIVO STUDY; NONHUMAN; NUTRIGENOMICS; PRIORITY JOURNAL; REVIEW;

ANIMALS; AVITAMINOSIS; CENTRAL NERVOUS SYSTEM; CYTOKINES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; VITAMINS;

MAMMALIA;

EID: 70450198181     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06417.x     Document Type: Review

References (272)

1. Agamanolis D. P. (2005) Metabolic and toxic disorders, in Neuropathology (Prayson R. A., ed pp. 339 420. Elsevier, Amsterdam.
2. Ahlemeyer B., Hühne R. Krieglstein J. (2000) Retinoic acid potentiated the protective effect of NGF against staurosporine-induced apoptosis in cultured chick neurons by increasing the trkA protein expression. J. Neurosci. Res. 60, 767 778.
3. Akeson A. L., Woods C. W., Mosher L. B., Thomas C. E. Jackson R. L. (1991) Inhibition of IL-1β expression in THP-1 cells by probucol and tocopherol. Atherosclerosis 86, 261 270.
4. 3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol. Cell. Biol. 15, 5789 5799.
5. Anderson P. (2008) Post-transcriptional control of cytokine production. Nat. Immunol. 9, 353 359.
6. Angelillo-Scherrer A., Burnier L., Lambrechts D. et al. (2008) Role of Gas6 in erythropoiesis and anemia in mice. J. Clin. Invest. 118, 583 596.
7. Asirvatham A. J., Magner W. J. Tomasi T. B. (2009) miRNA regulation of cytokine genes. Cytokine 45, 58 69.
8. Austenaa L. M., Carlsen H., Ertesvag A., Alexander G., Blomhoff H. K. Blomhoff R. (2004) Vitamin A status significantly alters nuclear factor-κB activity assessed by in vivo imaging. FASEB J. 18, 1255 1257.
9. Au-Yeung K. K., Woo C. W., Sung F. L., Yip J. C., Siow Y. L. Karmin O. (2004) Hyperhomocysteinemia activates nuclear factor-κB in endothelial cells via oxidative stress. Circ. Res. 94, 28 36.
10. Au-Yeung K. K., Yip J. C., Siow Y. L. Karmin O. (2006) Folic acid inhibits homocysteine-induced superoxide anion production and nuclear factor kappa B activation in macrophages. Can. J. Physiol. Pharmacol. 84, 141 147.
11. Azzi A. Stocker A. (2000) Vitamin E: non-antioxidant roles. Prog. Lipid Res. 39, 231 255.
12. Azzi A., Gysin R., Kempná P., Munteanu A., Villacorta L., Visarius T. Zingg J. M. (2004) Regulation of gene expression by α-tocopherol. Biol. Chem. 385, 585 591.
13. Bâ A. (2008) Metabolic and structural role of thiamine in nervous tissues. Cell. Mol. Neurobiol. 28, 923 931.
14. 3. GLIA 31, 59 68.
15. Ballow M., Xiang S., Greenberg S. J., Brodsky L., Allen C. Rich G. (1997) Retinoic acid-induced modulation of IL-2 mRNA production and IL-2 receptor expression on T cells. Int. Arch. Allergy Immunol. 113, 167 169.
16. Balmer J. E. Blomhoff R. (2002) Gene expression regulation by retinoic acid. J. Lipid Res. 43, 1773 1808.
17. Banks W. A. (2005) Blood-brain barrier transport of cytokines: a mechanism for neuropathology. Curr. Pharm. Des. 11, 973 984.
18. Basu T. K., Makhani N. Sedgwick G. (2002) Niacin (nicotinic acid) in non-physiological doses causes hyperhomocysteineaemia in Sprague-Dawley rats. Br. J. Nutr. 87, 115 119.
19. 2 in normal and human papillomavirus type 16-immortalized human keratinocytes. Cell Growth Differ. 3, 763 772.
20. Bauer S., Kerr B. J. Patterson P. H. (2007) The neuropoietic cytokine family in development, plasticity, disease and injury. Nat. Rev. Neurosci. 8, 221 232.
21. Bender D. A. (2003) Nutritional Biochemistry of the Vitamins, 2nd edn. Cambridge University Press, Cambridge.
22. Bendich A. Butterworth C. E. Jr. (1991) Micronutrients in Health and Disease Prevention. Marcel Dekker Inc., New York.
23. Benveniste E. N., Nguyen V. T. Wesemann D. R. (2004) Molecular regulation of CD40 gene expression in macrophages and microglia. Brain Behav. Immun. 18, 7 12.
24. 3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production. Cell. Immunol. 98, 311 322.
25. Bikle D. (2009) Nonclassic actions of vitamin D. J. Clin. Endocrinol. Metab. 94, 26 34.
26. Blackwell T. S. Christman J. W. (1997) The role of nuclear factor-κB in cytokine gene regulation. Am. J. Respir. Cell Mol. Biol. 17, 3 9.
27. Blomhoff R. Blomhoff H. K. (2006) Overview of retinoid metabolism and function. J. Neurobiol. 66, 606 630.
28. Booth S. L. (1997) Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore. Nutr. Rev. 55, 282 284.
29. Bouillon R. (2006) Vitamin D: from photosynthesis, metabolism, and action to clinical applications, in Endocrinology, 5th edn (DeGroot L. J. Jameson J. L., eds), vol. 2, pp. 1435 1463. Elsevier, Philadelphia.
30. Bourre J. M. (2006) Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. J. Nutr. Health Aging 10, 377 385.
31. Bowie A. G. O'Neill L. A. (2000) Vitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kinase. J. Immunol. 165, 7180 7188.
32. Brigelius-Flohé R. (2009) Vitamin E: the shrew waiting to be tamed. Free Radic. Biol. Med. 46, 543 554.
33. Brown A. J., Dusso A. Slatopolsky E. (1999) Vitamin D. Am. J. Physiol. Renal Physiol. 277, F157 F175.
34. 12 is a strong determinant of low methionine synthase activity and DNA hypomethylation in gastrectomized rats. Digestion 68, 133 140.
35. Buccellato F. R., Miloso M., Braga M., Nicolini G., Morabito A., Pravettoni G., Tredici G. Scalabrino G. (1999) Myelinolytic lesions in spinal cord of cobalamin-deficient rats are TNF-α mediated. FASEB J. 13, 297 304.
36. Buck I., Morceau F., Cristofanon S., Reuter S., Dicato M. Diederich M. (2009) The inhibitory effect of the proinflammatory cytokine TNFα on erythroid differentiation involves erythroid transcription factor modulation. Int. J. Oncol. 34, 853 860.
37. Calfee-Mason K. G., Spear B. T. Glauert H. P. (2002) Vitamin E inhibits hepatic NF-κB activation in rats administered the hepatic tumor promoter, phenobarbital. J. Nutr. 132, 3178 3185.
38. Cantorna M. T. (2000) Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc. Soc. Exp. Biol. Med. 223, 230 233.
39. Cantorna M. T., Nashold F. E. Hayes C. E. (1995) Vitamin A deficiency results in a priming environment conducive for Th1 cell development. Eur. J. Immunol. 25, 1673 1679.
40. Cantorna M. T., Nashold F. E., Chun T. Y. Hayes C. E. (1996a) Vitamin A down-regulation of IFN-γ synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway. J. Immunol. 156, 2674 2679.
41. 3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc. Natl Acad. Sci. USA 93, 7861 7864.
42. 3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-β1 and IL-4. J. Immunol. 160, 5314 5319.
43. 3, and the immune system. Am. J. Clin. Nutr. 80 (Suppl. 6 S1717 S1720.
44. Cárcamo J. M., Pedraza A., Bórquez-Ojeda O. Golde D. W. (2002a) Vitamin C suppresses TNFα-induced NFκB activation by inhibiting IκBα phosphorylation. Biochemistry 41, 12995 13002.
45. Cárcamo J. M., Bórquez-Ojeda O. Golde D. W. (2002b) Vitamin C inhibits granulocyte macrophage-colony-stimulating factor-induced signaling pathways. Blood 99, 3205 3212.
46. Carluccio M. A., Ancora M. A., Massaro M., Carluccio M., Scoditti E., Distante A., Storelli C. De Caterina R. (2007) Homocysteine induces VCAM-1 gene expression through NF-κB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants. Am. J. Physiol. Heart. Circ. Physiol. 293, H2344 H2354.
47. Casaccia-Bonnefil P., Pandozy G. Mastronardi F. (2008) Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: A contribution to the current debate on disease pathogenesis. Prog. Neurobiol. 86, 368 378.
48. Chang M. M., Harper R., Hyde D. M. Wu R. (2000) A novel mechanism of retinoic acid-enhanced interleukin-8 gene expression in airway epithelium. Am. J. Respir. Cell Mol. Biol. 22, 502 510.
49. Chasis J. A. Mohandas N. (2008) Erythroblastic islands: niches for erythropoiesis. Blood 112, 470 478.
50. Chatterjee M. (2001) Vitamin D and genomic stability. Mutat. Res. 475, 69 87.
51. Chattopadhyay N., Butters R. R. Brown E. M. (2001) Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells. Brain Res. Mol. Brain Res. 87, 100 108.
52. 3. Am. J. Physiol. Gastrointest. Liver Physiol. 283, G864 G874.
53. Cheung P. Lau P. (2005) Epigenetic regulation by histone methylation and histone variants. Mol. Endocrinol. 19, 563 573.
54. Chitnis T. Khoury S. J. (2003) Cytokine shifts and tolerance in experimental autoimmune encephalomyelitis. Immunol. Res. 28, 233 239.
55. Claycombe K. J. Meydani S. N. (2001) Vitamin E and genome stability. Mutat. Res. 475, 37 44.
56. Cobianchi L., Fornoni A., Pileggi A. et al. (2008) Riboflavin inhibits IL-6 expression and p38 activation in islet cells. Cell Transplant. 17, 559 566.
57. Cohen-Lahav M., Shany S., Tobvin D., Chaimovitz C. Douvdevani A. (2006) Vitamin D decreases NFκB activity by increasing IκBα levels. Nephrol. Dial. Transplant. 21, 889 897.
58. 3 in macrophages. J. Steroid Biochem. Mol. Biol. 103, 558 562.
59. Collins A. R. (2001) Carotenoids and genomic stability. Mutat. Res. 475, 21 28.
60. Combs G. F. Jr. (1998) The Vitamins. Academic Press San Diego, California.
61. Cornet A., Baudet C., Neveu I., Baron-Van Evercooren A., Brachet P. Naveilhan P. (1998) 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. J. Neurosci. Res. 53, 742 746.
62. Cranenburg E. C., Schurgers L. J. Vermeer C. (2007) Vitamin K: the coagulation vitamin that became omnipotent. Thromb. Haemost. 98, 120 125.
63. Cutroneo K. R. (2007) TGF-β-induced fibrosis and SMAD signaling: oligo decoys as natural therapeutics for inhibition of tissue fibrosis and scarring. Wound Repair Regen. 15 (Suppl. 1 S54 S60.
64. 3. J. Clin. Invest. 101, 252 262.
65. Dakshinamurti K. (2005) Biotin - a regulator of gene expression. J. Nutr. Biochem. 16, 419 423.
66. Dalal S., Parkin S. M., Homer-Vanniasinkam S. Nicolaou A. (2003) Effect of homocysteine on cytokine production by human endothelial cells and monocytes. Ann. Clin. Biochem. 40, 534 541.
67. 3 in NRP-152 rat prostatic epithelial cells. J. Cell. Physiol. 166, 231 239.
68. Deadwyler G. D., Pouly S., Antel J. P. Devries G. H. (2000) Neuroregulins and erbB receptor expression in adult human oligodendrocytes. GLIA 32, 304 312.
69. Delves P. J., Martin S. J., Burton D. R. Roitt I. M. (2006) Control mechanisms, in Roitt's Essential Immunology, 11th edn., pp. 211 228. Blackwell Publishing Ltd, Oxford.
70. Denisova N. A. Booth S. L. (2005) Vitamin K and sphingolipid metabolism: evidence to date. Nutr. Rev. 63, 111 121.
71. 3 and sirtuin function. Trends Biochem. Sci. 30, 479 483.
72. Devaraj S., Li D. Jialal I. (1996) The effects of alpha tocopherol supplementation on monocyte function. J. Clin. Invest. 98, 756 763.
73. Diaz B. V., Lenoir M. C., Ladoux A., Frelin C., Démarchez M. Michel S. (2000) Regulation of vascular endothelial growth factor expression in human keratinocytes by retinoids. J. Biol. Chem. 275, 642 650.
74. Diaz-Arrastia R. (2000) Homocysteine and neurologic disease. Arch. Neurol. 57, 1422 1428.
75. 3 and its analogs. J. Biol. Chem. 278, 49378 49385.
76. Estey E. H. Kantarjian H. M. (2005) Therapy for acute myeloid leukemia, in Hematology (Hoffman R., Benz E. J. Jr., Shattil S. J., Furie B., Cohen H. J., Silberstein L. E. McGlave P., eds pp. 1099 1120. Elsevier Inc, Philadelphia.
77. Falkenstein E., Tillmann H. C., Christ M., Feuring M. Wehling M. (2000) Multiple actions of steroid hormones- a focus on rapid, nongenomic effects. Pharmacol. Rev. 52, 513 556.
78. 3 signal response pathways in osteoblasts: cross-talk between genomic and membrane-initiated pathways. Am. J. Kidney Dis. 31, 729 742.
79. Fenech M. (2001) The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat. Res. 475, 57 67.
80. Feng J., Fouse S. Fan G. (2007) Epigenetic regulation of neural gene expression and neuronal function. Pediatr. Res. 61, R58 R63.
81. Ferland G. (1998) The vitamin K-dependent proteins: an update. Nutr. Rev. 56, 223 230.
82. Fernández-Fernández L., Bellido-Martín L. García de Frutos P. (2008) Growth arrest-specific gene 6 (GAS6). Thromb. Haemost. 100, 604 610.
83. Finkel T., Deng C. X. Mostoslavsky R. (2009) Recent progress in the biology and physiology of sirtuins. Nature 460, 587 591.
84. 12 during early embryogenesis. Food Nutr. Bull. 29 (Suppl. 2 S86 S98.
85. Funakoshi H., Yonemasu T., Nakano T., Matumoto K. Nakamura T. (2002) Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons. J. Neurosci. Res. 68, 150 160.
86. Furman I., Baudet C. Brachet P. (1996) Differential expression of M-CSF, LIF, and TNF-α genes in normal and malignant rat glial cells: regulation by lipopolysaccharide and vitamin D. J. Neurosci. Res. 46, 360 366.
87. Garcia A. Zanibbi K. (2004) Homocysteine and cognitive function in elderly people. Can. Med. Ass. J. 171, 897 904.
88. Garcion E., Wion-Barbot N., Montero-Menei C. N., Berger F. Wion D. (2002) New clues about vitamin D functions in the nervous system. Trends Endocrinol. Metab. 13, 100 105.
89. Giri S. N., Gurujeyalakshmi G. Wang Y. (2000) Suppression of bleomycin-induced increased production of nitric oxide and NF-κB activation by treatment with taurine and niacin. Adv. Exp. Med. Biol. 483, 545 561.
90. Gopalakrishnan S., Van Emburgh B. O. Robertson K. D. (2008) DNA methylation in development and human disease. Mutat. Res. 647, 30 38.
91. 1 mRNA expression by taurine and niacin in the bleomycin hamster model of lung fibrosis. Am. J. Respir. Cell Mol. Biol. 18, 334 342.
92. Gurujeyalakshmi G., Wang Y. Giri S. N. (2000) Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-κB in mice. J. Pharmacol. Exp. Ther. 293, 82 90.
93. 3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-κB-mediated interleukin-8 gene expression. Eur. J. Biochem. 250, 63 71.
94. Harding A. E., Muller D. P., Thomas P. K. Willison H. J. (1982) Spinocerebellar degeneration secondary to chronic intestinal malabsorption: a vitamin E deficiency syndrome. Ann. Neurol. 12, 419 424.
95. Härtel C., Strunk T., Bucsky P. Schultz C. (2004) Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Cytokine 27, 101 106.
96. 3 inhibits normal human keratinocyte growth by increasing transforming growth factor β2 release. Biochem. Biophys. Res. Commun. 229, 618 623.
97. Haussler M. R., Jurutka P. W., Hsieh J. C., Thompson P. D., Selznick S. H., Haussler C. A. Whitfield G. K. (1995) New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone 17 (Suppl. 2 S33 S38.
98. Hazell A. S. Butterworth R. F. (2009) Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation. Alcohol Alcohol. 44, 141 147.
99. Hiremath G. S., Cettomai D., Baynes M., Ratchford J. N., Newsome S., Harrison D., Kerr D., Greenberg B. M. Calabresi P. A. (2009) Vitamin D status and effect of low-dose cholecalciferol and high-dose ergocalciferol supplementation in multiple sclerosis. Mult. Scler. 15, 735 740.
100. Hsieh J. Gage F. H. (2005) Chromatin remodeling in neural development and plasticity. Curr. Opin. Cell Biol. 17, 664 671.
101. Husson M., Enderlin V., Alfos S., Boucheron C., Pallet V. Higueret P. (2004) Expression of neurogranin and neuromodulin is affected in the striatum of vitamin A-deprived rats. Mol. Brain Res. 123, 7 17.
102. Ito M., Sakai Y., Furumoto M., Segawa H., Haito S., Yamanaka S., Nakamura R., Kuwahata M. Miyamoto K. (2005) Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells. Am. J. Physiol. Endocrinol. Metab. 288, E1101 E1109.
103. Jeffery C. J. (2003) Moonlighting proteins: old proteins learning new tricks. Trends Genet. 19, 415 417.
104. Kalra S., Ahuja R., Mutti E., Veber D., Seetharam S., Scalabrino G. Seetharam B. (2007) Cobalamin-mediated regulation of transcobalamin receptor levels in rat organs. Arch. Biochem. Biophys. 463, 128 132.
105. Kaltschmidt B., Widera D. Kaltschmidt C. (2005) Signaling via NF-κB in the nervous system. Biochim. Biophys. Acta 1745, 287 299.
106. Kaput J. Rodriguez R. L. (2004) Nutritional genomics: the next frontier in the postgenomic era. Physiol. Genomics 16, 166 177.
107. Ke Z. J. Gibson G. E. (2004) Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism. Neurochem. Int. 45, 361 369.
108. Ke Z. J., DeGiorgio L. A., Volpe B. T. Gibson G. E. (2003) Reversal of thiamine deficiency-induced neurodegeneration. J. Neuropathol. Exp. Neurol. 62, 195 207.
109. Ke Z. J., Calingasan N. Y., DeGiorgio L. A., Volpe B. T. Gibson G. E. (2005a) CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Neurochem. Int. 47, 204 215.
110. Ke Z. J., Calingasan N. Y., Karuppagounder S. S., DeGiorgio L. A., Volpe B. T. Gibson G. E. (2005b) CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. J. Neuroimmunol. 164, 85 92.
111. Khabar K. S. (2007) Rapid transit in the immune cells: the role of mRNA turnover regulation. J. Leukoc. Biol. 81, 1335 1344.
112. Khanna S., Roy S., Parinandi N. L., Maurer M. Sen C. K. (2006) Characterization of the potent neuroprotective properties of the natural vitamin E α-tocotrienol. J. Neurochem. 98, 1474 1486.
113. Kirkland J. B. (2009) Niacin status and treatment-related leukemogenesis. Mol. Cancer Ther. 8, 725 732.
114. Kirkland J. B., Zempleni J., Buckles L. K. Christman J. K. (2007) Vitamin-dependent modifications of chromatin: epigenetic events and genomic stability, in Handbook of Vitamins, 4th edn Zempleni J., Rucker R. B., McCormick D. B. Suttie J. W., eds), pp. 521 544. CRC Press, Boca Raton.
115. Klass B. R., Grobbelaar A. O. Rolfe K. J. (2009) Transforming growth factor β1 signalling, wound healing and repair: a multifunctional cytokine with clinical implications for wound repair, a delicate balance. Postgrad. Med. J. 85, 9 14.
116. Klose R. J. Bird A. P. (2006) Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 31, 89 97.
117. 2 on the productions of proinflammatory cytokine and NO in endotoxin-induced shock in mice. Life Sci. 78, 134 139.
118. 3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am. J. Physiol. Gastrointest. Liver Physiol. 289, G1036 G1042.
119. 3 enhances the expression of transforming growth factor β1 and its latent form binding protein in cultured breast carcinoma cells. Cancer Res. 55, 1540 1546.
120. Kouzarides T. (2007) Chromatin modifications and their function. Cell 128, 693 705.
121. Krieglstein K. Krieglstein J. (1998) Transforming growth factor-β signaling and neuroprotection, in Neuroprotective Signal Transduction (Mattson M. P., ed pp. 119 144. Humana Press, New Jersey.
122. Kronenberg G., Colla M. Endres M. (2009) Folic acid, neurodegenerative and neuropsychiatric disease. Curr. Mol. Med. 9, 315 323.
123. Kumar N. (2007) Nutritional neuropathies. Neurol. Clin. 25, 209 255.
124. Kuno R., Yoshida Y., Nitta A., Nabeshima T., Wang J., Sonobe Y., Kawanokuchi J., Takeuchi H., Mizuno T. Suzumura A. (2006) The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes. Brain Res. 1116, 12 18.
125. Kuroishi T., Endo Y., Muramoto K. Sugawara S. (2008) Biotin deficiency up-regulates TNF-α production in murine macrophages. J. Leukoc. Biol. 83, 912 920.
126. Lahav Cohen M., Douvdevani A., Chaimovitz C. Shany S. (2001) Regulation of TNF-α by 1α,25-dihydroxyvitamin D3 in human macrophages from CAPD patients. Kidney Int. 59, 69 75.
127. Lane M. A. Bailey S. J. (2005) Role of retinoid signalling in the adult brain. Prog. Neurobiol. 75, 275 293.
128. Lanske B. Razzaque M. S. (2007) Mineral metabolism and aging: the fibroblast growth factor 23 enigma. Curr. Opin. Nephrol. Hypertens. 16, 311 318.
129. Le Grusse J. Watier B. (1995) Les Vitamines. Centre d'etude et information sur les vitamins (CEIV), France.
130. Le P. T., Lazorick S., Whichard L. P., Haynes B. F. Singer K. H. (1991) Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor a regulate mRNA levels of interleukin 1α (IL-1α), IL-1β and IL-6 in human thymic epithelial cells at a post-transcriptional level. J. Exp. Med. 174, 1147 1157.
131. 3. J. Steroid Biochem. Mol. Biol. 53, 599 602.
132. 3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J. Clin. Invest. 87, 1103 1107.
133. Li R., Chen J., Hammonds G. et al. (1996) Identification of Gas6 as a growth factor for human Schwann cells. J. Neurosci. 16, 2012 2019.
134. Liesveld J. L. Lichtman M. A. (2006) Acute myelogenous leukemia, in Williams Hematology, 7th edn (Lichtman M. A., Beutler E., Kipps T. J., Seligsohn U., Kaushansky K. Prchal J. T., eds), pp. 1183 1236. McGraw-Hill, London.
135. Lin Y., Huang R., Santanam N., Liu Y. G., Parthasarathy S. Huang R. P. (2002) Profiling of human cytokines in healthy individuals with vitamin E supplementation by antibody array. Cancer Lett. 187, 17 24.
136. Lösel R. M., Falkenstein E., Feuring M., Schultz A., Tillmann H. C., Rossol-Haseroth K. Wehling M. (2003) Nongenomic steroid action: controversies, questions, and answers. Physiol. Rev. 83, 965 1016.
137. Lukusa T. Fryns J. P. (2008) Human chromosome fragility. Biochim. Biophys. Acta 1779, 3 16.
138. Lyakhovich A., Aksenov N., Pennanen P., Miettinen S., Ahonen M. H., Syvälä H., Ylikomi T. Tuohimaa P. (2000) Vitamin D induced up-regulation of keratinocyte growth factor (FGF-7/KGF) in MCF-7 human breast cancer cells. Biochem. Biophys. Res. Commun. 273, 675 680.
139. Macián F., López-Rodríguez C. Rao A. (2001) Partners in transcription: NFAT and AP-1. Oncogene 20, 2476 2489.
140. Mahmood R., Flanders K. C. Morriss-Kay G. M. (1992) Interactions between retinoids and TGF βs in mouse morphogenesis. Development 115, 67 74.
141. Mangoni A. A. (2006) Folic acid, inflammation, and atherosclerosis: false hopes or the need for better trials? Clin. Chim. Acta 367, 11 19.
142. 3 and the immune system. Mol. Cell. Endocrinol. 43, 113 122.
143. Marguerite V., Beri-Dexheimer M., Ortiou S., Guéant J. L. Merten M. (2007) Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells. Cell. Physiol. Biochem. 20, 967 976.
144. 12. Appl. Microbiol. Biotechnol. 58, 275 285.
145. Martínez-Frías M. L. (2008) The biochemical structure and function of methylenetetrahydrofolate reductase provide the rationale to interpret the epidemiological results on the risk for infants with Down syndrome. Am. J. Med. Genet. 146A, 1477 1482.
146. Matsumoto K., Gaetano C., Daughaday W. H. Thiele C. J. (1992) Retinoic acid regulates insulin-like growth factor II expression in a neuroblastoma cell line. Endocrinology 130, 3669 3676.
147. Mattick J. S. Makunin I. V. (2005) Small regulatory RNAs in mammals. Hum. Mol. Genet. 14, R121 R132.
148. Mattson M. P. Shea T. B. (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 26, 137 146.
149. Mehler M. F. (2008a) Epigenetics and the nervous system. Ann. Neurol. 64, 602 617.
150. Mehler M. F. (2008b) Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog. Neurobiol. 86, 305 341.
151. Mey J. (2001) Retinoic acid as a regulator of cytokine signaling after nerve injury. Z. Naturforsch. 56c, 163 176.
152. Mey J. (2006) New therapeutic target for CNS injury? The role of retinoic acid signaling after nerve lesions. J. Neurobiol. 66, 757 779.
153. 3 receptors: gene regulation and genetic circuitry. FASEB J. 2, 3043 3053.
154. Molloy A. M. Weir D. G. (2001) Homocysteine and the nervous system, in Homocysteine in Health and Disease (Carmel R. Jacobsen D. W., eds pp. 183 187. Cambridge University Press, Cambridge.
155. 12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic acid fortification. Pediatrics 123, 917 923.
156. Montecino M., Stein G. S., Stein J. L., Lian J. B., van Wijnen A. J., Carvallo L., Marcellini S., Cruzat F. Arriagada G. (2008) Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery. Crit. Rev. Eukaryot. Gene Expr. 18, 163 172.
157. Morante M., Sandoval J., Gómez-Cabrera M. C., Rodríguez J. L., Pallardó F. V., Viña J. R., Torres L. Barber T. (2005) Vitamin E deficiency induces liver nuclear factor-κB DNA-binding activity and changes in related genes. Free Radic. Res. 39, 1127 1138.
158. 3 as a natural regulator of human immune functions. J. Investig. Dermatol. Symp. Proc. 1, 68 71.
159. 3. Immunol. Lett. 28, 115 120.
160. 3 inhibits cytokine production by human blood monocytes at the post-transcriptional level. Cytokine 4, 506 512.
161. 3 selectively reduces interleukin-2 levels and proliferation of human T cell lines in vitro. Immunol. Lett. 35, 177 182.
162. Müller M. Kersten S. (2003) Nutrigenomics: goals and strategies. Nat. Rev. Genet. 4, 315 322.
163. Muñoz E., Blázquez M. V., Ortiz C., Gomez-Díaz C. Navas P. (1997) Role of ascorbate in the activation of NF-κB by tumour necrosis factor-α in T-cells. Biochem. J. 325, 23 28.
164. Muraoka R. S., Waltz S. E. Degen S. J. (1999) Expression of hepatocyte growth factor-like protein is repressed by retinoic acid and enhanced by cyclic adenosine 3′,5′-monophosphate response element-binding protein (CREB)-binding protein (CBP). Endocrinology 140, 187 196.
165. Murphy K., Travers P. Walport M. (2008) Manipulation of immune response, in Janeway's Immunobiology, 7th edn, pp. 655-708. Garland Science, Taylor & Francis Group, New York.
166. Mutch D. M., Wahli W. Williamson G. (2005) Nutrigenomics and nutrigenetics: the emerging faces of nutrition. FASEB J. 19, 1602 1616.
167. Na S. Y., Kang B. Y., Chung S. W., Han S. J., Ma X., Trinchieri G., Im S. Y., Lee J. W. Kim T. S. (1999) Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFκB. J. Biol. Chem. 274, 7674 7680.
168. Nagpal S., Na S. Rathnachalam R. (2005) Noncalcemic actions of vitamin D receptor ligands. Endocr. Rev. 26, 662 687.
169. Nakao M., Hironaka S., Harada N. et al. (2009) Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-co-enzyme-A mutase expression in rat liver and COS-7 cells. Br. J. Nutr. 101, 492 498.
170. 3, an inducer of glial cell line-derived neurotrophic factor. Neuroreport 7, 2171 2175.
171. Navikas V. Link H. (1996) Cytokines and the pathogenesis of multiple sclerosis. J. Neurosci. Res. 45, 322 333.
172. Nelson J. S., Fitch C. D., Fischer V. W., Broun G. O. Jr. Chou A. C. (1981) Progressive neuropathologic lesions in vitamin E-deficient rhesus monkeys. J. Neuropathol. Exp. Neurol. 40, 166 186.
173. 3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes. Neuroreport 6, 124 126.
174. 3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res. Mol. Brain Res. 24, 70 76.
175. 6 deficiency on the synthesis and accumulation of S-adenosylhomocysteine and S-adenosylmethionine in rat tissues. J. Nutr. Sci. Vitaminol. 47, 188 194.
176. Obeid R. Herrmann W. (2006) Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett. 580, 2994 3005.
177. 12. J. Biol. Chem. 278, 20778 20784.
178. 12-responsive internal ribosome entry site (IRES) element in human methionine synthase. J. Biol. Chem. 280, 32662 32668.
179. 3-induced upregulation of calcineurin during leukemic HL-60 cell differentiation. Blood 87, 2947 2955.
180. Ooi L. Wood I. C. (2008) Regulation of gene expression in the nervous system. Biochem. J. 414, 327 341.
181. Parola M., Muraca R., Dianzani I., Barrera G., Leonarduzzi G., Bendinelli P., Piccoletti R. Poli G. (1992) Vitamin E dietary supplementation inhibits transforming growth factor β1 gene expression in the rat liver. FEBS Lett. 308, 267 270.
182. Pentschew A. Schwarz K. (1962) Systemic axonal dystrophy in vitamin E deficient adult rats. Acta Neurophatol. 1, 313 334.
183. Peracchi M., Bamonti Catena F., Pomati M., De Franceschi M. Scalabrino G. (2001) Human cobalamin deficiency: alterations in serum tumour necrosis factor-α and epidermal growth factor. Eur. J. Haematol. 67, 123 127.
184. 3 on intracellular IFN-γ and TNF-α positive T cell subsets in pulmonary tuberculosis. Cytokine 45, 105 110.
185. Probst A. V., Dunleavy E. Almouzni G. (2009) Epigenetic inheritance during the cell cycle. Nat. Rev. Mol. Cell Biol. 10, 192 206.
186. Quan N. Banks W. A. (2007) Brain-immune communication pathways. Brain Behav. Immun. 21, 727 735.
187. Ravaglia G., Forti P., Maioli F., Martelli M., Servadei L., Brunetti N., Porcellini E. Licastro F. (2005) Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am. J. Clin. Nutr. 82, 636 643.
188. 3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc. Natl Acad. Sci. USA 84, 3385 3389.
189. Richard G. (2004) Molecular genetics of the ichthyoses. Am. J. Med. Genet. C (Semin. Med. Genet.) 131C, 32 44.
190. Richards E. J. (2006) Inherited epigenetic variation - revisiting soft inheritance. Nat. Rev. Genet. 7, 395 401.
191. 3. J. Clin. Invest. 79, 1659 1664.
192. 3 regulates NF-κB DNA binding activity in cultured normal human keratinocytes through an increase in IκBα expression. Arch. Dermatol. Res. 296, 195 202.
193. Rodriguez-Melendez R. Zempleni J. (2003) Regulation of gene expression by biotin. J. Nutr. Biochem. 14, 680 690.
194. Rodriguez-Melendez R., Camporeale G., Griffin J. B. Zempleni J. (2003) Interleukin-2 receptor-γ-dependent endocytosis depends on biotin in Jurkat cells. Am. J. Physiol. Cell Physiol. 284, C415 C421.
195. Rosenberg S. S., Ng B. K. Chan J. R. (2006) The quest for remyelination: a new role for neurotrophins and their receptors. Brain Pathol. 16, 288 294.
196. Roy S., Lado B. H., Khanna S. Sen C. K. (2002) Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis. FEBS Lett. 530, 17 23.
197. Rusnak F. Mertz P. (2000) Calcineurin: form and function. Physiol. Rev. 80, 1483 1521.
198. 1 promoter by antagonizing AP-1 activity. Mol. Endocrinol. 7, 1347 1356.
199. Samuel S. Sitrin M. D. (2008) Vitamin D's role in cell proliferation and differentiation. Nutr. Rev. 66 (Suppl. 2 S116 S124.
200. 3 increases striatal GDNF mRNA and protein expression in adult rats. Mol. Brain Res. 108, 143 146.
201. 3-mediated induction of nerve growth factor mRNA and protein in L929 fibroblasts and in adult rat brain. Brain Res. 633, 189 196.
202. Scalabrino G. (2001) Subacute combined degeneration one century later. The neurotrophic action of cobalamin (vitamin B12) revisited. J. Neuropathol. Exp. Neurol. 60, 109 120.
203. 12) in subacute combined degeneration and beyond: traditional interpretations and novel theories. Exp. Neurol. 192, 463 479.
204. 12 (cobalamin) neurotrophism in adult central nervous system: Lessons learned from its deficiency. Prog. Neurobiol. 88, 203 220.
205. Scalabrino G. Peracchi M. (2006) New insights into the pathophysiology of cobalamin deficiency. Trends Mol. Med. 12, 247 254.
206. Scalabrino G., Buccellato F. R., Tredici G., Morabito A., Lorenzini E. C., Allen R. H. Lindenbaum J. (1997) Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord. Exp. Neurol. 144, 258 265.
207. 12 (cobalamin) in the rat central nervous system. FASEB J. 13, 2083 2090.
208. 12 (cobalamin) in the rat central nervous system. J. Neuropathol. Exp. Neurol. 59, 808 814.
209. 12) positively regulates interleukin-6 levels in rat cerebrospinal fluid. J. Neuroimmunol. 127, 37 43.
210. Scalabrino G., Carpo M., Bamonti F. et al. (2004) High tumor necrosis factor-α levels in cerebrospinal fluid of cobalamin-deficient patients. Ann. Neurol. 56, 886 890.
211. 12) deficiency. Neurosci. Lett. 396, 153 158.
212. Scalabrino G., Veber D. Mutti E. (2008) Experimental and clinical evidence of the role of cytokines and growth factors in the pathogenesis of acquired cobalamin-deficient leukoneuropathy. Brain Res. Rev. 59, 42 54.
213. 3 differentially regulates the production of insulin-like growth factor I (IGF-I) and IGF-binding protein-4 in mouse osteoblasts. Endocrinology 129, 3139 3146.
214. Schreiber V., Dantzer F., Ame J. C. de Murcia G. (2006) Poly(ADP-ribose): novel functions for an old molecule. Nat. Rev. Mol. Cell Biol. 7, 517 528.
215. Schwartz M., Zlotorynski E. Kerem B. (2006) The molecular basis of common and rare fragile sites. Cancer Lett. 232, 13 26.
216. Scott T. M., Tucker K. L., Bhadelia A. et al. (2004) Homocysteine and B vitamins relate to brain volume and white-matter changes in geriatric patients with psychiatric disorders. Am. J. Geriatr. Psychiatry 12, 631 638.
217. + T cells, in Fundamental Immunology, 4th edn (Paul W. E., ed), pp. 879 908. Lippincott-Raven Publisher, Philadelphia.
218. Sen C. K., Khanna S. Roy S. (2004) Tocotrienol. The natural vitamin E to defend the nervous system? Ann. N Y Acad. Sci. 1031, 127 142.
219. 2 analog on cancer cell proliferation and cytokine expression. Steroids 66, 319 325.
220. Smith F. (2003) The molecular genetics of keratin disorders. Am. J. Clin. Dermatol. 4, 347 364.
221. Smolders J., Damoiseaux J., Menheere P. Hupperts R. (2008) Vitamin D as an immune modulator in multiple sclerosis, a review. J. Neuroimmunol. 194, 7 17.
222. Snodgrass S. R. (1992) Vitamin neurotoxicity. Mol. Neurobiol. 6, 41 73.
223. Son E. W., Mo S. J., Rhee D. K. Pyo S. (2004) Vitamin C blocks TNF-α-induced NF-κB activation and ICAM-1 expression in human neuroblastoma cells. Arch. Pharm. Res. 27, 1073 1079.
224. Southam E., Thomas P. K., King R. H., Goss-Sampson M. A. Muller D. P. (1991) Experimental vitamin E deficiency in rats. Brain 114, 915 936.
225. Spector R. Johanson C. E. (2007) Vitamin transport and homeostasis in mammalian brain: focus on Vitamins B and E. J. Neurochem. 103, 425 438.
226. Sriram G., Martinez J. A., McCabe E. R., Liao J. C. Dipple K. M. (2005) Single-gene disorders: what role could moonlighting enzymes play? Am. J. Hum. Genet. 76, 911 924.
227. + T cells. J. Immunol. 168, 1181 1189.
228. Stein G. S., Lian J. B., Stein J. L., Van Wijnen A. J. Montecino M. (1996) Transcriptional control of osteoblast growth and differentiation. Physiol. Rev. 76, 593 629.
229. Steinman L. (2009) A molecular trio in relapse and remission in multiple sclerosis. Nat. Rev. Immunol. 9, 440 447.
230. Su S. J., Huang L. W., Pai L. S., Liu H. W. Chang K. L. (2005) Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression. Nutrition 21, 994 1002.
231. Suttie J. W. (1993) Synthesis of vitamin K-dependent proteins. FASEB J. 7, 445 452.
232. Suzuki M. M. Bird A. (2008) DNA methylation landscapes: provocative insight from epigenomics. Nat. Rev. Genet. 9, 465 476.
233. Suzuki Y. J. Packer L. (1993) Inhibition of NF-κB activation by vitamin E derivatives. Biochem. Biophys. Res. Commun. 193, 277 283.
234. Tafti M. Ghyselinck N. B. (2007) Functional implication of the vitamin A signaling pathway in the brain. Arch. Neurol. 64, 1706 1711.
235. Takei Y. Laskey R. (2008) Interpreting crosstalk between TNF-α and NGF: potential implications for disease. Trends Mol. Med. 14, 381 388.
236. Tan P. H., Sagoo P., Chan C., Yates J. B., Campbell J., Beutelspacher S. C., Foxwell B. M., Lombardi G. George A. J. (2005) Inhibition of NF-κB and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J. Immunol. 174, 7633 7644.
237. Tobler A., Gasson J., Reichel H., Norman A. W. Koeffler H. P. (1987) Granulocyte-macrophage colony-stimulating factor. J. Clin. Invest. 79, 1700 1705.
238. 3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) posttranscriptionally. J. Clin. Invest. 81, 1819 1823.
239. Towfighi J. (1981) Effects of chronic vitamin E deficiency on the nervous system of the rat. Acta Neuropathol. 54, 261 267.
240. 2 in mice with lipopolysaccharide-induced shock. Eur. J. Pharmacol. 493, 177 182. (Pubitemid 38746948)
241. Tsaioun K. I. (1999) Vitamin K-dependent proteins in the developing and aging nervous system. Nutr. Rev. 57, 231 240.
242. 3 induces biphasic NF-κB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IκB. Exp. Cell Res. 313, 1722 1734.
243. Twiss J. L., Chang J. H. Schanen N. C. (2006) Pathophysiological mechanisms for actions of the neurotrophins. Brain Pathol. 16, 320 332.
244. Ueno T., Suita S. Zaizen Y. (1993) Retinoic acid induces insulin-like growth factor II expression in a neuroblastoma cell line. Cancer Lett. 71, 177 182.
245. Ulrey C. L., Liu L., Andrews L. G. Tollefsbol T. O. (2005) The impact of metabolism on DNA methylation. Hum. Mol. Genet. 14, R139 R147.
246. Umapathi T. Chaudhry V. (2005) Toxic neuropathy. Curr. Opin. Neurol. 18, 574 580.
247. Ungvari Z., Csiszar A., Edwards J. G., Kaminski P. M., Wolin M. S., Kaley G. Koller A. (2003) Increased superoxide production in coronary arteries in hyperhomocysteinemia. Arterioscler. Thromb. Vasc. Biol. 23, 418 424.
248. Van den Veyver I. B. (2002) Genetic effects of methylation diets. Annu. Rev. Nutr. 22, 255 282.
249. Van Wagoner N. J. Benveniste E. N. (1999) Interleukin-6 expression and regulation in astrocytes. J. Neuroimmunol. 100, 124 139.
250. 12(cobalamin)-deficient central neuropathy. J. Neuroimmunol. 176, 24 33.
251. Veber D., Mutti E., Tacchini L., Gammella E., Tredici G. Scalabrino G. (2008) Indirect downregulation of nuclear NF-κB levels by cobalamin in spinal cord and liver of the rat. J. Neurosci. Res. 86, 1380 1387.
252. Vermeer C. Schurgers L. J. (2000) A comprehensive review of vitamin K and vitamin K antagonists. Hematol. Oncol. Clin. North Am. 14, 339 353.
253. Villacorta L., Graça-Souza A. V., Ricciarelli R., Zingg J. M. Azzi A. (2003) α-Tocopherol induces expression of connective tissue growth factor and antagonizes tumor necrosis factor-α-mediated downregulation in human smooth muscle cells. Circ. Res. 92, 104 110.
254. Walz T. M., Malm C., Nishikawa B. K., Willander K., Wingren S. Wasteson A. (1995) Production of transforming growth factor alpha by human leukemia cells (HL-60 and U-937) during monocytic differentiation. Leukemia 9, 671 676.
255. Wang Q. J., Giri S. N., Hyde D. M., Nakashima J. M. Javadi I. (1990) Niacin attenuates bleomycin-induced lung fibrosis in the hamster. J. Biochem. Toxicol. 5, 13 22.
256. Wang G., Siow Y. L. Karmin O. (2000) Homocysteine stimulates nuclear factor κB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C. Biochem. J. 352, 817 826.
257. Wang G., Siow Y. L. Karmin O. (2001) Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-κB in THP-1 macrophages. Am. J. Physiol. Heart Circ. Physiol. 280, H2840 H2847.
258. Weima S. M., Rooijen M. A., Mummery C. L., Feijen A., Kruijer W., de Laat S. W. van Zoelen E. J. (1988) Differentially regulated production of platelet-derived growth factor and of transforming growth factor beta by a human teratocarcinoma cell line. Differentiation 38, 203 210.
259. Weller I. (2001) Secondary immunodeficiency, in Immunology, 6th edn Roitt I. M., Brostoff J. Male D., eds), pp. 313 322. Harcourt Publishers Limited, London.
260. Weninger W., Rendl M., Mildner M. Tschachler E. (1998) Retinoids downregulate vascular endothelial growth factor/vascular permeability factor production by normal human keratinocytes. J. Invest. Dermatol. 111, 907 911.
261. 3. J. Nutr. 125, S1690 S1694.
262. Wiedmann S., Eudy J. D. Zempleni J. (2003) Biotin supplementation increases expression of genes encoding interferon-γ, interleukin-1β, and 3-methylcrotonyl-CoA carboxylase, and decreases expression of the gene encoding interleukin-4 in human peripheral blood mononuclear cells. J. Nutr. 133, 716 719.
263. Wilson A. S., Power B. E. Molloy P. L. (2007) DNA hypomethylation and human diseases. Biochim. Biophys. Acta 1775, 138 162.
264. 3 is a potent inducer of nerve growth factor synthesis. J. Neurosci. Res. 28, 110 114.
265. 3 increases transforming growth factor and transforming growth factor receptor type I and II synthesis in human bone cells. Biochem. Biophys. Res. Commun. 239, 734 739.
266. Yamamoto H., Schoonjans K. Auwerx J. (2007) Sirtuin functions in health and disease. Mol. Endocrinol. 21, 1745 1755.
267. Yanaka N., Koyama T. A., Komatsu S., Nakamura E., Kanda M. Kato N. (2005) Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages. Int. J. Mol. Med. 16, 1071 1075.
268. Ylikomi T., Laaksi I., Lou Y. R. et al. (2002) Antiproliferative action of vitamin D. Vitam. Horm. 64, 357 406.
269. 3. Proc. Natl Acad. Sci. USA 92, 10990 10994.
270. Zawia N. H., Lahiri D. K. Cardozo-Pelaez F. (2009) Epigenetics, oxidative stress, and Alzheimer disease. Free Radic. Biol. Med. 46, 1241 1249.
271. Zempleni J., Helm R. M. Mock D. M. (2001) In vivo biotin supplementation at a pharmacologic dose decreases proliferation rates of human peripheral blood mononuclear cells and cytokine release. J. Nutr. 131, 1479 1484.
272. Zempleni J., Rucker R. B., McCormick D. B. Suttie J. W. (2007) Handbook of Vitamins, 4th edn. CRC Press, Boca Raton.