Carotenoids and genomic stability

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 475, Issue 1-2, 2001, Pages 21-28

  Collins, Andrew R ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Carotene; Carotenoids; DNA damage

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; CAROTENOID; CELL DNA; GAP JUNCTION PROTEIN;

ANTIOXIDANT ACTIVITY; APOPTOSIS; CANCER PREVENTION; CELL COMMUNICATION; CELL PROLIFERATION; CELL TRANSFORMATION; DIETARY INTAKE; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS INHIBITION; FRUIT; GENE EXPRESSION; HUMAN; LUNG CARCINOMA; LYMPHOCYTE; MICRONUCLEUS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TISSUE LEVEL; VEGETABLE;

ANTIOXIDANTS; BETA CAROTENE; CAROTENOIDS; DNA; DNA DAMAGE; DNA REPAIR; HUMANS;

ANIMALIA; RODENTIA;

EID: 0035906336     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00071-9     Document Type: Review

References (44)

1. Antioxidant functions of vitamins: Vitamin E and C, β-carotene and other carotenoids
2. Lycopene and β-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses
3. In vitro effects of β-carotene on human oral keratinocytes from pre-cancerous lesions and squamous carcinoma
4. Modifying effect of Vitamins C, E and β-carotene against gamma-ray-induced DNA damage in mouse cells
5. Carotenoids inhibit DNA synthesis in human aortic smooth muscle cells
6. Inhibitory effects of α-carotene on proliferation of the human neuroblastoma cell line GOTO
7. Carotenoids induce morphological changes in human mammary epithelial cell cultures
8. Enhanced protection of human cells against ultraviolet light by antioxidant combinations involving dietary carotenoids
9. β-carotene inhibition of chemically-induced toxicity in vivo and in vitro
10. Canthaxanthin induces apoptosis in human cancer cell lines
11. Diverse carotenoids protect against chemically-induced neoplastic transformation
12. Carotenoids up-regulate connexin 43 gene expression independent of their pro-Vitamin A or antioxidant properties
13. Enhancement of the UVA induction of haem oxygenase-1 expression by β-carotene in human skin fibroblasts
14. The role of carotenoids in modulating DNA stability and lipid peroxidation: Importance for human health
15. Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis
16. In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids
17. Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation
18. Retinoid signalling and activator protein-1 expression in ferrets given β-carotene supplements and exposed to tobacco smoke
19. Co-carcinogenic effect of β-carotene
20. Absorption, metabolism and transport of carotenoids
21. Recovery of human lymphocytes from oxidative DNA damage; the apparent enhancement of DNA repair by carotenoids is probably simply an antioxidant effect
22. Serum carotenoids and oxidative DNA damage in human lymphocytes
23. Bioavailability of lutein from vegetables is five times higher than that of β-carotene
24. Carotenoids in the human macula and whole retina
25. Can dietary β-carotene materially reduce human cancer rates?
26. A review of epidemiological evidence that carotenoids reduce the risk of cancer
27. Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population
28. The effect of Vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers
29. Effects of a combination of β-carotene and Vitamin A on lung cancer and cardiovascular disease
30. Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease
31. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes
32. Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (Vitamin E, Vitamin C, β-carotene and red ginseng)
33. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in prevention of cancer
34. Reduction with Vitamin A and β-carotene administration of proportion of micronucleated buccal mucosal cells in Asian betel nut and tobacco chewers
35. β-carotene supplementation in smokers reduces the frequency of micronuclei in sputum
36. Consumption of vegetables reduces genetic damage in humans: First results of a human intervention trial with carotenoid-rich foods
37. Ex vivo assessment of lymphocyte antioxidant status using the comet assay
38. Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?
39. β-carotene prevents X-ray induction of micronuclei in human lymphocytes
40. The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells
41. Reduction of oxidative DNA damage in humans by Brussels sprouts
42. No influence of β-carotene on oxidative DNA damage in male smokers
43. Chemoprevention of lung cancer: The rise and demise of β-carotene
44. Oxidative DNA damage, antioxidants and cancer