메뉴 건너뛰기




Volumn 28, Issue 3, 2003, Pages 223-239

Cytokine Shifts and Tolerance in Experimental Autoimmune Encephalomyelitis

Author keywords

Cytokines; Experimental autoimmune encephalomyelitis; Multiple sclerosis; STAT; T cell; T helper cell; Tolerance

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; JANUS KINASE; LYMPHOTOXIN; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROTEOLIPID PROTEIN; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 13; RECOMBINANT INTERLEUKIN 4; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; STAT PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

EID: 0347756797     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:28:3:223     Document Type: Review
Times cited : (55)

References (121)
  • 1
    • 0029319566 scopus 로고
    • Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species
    • Brosnan CF, Cannella B, Battistini L, et al.: Cytokine localization in multiple sclerosis lesions: correlation with adhesion molecule expression and reactive nitrogen species. Neurology 1995;45(6Suppl 6):S16-S21.
    • (1995) Neurology , vol.45 , Issue.6 SUPPL. 6
    • Brosnan, C.F.1    Cannella, B.2    Battistini, L.3
  • 2
    • 0031027581 scopus 로고    scopus 로고
    • Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand
    • Balashov KE, Smith DR, Khoury SJ, et al.: Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proc Natl Acad Sci USA 1997;94(2):599-603.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.2 , pp. 599-603
    • Balashov, K.E.1    Smith, D.R.2    Khoury, S.J.3
  • 3
    • 0032528896 scopus 로고    scopus 로고
    • Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
    • Comabella M, Balashov K, Issazadeh S, et al.:Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. J Clin Invest 1998;102(4): 671-678.
    • (1998) J Clin Invest , vol.102 , Issue.4 , pp. 671-678
    • Comabella, M.1    Balashov, K.2    Issazadeh, S.3
  • 4
    • 0033623923 scopus 로고    scopus 로고
    • Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS
    • Balashov KE, Comabella M, Ohashi T, et al.: Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS. Neurology 2000;55(2):192-198.
    • (2000) Neurology , vol.55 , Issue.2 , pp. 192-198
    • Balashov, K.E.1    Comabella, M.2    Ohashi, T.3
  • 5
    • 0036229763 scopus 로고    scopus 로고
    • IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4(+) T cells via CD40-CD40 ligand interactions
    • Karni A, Koldzic DN, Bharanidharan P, et al.: IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4(+) T cells via CD40-CD40 ligand interactions. J Neuroimmunol 2002;125(1-2): 134-140.
    • (2002) J Neuroimmunol , vol.125 , Issue.1-2 , pp. 134-140
    • Karni, A.1    Koldzic, D.N.2    Bharanidharan, P.3
  • 6
    • 0033953738 scopus 로고    scopus 로고
    • Reduction of both pro- and anti-inflammatory cytokines after 6 months of Interferon beta-1a treatment of multiple sclerosis
    • Khademi M, Wallstrom E, Andersson M, et al. : Reduction of both pro-and anti-inflammatory cytokines after 6 months of Interferon beta-1a treatment of multiple sclerosis. J Neuroimmunol 2000;103(2):202-210.
    • (2000) J Neuroimmunol , vol.103 , Issue.2 , pp. 202-210
    • Khademi, M.1    Wallstrom, E.2    Andersson, M.3
  • 7
    • 0035949745 scopus 로고    scopus 로고
    • Down-regulation of transforming growth factor-beta1 in interferon-betal a-treated MS patients
    • Lunemann JD, Aktas O, Gniadek P, et al.: Down-regulation of transforming growth factor-beta1 in interferon-betal a-treated MS patients. Neurology 2001; 57(6): 1132-1134.
    • (2001) Neurology , vol.57 , Issue.6 , pp. 1132-1134
    • Lunemann, J.D.1    Aktas, O.2    Gniadek, P.3
  • 8
    • 0034855936 scopus 로고    scopus 로고
    • Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes
    • Wandinger KP, Sturzebecher CS, Bielekova B, et al.: Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes. Ann Neurol 2001;50(3):349-357.
    • (2001) Ann Neurol , vol.50 , Issue.3 , pp. 349-357
    • Kp, W.1    Sturzebecher, C.S.2    Bielekova, B.3
  • 9
    • 0037161237 scopus 로고    scopus 로고
    • Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis
    • Dhib-Jalbut S.: Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis. Neurology 2002;58(8 Suppl 4):S3-S9.
    • (2002) Neurology , vol.58 , Issue.8 SUPPL. 4
    • Dhib-Jalbut, S.1
  • 10
    • 0037167526 scopus 로고    scopus 로고
    • Differential mechanisms of action of interferon-beta and glatiramer aetate in MS
    • Yong VW: Differential mechanisms of action of interferon-beta and glatiramer aetate in MS. Neurology 2002;59(6):802-808.
    • (2002) Neurology , vol.59 , Issue.6 , pp. 802-808
    • Yong, V.W.1
  • 11
    • 0034041863 scopus 로고    scopus 로고
    • Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis
    • Duda PW, Schmied MC, Cook SL, et al.: Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J Clin Invest 2000;105(7):967-976.
    • (2000) J Clin Invest , vol.105 , Issue.7 , pp. 967-976
    • Duda, P.W.1    Schmied, M.C.2    Cook, S.L.3
  • 12
    • 0034982136 scopus 로고    scopus 로고
    • Interferon-beta in multiple sclerosis: Altering the balance of interleukin-12 and interleukin-10?
    • Karp CL, van Boxel-Dezaire AH, Byrnes AA, et al.: Interferon-beta in multiple sclerosis: altering the balance of interleukin-12 and interleukin-10? Curr Opin Neurol 2001;14(3):361-368.
    • (2001) Curr Opin Neurol , vol.14 , Issue.3 , pp. 361-368
    • Karp, C.L.1    Van Boxel-Dezaire, A.H.2    Byrnes, A.A.3
  • 13
    • 0036197846 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with cyclophosphamide: Critical review of clinical and immunologic effects
    • Weiner HL, Cohen JA: Treatment of multiple sclerosis with cyclophosphamide: critical review of clinical and immunologic effects. Mult Scler 2002;8(2):142-154.
    • (2002) Mult Scler , vol.8 , Issue.2 , pp. 142-154
    • Weiner, H.L.1    Cohen, J.A.2
  • 14
    • 0027957780 scopus 로고
    • Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Zhang J, Markovic-Plese S, Lacet B, et al.: Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med, 1994;179(3):973-984.
    • (1994) J Exp Med , vol.179 , Issue.3 , pp. 973-984
    • Zhang, J.1    Markovic-Plese, S.2    Lacet, B.3
  • 15
    • 0031578938 scopus 로고    scopus 로고
    • Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis
    • Hafler DA, Kent SC, Pietrusewicz MJ, et al.: Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis. Ann N Y Acad Sci 1997;835(1):120-131.
    • (1997) Ann N Y Acad Sci , vol.835 , Issue.1 , pp. 120-131
    • Hafler, D.A.1    Kent, S.C.2    Pietrusewicz, M.J.3
  • 16
    • 0030035509 scopus 로고    scopus 로고
    • Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
    • Fukaura H, Kent SC, Pietrusewicz MJ, et al.: Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 1996;98(1):70-77.
    • (1996) J Clin Invest , vol.98 , Issue.1 , pp. 70-77
    • Fukaura, H.1    Kent, S.C.2    Pietrusewicz, M.J.3
  • 17
    • 0032987396 scopus 로고    scopus 로고
    • Implication of Th1, Th2, and Th3 cytokines in liver graft acceptance
    • Minguela A, Torio A, Marin L, et al. : Implication of Th1, Th2, and Th3 cytokines in liver graft acceptance. Transplant Proc 1999;31(1-2):519-520.
    • (1999) Transplant Proc , vol.31 , Issue.1-2 , pp. 519-520
    • Minguela, A.1    Torio, A.2    Marin, L.3
  • 18
    • 0025313253 scopus 로고
    • Lympho-toxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity
    • Powell MB, Mitchell D, Lederman J, et al.: Lympho-toxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int Immunol 1990;2(6): 539-544.
    • (1990) Int Immunol , vol.2 , Issue.6 , pp. 539-544
    • Powell, M.B.1    Mitchell, D.2    Lederman, J.3
  • 19
    • 0022311668 scopus 로고
    • Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition
    • Zamvil SS, Nelson PA, Mitchell DJ, et al.: Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition. J Exp Med 1985; 162(6):2107-2124.
    • (1985) J Exp Med , vol.162 , Issue.6 , pp. 2107-2124
    • Zamvil, S.S.1    Nelson, P.A.2    Mitchell, D.J.3
  • 20
    • 0026713026 scopus 로고
    • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain
    • Khoury SJ, Hancock WW, Weiner HL: Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 1992;176(5):1355-1364.
    • (1992) J Exp Med , vol.176 , Issue.5 , pp. 1355-1364
    • Khoury, S.J.1    Hancock, W.W.2    Weiner, H.L.3
  • 21
    • 0032145434 scopus 로고    scopus 로고
    • Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo
    • Issazadeh S, Navikas V, Schaub M, et al.: Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo. J Immunol 1998;161(3): 1104-1112.
    • (1998) J Immunol , vol.161 , Issue.3 , pp. 1104-1112
    • Issazadeh, S.1    Navikas, V.2    Schaub, M.3
  • 22
    • 0028806468 scopus 로고
    • Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: Dynamics of mRNA expression forinterleukin-10, interleukin-12, cytolysin, tumor necrosis factor alpha and tumor necrosis factor beta
    • Issazadeh S, Ljungdahl A, Hojeberg B, et al.: Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression forinterleukin-10, interleukin-12, cytolysin, tumor necrosis factor alpha and tumor necrosis factor beta. J Neuroimmunol 1995; 61(2):205-212.
    • (1995) J Neuroimmunol , vol.61 , Issue.2 , pp. 205-212
    • Issazadeh, S.1    Ljungdahl, A.2    Hojeberg, B.3
  • 23
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J, et al.: Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994:265(5176): 1237-1240.
    • (1994) Science , vol.265 , Issue.5176 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3
  • 24
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Thl/ Th2 developmental pathways: Application to autoimmune disease therapy
    • Kuchroo VK, Das MP, Brown JA, et al.: B7-1 and B7-2 costimulatory molecules activate differentially the Thl/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995;80(5):707-718.
    • (1995) Cell , vol.80 , Issue.5 , pp. 707-718
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3
  • 25
    • 0029150012 scopus 로고
    • Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease
    • Cua DJ, Hinton DR, Stohlman SA:Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease. J Immunol 1995;155(8): 4052-4059.
    • (1995) J Immunol , vol.155 , Issue.8 , pp. 4052-4059
    • Cua, D.J.1    Hinton, D.R.2    Stohlman, S.A.3
  • 26
    • 0028829010 scopus 로고
    • Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells
    • Khoruts A, Miller SD, Jenkins MK: Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells. J Immunol, 1995;155(10):5011-5017.
    • (1995) J Immunol , vol.155 , Issue.10 , pp. 5011-5017
    • Khoruts, A.1    Miller, S.D.2    Jenkins, M.K.3
  • 27
    • 0030739650 scopus 로고    scopus 로고
    • Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
    • Lafaille JJ, Keere FV, Hsu AL, et al.: Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med 1997;186(2):307-312.
    • (1997) J Exp Med , vol.186 , Issue.2 , pp. 307-312
    • Lafaille, J.J.1    Keere, F.V.2    Hsu, A.L.3
  • 28
    • 0035884845 scopus 로고    scopus 로고
    • The role of IFN-gamma in the production of Th2 subpopulations: Implications for variable Th2-mediated pathologies in autoimmunity
    • Wensky A, Marcondes MC, Lafaille JJ: The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunity. J Immunol, 2001;167(6):3074-3081.
    • (2001) J Immunol , vol.167 , Issue.6 , pp. 3074-3081
    • Wensky, A.1    Marcondes, M.C.2    Lafaille, J.J.3
  • 29
    • 0028956025 scopus 로고
    • Interferon gamma, interleukin 4 and transforming growth factor beta in experimental autoimmune encephalomyelitis in Lewis rats: Dynamics of cellular mRNA expression in the central nervous system and lymphoid cells
    • Issazadeh S, Mustafa M, Ljungdahl A, et al.: Interferon gamma, interleukin 4 and transforming growth factor beta in experimental autoimmune encephalomyelitis in Lewis rats: dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J Neurosci Res 1995;40(5):579-590.
    • (1995) J Neurosci Res , vol.40 , Issue.5 , pp. 579-590
    • Issazadeh, S.1    Mustafa, M.2    Ljungdahl, A.3
  • 30
    • 0032532022 scopus 로고    scopus 로고
    • Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis
    • Begolka WS, Vanderlugt CL, Rahbe SM, et al.: Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis. J Immunol 1998;161(8):4437-4446.
    • (1998) J Immunol , vol.161 , Issue.8 , pp. 4437-4446
    • Begolka, W.S.1    Vanderlugt, C.L.2    Rahbe, S.M.3
  • 31
    • 0032419459 scopus 로고    scopus 로고
    • Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE
    • Renno T, Taupin V, Bourbonniere L, et al.: Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE. Mol Cell Neurosci 1998;12(6):376-389.
    • (1998) Mol Cell Neurosci , vol.12 , Issue.6 , pp. 376-389
    • Renno, T.1    Taupin, V.2    Bourbonniere, L.3
  • 32
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber IA, Brocke S, Taylor-Edwards C, et al.: Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 1996;156(1):5-7.
    • (1996) J Immunol , vol.156 , Issue.1 , pp. 5-7
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3
  • 33
    • 0027889130 scopus 로고
    • Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis
    • Lublin FD, Knobler RL, Kalman B, et al.: Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis. Autoimmunity, 1993; 16(4):267-274.
    • (1993) Autoimmunity , vol.16 , Issue.4 , pp. 267-274
    • Lublin, F.D.1    Knobler, R.L.2    Kalman, B.3
  • 34
    • 0029957071 scopus 로고    scopus 로고
    • Interferon-gamma confers resistance to experimental allergic encephalomyelitis
    • Krakowski M, Owens T: Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol 1996;26(7):1641-1646.
    • (1996) Eur J Immunol , vol.26 , Issue.7 , pp. 1641-1646
    • Krakowski, M.1    Owens, T.2
  • 35
    • 0032031409 scopus 로고    scopus 로고
    • IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways
    • Konieczny BT, Dai Z, Elwood ET, et al.: IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 1998;160(5):2059-2064.
    • (1998) J Immunol , vol.160 , Issue.5 , pp. 2059-2064
    • Konieczny, B.T.1    Dai, Z.2    Elwood, E.T.3
  • 36
    • 0033565531 scopus 로고    scopus 로고
    • Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-gamma: Implications for long-term allograft acceptance
    • Hassan AT, Dai Z, Konieczny BT, et al: Regulation of alloantigen- mediated T-cell proliferation by endogenous interferon-gamma: implications for long-term allograft acceptance. Transplantation 1999;68(1):124-129.
    • (1999) Transplantation , vol.68 , Issue.1 , pp. 124-129
    • Hassan, A.T.1    Dai, Z.2    Konieczny, B.T.3
  • 37
    • 0034680811 scopus 로고    scopus 로고
    • Regulation of antigen-specific CD8+ T cell homeostasis by perform and interferon-gamma
    • Badovinac VP, Tvinnereim AR, Harty JT: Regulation of antigen-specific CD8+ T cell homeostasis by perform and interferon-gamma. Science 2000;290(5495): 1354-1358.
    • (2000) Science , vol.290 , Issue.5495 , pp. 1354-1358
    • Badovinac, V.P.1    Tvinnereim, A.R.2    Harty, J.T.3
  • 38
    • 0034601012 scopus 로고    scopus 로고
    • Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    • Chu CQ, Wittmer S, Dalton DK: Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med 2000;192(1):123-128.
    • (2000) J Exp Med , vol.192 , Issue.1 , pp. 123-128
    • Chu, C.Q.1    Wittmer, S.2    Dalton, D.K.3
  • 39
    • 0033571331 scopus 로고    scopus 로고
    • IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: A possible role for nitric oxide
    • Willenborg DO, Fordham SA, Staykova MA, et al.: IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J Immunol 1999;163(10):5278-5286.
    • (1999) J Immunol , vol.163 , Issue.10 , pp. 5278-5286
    • Willenborg, D.O.1    Fordham, S.A.2    Staykova, M.A.3
  • 40
    • 0025685264 scopus 로고
    • Interferon gamma plays a critical role in induced cell death of effector T cell: A possible third mechanism of self-tolerance
    • Liu Y, Janeway CA Jr.: Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J Exp Med 1990;172(6):1735-1739.
    • (1990) J Exp Med , vol.172 , Issue.6 , pp. 1735-1739
    • Liu, Y.1    Janeway Jr., C.A.2
  • 41
    • 0034627986 scopus 로고    scopus 로고
    • Macrophage-derived nitric oxide inhibits the proliferation of activated T helper cells and is induced during antigenic stimulation of resting T cells
    • van der Veen RC, Dietlin TA, Dixon Gray J, et al,: Macrophage-derived nitric oxide inhibits the proliferation of activated T helper cells and is induced during antigenic stimulation of resting T cells. Cell Immunol 2000;199(1):43-49.
    • (2000) Cell Immunol , vol.199 , Issue.1 , pp. 43-49
    • Van Der Veen, R.C.1    Dietlin, T.A.2    Dixon Gray, J.3
  • 42
    • 0032536869 scopus 로고    scopus 로고
    • Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
    • Sallusto F, Lenig D, Mackay CR, et al.: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998; 187(6):875-883.
    • (1998) J Exp Med , vol.187 , Issue.6 , pp. 875-883
    • Sallusto, F.1    Lenig, D.2    Mackay, C.R.3
  • 43
    • 0028347462 scopus 로고
    • IFN and virus-inducible expression of an immediate early gene, crg-2/IP-10, and a delayed gene, I-A alpha in astrocytes and microglia
    • Vanguri P, Farber JM: IFN and virus-inducible expression of an immediate early gene, crg-2/IP-10, and a delayed gene, I-A alpha in astrocytes and microglia. J Immunol 1994;152(3):1411-1418.
    • (1994) J Immunol , vol.152 , Issue.3 , pp. 1411-1418
    • Vanguri, P.1    Farber, J.M.2
  • 44
    • 0034162486 scopus 로고    scopus 로고
    • IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines
    • Tran EH, Prince EN, Owens T: IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines. J Immunol 2000:164(5): 2759-2768.
    • (2000) J Immunol , vol.164 , Issue.5 , pp. 2759-2768
    • Tran, E.H.1    Prince, E.N.2    Owens, T.3
  • 45
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    • Chitnis T, Najafian N, Benou C, et al.: Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest 2001;108(5):739-747.
    • (2001) J Clin Invest , vol.108 , Issue.5 , pp. 739-747
    • Chitnis, T.1    Najafian, N.2    Benou, C.3
  • 46
    • 0030248470 scopus 로고    scopus 로고
    • Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: Persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta
    • Issazadeh S, Lorentzen JC, Mustafa MI, et al.: Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-beta. J Neuroimmunol, 1996;69(1-2):103-115.
    • (1996) J Neuroimmunol , vol.69 , Issue.1-2 , pp. 103-115
    • Issazadeh, S.1    Lorentzen, J.C.2    Mustafa, M.I.3
  • 47
    • 0025999081 scopus 로고
    • Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats
    • Kuroda Y, Shimamoto Y: Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats. J Neuroimmunol 1991;34(2-3):159-164.
    • (1991) J Neuroimmunol , vol.34 , Issue.2-3 , pp. 159-164
    • Kuroda, Y.1    Shimamoto, Y.2
  • 48
    • 0026094706 scopus 로고
    • Anti-tumor necrosis factor therapy abrogates autoimmune demyelination
    • Selmaj K, Raine CS, Cross AH: Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann Neurol 1991;30(5):694-700.
    • (1991) Ann Neurol , vol.30 , Issue.5 , pp. 694-700
    • Selmaj, K.1    Raine, C.S.2    Cross, A.H.3
  • 49
    • 0025000863 scopus 로고
    • An anti-body to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis
    • Ruddle NH, Bergman CM, McGrath KM, et al.: An anti-body to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med 1990;172(4):1193-1200.
    • (1990) J Exp Med , vol.172 , Issue.4 , pp. 1193-1200
    • Ruddle, N.H.1    Bergman, C.M.2    McGrath, K.M.3
  • 50
    • 0028864801 scopus 로고
    • Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha
    • Probert L, Akassoglou K, Pasparakis M, et al.: Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc Natl Acad Sci USA 1995;92(24):11294-11298.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.24 , pp. 11294-11298
    • Probert, L.1    Akassoglou, K.2    Pasparakis, M.3
  • 51
    • 0023904746 scopus 로고
    • Tumor necrosis factor mediates myelin andoligodendrocyte damage in vitro
    • Selmaj KW, Raine CS: Tumor necrosis factor mediates myelin andoligodendrocyte damage in vitro. Ann Neurol 1988;23(4):339-346.
    • (1988) Ann Neurol , vol.23 , Issue.4 , pp. 339-346
    • Selmaj, K.W.1    Raine, C.S.2
  • 52
    • 0031659763 scopus 로고    scopus 로고
    • Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: Models for multiple sclerosis with primary oligodendrogliopathy
    • Akassoglou K, Bauer J, Kassiotis G, et al.: Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol 1998;153(3):801-813.
    • (1998) Am J Pathol , vol.153 , Issue.3 , pp. 801-813
    • Akassoglou, K.1    Bauer, J.2    Kassiotis, G.3
  • 53
    • 0031916192 scopus 로고    scopus 로고
    • TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
    • Liu J, Marino MW, Wong G, et al.: TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat Med 1998;4(1):78-83.
    • (1998) Nat Med , vol.4 , Issue.1 , pp. 78-83
    • Liu, J.1    Marino, M.W.2    Wong, G.3
  • 54
    • 0030918326 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis
    • Frei K, Eugster HP, Bopst M, et al.: Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis. J Exp Med 1997;185(12):2177-2182.
    • (1997) J Exp Med , vol.185 , Issue.12 , pp. 2177-2182
    • Frei, K.1    Eugster, H.P.2    Bopst, M.3
  • 55
    • 0032934534 scopus 로고    scopus 로고
    • Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice
    • Bachmann R, Eugster HP, Frei K, et al.: Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice. Am J Pathol 1999;154(5): 1417-1422.
    • (1999) Am J Pathol , vol.154 , Issue.5 , pp. 1417-1422
    • Bachmann, R.1    Eugster, H.P.2    Frei, K.3
  • 56
    • 0034633542 scopus 로고    scopus 로고
    • Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis
    • Suvannavejh GC, Lee HO, Padilla J, et al.: Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis. Cell Immunol 2000; 205(1):24-33.
    • (2000) Cell Immunol , vol.205 , Issue.1 , pp. 24-33
    • Suvannavejh, G.C.1    Lee, H.O.2    Padilla, J.3
  • 57
    • 0028855346 scopus 로고
    • Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I
    • Selmaj K, Papierz W, Glabinski A, et al.: Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I. J Neuroimmunol 1995;56(2):135-141.
    • (1995) J Neuroimmunol , vol.56 , Issue.2 , pp. 135-141
    • Selmaj, K.1    Papierz, W.2    Glabinski, A.3
  • 58
    • 1842407250 scopus 로고    scopus 로고
    • Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system
    • Korner H, Lemckert FA, Chaudhri G, et al.: Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system. Eur J Immunol 1997;27(8):1973-1981.
    • (1997) Eur J Immunol , vol.27 , Issue.8 , pp. 1973-1981
    • Korner, H.1    Lemckert, F.A.2    Chaudhri, G.3
  • 59
    • 0029848966 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo
    • Speiser DE, Sebzda E, Ohteki T, et al.: Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur J Immunol 1996; 26(12):3055-3060.
    • (1996) Eur J Immunol , vol.26 , Issue.12 , pp. 3055-3060
    • Speiser, D.E.1    Sebzda, E.2    Ohteki, T.3
  • 60
    • 0032005162 scopus 로고    scopus 로고
    • Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis
    • Bright JJ, Musuro BF, Du C, et al.: Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis. J Neuroimmunol 1998:82(1): 22-30.
    • (1998) J Neuroimmunol , vol.82 , Issue.1 , pp. 22-30
    • Bright, J.J.1    Musuro, B.F.2    Du, C.3
  • 61
    • 0032476702 scopus 로고    scopus 로고
    • Differential induction of interleukin-12, interleukin-18, and interleukin-Ibeta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat
    • Jander S, Stoll G.: Differential induction of interleukin-12, interleukin-18, and interleukin-Ibeta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat. J Neuroimmunol 1998; 91(1-2):93-99.
    • (1998) J Neuroimmunol , vol.91 , Issue.1-2 , pp. 93-99
    • Jander, S.1    Stoll, G.2
  • 62
    • 0030944709 scopus 로고    scopus 로고
    • Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat
    • Smith T, Hewson AK, Kingsley CI, et al.: Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat. Am J Pathol 1997;150(6): 1909-1917.
    • (1997) Am J Pathol , vol.150 , Issue.6 , pp. 1909-1917
    • Smith, T.1    Hewson, A.K.2    Kingsley, C.I.3
  • 63
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by anti-bodies against interleukin 12
    • Leonard JP, Waldburger KE, Goldman SJ: Prevention of experimental autoimmune encephalomyelitis by anti-bodies against interleukin 12. J Exp Med 1995;181(1): 381-386.
    • (1995) J Exp Med , vol.181 , Issue.1 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 64
    • 0029788704 scopus 로고    scopus 로고
    • IL-12 unmasks latent autoimmune disease in resistant mice
    • Segal BM, Shevach EM: IL-12 unmasks latent autoimmune disease in resistant mice. J Exp Med 1996;184(2): 771-775.
    • (1996) J Exp Med , vol.184 , Issue.2 , pp. 771-775
    • Segal, B.M.1    Shevach, E.M.2
  • 65
    • 0030039962 scopus 로고    scopus 로고
    • Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms
    • Waldburger KE, Hastings RC, Schaub RG, et al.: Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms. Am J Pathol 1996;148(2):375-382.
    • (1996) Am J Pathol , vol.148 , Issue.2 , pp. 375-382
    • Waldburger, K.E.1    Hastings, R.C.2    Schaub, R.G.3
  • 66
    • 0030475608 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis by interleukin-12
    • Leonard JP, Waldburger KE, Goldman SJ: Regulation of experimental autoimmune encephalomyelitis by interleukin-12. Ann N Y Acad Sci 1996;795:216-226.
    • (1996) Ann N Y Acad Sci , vol.795 , pp. 216-226
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 67
    • 0031713845 scopus 로고    scopus 로고
    • Transgenic models to study the actions of cytokines in the central nervous system
    • Campbell IL, Stalder AK, Akwa Y, et al.: Transgenic models to study the actions of cytokines in the central nervous system. Neuroimmunomodulation, 1998; 5(3-4): 126-135.
    • (1998) Neuroimmunomodulation , vol.5 , Issue.3-4 , pp. 126-135
    • Campbell, I.L.1    Stalder, A.K.2    Akwa, Y.3
  • 68
    • 0032536447 scopus 로고    scopus 로고
    • An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
    • Segal BM, Dwyer BK, Shevach EM: An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med 1998; 187(4):537-546.
    • (1998) J Exp Med , vol.187 , Issue.4 , pp. 537-546
    • Segal, B.M.1    Dwyer, B.K.2    Shevach, E.M.3
  • 69
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran B, Zhang GX, Yu S, et al.: IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol 2002;169(12):7104-7110.
    • (2002) J Immunol , vol.169 , Issue.12 , pp. 7104-7110
    • Gran, B.1    Zhang, G.X.2    Yu, S.3
  • 70
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua DJ, Sherlock J, Chen Y, et al.: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003; 421(6924):744-748.
    • (2003) Nature , vol.421 , Issue.6924 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3
  • 71
    • 0028845730 scopus 로고
    • Cloning of a new cytokine that induces IFN-gamma production by T cells
    • Okamura H, Tsuti H, Komatsu T, et al.: Cloning of a new cytokine that induces IFN-gamma production by T cells [see comments]. Nature 1995;378(6552):88-91.
    • (1995) Nature , vol.378 , Issue.6552 , pp. 88-91
    • Okamura, H.1    Tsuti, H.2    Komatsu, T.3
  • 72
    • 15844367093 scopus 로고    scopus 로고
    • Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
    • Ushio S, Namba M, Okura T, et al.: Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol 1996;156(11):4274-4279.
    • (1996) J Immunol , vol.156 , Issue.11 , pp. 4274-4279
    • Ushio, S.1    Namba, M.2    Okura, T.3
  • 73
    • 0031573558 scopus 로고    scopus 로고
    • Regulation of IL-18 (IFN-gamma-inducing factor) gene expression
    • Tone M, Thompson SA, Tone Y, et al.: Regulation of IL-18 (IFN-gamma-inducing factor) gene expression. J Immunol 1997;159(12):6156-6163.
    • (1997) J Immunol , vol.159 , Issue.12 , pp. 6156-6163
    • Tone, M.1    Thompson, S.A.2    Tone, Y.3
  • 74
    • 0031578229 scopus 로고    scopus 로고
    • Interleukin-18 activates NF-kappaB in murine T helper type 1 cells
    • Matsumoto S, Tsuji-Takayama K, Aizawa Y, et al.: Interleukin-18 activates NF-kappaB in murine T helper type 1 cells. Biochem Biophys Res Commun 1997; 234(2):454-457.
    • (1997) Biochem Biophys Res Commun , vol.234 , Issue.2 , pp. 454-457
    • Matsumoto, S.1    Tsuji-Takayama, K.2    Aizawa, Y.3
  • 75
    • 0028943484 scopus 로고
    • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
    • Jacobson NG, Szabo SJ, Weber-Nordt RM, et al.: Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 1995; 181(5):1755-1762.
    • (1995) J Exp Med , vol.181 , Issue.5 , pp. 1755-1762
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3
  • 76
    • 0034002472 scopus 로고    scopus 로고
    • The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit
    • Chang JT, Segal BM, Nakanishi K, et al.: The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. Eur J Immunol 2000; 30(4): 1113-1119.
    • (2000) Eur J Immunol , vol.30 , Issue.4 , pp. 1113-1119
    • Chang, J.T.1    Segal, B.M.2    Nakanishi, K.3
  • 77
    • 0032193770 scopus 로고    scopus 로고
    • IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production
    • Yoshimoto T, Takeda K, Tanaka T, et al.: IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol 1998;161(7):3400-3407.
    • (1998) J Immunol , vol.161 , Issue.7 , pp. 3400-3407
    • Yoshimoto, T.1    Takeda, K.2    Tanaka, T.3
  • 78
    • 3643120790 scopus 로고    scopus 로고
    • Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
    • Xu D, Chan WL, Leung BP, et al.: Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J Exp Med 1998;188(8): 1485-1492.
    • (1998) J Exp Med , vol.188 , Issue.8 , pp. 1485-1492
    • Xu, D.1    Chan, W.L.2    Leung, B.P.3
  • 79
    • 0032698471 scopus 로고    scopus 로고
    • IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
    • Fantuzzi G, Reed DA, Dinarello CA: IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor. J Clin Invest 1999;104(6):761-767.
    • (1999) J Clin Invest , vol.104 , Issue.6 , pp. 761-767
    • Fantuzzi, G.1    Reed, D.A.2    Dinarello, C.A.3
  • 80
    • 0026707402 scopus 로고
    • Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
    • Kennedy MK, Torrance DS, Picha KS, et al.: Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol 1992;149(7): 2496-2505.
    • (1992) J Immunol , vol.149 , Issue.7 , pp. 2496-2505
    • Kennedy, M.K.1    Torrance, D.S.2    Picha, K.S.3
  • 81
    • 0032126890 scopus 로고    scopus 로고
    • The pattern of cytokine gene expression in lymphoid organs and peripheral blood mononuclear cells of mice with experimental allergic encephalomyelitis
    • Okuda Y, Sakoda S, Yanagihara T: The pattern of cytokine gene expression in lymphoid organs and peripheral blood mononuclear cells of mice with experimental allergic encephalomyelitis. J Neuroimmunol 1998;87(1-2): 147-155.
    • (1998) J Neuroimmunol , vol.87 , Issue.1-2 , pp. 147-155
    • Okuda, Y.1    Sakoda, S.2    Yanagihara, T.3
  • 82
    • 0031802920 scopus 로고    scopus 로고
    • The development of autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein is associated with an upregulation of both proinflammatory and immunoregulatory cytokines in the central nervous system
    • Okuda Y, Sakoda S, Bernard CC, et al.: The development of autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein is associated with an upregulation of both proinflammatory and immunoregulatory cytokines in the central nervous system. J Interferon Cytokine Res 1998;18(6):415-421.
    • (1998) J Interferon Cytokine Res , vol.18 , Issue.6 , pp. 415-421
    • Okuda, Y.1    Sakoda, S.2    Bernard, C.C.3
  • 83
    • 0031921636 scopus 로고    scopus 로고
    • Interleukin-6 functions in autoimmune encephalomyelitis: A study in genetargeted mice
    • Mendel I, Katz A, Nozak N, et al.: Interleukin-6 functions in autoimmune encephalomyelitis: a study in genetargeted mice. Eur J Immunol 1998;28(5): 1727-1737.
    • (1998) Eur J Immunol , vol.28 , Issue.5 , pp. 1727-1737
    • Mendel, I.1    Katz, A.2    Nozak, N.3
  • 84
    • 0030777027 scopus 로고    scopus 로고
    • High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats
    • Diab A, Zhu J, Xiao BG, et al.: High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats. J Neuropathol Exp Neurol 1997;56(6):641-650.
    • (1997) J Neuropathol Exp Neurol , vol.56 , Issue.6 , pp. 641-650
    • Diab, A.1    Zhu, J.2    Xiao, B.G.3
  • 85
    • 0029411144 scopus 로고
    • Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation
    • Gijbels K, Brocke S, Abrams JS, et al.: Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation. Mol Med 1995; 1(7):795-805.
    • (1995) Mol Med , vol.1 , Issue.7 , pp. 795-805
    • Gijbels, K.1    Brocke, S.2    Abrams, J.S.3
  • 86
    • 0032700063 scopus 로고    scopus 로고
    • IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35-55 induced experimental autoimmune encephalomyelitis
    • Okuda Y, Sakoda S, Fujimura H, et al.: IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35-55 induced experimental autoimmune encephalomyelitis. J Neuroimmunol 1999; 101(2):188-196.
    • (1999) J Neuroimmunol , vol.101 , Issue.2 , pp. 188-196
    • Okuda, Y.1    Sakoda, S.2    Fujimura, H.3
  • 87
    • 0031852288 scopus 로고    scopus 로고
    • IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Eugster HP, Frei K, Kopf M, et al.: IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Eur J Immunol 1998; 28(7):2178-2187.
    • (1998) Eur J Immunol , vol.28 , Issue.7 , pp. 2178-2187
    • Eugster, H.P.1    Frei, K.2    Kopf, M.3
  • 88
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
    • Samoilova EB, Horton JL, Hilliard B, et al.: IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 1998; 161(12):6480-6486.
    • (1998) J Immunol , vol.161 , Issue.12 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3
  • 89
    • 0026696776 scopus 로고
    • CD4+ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion
    • Karpus WJ, Gould KE, Swanborg RH: CD4+ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion. Eur J Immunol 1992;22(7): 1757-1763.
    • (1992) Eur J Immunol , vol.22 , Issue.7 , pp. 1757-1763
    • Karpus, W.J.1    Gould, K.E.2    Swanborg, R.H.3
  • 90
    • 0028116618 scopus 로고
    • Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
    • Racke MK, Bonomo A, Scott DE, et al.: Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med, 1994;180(5): 1961-1966.
    • (1994) J Exp Med , vol.180 , Issue.5 , pp. 1961-1966
    • Racke, M.K.1    Bonomo, A.2    Scott, D.E.3
  • 91
    • 0032193696 scopus 로고    scopus 로고
    • IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice
    • Bettelli E, Das MP, Howard ED, et al.: IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10-and IL-4-deficient and transgenic mice. J Immunol 1998;161(7): 3299-3306.
    • (1998) J Immunol , vol.161 , Issue.7 , pp. 3299-3306
    • Bettelli, E.1    Das, M.P.2    Howard, E.D.3
  • 92
    • 0030918701 scopus 로고    scopus 로고
    • Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis
    • Shaw MK, Lorens JB, Dhawan A, et al.: Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J Exp Med 1997;185(9):1711-1714.
    • (1997) J Exp Med , vol.185 , Issue.9 , pp. 1711-1714
    • Shaw, M.K.1    Lorens, J.B.2    Dhawan, A.3
  • 93
    • 0031011146 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in IL-4-deficient mice
    • Liblau R, Steinman L, Brocke S: Experimental autoimmune encephalomyelitis in IL-4-deficient mice. Int Immunol 1997;9(5):799-803.
    • (1997) Int Immunol , vol.9 , Issue.5 , pp. 799-803
    • Liblau, R.1    Steinman, L.2    Brocke, S.3
  • 94
    • 0032525044 scopus 로고    scopus 로고
    • A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice
    • Falcone M, Rajan AJ, Bloom BR, et al.: A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice. J Immunol 1998;160(10):4822-4830.
    • (1998) J Immunol , vol.160 , Issue.10 , pp. 4822-4830
    • Falcone, M.1    Rajan, A.J.2    Bloom, B.R.3
  • 95
    • 0031716664 scopus 로고    scopus 로고
    • IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis
    • Inobe J, Slavin AJ, Komagata Y, et al.: IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis. Eur J Immunol 1998;28(9): 2780-2790.
    • (1998) Eur J Immunol , vol.28 , Issue.9 , pp. 2780-2790
    • Inobe, J.1    Slavin, A.J.2    Komagata, Y.3
  • 96
    • 0028245010 scopus 로고
    • Interleukin-10 prevents experimental allergic encephalomyelitis in rats
    • Rott O, Fleischer B, Cash E: Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 1994;24(6):1434-1440.
    • (1994) Eur J Immunol , vol.24 , Issue.6 , pp. 1434-1440
    • Rott, O.1    Fleischer, B.2    Cash, E.3
  • 97
    • 0033559981 scopus 로고    scopus 로고
    • Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis
    • Cua DJ, Groux H, Hinton DR, et al: Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis. J Exp Med 1999;189(6): 1005-1010.
    • (1999) J Exp Med , vol.189 , Issue.6 , pp. 1005-1010
    • Cua, D.J.1    Groux, H.2    Hinton, D.R.3
  • 98
    • 0029742433 scopus 로고    scopus 로고
    • IL-10 fails to abrogate experimental autoimmune encephalomyelitis
    • Cannella B, Gao YL, Brosnan C, et al.: IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J Neurosci Res 1996;45(6):735-746.
    • (1996) J Neurosci Res , vol.45 , Issue.6 , pp. 735-746
    • Cannella, B.1    Gao, Y.L.2    Brosnan, C.3
  • 99
    • 0025902307 scopus 로고
    • Suppressive effects of monocytic cells and transforming growth factor-beta on natural killercell differentiation in autoimmune viable motheaten mutant mice
    • Koo GC, Manyak CL, Dasch J, et al.: Suppressive effects of monocytic cells and transforming growth factor-beta on natural killercell differentiation in autoimmune viable motheaten mutant mice. J Immunol, 1991;147(4): 1194-1200.
    • (1991) J Immunol , vol.147 , Issue.4 , pp. 1194-1200
    • Koo, G.C.1    Manyak, C.L.2    Dasch, J.3
  • 100
    • 0028178443 scopus 로고
    • Transforming growth factor-beta 1 inhibits tumor necrosis factor-alpha/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis
    • Stevens DB, Gould KE, Swanborg RH: Transforming growth factor-beta 1 inhibits tumor necrosis factor-alpha/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis. J Neuroimmunol 1994;51(1):77-83.
    • (1994) J Neuroimmunol , vol.51 , Issue.1 , pp. 77-83
    • Stevens, D.B.1    Gould, K.E.2    Swanborg, R.H.3
  • 101
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull MM, Ormsby I, Kier AB, et al.: Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992; 359(6397):693-699.
    • (1992) Nature , vol.359 , Issue.6397 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3
  • 102
    • 0026006736 scopus 로고
    • Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1
    • Johns LD, Flanders KC, Ranges GE, et al.: Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1. J Immunol 1991;147(6):1792-1796.
    • (1991) J Immunol , vol.147 , Issue.6 , pp. 1792-1796
    • Johns, L.D.1    Flanders, K.C.2    Ranges, G.E.3
  • 103
    • 0025767669 scopus 로고
    • Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice
    • Kuruvilla AP, Shah R, Hochwald GM, et al.: Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice. Proc Natl Acad Sci USA 1991;88(7):2918-2921.
    • (1991) Proc Natl Acad Sci USA , vol.88 , Issue.7 , pp. 2918-2921
    • Kuruvilla, A.P.1    Shah, R.2    Hochwald, G.M.3
  • 104
    • 0027313082 scopus 로고
    • Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor
    • Santambrogio L, Hochwald GM, Saxena B, et al.: Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor. J Immunol 1993;151(2): 1116-1127.
    • (1993) J Immunol , vol.151 , Issue.2 , pp. 1116-1127
    • Santambrogio, L.1    Hochwald, G.M.2    Saxena, B.3
  • 105
    • 0027422999 scopus 로고
    • Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 2
    • Racke MK, Sriaram S, Carlino J, et al.: Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 2. J Neuroimmunol 1993;46(1-2): p. 175-183.
    • (1993) J Neuroimmunol , vol.46 , Issue.1-2 , pp. 175-183
    • Racke, M.K.1    Sriaram, S.2    Carlino, J.3
  • 106
    • 0034121583 scopus 로고    scopus 로고
    • When engineered to produce latent TGF-beta1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes
    • Thorbecke GJ, Umetsu DT, deKruyff RH, et al.: When engineered to produce latent TGF-beta1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes. Cytokine Growth Factor Rev 2000;11(1-2): 89-96.
    • (2000) Cytokine Growth Factor Rev , vol.11 , Issue.1-2 , pp. 89-96
    • Thorbecke, G.J.1    Umetsu, D.T.2    DeKruyff, R.H.3
  • 107
    • 0032514763 scopus 로고    scopus 로고
    • Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-beta1
    • Chen LZ, Hochwald GM, Huang C, et al.: Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-beta1. Proc Natl Acad Sci USA 1998;95(21):12516-12521.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.21 , pp. 12516-12521
    • Chen, L.Z.1    Hochwald, G.M.2    Huang, C.3
  • 108
    • 0027209457 scopus 로고
    • Experimental allergic encephalomyelitis: Neutralizing antibody to TGF beta 1 enhances the clinical severity of the disease
    • Johns LD, Sriram S: Experimental allergic encephalomyelitis: neutralizing antibody to TGF beta 1 enhances the clinical severity of the disease. J Neuroimmunol 1993;47(1):1-7.
    • (1993) J Neuroimmunol , vol.47 , Issue.1 , pp. 1-7
    • Johns, L.D.1    Sriram, S.2
  • 109
    • 0030793527 scopus 로고    scopus 로고
    • Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice
    • Wyss-Coray T, Borrow P, Brooker MJ, et al.: Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice. J Neuroimmunol 1997;77(1):45-50.
    • (1997) J Neuroimmunol , vol.77 , Issue.1 , pp. 45-50
    • Wyss-Coray, T.1    Borrow, P.2    Brooker, M.J.3
  • 110
    • 0028089802 scopus 로고
    • Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats
    • Cash E, Minty A, Ferrara P, et al.: Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats. J Immunol 1994;153(9): 4258-4267.
    • (1994) J Immunol , vol.153 , Issue.9 , pp. 4258-4267
    • Cash, E.1    Minty, A.2    Ferrara, P.3
  • 111
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan MH, Schindler U, Smiley ST, et al.: Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996;4(3):313-319.
    • (1996) Immunity , vol.4 , Issue.3 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3
  • 112
    • 15844404509 scopus 로고    scopus 로고
    • Essential role of Stat6 in IL-4 signalling
    • Takeda K, Tanaka T, Shi W, et al.: Essential role of Stat6 in IL-4 signalling. Nature 1996;380(6575):627-630.
    • (1996) Nature , vol.380 , Issue.6575 , pp. 627-630
    • Takeda, K.1    Tanaka, T.2    Shi, W.3
  • 113
    • 15844396183 scopus 로고    scopus 로고
    • Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    • Thierfelder WE, van Deursen JM, Yamamoto K, et al.: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996; 382(6587):171-174.
    • (1996) Nature , vol.382 , Issue.6587 , pp. 171-174
    • Thierfelder, W.E.1    Van Deursen, J.M.2    Yamamoto, K.3
  • 114
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan MH, Sun YL, Hoey T, et al.: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996;382(6587):174-177.
    • (1996) Nature , vol.382 , Issue.6587 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3
  • 115
    • 0032521933 scopus 로고    scopus 로고
    • IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes
    • Barbulescu K, Becker C, Schlaak JF, et al.: IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes. J Immunol 1998;160(8):3642-3647.
    • (1998) J Immunol , vol.160 , Issue.8 , pp. 3642-3647
    • Barbulescu, K.1    Becker, C.2    Schlaak, J.F.3
  • 116
    • 0030694235 scopus 로고    scopus 로고
    • IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB
    • Robinson D, Shibuya K, Mui A, et al.: IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. Immunity 1997;7(4):571-581.
    • (1997) Immunity , vol.7 , Issue.4 , pp. 571-581
    • Robinson, D.1    Shibuya, K.2    Mui, A.3
  • 117
    • 0035092850 scopus 로고    scopus 로고
    • CD28-independent induction of experimental autoimmune encephalomyelitis
    • Chitnis T, Najafian N, Abdallah KA, et al.: CD28-independent induction of experimental autoimmune encephalomyelitis. J Clin Invest 2001;107(5):575-583.
    • (2001) J Clin Invest , vol.107 , Issue.5 , pp. 575-583
    • Chitnis, T.1    Najafian, N.2    Abdallah, K.A.3
  • 118
    • 0033519322 scopus 로고    scopus 로고
    • Costimulatory signal blockade in murine relapsing experimental autoimmune encephalomyelitis
    • Schaub M, Issazadeh S, Stadibauer TH, et al.: Costimulatory signal blockade in murine relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol 1999; 96(2):158-166.
    • (1999) J Neuroimmunol , vol.96 , Issue.2 , pp. 158-166
    • Schaub, M.1    Issazadeh, S.2    Stadibauer, T.H.3
  • 119
    • 0030587810 scopus 로고    scopus 로고
    • Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat
    • Khoury SJ, Galloon L, Verburg RR, et al.: Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat. J Immunol 1996;157(8):3700-3705.
    • (1996) J Immunol , vol.157 , Issue.8 , pp. 3700-3705
    • Khoury, S.J.1    Galloon, L.2    Verburg, R.R.3
  • 120
    • 0028868424 scopus 로고
    • CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system
    • Khoury SJ, Akalin E, Chandraker A, et al.: CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J Immunol 1995;155(10): 4521-4524.
    • (1995) J Immunol , vol.155 , Issue.10 , pp. 4521-4524
    • Khoury, S.J.1    Akalin, E.2    Chandraker, A.3
  • 121
    • 0035887739 scopus 로고    scopus 로고
    • Activation of CD25(+) CD4(+) regulatory T cells by oral antigen administration
    • Zhang X, Izikson L, Liu L, et al.: Activation of CD25(+) CD4(+) regulatory T cells by oral antigen administration. J Immunol 2001;167(8):4245-4253.
    • (2001) J Immunol , vol.167 , Issue.8 , pp. 4245-4253
    • Zhang, X.1    Izikson, L.2    Liu, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.