Update of cell damage mechanisms in thiamine deficiency: Focus on oxidative stress, excitotoxicity and inflammation

Alcohol and Alcoholism

Volumn 44, Issue 2, 2009, Pages 141-147

  Hazell, Alan S ^a,b   Butterworth, Roger F ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCYSTEINE; DIZOCILPINE; GLUTAMIC ACID; LACTIC ACID; NITRIC OXIDE SYNTHASE; POTASSIUM; SELEGILINE;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ASTROCYTE; BRAIN DAMAGE; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN NECROSIS; CELL LOSS; CELL PROTECTION; DISEASE ASSOCIATION; DISEASE COURSE; DRUG EFFICACY; ENCEPHALITIS; ENERGY METABOLISM; EXCITOTOXICITY; GENE EXPRESSION; GLIA CELL; HUMAN; LACTIC ACIDOSIS; NERVE CELL LESION; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; THIAMINE DEFICIENCY; WERNICKE ENCEPHALOPATHY;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN CHEMISTRY; EXCITATORY AMINO ACIDS; GLUTAMIC ACID; HUMANS; INFLAMMATION; KETOGLUTARATE DEHYDROGENASE COMPLEX; NEURONS; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; THIAMINE DEFICIENCY; WERNICKE ENCEPHALOPATHY;

EID: 61449205168     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agn120     Document Type: Article

References (112)

1. Agostinho P, Duarte CB, Oliveira CR. (1997) Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: Effect of antioxidants. FASEB J 11:154-63.
2. Aikawa H, Watanabe IS, Furuse T et al. (1984) Low energy levels in thiamine-deficient encephalopathy. J Neuropathol Exp Neurol 43 276-287.
3. Armstrong-James M, Ross DT, Chen F et al. (1988) The effect of thiamine deficiency on the structure and physiology of the rat forebrain. Metab Brain Dis 3:91-124.
4. Baines M. (1978) Detection and incidence of B and C vitamin deficiency in alcohol related illness. Ann Clin Biochem 15:307-12.
5. Bartel DP, Sheng M, Lau LF et al. (1989) Growth factors and membrane depolarization activate distinct programs of early response gene expression: Dissociation of fos and jun induction. Genes Dev 3:304-13.
6. Bender AS, Young LP, Norenberg MD. (1997) Effect of lactic acid on L-glutamate uptake in cultured astrocytes: Mechanistic considerations. Brain Res 750:59-66.
7. Bergui M, Bradac GB, Zhong JJ et al. (2001) Diffusion-weighted MR in reversible Wernicke encephalopathy. Neuroradiology 43: 969-72.
8. Brown GC. (2001) Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome C oxidase. Biochim Biophys Acta 1504 46-57.
9. Butterworth RF, Gaudreau C, Vincelette J et al. (1991) Thiamine deficiency and Wernicke's encephalopathy in AIDS. Metab Brain Dis 6:207-12.
10. Butterworth RF, Giguere JF, Besnard AM. (1986) Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy: 2. α-Ketoglutarate. Neurochem Res 11:567-77.
11. Butterworth RF, Kril JJ, Harper C. (1993) Thiamine-dependent enzyme changes in brain of alcoholics: Relationship to Wernicke-Korsakoff syndrome. Alcohol Clin Exp Res 17:1084-8.
12. Calingasan N, Baker H, Sheu K-FR et al. (1995) Blood-brain abnormalities in vulnerable brain regions during thiamine deficiency. Exp Neurol 134:64-72.
13. Calingasan NY, Chun WJ, Park LC et al. (1999) Oxidative stress is associated with region-specific neuronal death during thiamine deficiency. J Neuropathol Exp Neurol 58:946-58.
14. Calingasan NY, Gibson GE. (2000) Vascular endothelium is a site of free radical production and inflammation in areas of neuronal loss in thiamine-deficient brain. Ann N Y Acad Sci 903:353-6.
15. Calingasan NY, Park LC, Calo LL et al. (1998) Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism. Am J Pathol 153:599-610.
16. Camilo ME, Morgan MY, Sherlock S. (1981) Erythrocyte transketolase activity in alcoholic liver disease. Scand J Gastroenterol 16 273-9.
17. Cao W, Carney JM, Duchon A et al. (1988) Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci Lett 88:235-8.
18. Chan H, Butterworth RF, Hazell AS. (2004) Astrocytes respond to thiamine deficiency-induced swelling by downregulating aquaporin-4 levels. Neurosci Lett 366:231-4.
19. Chan PH, Schmidley JW, Fishman RA et al. (1984) Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals. Neurology 34:315-20.
20. Collins GH. (1967) Glial cell changes in the brain stem of thiamine-deficient rats. Am J Pathol 50:791-814.
21. Colotta F, Polentarutti N, Sironi M et al. (1992) Expression of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J Biol Chem 267:18278-83.
22. Cook CC, Hallwood PM, Thomson AD. (1998) B Vitamin deficiency and neuropsychiatric syndromes in alcohol misuse. Alcohol Alcohol 33:317-36.
23. Danbolt NC. (2001) Glutamate uptake. Prog Neurobiol 65:1-105.
24. Del Maestro R, Thaw HH, Björk J et al. (1980) Free radicals as mediators of tissue injury. Acta Physiol Scand 492(Suppl): 43-57.
25. Dragunow M, Young D, Hughes P et al. (1993) Is c-jun involved in nerve cell death following status epilepticus and hypoxic-ischemic injury? Mol Brain Res 18:347-52.
26. Ebels EJ. (1978) How common is Wernicke-Korsakoff syndrome? Lancet 2:781-2.
27. Estus S, Zaks WJ, Freeman RS et al. (1994) Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 127:1717-27.
28. Gaitonde MK, FayeinNA, Johnson AL. (1975) Decreased metabolism in vivo of glucose into amino acids of the brain of thiamine-deficient rats after treatment with pyrithiamine. J Neurochem 24 1215-23.
29. Gibson GE, Ksiezak-Reding H, Sheu KFR et al. (1984) Correlation of enzymatic, metabolic and behavioural deficits in thiamine deficiency and its reversal. Neurochem Res 9:803-14.
30. Gibson GE, Park LC, Zhang H et al. (1999) Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits. Ann N Y Acad Sci 893 79-94.
31. Gibson GE, Zhang H. (2002) Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration. Neurochem Int 40:493-504.
32. González-Martín C, de Deigo I, Crespo D et al. (1992) Transient c-fos expression accompanies naturally occurring cell death in the developing interhemispheric cortex of the rat. Dev Brain Res 68:83-95.
33. Hakim AM. (1984) The induction and reversibility of cerebral acidosis in thiamine deficiency. Ann Neurol 16:673-9.
34. Hakim AM, Pappius HM. (1981) The effect of thiamine deficiency on local cerebral glucose utilization. Ann Neurol 9:334-9.
35. Hakim AM, Pappius HM. (1983) Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency. Ann Neurol 13:365-75.
36. Hansson E, Johansson BB, Westergren I et al. (1994) Glutamate-induced swelling of single astroglial cells in primary culture. Neuroscience 63:1057-66.
37. Harata N, Iwasaki Y. (1995) Evidence for early blood-brain barrier breakdown in experimental thiamine deficiency in the mouse. Metab Brain Dis 10:159-74.
38. Harper CG, Butterworth RF. (1997) Nutritional and Metabolic Disorders. In Graham DI, Lantos PL (eds). Greenfield's Neuropathology. London: Arnold, 601-55.
39. Hazell AS, Butterworth RF, Hakim AM. (1993) Cerebral vulnerability is associated with selective increase in extracellular glutamate concentration in experimental thiamine deficiency. J Neurochem 61:1155-8.
40. Hazell AS, Hakim AM, Senterman MK et al. (1998b) Regional activation of L-type voltage-sensitive calcium channels in experimental thiamine deficiency. J Neurosci Res 52:742-9.
41. Hazell AS, McGahan L, Tetzlaff W et al. (1998a) Immediate-early gene expression in the brain of the thiamine deficient rat. J Mol Neurosci 10:1-15.
42. Hazell AS, Pannunzio P, Rama Rao KV et al. (2003) Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes. Glia 43:175-84.
43. Hazell AS, Rao KV, Danbolt NC et al. (2001) Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy. J Neurochem 78:560-8.
44. Hazell AS, Wang C. (2005) Downregulation of complexin I and complexin II in the medial thalamus is blocked by N-acetylcysteine in experimentalWernicke's encephalopathy. J Neurosci Res 79 200-7.
45. Hertz L. (1965) Possible role of neuroglia: A potassium-mediated neuronal-neuroglial-neuronal impulse transmission system. Nature 206:1091-4.
46. Holowach J, Kauffman F, Ikossi MG et al. (1968) The effects of a thiamine antagonist, pyrithiamine, on levels of selected metabolic intermediates and on activities of thiamine-dependent enzymes in brain and liver. J Neurochem 15:621-31.
47. Jenkins LW, Becher DP, Coburn TH. (1984) A quantitative analysis of glial swelling and ischemic neuronal injury following complete cerebral ischemia. In Go TG, Baethmann A (eds). Recent Progress in the Study and Therapy of Brain Edema. New York: Plenum, 523-37.
48. Kalimo H,Rehncrona S, Söderfeldt B et al. (1981) Brain lactic acidosis and ischemic cell damage: 2. Histopathology. J Cereb Blood Flow Metab 1:313-27.
49. Karuppagounder SS, Shi Q, Xu H et al. (2007) Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiol Dis 26 353-62.
50. Karwoski CJ, Lu HK, Newman EA. (1989) Spatial buffering of light-evoked potassium increases by retinal Muller (glial) cells. Science 244:578-80.
51. Ke ZJ, Bowen WM, Gibson GE. (2006) Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochem Int 49:548-56.
52. Kimelberg HK, Goderie SK, Higman S et al. (1990) Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures. J Neurosci 10:1583-91.
53. + medium causes inhibition of glutamate and aspartate uptake and increases their release. J Cereb Blood Flow Metab 15:409-16.
54. Kinnersley HW, Peters RA. (1930) Brain localization of lactic acidosis in avitaminosis B1 and its relation to the origin of symptoms. Biochem J 24:711-22.
55. Kruse M, Navarro D, Desjardins P et al. (2004) Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability. Neurochem Int 45 49-56.
56. Kuffler SW, Nicholls JG, Orkand RK. (1966) Physiological properties of glial cells in the central nervous system of amphibia. J Neurophysiol 29:768-87.
57. Langlais PJ, Anderson G, Guo SX et al. (1997) Increased cerebral free radical production during thiamine deficiency. Metab Brain Dis 12:137-43.
58. Langlais PJ, Mair RG. (1990) Protective effects of the glutamate antagonist MK-801 on pyrithiamine-induced lesions and amino acid changes in rat brain. J Neurosci 10:1664-74.
59. Langlais PJ, Zhang SX. (1993) Extracellular glutamate is increased in thalamus during thiamine deficiency-induced lesions and is blocked by MK-801. J Neurochem 61:2175-82.
60. Lê O, Heroux M, Butterworth RF. (1991) Pyrithiamine-induced thiamine deficiency results in decreased Ca(2+)-dependent release of glutamate from rat hippocampal slices. Metab Brain Dis 6:125-32.
61. Lévy S, Hervé C, Delacoux E et al. (2002) Thiamine deficiency in hepatitis C virus and alcohol-related liver diseases. Dig Dis Sci 47:543-8
62. Lindboe CF, Loberg EM. (1989) Wernicke's encephalopathy in non-alcoholics. An autopsy study. J Neurol Sci 90:125-9.
63. Manz HJ, Robertson DM. (1972) Vascular permeability to horseradish peroxidase in brainstem lesions of thiamine-deficient rats. Am J Pathol 66:565-76.
64. Matsushima K, MacManus JP, Hakim AM. (1997) Apoptosis is restricted to the thalamus in thiamine-deficient rats. Neuroreport 8 867-70.
65. McCandless DW. (1982) Energy metabolism in the lateral vestibular nucleus in pyrithiamin-induced thiamin deficiency. Ann N Y Acad Sci 378:355-64.
66. McCandless DW, Schenker S. (1968) Encephalopathy of thiamine deficiency: studies of intracerebral mechanisms. J Clin Invest 47 2268-80.
67. McDowell JE, Leblanc HJ. (1984) Computed tomographic findings in Wernicke-Korsakoff syndrome. Arch Neurol 41:453-4.
68. McMahon HT, Missler M, Li C et al. (1995) Complexins: Cytosolic proteins that regulate SNAP receptor function. Cell 83:111-9.
69. Miyajima Y, Fukuda M, Kojima S et al. (1993) Wernicke's encephalopathy in a child with acute lymphoblastic leukemia. Am J Pediatr Hematol/Oncol 15:331-4.
70. Moncada S, Palmer RM, Higgs EA. (1991) Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-42.
71. Morgan JI, Curran T. (1986) Role of ion flux in the control of c-fos expression. Nature 322:552-5.
72. Morgan MY. (1999) Nutritional aspects of liver and biliary disease. In Bircher J, Benhamou JP, McIntyre N, Rizzetto M, Rode's J (eds). Oxford Textbook of Clinical Hepatology. Oxford: Oxford Medical Publication, 1923-81.
73. Morishima T, Aoyama M, Iida Y et al. (2008) Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes. Neurosci Res 61:18-26.
74. Munujos P, Vendrell M, Ferrer I. (1993) ProtoBoncogene c-fos induction in thiamine-deficient encephalopathy. Protective effects of nicardipine on pyrithiamine-induced lesions. J Neurol Sci 118 175-80.
75. Murphy S, Minor RL Jr, Welk G et al. (1990) Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide. J Neurochem 55:349-51.
76. Murphy TH, Worley PF, Baraban JM. (1991) L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron 7:625-35.
77. Mutch WAC, Hansen AJ. (1984) Extracellular pH changes during spreading depression and cerebral ischemia: Mechanisms of brain pH regulation. J Cereb Blood Flow Metab 4:17-27.
78. Myers RE. (1979) Lactic acid accumulation as cause of brain edema and cerebral necrosis resulting from oxygen deprivation. In Korobkin R, Guilleminault G (eds). Advances in Perinatal Neurology. New York: Spectrum, 85-114.
79. 13C nuclear magnetic resonance spectroscopy. J Neurosci Res 79 33-41.
80. Oakes D. (1993) Antiparkinson efficacy of deprenyl.DATATOP Steering Committee of Parkinson Study Group. Ann Neurol 34:634.
81. Ohkoshi N, Ishii A, Shoji S. (1994) Wernicke's encephalopathy induced by hyperemesis gravidarum, associated with bilateral caudate lesions on computed tomography and magnetic resonance imaging. Eur Neurol 34:177-80.
82. Olney JW. (1978) Neurotoxicity of excitatory amino acids. In McGreer EG, Olney JW, McGreer PL (eds). Kainic Acid as a Tool in Neurobiology. New York: Raven Press, 95-121.
83. Pabst S, Hazzard JW, Antonin W et al. (2000) Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions. J Biol Chem 275:19808-18.
84. Park LC, Zhang H, Sheu KF et al. (1999) Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. J Neurochem 72:1948-58.
85. Pellerin L, Bouzier-Sore AK, Aubert A et al. (2007) Activity-dependent regulation of energy metabolism by astrocytes: An update. Glia 55:1251-62.
86. Pulsinelli WA, Waldman S, Rawlinson D et al. (1982) Moderate hyperglycemia augments ischemic brain damage: A neuropathologic study in the rat. Neurology 32:1239-46.
87. Rao VL, Mousseau DD, Butterworth RF. (1996) Nitric oxide synthase activities are selectively decreased in vulnerable brain regions in thiamine deficiency. Neurosci Lett 208:17-20.
88. Robertson DM, Manz HJ, Haas RA et al. (1975) Glucose uptake in the brainstem of thiamine-deficient rats. Am J Pathol 79:107-18.
89. Robertson DM, Wasan SM, Skinner DB. (1968) Ultrastructural features of early brain stem lesions of thiamine-deficient rats. Am J Pathol 52:1081-97.
90. Sacks T, Moldow CF, Craddock PR et al. (1977) Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. J Clin Invest 61:1161-7.
91. Schneider LS, Pollock VE, Zemansky MF et al. (1991) A pilot study of low dose L-deprenyl in Alzheimer's disease. J Geriatr Psychiatry Neurol 4:143-8.
92. Shah N, Wolff JA. (1973) Thiamine deficiency: Probable Wernicke's encephalopathy successfully treated in a child with acute lymphocytic leukemia. Pediatrics 51:750-1.
93. Sheng M, McFadden G, Greenberg ME. (1990) Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron 4:477-85.
94. Sheu KF, Calingasan NY, Lindsay JG et al. (1998) Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain. J Neurochem 70:1143-50.
95. Soffer D, Zirkin H, Alkan M et al. (1989)Wernicke's encephalopathy in acquired immune deficiency syndrome (AIDS): A case report. Clin Neuropathol 8:192-4.
96. Tang J, Maximov A, Shin OH et al. (2006) A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell 126 1175-87.
97. Thomson AD, Jeyasingham MD, Pratt OE et al. (1987) Nutrition and alcoholic encephalopathies. Acta Med Scand Suppl 717: 55-65.
98. Todd KG, Butterworth RF. (1997) Evidence that oxidative stress plays a role in neuronal cell death due to thiamine deficiency. J Neurochem 69(Suppl): S136A.
99. Todd KG, Butterworth RF. (1998) Increased neuronal cell survival after L-deprenyl treatment in experimental thiamine deficiency. J Neurosci Res 52:240-6.
100. Todd KG, Butterworth RF. (1999) Early microglial response in experimental thiamine deficiency: An immunohistochemical analysis. Glia 25:190-8.
101. Trotti D, Danbolt NC, Volterra A. (1998) Glutamate transporters are oxidant-vulnerable: A molecular link between oxidative and excitotoxic neurodegeneration? Trends Pharmacol Sci 19: 328-34.
102. Trotti D, Rossi D, Gjesdal O et al. (1996) Peroxynitrite inhibits glutamate transporter subtypes. J Biol Chem 271:5976-9.
103. Vemuganti R, Kalluri H, Yi J-H et al. (2006) Gene expression changes in thalamus and inferior colliculus associated with inflammation, cellular stress, metabolism, and structural damage in thiamine deficiency. Eur J Neurosci 23:1172-88.
104. Volterra A, Trotti D, Tromba C et al. (1994) Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci 14:2924-32.
105. Walz W, Hertz L. (1982) Ouabain-sensitive and ouabain-resistant net uptake of potassium into astrocytes and neurons in primary cultures. J Neurochem 39:70-7.
106. Warnock LG, Burkhalter VJ. (1968) Evidence of malfunctioning blood-brain barrier in experimental thiamine deficiency in rats. J Nutr 94 256-60.
107. Watanabe I. (1978) Pyrithiamine-induced acute thiamine-deficient encephalopathy in the mouse. Exp Mol Pathol 28:381-94.
108. Watanabe I, Kanabe S. (1978) Early edematous lesion of pyrithiamine induced acute thiamine deficient encephalopathy in the mouse. J Neuropathol Exp Neurol 37:401-13.
109. Watanabe I, Tomita T, Hung KS et al. (1981) Edematous necrosis in thiamine-deficient encephalopathy of the mouse. J Neuropathol Exp Neurol 40:454-71.
110. Wernicke C. (1881) Lehrbuch der Gehirnkrankheiten fur Aerzte und Studirende, Vol. 2. Kassel: Theodor Fischer, 229-42.
111. Yamada M, Saisu H, Ishizuka T et al. (1999) Immunohistochemical distribution of the two isoforms of synaphin/complexin involved in neurotransmitter release: Localization at the distinct central nervous system regions and synaptic types. Neuroscience 93:7-18.
112. Zafra F, Hengerer B, Leibrock J et al. (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 9: 3545-50.