Vitamin transport and homeostasis in mammalian brain: Focus on vitamins B and E

Journal of Neurochemistry

Volumn 103, Issue 2, 2007, Pages 425-438

  Spector, Reynold ^b,c   Johanson, Conrad E ^a  

^a BROWN UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

tocopherol; Cerebral endothelium; Choroidal epithelium; CSF homeostasis; Ependyma; Niacinamide; Pyridoxine; Thiamine; Vitamer transporters

Indexed keywords

ALPHA TOCOPHEROL; BIOTIN; NICOTINAMIDE; PANTOTHENIC ACID; PYRIDOXINE; THIAMINE; VITAMIN B GROUP;

BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID; CHOROID PLEXUS; HOMEOSTASIS; HUMAN; NONHUMAN; NUTRIENT UPTAKE; PRIORITY JOURNAL; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BIOTIN; BRAIN CHEMISTRY; HOMEOSTASIS; HUMANS; NIACINAMIDE; PANTOTHENIC ACID; THIAMINE; VITAMIN B 6; VITAMIN B COMPLEX; VITAMIN E;

MAMMALIA; MUS;

EID: 34848815722     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04773.x     Document Type: Review

References (68)

1. Adams J. D. Wang B. (1994) Vitamin E uptake into the brain and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity. J. Cereb. Blood Flow Metab. 14, 362 363.
2. Balamurugan K., Ortiz A. Said H. M. (2003) Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G73 G77.
3. Baur B. Baumgartner E. R. (2000) Biotin and biocytin uptake into cultured primary calf brain microvessel endothelial cells of the blood-brain barrier. Brain Res. 858, 348 355.
4. + metabolism in health and disease. Trends Biochem. Sci. 32, 12 19.
5. 6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants. Photochem. Photobiol. 71, 129 134.
6. 6-responsive disorders: a model of vitamin dependency. J. Inherit. Metab. Dis. 29, 317 326.
7. Copp R. P., Wisniewski T., Hentati F., Larnaout A., Hamida M. B. Kayden H. J. (1999) Localization of α-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders. Brain Res. 822, 80 87.
8. Desrumaux C., Risold P.-Y., Schroeder H. et al. (2005) Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice. FASEB J. 19, 296 297.
9. Eudy J. D., Spiegelstein O., Barber R. C., Wlodarczyk B. J., Talbot J. Finnell R. H. (2000) Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes. Mol. Gen. Metab. 71, 581 590.
10. Gander R., Eller P., Kaser S., Theurl I., Walter D., Sauper T., Ritsch A., Patsch J. R. Föger B. (2002) Molecular characterization of rabbit phospholipid transfer protein: choroid plexus and ependyma synthesize high levels of phospholipid transfer protein. J. Lipid Res. 43, 636 645.
11. Goti D., Hrzenjak A., Levak-Frank S., Frank S., van der Westhuyzen D. R., Malle E. Sattler W. (2001) Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E. J. Neurochem. 76, 498 508.
12. Grafe F., Wohlrab W., Neubert R. H. Brandsch M. (2003) Transport of biotin in human keratinocytes. J. Invest. Dermatol. 120, 428 433.
13. Hisahara S., Chiba S., Matsumoto H. Horio Y. (2005) Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2α). J. Pharmacol. Sci. 98, 200 204.
14. Hoane M. R., Kaplan S. A. Ellis A. L. (2006a) The effects of nicotinamide on apoptosis and blood-brain barrier breakdown following traumatic brain injury. Brain Res. 1125, 185 193.
15. Hoane M. R., Tan A. A., Pierce J. L., Anderson G. D. Smith D. C. (2006b) Nicotinamide treatment reduces behavioral impairments and provides cortical protection after fluid percussion injury in the rat. J. Neurotrauma 23, 1535 1548.
16. Hymes J. Wolf B. (1996) Biotinidase and its roles in biotin metabolism. Clin. Chim. Acta 255, 1 11.
17. Johanson C. E. (2003) Choroid plexus and volume transmission, in Encyclopedia for Neuroscience, Vol. I, 3rd Electronic Edn (Adelman G., ed.). Birkhauser, Boston.
18. Johanson C. E., Duncan J. A., Stopa E. G. Baird A. (2005) Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. Pharm. Res. 22, 1011 1037.
19. Kaempf-Rotzoll D. E., Traber M. G. Arai H. (2003) Vitamin E and transfer proteins. Curr. Opin. Lipidol. 14, 249 254.
20. Kansara V., Luo S., Balasubrahmanyam B., Pal D. Mitra A. K. (2006) Biotin uptake and cellular translocation in human derived retinoblastoma cell line (Y-79): a role of hSMVT system. Int. J. Pharm. 312, 43 52.
21. Lindhurst M. J., Fiermonte G., Song S. et al. (2006) Knockout of SIc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CSF malformations, and anemia. Proc. Natl Acad. Sci. 103, 15927 15932.
22. Lockman P. R., Mumper R. J. Allen D. D. (2003) Evaluation of blood-brain barrier thiamine efflux using the in situ rat brain perfusion method. J. Neurochem. 86, 627 634.
23. Mardones P., Strobel P., Miranda S., Leighton F., Quiñones V., Amigo L., Rozowski J., Krieger M. Rigotti A. (2002) α-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice. J. Nutr. 132, 443 449.
24. Martin A., Janigian D., Shukitt-Hale B., Prior R. L. Joseph J. A. (1999) Effect of vitamin E intake on levels of vitamins E and C in the central nervous system and peripheral tissues: implications for health recommendations. Brain Res. 845, 50 59.
25. McCandless D. W. Schenker S. (1968) Encephalopathy of thiamine deficiency: studies of intracerebral mechanisms. J. Clin. Invest. 47, 2268 2280.
26. Nose Y., Iwashima A. Nishino H. (1976) Thiamine uptake by rat brain slices, in Thiamin (Gubler C. J., Fujiwara M. Dreyfus P. M., eds), pp. 157 168. Wiley-Interscience, NY.
27. Oishi K., Hofmann S., Diaz G. A. et al. (2002) Targeted disruption of Sic19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice. Human Mol. Gen. 11, 2951 2960.
28. Pappert E. J., Tangney C. C., Goetz C. G., Ling Z. D., Lipton J. W., Stebbins G. T. Carvey P. M. (1996) Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: dose-response study and correlations with plasma levels. Neurology 47, 1037 1042.
29. Pardridge W. M. (1999) Introduction to the blood-brain barrier: Methodology, biology and pathology. Cambridge University Press, UK.
30. Park S. Sinko P. J. (2005) The blood-brain barrier sodium-dependent multivitamin transporter: a molecular functional in vitro-in situ correlation. Drug Metab. Dispos. 33, 1547 1554.
31. Patrini C., Reggiani C., Laforenza U. Rindi G. (1988) Blood-brain transport of thiamine monophosphate in the rat: a kinetic study in vivo. J. Neurochem. 50, 90 93.
32. Qian J., Atkinson J. Manor D. (2006) Biochemical consequences of heritable mutations in the α-tocopherol transfer protein. Biochemistry 45, 8236 8242.
33. Rajgopal A., Edmondson A., Goldman I. D. Zhao R. (2001) SLC19A3 encodes a second thiamine transporter ThTr2. Biochim. Biophys. Acta 1537, 175 178.
34. Reggiani C., Patrini C. Rindi G. (1984) Nervous tissue thiamine metabolism in vivo. I. Transport of thiamine and thiamine monophosphate from plasma to different brain regions of rat. Brain Res. 293, 319 327.
35. Reyes A. M., Bustamante F., Rivas C. I., Ortega M., Donnet C., Rossi J. P., Fischbarg J. Vera J. C. (2002) Nicotinamide is not a substrate of the facilitative hexose transporter GLUT1. Biochemistry 41, 8075 8081.
36. Rindi G., Comincioli V., Reggiani C. Patrini C. (1984) Nervous tissue thiamine metabolism in vivo. II. Thiamine and its phosphoesters dynamics in different brain regions and sciatic nerve of the rat. Brain Res. 293, 329 342.
37. Sharma S. K. Quastel J. H. (1965) Transport and metabolism of thiamine in rat brain cortex in vitro. Biochem. J. 94, 790 800.
38. Smith D. E., Johanson C. E. Keep R. F. (2004) Peptide and peptide analog transport systems at the blood-CSF barrier, in Drug Transfer in the Choroid Plexus. Multiplicities and Substrate Specificities of Transporters (Sugiyama Y. Ghersi-Egea J.-F., eds), pp. 1765 1791. Adv. Drug Deliv. Rev. 56.
39. Spector R. (1976) Thiamine transport in the central nervous system. Am. J. Physiol. 230, 1101 1107.
40. 6 transport in the central nervous system. In vivo studies. J. Neurochem. 30, 881 887.
41. 6 transport in the central nervous system. In vitro studies. J. Neurochem. 30, 889 897.
42. Spector R. (1979) Niacin and niacinamide transport in the central nervous system. In vivo studies. J. Neurochem. 33, 895 904.
43. Spector R. (1981) Penetration of ascorbic acid from cerebrospinal fluid into brain. Exp. Neurol. 72, 645 653.
44. Spector R. (1982) Thiamin homeostasis in the central nervous system. Ann. N Y Acad. Sci. 378, 344 354.
45. Spector R. (1986a) Pantothenic acid transport and metabolism in the central nervous system. Am. J. Physiol. 250, R292 R297.
46. Spector R. (1986b) Development and characterization of the pantothenic acid transport system in brain. J. Neurochem. 47, 563 568.
47. Spector R. (1987) Niacinamide transport through the blood-brain barrier. Neurochem. Res. 12, 27 31.
48. Spector R. (1989) Micronutrient homeostasis in mammalian brain and cerebrospinal fluid. J. Neurochem. 53, 1667 1674.
49. Spector R. (2000) Drug transport in the mammalian central nervous system: multiple complex systems. Pharmacology 60, 58 73.
50. Spector R. Boose B. (1984) Accumulation of pantothenic acid by the isolated choroid plexus and brain slices in vitro. J. Neurochem. 43, 472 478.
51. 6 in rabbit brain and choroid plexus. J. Biol. Chem. 253, 2373 2379.
52. Spector R. Johanson C. E. (1989) The mammalian choroid plexus: structure, development and function. Sci. Am., 261, 68 74.
53. Spector R. Johanson C. E. (2006) Micronutrient and urate transport in choroid plexus and kidney: implications for drug therapy. Pharm. Res. 23, 2514 2524.
54. Spector R. Kelley P. (1979) Niacin and niacinamide accumulation by brain slices and choroid plexus in vitro. J. Neurochem. 33, 291 298.
55. Spector R. Mock D. M. (1987) Biotin transport through the blood-brain barrier. J. Neurochem. 48, 400 404.
56. Spector R. Mock D. M. (1988) Biotin transport and metabolism in the central nervous system. Neurochem. Res. 13, 213 219.
57. 6 accumulation and pyridoxal kinase activity in rabbit brain and choroid plexus. J. Neurochem. 31, 1403 1410.
58. Spector R. Vesell E. S. (2002) Which studies of therapy merit credence? Vitamin E and estrogen therapy as cautionary examples J. Clin. Pharmacol. 42, 1 8.
59. Spector R. Vesell E. S. (2006) Pharmacology and statistics: recommendations to strengthen a productive partnership. Pharmacology 78, 113 122.
60. Spector R., Sivesind C. Kinzenbaw D. (1986) Pantothenic acid transport at the blood-brain barrier. J. Neurochem. 47, 966 971.
61. Subramanian V. S., Marchant J. S. Said H. M. (2006) Targeting and trafficking of the human thiamine transporter-2 in epithelial cells. J. Biol. Chem. 281, 5233 5245.
62. Vatassery G. T. (1992) Vitamin E: neurochemistry and implications for neurodegeneration in Parkinson's disease. Ann. N Y Acad. Sci. 669, 97 110.
63. Waymire K. G., Mahuren J. D., Jaje J. M., Guilarte T. R., Coburn S. P. MacGregor G. R. (1995) Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Nat. Genet. 11, 45 51.
64. Whyte M. P., Mahuren J. D., Fedde K. N., Cole F. S., McCabe E. R. B. Coburn S. P. (1988) Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. J. Clin. Invest. 81, 1234 1239.
65. Yokota T., Igarashi K., Uchihara T. et al. (2001) Delayed-onset ataxia in mice lacking α-tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Proc. Natl Acad. Sci. 98, 15185 15190.
66. Zempleni J. Mock D. M. (1999) Human peripheral blood mononuclear cells: inhibition of biotin transport by reversible competition with pantothenic acid is quantitatively minor. J. Nutr. Biochem. 10, 427 432.
67. Zhao R., Gao F. Goldman I. D. (2002) Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. Am. J. Physiol. Cell Physiol. 282, C1512 C1517.
68. Zingg J.-M. Azzi A. (2004) Non-antioxidant activities of vitamin E. Cur. Med. Chem. 11, 1113 1133.