Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-κB in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 1, 2000, Pages 82-90

  Gurujeyalakshmi, Gopalakrishnan ^a   Wang, Yingjin ^a   Giri, Shri N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; KETAMINE; NICOTINIC ACID; REACTIVE OXYGEN METABOLITE; TAURINE; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA; XYLAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; DNA BINDING; ELECTROPHORETIC MOBILITY; LUNG FIBROSIS; LUNG INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-BACTERIAL AGENTS; BLEOMYCIN; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; DOWN-REGULATION; HYDROXYPROLINE; INTERLEUKIN-1; INTERLEUKIN-6; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; NIACIN; PULMONARY FIBROSIS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TAURINE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034033867     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Barchowsky A, Dudek EJ, Treadwell MD And Wetterhan KE (1996) Arsenic induces oxidant stress and NF-κB activation in cultured aortic endothelial cells. Free Radic Biol Med 18:321-336.
2. Bauerle PA and Henkel T (1994) Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12:141-179.
3. Blackwell TS and Christman JW (1997) The role of nuclear factor-κB in cytokine gene regulation. Am J Respir Cell Mol Biol 17:3-9.
4. Brennan P and O'Neil LAJ (1995) Effects of oxidant and antioxidants on nuclear factor kappa B activation in three different cell lines. Biochim Biophys Acta 1260:167-175.
5. Caspary WJ, Lanzo DA and Niziak C (1982) Effect of deoxyribonucleic acid on the production of reduced oxygen by bleomycin and iron. Biochemistry 21:334-338.
6. Choi AMK, Sylvester S, Otterbein L and Holbrook NJ (1995) Molecular responses to hyperoxia in vivo: Relationship to increased tolerance in aged rats. Am J Respir Cell Mol Biol 13:74-82.
7. Coker RK and Laurent GJ (1995) Pathogenesis of pulmonary fibrosis: Implications for pharmacological intervention, in Immunology and Management of Interstitial Lung Disease (Walter EH and Du Bois RM eds) pp 19-36, Chapman & Hall, London.
8. Collins T, Read MA Neish AS, Whitley MJ, Thanos D and Maniatis T (1995) Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J 9:899-909.
9. Di Donato JA, Mercurio F and Karin M (1995) Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B. Mol Cell Biol 15:1302-1311.
10. Giri SN, Hollinger MA and Schiedt MJ (1981) The effects of paraquat and superoxide dismutase on pulmonary vascular permeability and edema in mice. Arch Environ Health 36:149-154.
11. Giri SN, Hyde DM and Hollinger MA (1993) Effect of antibody to transforming growth factor-β on bleomycin induced accumulation of lung collagen in mice. Thorax 48:959-966.
12. Giri SN, Hyde DM and Marfino BJ Jr (1986) Ameliorating effect of murine interferon gamma on bleomycin-induced lung collagen fibrosis in mice. Biochem Med Metab Biol 36:194-197.
13. 2 and collagen levels of the lung in hamsters. Exp Lung Res 9:119-133.
14. 1 mRNA expression by taurine and niacin in the bleomycin hamster model of lung fibrosis. Am J Respir Cell Mol Biol 18:334-342.
15. Gurujeyalakshmi G, Hollinger MA and Giri SN (1999) Pirfenidone inhibits PDGF isoforms in the bleomycin hamster model of lung fibrosis at the translational level. Am J Physiol 276:L311-L318.
16. Gurujeyalakshmi G, Iyer SN, Hollinger MA and Giri SN (1996) Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis. J Pharmacol Exp Ther 277:1152-1157.
17. Henkel T, Mechleidt T, Alkalay J, Kronke M, Ben-Neriah Y and Baeuerle PA (1993) Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature (Lond) 365:182-185.
18. Hunninghake GW and Kalica AW (1995) Approaches to the treatment of pulmonary fibrosis. Am Respir Crit Care Med 151:915-918.
19. Janssen Y, Barchowsky A, Treadwell M, Driscoll KE and Mossman BT (1995) Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B dependent gene expression in tracheal epithelial cells. Proc Natl Acad Sci USA 92:8458-8462.
20. Jany B, Bertz R and Schreck R (1995) Activation of transcription factor NF-kappa B in human tracheobronchial epithelial cells by inflammatory stimuli. Ear Resp J 8:387-391.
21. Khalil N and O'Connor RN (1995) Cytokine regulation of pulmonary fibrosis, in Pulmonary Fibrosis (Phan SM and Thrall RS eds) vol 80, pp 627-646, Marcel Dekker, New York.
22. Leff JA, Wilke CP, Hybertson BM, Shanley PF, Beehler CJ and Repine JE (1993) Postinsult treatment with N-acetylcysteine decreases IL-1 induced neutrophil influx and lung leak in rats. Am J Physiol 265:L501-L506.
23. Lin YL and Lin JK (1997) (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-κB. Mol Pharmacol 52:465-472.
24. Nathens AB, Bitar R, Davreux C, Bujard M, Marshall JC, Dackiw APB, Watson RWG and Rotstein OD (1997) Pyrrolidine dithiocarbamate attenuates endotoxin-induced acute lung injury. Am J Respir Cell Mol Biol 17:608-616.
25. Newton R, Adcock IM and Barnes PJ (1996) Superinduction of NF-kappa B by actinomycin D and cyclohexamide in epithelial cells. Biochem Biophys Res Commun 218:518-523.
26. Pabo CO and Saver RT (1992) Transcription factors-structural families and principles of DNA recognition. Annu Rev Biochem 61:1053-1095.
27. Park E, Schuller-Levis G and Quinn MR (1995) Taurine chloramine inhibits production of nitric oxide and TNF-αin activated RAW 264.7 cells by mechanisms that involve transcriptional and translational events. J Immunol 154:4778-4784.
28. Phan SH and Kunkel SL (1992) Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res 18:29-43.
29. Piguet PF, Collart MA, Grau GE, Kapanchi Y and Vassali P (1989) Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 170:655-663.
30. Piguet PF and Vesin C (1994) Treatment of human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur Respir J 7:515-518.
31. Ray KP and Kennard N (1993) Interleukin-1 induces a nuclear form of transcription factor NF-kappa B in human lung epithelial cells. Agents Actions 38:C61-C63.
32. Rodenas J, Mitjavila MT and Carbonell T (1995) Simultaneous generation of nitric oxide and superoxide by inflammatory cells in rats. Free Radic Biol Med 18:869-875.
33. Scheule RK, Perkins RC, Hamilton R and Holian A (1992) Bleomycin stimulation of cytokine secretion by the human alveolar macrophages. Am J Physiol 262:L386-L391.
34. Schreck R, Albermann K and Bauerle PA (1992) Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 17:221-237.
35. Schuller-Levis G, Gordon RE, Park E, Pendino KJ and Laskin DL (1994a) Taurine protects rat bronchioles from acute ozone-induced lung inflammation and hyperplasia. Exp Lung Res 21:877-888.
36. Schuller-Levis G, Quinn MR, Wright C and Park E (1994b) Taurine protects against oxidant-induced lung injury: Possible mechanism(s) of action. Adv Exp Med Biol 359:31-39.
37. Smith RE, Strieter RM, Phan SH, Lukacs NW, Huffnagle GB, Wilke CA, Burdick MD, Lincoln P, Evanoff H and Kunkel SL (1994) Production and function of murine macrophage inflammatory protein-1α in bleomycin-induced lung injury. J Immunol 153:4704-4712.
38. Smith RE, Strieter RM, Phan SH and Kunkel SL (1996) C-C Chemokines: Novel mediators of the profibrotic inflammatory response to bleomycin challenge. Am J Respir Cell Mol Biol 15:693-702.
39. Sun Y and Oberley LW (1996) Redox regulation of transcriptional activators. Free Radic Biol Med 21:335-348.
40. Tracey KJ and Cerami A (1993) Tumor necrosis factor, other cytokines and disease. Annu. Rev Cell Biol 9:317-343.
41. Wang Q, Wang Y, Hyde DM, Gotwals PJ, Koteliansky VE, Ryan ST and Giri SN (1999) Reduction of bleomycin induced lung fibrosis by transforming growth factor β sluble receptor in hamsters. Thorax 54:805-812.
42. Wang Q, Giri SN, Hyde DM and Li C (1991) Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin. Biochem Pharmacol 42:1115-1122.
43. Wang Q, Giri SN Hyde DM and Nakashima JM (1989) Effect of taurine on bleomycin-induced lung fibrosis in hamsters. Proc Soc Exp Biol Med 190:330-338.
44. Wang Q, Giri SN, Hyde DM, Nakamshima JM and Javadi I (1990) Niacin attenuates bleomycin-induced lung fibrosis in the hamster. J Biochem Toxicol 5:13-22.
45. Woessner JF Jr (1961) The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Anal Biochem 93:440-444.