1,25-dihydroxyvitamin d3 as a natural regulator of human immune functions

Journal of Investigative Dermatology Symposium Proceedings

Volumn 1, Issue 1, 1996, Pages 68-71

  Müller, Klaus ^a   Bendtzen, Klaus ^b,c  

^a Rigshospitalet   (Denmark)

^b Laboratory of Medical Immunology 7544   (Denmark)

^c RHIMA Center   (Denmark)

Author keywords

Cytokineslimmunoylobulinl; Lymphocyteslmonocytes

Indexed keywords

CALCITRIOL;

DRUG EFFECT; HUMAN; IMMUNITY; INFLAMMATION; LYMPHOCYTE; MONOCYTE; REVIEW;

CALCITRIOL; HUMANS; IMMUNITY; INFLAMMATION; LYMPHOCYTES; MONOCYTES;

EID: 0030112310     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. 3 receptors in human leukocytes. Stietue 221:1181-1183, 1983
2. 3 metabolism by lipopolysaccharide-stimulated normal human macrophages. J Clin Endocrinol Mclab 64:1-9, 1987
3. Bendtzen K: Clinical significance of cytokines. Natural and therapeutic regulation. Semin Clin /nimmol 3:5-13, 1991
4. Bendtzen K: Cytokines and natural regulators of cytokines. Immunol Lett 43:111-123, 1994
5. Müller K, Diamant M, Bendtzen K: Inhibition of production and function of interleukin-6 by 1,25-dihydroxyvitamin Dj. Immunol Lett 28:115-120, 1991
6. 3. Jut J Immnnopliannacol 13:525-530, 1991
7. 3 inhibits cytokine production by human blood monocytcs at the post-transcriptional level. Cytokint 4:506- 512, 1992
8. 3 analogue 22-oxacalcitriol suppresses the production of tumor necrosis factor-tr by peripheral mononuclear cells. Imiminol Lett 30:307-312, 1991
9. 3 and MC-903 on the production of IL-6, IFNy and lymphocyte proliferation in peripheral blood mononuclear cells. J Bone Miner Res 6: (Suppl.) s292-s290, 1991
10. 3-binding macromolecules in human B lymphocytes: effects on immunoglobulin production. J Immunol 136:2734-2740, 1986
11. 3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-l production. Cell Itntnitnol 98:311322, 1986
12. 3 metabolites and tumour necrosis factor in the patliogcnesis of tuberculosis. Immunology 62:229-234, 1987
13. 3. Blood 76:2457-2461, 1990
14. Janson RW, Joslin FG, Arend WP: The effects of differentiating agents on IL-113 production in cultured human monocytes. J Immunol 145:2161-2166, 1990
15. 3: a novel immunoregulatory hormone. Science 224:1438-1440, 1984
16. 3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear,cells. J din Invest 74:657-661, 1984
17. 3 inhibits proliféra live response of T- and B-lymphocytes in a serum-free culture. InlJ Immmwpliannacol 9:719-723, 1987
18. Vanham G, Van-Baelen H, Tan BK, Bouillon R: The effect of vitamin D analogs and of vitamin D-binding protein on lymphocyte proliferation. J Steroid Rhchein 29:381-386, 1988
19. 3 on human T lymphocyte activation and proliferation: a cell cycle analysis. J Immunol 135:2279-2286, 1985
20. 3 and the immune system. Proc Sue Exp Biol Med 191:238-245, 1989
21. 3 suppresses human T helper/inducer lymphocyte activity in vitro. J Immunol 134:3032-3035, 1985
22. Matsui T, Nakao Y, Koizumi T, Nakagawa T, Fujita T: 1,25-Dihydroxyvitamin Dj regulates proliferation of activated T-lymphocyte subsets. Life Sei 37:95101, 1985
23. Saggese G, Federico G, Balestri M, Toniolo A: Calcitriol inhibits the PHAinduced production of IL-2 and IFN-gamma and the proliferation of human peripheral blood leukocytes while enhancing the surface expression of HLA class II molecules. J EnJxrinol Invest 12:329-335, 1989
24. 3. Specific inhibition at the level of messenger RNA. J Clin Im-cst 79:1659-1664, 1987
25. 3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc Natl AcaJ Sei USA 84:3385-3389, 1987
26. 3 in normal human peripheral blood lymphocytes. J Clin Invest 79:1700-1705, 1987
27. 3 on Interferon gamma production in vitro. Immunol Lett 17:121-124, 1988
28. 3-mediated suppression of T lymphocyte functions and failure of T cellactivating cytokines to restore proliferation. Immunol Lett 34:37-44, 1992
29. 3. Differential effects on CD45RA+ and CD45RO-I- cells. Autoimmunity 14:37-43, 1992
30. 3 modulates the expression of a lymphokine (granulocyte-macrophage colonystimulating factor) posttranscriptionally.J Clin Invest 81:1819-1823, 1988
31. 3. Eighth Workshop on Vitamin D.July 5-10, p 196, 1991 (abstr.)
32. 3 on T lymphocyte subpopulations. EtirJ Immunol 17:563-566, 1987
33. Manolagas SC, Provvedini DM, Murray EJ, Tsoukas CD, Deftos LJ: The antiproliferarive effect of calcitriol on human peripheral blood mononuclear cells. J Clin Enâocrinol Metab 63:394-400, 1986
34. 3 receptor distribution and effects in subpopulations of normal human T lymphocyte s._/ Clin Endocrinol Metab 68:774 -779. 1989
35. 3 regulation of interleukin-2 and interleukin-2 receptor levels and gene expression in human T cells. Mol Immunol 26:979-984, 1989
36. 3 on human peripheral blood lymphocyte immunoglobulm production. Mol Immu0/27:95-100, 1990
37. 3-induced suppression of helper/suppressor function of CD4/ CDS cells to immunoglobulm production in B cells. Cell Immunol 127:12-25, 1990
38. Janeway CA: The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Anna Ret' Immunol 10:645-674, 1992
39. 3 selectively reduces intcrleukin-2 levels and proliferation of human T cell lines in vitro. Immunol Lett 35:177-182, 1993
40. 3 mediated inhibition of B cell function in vitro. Immnnophannacol 21:121-128, 1991
41. 3. J Nittr Sei VUam'mol (Tokyo) 36:21-31, 1990
42. 3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J Clin Invest 87:1103-1107, 1991
43. Lillevang ST, Roscnkvist J, Andersen CB, Larsen S, Kemp E, Kristensen T: Single and combined effects of the vitamin D analogue KH1060 and cyclosporin A on mercuric-cliloride-induced autoimmune disease in the BN rat. dm Exp Immunol 88:301-306, 1992
44. 3 attenuates the expression of experimental murine lupus of MRL/I mice. Autoimmunity 12:143-148, 1992
45. Boissier MC, Chïocchia G, Foumier C: Combination of cyclosporine A and calcitriol in the treatment of adjuvant arthritis. J Rheumatol 19:754-757, 1992
46. 3. J Cell Biochem 49:26-31, 1992
47. Bendtzen K: Immune hormones (cytokines); pathogenic role in autoimmune rheumatic diseases and endocrine diseases. Autoimmunity 2:177-189, 1989
48. Arend WP, Dayer J-M: Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum 33:305-315, 1990
49. Lasky HP, Bauer K, Pope RM: Increased helper inducer and decreased suppressor inducer phenotypes in the rheumatoid joint. Arthritis Rheum 31:52-59, 1988
50. ChofHon M, Gonzalez V, Weiner HL, Hafler DA: Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4 + CD45RA- T cells. EurJ Immunol 19:1791-1795, 1989
51. Koch AE, Robinson PG, Radosevich JA, Pope RM: Distribution of CD45RA and CD45RO T-Iymphocyte subsets in rheumatoid arthritis synovial tissue. J Clin Immunol 10:192-199, 1990