Molecular regulation of CD40 gene expression in macrophages and microglia

Brain, Behavior, and Immunity

Volumn 18, Issue 1, 2004, Pages 7-12

  Benveniste, Etty N ^a   Nguyen, Vince T ^a   Wesemann, Duane R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

CD40; Cytokines; IFN ; Microglia; NF B; STAT 1 ; Transcriptional regulation

Indexed keywords

ATORVASTATIN; CD40 ANTIGEN; CD40 LIGAND; CERIVASTATIN; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOMODULATING AGENT; INTERLEUKIN 4; MATRIX METALLOPROTEINASE; NEUROPEPTIDE; NEUROTOXIN; NEUROTROPHIN; PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; CELL ACTIVITY; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; INFLAMMATORY DISEASE; MACROPHAGE; MICROGLIA; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NERVE CELL LESION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0344825120     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2003.09.001     Document Type: Short Survey

References (31)

1. Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G.M., Cooper, N.R., Eikelenboom, P., Emmerling, M., Fiebich, B. L., Finch, C.E., Frautschy, S., Griffin, W.S.T., Hampel, H., Hull, M., Landreth, G., Lue, L.-F., Mrak, R., Mackenzie, I.R., McGeer, P.L., O'Banion, K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyoma, I., van Muiswinkel, F.L., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G., Wyss-Coray, T., 2000. Group, neuroinflammation working. Inflammation and Alzheimer's disease. Neurobiol. Aging, 21, 383-421.
2. Aloisi F., Ambrosini E., Columba-Cabezas S., Magliozzi R., Serafini B. Intracerebral regulation of immune responses. Ann. Med. 33:2001;510-515.
3. Becher B., Durell B.G., Miga A.V., Hickey W.F., Noelle R.J. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J. Exp. Med. 193:2001;967-974.
4. Boon L., Brok H.P.M., Bauer J., Ortiz-Buijsse A., Schellekens M.M., Ramdien-Murli S., Blezer E., van Meurs M., Ceuppens J., de Boer M., 't Hart B.A., Laman J.D. Prevention of experimental autoimmune encephalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B cell responses. J. Immunol. 167:2001;2942-2949.
5. Calingasan N.Y., Erdely H.A., Altar C.A. Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury. Neurobiol. Aging. 23:2002;31-39.
6. D'Aversa T.G., Weidenheim K.M., Berman J.W. CD40-CD40L interactions induce chemokine expression by human microglia. Am. J. Pathol. 160:2002;559-567.
7. Delgado M. Inhibition of IFN-γ-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide. Inhibitory effect on CD40, IP-10 and iNOS expression. J. Biol. Chem. 165:2003;3051-3057.
8. Garlichs C.D., John S., Schmeißer A., Eskafi S., Stumpf C., Karl M., Goppelt-Struebe M., Schmieder R., Daniel W.G. Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia. Circulation. 104:2001;2395-2400.
9. Garlichs C.D., Kozina S., Fateh-Moghadam S., Tomandl B., Stumpf C., Eskafi S., Raaz D., Schmeier A., Yilmaz A., Ludwig J., Neundorfer B., Daniel W.G. Upregulation of CD40-CD40 ligand (CD154) in patients with acute cerebral ischemia. Stroke. 34:2003;1412-1418.
10. Gerritse K., Laman J.D., Noelle R.J., Aruffo A., Ledbetter J.A., Boersma W.J.A., Claassen E. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. USA. 93:1996;2499-2504.
11. Grewal I., Foellmer H., Grewal K., Xu J., Hardardottir F., Baron J., Janeway C., Flavell R. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science. 273:1996;1864-1867.
12. Howard L.M., Neville K.L., Haynes L.M., Dal Canto M.C., Miller S.D. CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease. J. Virol. 77:2003;2247-2250.
13. Kim W.-K., Ganea D., Jonakait G.M. Inhibition of microglial CD40 expression by pituitary adenylate cyclase-activating polypeptide is mediated by interleukin-10. J. Neuroimmunol. 126:2002;16-24.
14. Laman J.D., van Meurs M., Schellekens M.M., de Boer M., Melchers B., Massacesi L., Lassmann H., Claassen E., 't Hart B.A. Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus). J. Neuroimmunol. 86:1998;30-45.
15. Nguyen V., Benveniste E.N. Interleukin-4 activated STAT-6 inhibits IFN-γ induced CD40 gene expression in macrophages/microglia. J. Immunol. 165:2000;6235-6243.
16. Nguyen V.T., Benveniste E.N. Involvement of STAT-1α and ets family members in interferon-γ induction of CD40 transcription in macrophages/microglia. J. Biol. Chem. 271:2000;23674-23684.
17. Nguyen V.T., Benveniste E.N. Critical role of TNF-α and NF-κB in IFN-γ-induced CD40 expression in microglia/macrophages. J. Biol. Chem. 277:2002;13796-13803.
18. Nguyen V., Walker W.S., Benveniste E.N. Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-β Eur. J. Immunol. 28:1998;2537-2548.
19. Popovich P.G., Guan Z., McGaughy V., Fisher L., Hickey W.F., Basso D.M. The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation. J. Neuropathol. Exp. Neurol. 61:2002;623-633.
20. Schönbeck U., Libby P. The CD40/CD154 receptor/ligand dyad. Cell Mol. Life Sci. 58:2001;4-43.
21. Tan J., Town T., Crawford F., Mori T., DelleDonne A., Crescentini R., Obregon D., Flavell R.A., Mullan M.J. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat. Neurosci. 5:2002;1288-1293.
22. Tan J., Town T., Mullan M. CD40-CD40L interaction in Alzheimer's disease. Curr. Opin. Pharmacol. 2:2002;445-451.
23. Tan J., Town T., Paris D., Mori T., Suo Z., Crawford F., Mattson M.P., Flavell R.A., Mullan M. Microglial activation resulting from CD40-CD40L interaction after β-amyloid stimulation. Science. 286:1999;2352-2355.
24. Togo T., Akiyama H.l., Kondo H., Ikeda K., Kato M., Iseki E., Kosaka K. Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases. Brain Res. 885:2000;117-121.
25. Tone M., Tone Y., Babik J.M., Lin C.Y., Waldmann H. The role of Sp1 and NF-κB in regulating CD40 gene expression. J. Biol. Chem. 277:2002;8890-8897.
26. Town T., Tan J., Mullan M. CD40 signaling and Alzheimer's disease pathogenesis. Neurochem. Int. 39:2001;371-380.
27. van Kooten C., Banchereau J. CD40-CD40 ligand. J. Leukoc. Biol. 67:2000;2-17.
28. Wei R., Jonakait G.M. Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-β1 (TGF-β1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia. J. Neuroimmunol. 95:1999;8-18.
29. Wesemann D., Dong Y., O'Keefe G.M., Nguyen V.T., Benveniste E.N. Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages. J. Immunol. 169:2002;2354-2360.
30. Youssef S., Stüve O., Patarroyo J.C., Ruiz P.J., Radosevich J.L., Hur E.M., Bravo M., Mitchell D.J., Sobel R.A., Steinman L., Zamvil S.S. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature. 420:2002;78-84.
31. Zamvil S.S., Steinman L. Cholesterol-lowering statins possess anti-inflammatory activity that might be useful for treatment of MS. Neurology. 59:2002;970-971.