In vivo biotin supplementation at a pharmacologic dose decreases proliferation rates of human peripheral blood mononuclear cells and cytokine release

Journal of Nutrition

Volumn 131, Issue 5, 2001, Pages 1479-1484

  Zempleni, J ^a   Helm, R M ^a   Mock, D M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Biotin; Cytokines; Humans; Lymphocytes; Proliferation

Indexed keywords

BIOTIN; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 2;

ADULT; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CYTOKINE RELEASE; DOSE RESPONSE; FEMALE; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; MONONUCLEAR CELL; NORMAL HUMAN; VITAMIN SUPPLEMENTATION;

EID: 0035013946     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.5.1479     Document Type: Article

References (58)

1. Determination of coenzyme A and acetyl CoA in tissue extracts
2. Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice
3. Simultaneous determination of pantothenic acid and hopantenic acid in biological samples and natural products by gas chromatography-mass fragmentography
4. Studies on bioavailability of oral biotin doses for humans
5. Effect of biotin on glucokinase activity, mRNA expression and insulin release in cultured beta-cells
6. 90yDOTA-Biotin
7. Transcriptional regulation of the glucokinase gene by biotin in starved rats
8. Biotin-dependent expression of the asialoglycoprotein receptor in HepG2
9. Requirement for biotin and the function of biotin in cells in culture
10. Liver glucokinase of the biotin deficient rat
11. Biotin kinetics in serum of cattle after intravenous and oral dosing
12. The uptake of vitamin B12 by human lymphocytes and the relationships to the cell cycle
13. Flow cytometric analysis of lymphocytes from rats following chronic ethanol treatment
14. Biotinylation of biotinidase following incubation with biocytin
15. Biotinylation of histones by human serum biotinidase: Assessment of biotinyl-transferase activity in sera from normal individuals and children with biotinidase deficiency
16. Effects of biotin and high copper levels on performance and immune response of weanling pigs
17. Vitamin status in patients on chronic anticonvulsant therapy
18. Cellular antibody synthesis in thiamin, riboflavin, biotin and folic acid-deficient rats
19. Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. III. Stimulation by tuberculin and allogeneic cells
20. Biotin deficiency decreases ornithine transcarbamylase activity and mRNA in rat liver
21. Culture of one-cell hamster embryos with water soluble vitamins: Pantothenate stimulates blastocyst production
22. Biotin
23. Determination of biotin in biological fluids
24. Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants
25. Biotin accounts for only half of the total avidin-binding substances in human serum
26. Serum concentrations of bisnorbiotin and biotin sulfoxide increase during both acute and chronic biotin supplementation
27. Combined treatment of advanced oropharyngeal cancer with external radiotherapy and three-step radioimmunotherapy
28. Studies on the relationships between the function of biotin and activity of the RES in the rat
29. Studies on the relationships between biotin and the behaviour of B and T lymphocytes in the guinea pig
30. Pantothenic acid
31. Characterization of a sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin and lipoate in human placental choriocarcinoma cells
32. Inhibition of experimentally induced autoimmunity in rats by biotin deficiency
33. Dose-response of lymphocyte carbohydrate metabolism to phytohemagglutinin
34. Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation
35. Biotin transport in the human intestine: Inhibition by anticonvulsant drugs
36. Amino acid transport in human lymphocytes: Distinctions in the enhanced uptake with PHA treatment or amino acid deprivation
37. Clinical laboratory methods for detection of cellular immune function
38. Determination of lipoic acid in human plasma by high-performance liquid chromatography with electrochemical detection
39. Protein synthesis in stimulated lymphocytes. II. Amino acid requirements
40. +dependent multivitamin transporter
41. 14C-Biotin administered intravenously to pigs in physiologic amounts
42. Studies on wound healing: Effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture
43. NAD metabolism and mitogen stimulation of human lymphocytes
44. Disorders of biotin metabolism
45. Biotinidase deficiency
46. Metabolic requirements for the hepatocellular proliferation induced by peroxisome proliferators: Role of coenzyme A
47. Uptake and metabolism of biotin by human peripheral blood mononuclear cells
48. Bioavailability of biotin given orally to humans in pharmacologic doses
49. The efflux of biotin from human peripheral blood mononuclear cells
50. Mitogen-induced proliferation increases biotin uptake into human peripheral blood mononuclear cells
51. Biotin
52. Proliferation of peripheral blood mononuclear cells increases riboflavin influx
53. Utilization of biotin in proliferating human lymphocytes