Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex

Current Biology

Volumn 14, Issue 23, 2004, Pages 2107-2112

  Lobachev, Kirill ^a,c   Vitriol, Eric ^b   Stemple, Jennifer ^b   Resnick, Michael A ^a   Bloom, Kerry ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA FRAGMENT; PHOTOPROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAD50 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CHROMOSOME BREAKAGE; CHROMOSOME SEGREGATION; COMPARATIVE STUDY; DNA REPAIR; GENETICS; METABOLISM; MITOSIS; MITOSIS SPINDLE; MUTATION; PHYSIOLOGY; SOUTHERN BLOTTING; YEAST;

BLOTTING, SOUTHERN; CHROMOSOME BREAKAGE; CHROMOSOME SEGREGATION; DNA FRAGMENTATION; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; LUMINESCENT PROTEINS; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; SACCHAROMYCES CEREVISIAE PROTEINS; YEASTS;

EID: 10344240414     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2004.11.051     Document Type: Article

References (19)

1. Mills K.D., Ferguson D.O., Alt F.W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 194:2003;77-95
2. Albertson D.G., Collins C., McCormick F., Gray J.W. Chromosome aberrations in solid tumors. Nat. Genet. 34:2003;369-376
3. Thompson L.H., Schild D. Recombinational DNA repair and human disease. Mutat. Res. 509:2002;49-78
4. Haber J.E. The many interfaces of Mre11. Cell. 95:1998;583-586
5. Lee S.E., Moore J.K., Holmes A., Umezu K., Kolodner R.D., Haber J.E. Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell. 94:1998;399-409
6. Hopfner K.P., Craig L., Moncalian G., Zinkel R.A., Usui T., Owen B.A., Karcher A., Henderson B., Bodmer J.L., McMurray C.T., et al. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature. 418:2002;562-566
7. Furuse M., Nagase Y., Tsubouchi H., Murakami-Murofushi K., Shibata T., Ohta K. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J. 17:1998;6412-6425
8. Moreau S., Ferguson J.R., Symington L.S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19:1999;556-566
9. de Jager M., van Noort J., van Gent D.C., Dekker C., Kanaar R., Wyman C. Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol. Cell. 8:2001;1129-1135
10. Jackson S.P. Sensing and repairing DNA double-strand breaks. Carcinogenesis. 23:2002;687-696
11. Thrower D.A., Stemple J., Yeh E., Bloom K. Nuclear oscillations and nuclear filament formation accompany single-strand annealing repair of a dicentric chromosome in Saccharomyces cerevisiae. J. Cell Sci. 116:2003;561-569
12. Hopfner K.P., Karcher A., Shin D.S., Craig L., Arthur L.M., Carney J.P., Tainer J.A. Structural biology of Rad50 ATPase. ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily Cell. 101:2000;789-800
13. Anderson D.E., Trujillo K.M., Sung P., Erickson H.P. Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. J. Biol. Chem. 276:2001;37027-37033
14. Thrower D.A., Bloom K. Dicentric chromosome stretching during anaphase reveals roles of Sir2/Ku in chromatin compaction in budding yeast. Mol. Biol. Cell. 12:2001;2800-2812
15. Pearson C.G., Maddox P.S., Salmon E.D., Bloom K. Budding yeast chromosome structure and dynamics during mitosis. J. Cell Biol. 152:2001;1255-1266
16. Nicklas R.B. Measurements of the force produced by the mitotic spindle in anaphase. J. Cell Biol. 97:1983;542-548
17. Bennink M.L., Leuba S.H., Leno G.H., Zlatanova J., de Grooth B.G., Greve J. Unfolding individual nucleosomes by stretching single chromatin fibers with optical tweezers. Nat. Struct. Biol. 8:2001;606-610
18. Brower-Toland B.D., Smith C.L., Yeh R.C., Lis J.T., Peterson C.L., Wang M.D. Mechanical disruption of individual nucleosome reveals a reversible multistage release of DNA. Proc. Natl. Acad. Sci. USA. 99:2002;1960-1965
19. D'Amours D., Jackson S.P. The Mre11 complex. At the crossroads of dna repair and checkpoint signalling Nat. Rev. Mol. Cell Biol. 3:2002;317-327