Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps

Physiological Reviews

Volumn 81, Issue 1, 2001, Pages 21-50

  Strehler, E E ^a   Zacharias, D A ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE INHIBITOR; ISOPROTEIN; PHOSPHOLIPID;

ALTERNATIVE RNA SPLICING; CALCIUM SIGNALING; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE TRANSPORT; CYTOSOL; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW;

EID: 0035137205     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.1.21     Document Type: Review

References (190)

1. Differential expression of plasma membrane calcium pump mRNA isoforms in rat osteoblast-like cells
2. 2+ pump isoforms generated by alternative splicing of rPMCA2 mRNA
3. 2+ pump in COS-1 cells
4. 2+-ATPase-1 promoter
5. Primary ion pumps
6. Plasmalemmal ATPase calcium pump localizes to inner and outer hair bundles
7. +-ATPase in the open conformation
8. Evolution of substrate specificities in the P-type ATPase superfamily
9. 2+ signaling
10. Plasma membrane calcium pump isoform 1 gene expression is repressed by corticosterone and stress in rat hippocampus
11. Sodium/calcium exchange: Its physiological implications
12. Plasma membrane calcium pump and 28-kDa calcium binding protein in cells of rat kidney distal tubules
13. 2+-pump epitopes in rat intestine
14. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels
15. 2+-pumping ATPase isoform PMCA2
16. Expression of plasma membrane calcium-pumping ATPase mRNAs in developing rat brain and adult brain subregions: Evidence for stage-specific expression
17. Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels
18. 2+-ATPase isoform PMCA1c is associated with cell fusion in C2 myocytes
19. Blockade of plasma membrane calcium pumping ATPase isoform I impairs nerve growth factor-induced neurite extension in pheochromocytoma cells
20. 2+ pump
21. 2+-ATPase isoform 3
22. 2+-ATPase isoform 3 gene and characterization of alternative splicing and transcription products
23. Intracellular calcium homeostasis
24. Calcium pump of the plasma membrane
25. Biogenesis: Plasma membrane calcium ATPase: 15 years of work on the purified enzyme
26. Calcium controls the transcription of its own transporters and channels in developing neurons
27. The plasma membrane calcium pump: Functional domains, regulation of the activity, and tissue specificity of isoform expression
28. mRNA encoding four isoforms of the plasma membrane calcium pump and their variants in rat kidney and nephron segments
29. 2+ pump isoform 3 in rat thin descending loop of Henle
30. 2+ pump is slow and is changed by alternative splicing
31. Detection of isoform 4 of the plasma membrane calcium pump in human tissues by using isoform-specific monoclonal antibodies
32. 2+-ATPase of heart sarcolenuma by a phosphorylation/dephosphorylation process
33. A region of adenylyl cyclase 2 critical for regulation by G protein βγ subunits
34. Unconventional myosins
35. Identification and cloning of site C splice variants of plasma membrane Ca-ATPase in the gerbil cochlea
36. 2+-ATPase by cAMP-dependent and tyrosine phosphorylation
37. 3H1 muscle cells
38. 2+ pump of pig smooth muscle
39. Protein kinase A anchoring
40. Direct binding of G-protein βγ complex to voltage-dependent calcium channels
41. 2+pumping ATPase of cardiac sarcolemma in four states of activation
42. Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
43. 2+ pump isoform 1 promoter: Cloning and characterization
44. 2+-ATPase isoform PMCA3 in rat cerebellum, choroid plexus and hippocampus
45. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor
46. 2+ pump
47. 2+
48. 2+ pump isoforms 2 and 3 and prevents binding of calmodulin
49. 2+ pump have different regulatory properties
50. The maximum velocity and the calcium affinity of the red cell calcium pump may be regulated independently
51. 2+ pump isoform 4b by phosphorylation of an inhibitory region downstream of the calmodulin-binding domain
52. 2+ pump is controlled by alternative splicing
53. 2+ pump interacts both with calmodulin and with another part of the pump
54. P-type calcium ATPases in higher plants: Biochemical, molecular and functional properties
55. 2+ pump contains a site that interacts with its calmodulin-binding domain
56. 2+ pump interacts with the transduction domain of the enzyme
57. PDZ domains and the formation of protein networks at the plasma membrane
58. 2+ pump in rat brain. Patterns of alternative splices seen by isoform-specific antibodies
59. 2+ pump binds calmodulin and the primary calmodulin-binding domain interacts with lipid
60. 2+ pump isoform 3f is weakly stimulated by calmodulin
61. Plasma membrane calcium ATPase isoforms in astrocytes
62. Plasma membrane calcium ATPase in synaptic terminals of chick Edinger-Westphal neurons
63. Calcium pump of the plasma membrane is localized in caveolae
64. Evidence for differential regulation of calcium by outer versus inner hair cells: Plasma membrane Ca-ATPase gene expression
65. Seizure induced alterations of plasma membrane calcium ATPase isoforms 1, 2, and 3 mRNA and protein in rat hippocampus
66. Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function
67. The plasma membrane calcium ATPase is an important determinant of survival for PC12 cells incubated with A23187
68. Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins
69. Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I
70. 2+-transporting ATPase that is expressed predominantly in brain and skeletal muscle
71. The significance of the isoforms of plasma membrane calcium ATPase
72. 2+
73. 2+ pump in neurons
74. 2+-ATPase
75. 2+-ATPase in myogenic cells
76. Overexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats
77. Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region
78. 2+ pump and of its N-terminally truncated 105-kDa fragment
79. 2+ loads from rat adrenal chromaffin cells
80. 2+ ATPase
81. Structure of the gene encoding the human plasma membrane calcium pump isoform 1
82. Ultrastructural localization of the plasmalemmal calcium pump in cerebellar neurons
83. 2+ pump by protein kinase C reduces interaction with calmodulin and with its pump receptor site
84. 2+ binding sites
85. Plasma-membrane calcium-pump isoforms in human and rat liver
86. Plasma membrane calcium pump expression in human placenta and small intestine
87. Human and rat intestinal plasma membrane calcium pump isoforms
88. 2 and its stabilization by Gβγ
89. Neuroligin 1: A splice site-specific ligand for beta-neurexins
90. 2+ pump of human erythrocytes
91. Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump
92. Gene targeting: Things go better with Cre
93. s mediates hormonal inhibition of the calcium pump in liver plasma membranes
94. q in rat liver
95. 2+-ATPase isoforms 1, 2, 3, and 4
96. 2+-ATPase isoform 4 and analysis of alternative splicing patterns at splice site A
97. The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence
98. 2+ pump
99. 2+ pump in smooth muscle and other tissues
100. 2+ ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains
101. + channels by interaction with a family of membrane-associated guanylate kinases
102. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
103. Interaction of ion channels and receptors with PDZ domain proteins
104. 2+-ATPase by either self-association or interaction with calmodulin
105. 2+-ATPase in different oligomerization states
106. 2+-ATPase isoform 1
107. 2+
108. 2+-transporting adenosine triphosphatase isoform 2 genes
109. The 2.0 Å crystal structure of a heterotrimeric G protein
110. 2+-transporting ATPase isoform 2 gene that resides in the Von Hippel-Lindau gene region
111. 2+-pump functional specialization in the brain. Complex of isoform expression and regulation by effectors
112. 2+ pump isoform 1a
113. 2+ pump
114. Cloning and characterization of hdlg: The human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1
115. Organization of P-type ATPases: Significance of structural diversity
116. 2+-ATPase pump in rat kidney
117. 2+-transporting ATPase
118. Structural organization, ion transport, and energy transduction of P-type ATPases
119. The plasma membrane calcium pump: A physiological perspective on its regulation
120. i2 to the Golgi by alternative spliced carboxyl-terminal region
121. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein
122. Emerging roles of Dlg-like PDZ proteins in the organization of the NMDA-type glutamatergic synapse
123. 2+ pumping ATPase of heart sarcolemma and erythrocyte plasma membrane by the cAMP-dependent protein kinase
124. 2+-ATPase
125. 2+)-ATPase of the erythrocyte membrane: Reconstitution and effect of calmodulin and phospholipids
126. 2+ transporting ATPases to human chromosomes 1q25-32 and 12q21-23
127. Expression of hPMCA4b, the major form of the plasma membrane calcium pump in megakaryoblastoid cells is greatly reduced in mature human platelets
128. 2+ pumps
129. 2+ pump
130. PDZ domains: Targeting signalling molecules to submembranous sites
131. 2+ pumps in smooth muscle cells
132. 2+-ATPases and their expression in the mammary gland of pregnant and lactating rats
133. 2+-ATPase expression in control and SV40-transformed human fibroblasts
134. 2+ channels with the presynaptic proteins syntaxin and SNAP-25
135. Sequence motifs for calmodulin recognition
136. Plasma membrane calcium ATPase isoform expression in cultured rat mesangial cells
137. PDZ domains bind carboxy-terminal sequences of target proteins
138. Active calcium transport in human red cells
139. Use of the polymerase chain reaction for the detection of alternatively spliced mRNAs of plasma membrane calcium pump
140. Structure and function of the P-type ATPases
141. 2+ extrusion from human red cells
142. Expression and functional characterization of isoforms 4 of the plasma membrane calcium pump
143. Ion channel associated proteins
144. 2+-transporting ATPase from rat brain
145. 2+ pump activity by protein kinase C
146. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
147. Skeletal muscle glycogenolysis, glycolysis, and pH during electrical stimulation in men
148. Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus
149. 2+-ATPase isoforms: Distribution of mRNAs in rat brain by in situ hybridization
150. 2+-ATPase mRNA isoform PMCA 4 is expressed at high levels in neurons of rat piriform cortex and neocortex
151. 2+ pump. A study using specific antibodies
152. 2+ pump isoforms in the rat brain
153. Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes
154. 2+-ATPase suggests that a large conformational change initiates P-type ion pump reaction cycles
155. 2+-ATPase gene cause deafness in deafwaddler mice
156. 2+ exchangers
157. 2+ pumps
158. Sodium-calcium exchangers and calcium pumps
159. 2+ pump: Structural, functional and genetic aspects of isoform diversity
160. Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane
161. The plasma membrane calcium ATPase 2b binds to membrane cytoskeleton-associated PDZ domain proteins
162. mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon
163. Ordered and cooperative binding of opposing globular domains of calmodulin to the plasma membrane Ca-ATPase
164. 2+-ATPase gene causes deafness in Wriggle Mouse Sagami
165. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
166. 2+ efflux from cultured rat dorsal root ganglion (DRG) neurons by protein kinase C
167. 2+ pump. 28 residues suffice to bind calmodulin but more are needed for full auto-inhibition of the activity
168. Plasma membrane calcium pump isoform 4a has a longer calmodulin-binding domain than 4b
169. 2+ pump
170. 2+ pump isoform 4a at its calmodulin binding domain
171. Calmodulin and the plasma membrane calcium pump
172. 2+ pump
173. The plasma membrane calcium pump: A multiregulated transporter
174. 2+-ATPase from human erythrocytes
175. 2+ ATPases isoform 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26→p25 and Xq28, respectively
176. Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF)
177. Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons
178. Modulation of calcium efflux from cultured rat dorsal root ganglion neurons
179. Transposon-generated "knock-out" and "knock-in" gene-targeting constructs for use in mice
180. 2+ efflux in immortalized proximal tubule cells
181. 2+-transport ATPases from the plasma membrane
182. 2+ from hair cell stereocilia
183. 2+ pump isoforms and splice variants in the human brain
184. 2+-ATPase in human hippocampus
185. Characterization of persistent artifacts resulting from RT-PCR of alternatively spliced mRNAs
186. Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse
187. 2
188. 1 subunit
189. Structure of the calcium pump from sarcoplasmic reticulum at 8-Å resolution
190. 2+ pump using trypsin proteolysis