Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only

Circulation Research

Volumn 92, Issue 8, 2003, Pages 881-887

  Antoons, Gudrun ^a   Ver Heyen, Mark ^b   Raeymaekers, Luc ^b   Vangheluwe, Peter ^b   Wuytack, Frank ^b   Sipido, Karin R ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Excitation contraction coupling; Na+ Ca2+ exchange; Sarcoplasmic reticulum Ca2+ ATPase; Transgenic mice; Ventricular myocytes

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION; SODIUM CALCIUM EXCHANGE PROTEIN; ATP2A2 PROTEIN, MOUSE; CALCIUM; ISOENZYME; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; EXCITATION CONTRACTION COUPLING; HEART CELL CULTURE; HEART FAILURE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOLOGY; GENETICS; GENOTYPE; HEART MUSCLE CELL; HEART VENTRICLE; METABOLISM; MOUSE MUTANT; MUTATION; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CALCIUM-TRANSPORTING ATPASES; GENOTYPE; HEART VENTRICLES; ISOENZYMES; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MUTATION; MYOCYTES, CARDIAC; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-CALCIUM EXCHANGER;

EID: 0037968269     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000069032.81501.98     Document Type: Article

References (47)

1. Bers DM. Sarcoplasmic reticulum Ca release in intact ventricular myocytes. Front Biosci. 2002;7:D1697-D1711.
2. Trafford AW, Diaz ME, O'Neill SC, Eisner DA. Integrative analysis of calcium signaling in cardiac muscle. Front Biosci. 2002;7:D843-D852.
3. Simmerman HK, Jones LR. Phospholamban: protein structure, mechanism of action, and role in cardiac function. Physiol Rev. 1998;78:921-947.
4. Brittsan AG, Kranias EG. Phospholamban and cardiac contractile function. J Mol Cell Cardiol. 2000;32:2131-2139.
5. 2+ transient in rat myocytes during β-adrenergic stimulation. J Physiol. 1997;505:385-402.
6. Hagemann D, Kuschel M, Kuramochi T, Zhu W, Cheng H, Xiao RP. Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes. J Biol Chem. 2000;275:22532-22536.
7. Li L, Chu G, Kranias EG, Bers DM. Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects. Am J Physiol. 1998;274:H1335-H1347.
8. 2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J Clin Invest. 1992;90:927-935.
9. 2+-ATPase in failing and nonfailing human myocardium. Circ Res. 1994;75:434-442.
10. Schmidt U, Hajjar RJ, Helm PA, Kim CS, Doye AA, Gwathmey JK. Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure. J Mol Cell Cardiol. 1998;30:1929-1937.
11. 2+ transient of failing human ventricular myocytes. Circ Res. 1999;84:435-444.
12. Lindner M, Erdmann E, Beuckelmann DJ. Calcium content of the sarcoplasmic reticulum in isolated ventricular myocytes from patients with terminal heart failure. J Mol Cell Cardiol. 1998;30:743-749.
13. 2+ content in isolated failing and nonfailing human myocardium. Circ Res. 1999;85:38-46.
14. O'Rourke B, Kass DA, Tomaselli GF, Kaab S, Tunin R, Marban E. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies. Circ Res. 1999;84:562-570.
15. Hobai IA, O'Rourke B. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation. 2001;103:1577-1584.
16. Gomez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science. 1997;276:800-806.
17. 2+-exchanger protein levels and diastolic function of failing human myocardium. Circulation. 1999;99:641-648.
18. Sipido KR, Volders PG, Vos MA, Verdonck F. Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovasc Res. 2002;53:782-805.
19. 2+ exchanger. Circ Res. 2000;87:581-587.
20. Miyamoto MI, del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T, Guerrero JL, Gwathmey JK, Rosenzweig A, Hajjar RJ. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci USA. 2000;97:793-798.
21. 2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ Res. 1998;83:1205-1214.
22. Yao A, Su Z, Dillmann WH, Barry WH. Sarcoplasmic reticulum function in murine ventricular myocytes overexpressing SR CaATPase. J Mol Cell Cardiol. 1998;30:2711-2718.
23. Luo W, Grupp IL, Harrer J, Ponniah S, Grupp G, Duffy JJ, Doetschman T, Kranias EG. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation. Circ Res. 1994;75:401-409.
24. 2+. Am J Physiol. 1996;271:C391-C397.
25. 2+ homeostasis and cardiomyocyte function. J Biol Chem. 2000;275:38073-38080.
26. 2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem. 1999;274:2556-2562.
27. 2+-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart. Circ Res. 2001;89:838-846.
28. 2+ concentration transients in mouse ventricular myocytes. J Physiol (Lond). 2002;543:889-898.
29. 2+ release from the sarcoplasmic reticulum. Circ Res. 1997;81:1034-1044.
30. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth F. Improved patch-clamp techniques for high-resolution current recording from cell and cell-free membrane patches. Pflügers Arch. 1981;391:85-100.
31. Cheng H, Lederer WJ, Cannell MB. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science. 1993;262:740-744.
32. Satoh H, Delbridge LM, Blatter LA, Bers DM. Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects. Biophys J. 1996;70:1494-1504.
33. Varro A, Negretti N, Hester SB, Eisner DA. An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes. Pflügers Arch. 1993;423:158-160.
34. Trafford AW, Diaz ME, Eisner DA. A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes. Pflügers Arch. 1999;437:501-503.
35. Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential, I: simulations of ionic currents and concentration changes. Circ Res. 1994;74:1071-1096.
36. i overloaded cardiac myocytes: a simulation study. Biophys J. 2000;78:2392-2404.
37. 2+ exchanger. J Gen Physiol. 1997;109:717-729.
38. 2+ exchanger. J Physiol (Lond). 1998;512:651-667.
39. 2+-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes. J Mol Cell Cardiol. 2002;34:389-400.
40. Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol Rev. 1999;79:215-262.
41. Hasenfuss G. Alterations of calcium-regulatory proteins in heart failure. Cardiovasc Res. 1998;37:279-289.
42. Aronow BJ, Toyokawa T, Canning A, Haghighi K, Delling U, Kranias E, Molkentin JD, Dom GW. Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy. Physiol Genomics. 2001;6:19-28.
43. 2+ exchanger are antithetically regulated during mouse cardiac development and in hypo/hyperthyroidism. J Mol Cell Cardiol. 2000;32:453-464.
44. 2+ pump mRNA stability in cardiac and smooth muscle: role of the 3′-untranslated region. Am J Physiol Cell Physiol. 2002;283:C560-C568.
45. 2+-ATPase. Circ Res. 1998;83:889-897.
46. O'Donnell JM, Sumbilla CM, Ma H, Farrance IK, Cavagna M, Klein MG, Inesi G. Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes. Circ Res. 2001;88:415-421.
47. 2+ handling capacity. Circ Res. 2001;89:160-167.