메뉴 건너뛰기




Volumn 14, Issue 17-18, 2009, Pages 851-858

siRNAs: their potential as therapeutic agents - Part I. Designing of siRNAs

Author keywords

[No Author keywords available]

Indexed keywords

SMALL INTERFERING RNA;

EID: 69549105796     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2009.06.001     Document Type: Review
Times cited : (35)

References (89)
  • 1
    • 33845202133 scopus 로고    scopus 로고
    • A pathogen-inducible endogenous siRNA in plant immunity
    • Katiyar-Agarwal S., et al. A pathogen-inducible endogenous siRNA in plant immunity. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 18002-18007
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 18002-18007
    • Katiyar-Agarwal, S.1
  • 2
    • 33645967758 scopus 로고    scopus 로고
    • A plant miRNA contributes to antibacterial resistance by repressing auxin signaling
    • Navarro L., et al. A plant miRNA contributes to antibacterial resistance by repressing auxin signaling. Science 312 (2006) 436-439
    • (2006) Science , vol.312 , pp. 436-439
    • Navarro, L.1
  • 3
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1
  • 4
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi R., et al. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17 (2003) 3011-3016
    • (2003) Genes Dev. , vol.17 , pp. 3011-3016
    • Yi, R.1
  • 5
    • 52449115141 scopus 로고    scopus 로고
    • MicroRNAs - micro in size but macro in function
    • Singh S.K., et al. MicroRNAs - micro in size but macro in function. FEBS J. 275 20 (2008) 4929-4944
    • (2008) FEBS J. , vol.275 , Issue.20 , pp. 4929-4944
    • Singh, S.K.1
  • 6
    • 34547944309 scopus 로고    scopus 로고
    • MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
    • Mathonnet G., et al. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science 317 (2007) 1764-1767
    • (2007) Science , vol.317 , pp. 1764-1767
    • Mathonnet, G.1
  • 7
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • Valencia-Sanchez M.A., et al. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20 (2006) 515-524
    • (2006) Genes Dev. , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1
  • 8
    • 55949134303 scopus 로고    scopus 로고
    • DNA methylomes, histone codes and miRNAs: tying it all together
    • Guil S., and Esteller M. DNA methylomes, histone codes and miRNAs: tying it all together. Int. J. Biochem. Cell Biol. 41 1 (2009) 87-95
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , Issue.1 , pp. 87-95
    • Guil, S.1    Esteller, M.2
  • 9
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S.M., et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1
  • 10
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir S.M., et al. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15 (2001) 188-200
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1
  • 11
    • 34547650779 scopus 로고    scopus 로고
    • RFRCDB-siRNA: improved design of siRNAs by random forest regression model coupled with database searching
    • Jiang P., et al. RFRCDB-siRNA: improved design of siRNAs by random forest regression model coupled with database searching. Comput. Methods Progr. Biomed. 87 (2007) 230-238
    • (2007) Comput. Methods Progr. Biomed. , vol.87 , pp. 230-238
    • Jiang, P.1
  • 12
    • 23444437819 scopus 로고    scopus 로고
    • Design of a genome-wide siRNA library using an artificial neural network
    • Huesken D., et al. Design of a genome-wide siRNA library using an artificial neural network. Nat. Biotechnol. 23 (2005) 995-1001
    • (2005) Nat. Biotechnol. , vol.23 , pp. 995-1001
    • Huesken, D.1
  • 13
    • 3242889236 scopus 로고    scopus 로고
    • siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference
    • Naito Y., et al. siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference. Nucleic Acids Res. 32 Web Server issue (2004) W124-W129
    • (2004) Nucleic Acids Res. , vol.32 , Issue.Web Server issue
    • Naito, Y.1
  • 14
    • 3242882171 scopus 로고    scopus 로고
    • TROD: T7 RNAi oligo designer
    • Dudek P., and Picard D. TROD: T7 RNAi oligo designer. Nucleic Acids Res. 32 Web Server issue (2004) W121-W123
    • (2004) Nucleic Acids Res. , vol.32 , Issue.Web Server issue
    • Dudek, P.1    Picard, D.2
  • 15
    • 33747869038 scopus 로고    scopus 로고
    • siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
    • Naito Y., et al. siVirus: web-based antiviral siRNA design software for highly divergent viral sequences. Nucleic Acids Res. 34 Web Server issue (2006) W448-450
    • (2006) Nucleic Acids Res. , vol.34 , Issue.Web Server issue
    • Naito, Y.1
  • 16
    • 48449098277 scopus 로고    scopus 로고
    • OligoWalk: an online siRNA design tool utilizing hybridization thermodynamics
    • Lu Z.J., and Mathews D.H. OligoWalk: an online siRNA design tool utilizing hybridization thermodynamics. Nucleic Acids Res. 36 Web Server issue (2008) W104-108
    • (2008) Nucleic Acids Res. , vol.36 , Issue.Web Server issue
    • Lu, Z.J.1    Mathews, D.H.2
  • 17
    • 34347229441 scopus 로고    scopus 로고
    • sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database
    • Shah J.K., et al. sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database. BMC Bioinformatics 8 (2007) 178
    • (2007) BMC Bioinformatics , vol.8 , pp. 178
    • Shah, J.K.1
  • 18
    • 3242890471 scopus 로고    scopus 로고
    • siRNA Selection Server: an automated siRNA oligonucleotide prediction server
    • Yuan B., et al. siRNA Selection Server: an automated siRNA oligonucleotide prediction server. Nucleic Acids Res. 32 Web Server issue (2004) W130-134
    • (2004) Nucleic Acids Res. , vol.32 , Issue.Web Server issue
    • Yuan, B.1
  • 19
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir S.M., et al. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20 (2001) 6877-6888
    • (2001) EMBO J. , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1
  • 20
    • 15044354554 scopus 로고    scopus 로고
    • RNAi-induced gene silencing by local electroporation in targeting brain region
    • Akaneya Y., et al. RNAi-induced gene silencing by local electroporation in targeting brain region. J. Neurophysiol. 93 (2005) 594-602
    • (2005) J. Neurophysiol. , vol.93 , pp. 594-602
    • Akaneya, Y.1
  • 21
    • 0344394958 scopus 로고    scopus 로고
    • Free energy lights the path toward more effective RNAi
    • Silva J.M., et al. Free energy lights the path toward more effective RNAi. Nat. Genet. 35 (2003) 303-305
    • (2003) Nat. Genet. , vol.35 , pp. 303-305
    • Silva, J.M.1
  • 22
    • 2342564353 scopus 로고    scopus 로고
    • A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens
    • Hsieh A.C., et al. A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Res. 32 (2004) 893-901
    • (2004) Nucleic Acids Res. , vol.32 , pp. 893-901
    • Hsieh, A.C.1
  • 23
    • 1642346273 scopus 로고    scopus 로고
    • Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference
    • Ui-Tei K., et al. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. 32 (2004) 936-948
    • (2004) Nucleic Acids Res. , vol.32 , pp. 936-948
    • Ui-Tei, K.1
  • 24
    • 13844281898 scopus 로고    scopus 로고
    • Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
    • Kim D.H., et al. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat. Biotechnol. 23 (2005) 222-226
    • (2005) Nat. Biotechnol. , vol.23 , pp. 222-226
    • Kim, D.H.1
  • 25
    • 13844280638 scopus 로고    scopus 로고
    • Synthetic shRNAs as potent RNAi triggers
    • Siolas D., et al. Synthetic shRNAs as potent RNAi triggers. Nat. Biotechnol. 23 (2005) 227-231
    • (2005) Nat. Biotechnol. , vol.23 , pp. 227-231
    • Siolas, D.1
  • 26
    • 1542336952 scopus 로고    scopus 로고
    • Rational siRNA design for RNA interference
    • Reynolds A., et al. Rational siRNA design for RNA interference. Nat. Biotechnol. 22 (2004) 326-330
    • (2004) Nat. Biotechnol. , vol.22 , pp. 326-330
    • Reynolds, A.1
  • 27
    • 21844471799 scopus 로고    scopus 로고
    • Sequence characteristics of functional siRNAs
    • Jagla B., et al. Sequence characteristics of functional siRNAs. RNA 11 (2005) 864-872
    • (2005) RNA , vol.11 , pp. 864-872
    • Jagla, B.1
  • 28
    • 33748701701 scopus 로고    scopus 로고
    • Computational models with thermodynamic and composition features improve siRNA design
    • Shabalina S.A., et al. Computational models with thermodynamic and composition features improve siRNA design. BMC Bioinformatics 7 (2006) 65
    • (2006) BMC Bioinformatics , vol.7 , pp. 65
    • Shabalina, S.A.1
  • 29
    • 34250805982 scopus 로고    scopus 로고
    • MicroRNA targeting specificity in mammals: determinants beyond seed pairing
    • Grimson A., et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell 27 (2007) 91-105
    • (2007) Mol. Cell , vol.27 , pp. 91-105
    • Grimson, A.1
  • 30
    • 52949095730 scopus 로고    scopus 로고
    • Effects of local mRNA structure on posttranscriptional gene silencing
    • Rudnick S.I., et al. Effects of local mRNA structure on posttranscriptional gene silencing. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 13787-13792
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 13787-13792
    • Rudnick, S.I.1
  • 31
    • 39149106448 scopus 로고    scopus 로고
    • Efficient siRNA selection using hybridization thermodynamics
    • Lu Z.J., and Mathews D.H. Efficient siRNA selection using hybridization thermodynamics. Nucleic Acids Res. 36 (2008) 640-647
    • (2008) Nucleic Acids Res. , vol.36 , pp. 640-647
    • Lu, Z.J.1    Mathews, D.H.2
  • 32
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson A.L., et al. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 21 (2003) 635-637
    • (2003) Nat. Biotechnol. , vol.21 , pp. 635-637
    • Jackson, A.L.1
  • 33
    • 33646188259 scopus 로고    scopus 로고
    • 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets
    • Birmingham A., et al. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat. Methods 3 (2006) 199-204
    • (2006) Nat. Methods , vol.3 , pp. 199-204
    • Birmingham, A.1
  • 34
    • 33646063801 scopus 로고    scopus 로고
    • EsiRNAs inhibit Hepatitis B virus replication in mice model more efficiently than synthesized siRNAs
    • Xuan B., et al. EsiRNAs inhibit Hepatitis B virus replication in mice model more efficiently than synthesized siRNAs. Virus Res. 118 (2006) 150-155
    • (2006) Virus Res. , vol.118 , pp. 150-155
    • Xuan, B.1
  • 35
    • 25444482662 scopus 로고    scopus 로고
    • Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs
    • Kittler R., and Buchholz F. Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs. Cell Cycle 4 (2005) 564-567
    • (2005) Cell Cycle , vol.4 , pp. 564-567
    • Kittler, R.1    Buchholz, F.2
  • 36
    • 33745614074 scopus 로고    scopus 로고
    • Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
    • Jackson A.L., et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 12 (2006) 1197-1205
    • (2006) RNA , vol.12 , pp. 1197-1205
    • Jackson, A.L.1
  • 37
    • 38649099969 scopus 로고    scopus 로고
    • Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
    • Chen P.Y., et al. Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA 14 (2008) 263-274
    • (2008) RNA , vol.14 , pp. 263-274
    • Chen, P.Y.1
  • 38
    • 33745608078 scopus 로고    scopus 로고
    • Off-target effects by siRNA can induce toxic phenotype
    • Fedorov Y., et al. Off-target effects by siRNA can induce toxic phenotype. RNA 12 (2006) 1188-1196
    • (2006) RNA , vol.12 , pp. 1188-1196
    • Fedorov, Y.1
  • 39
    • 44649124293 scopus 로고    scopus 로고
    • Small RNAs tell big stories in Whistler
    • Seila A.C., and Sharp P.A. Small RNAs tell big stories in Whistler. Nat. Cell Biol. 10 (2008) 630-633
    • (2008) Nat. Cell Biol. , vol.10 , pp. 630-633
    • Seila, A.C.1    Sharp, P.A.2
  • 40
    • 42449091989 scopus 로고    scopus 로고
    • Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
    • Ui-Tei K., et al. Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res. 36 (2008) 2136-2151
    • (2008) Nucleic Acids Res. , vol.36 , pp. 2136-2151
    • Ui-Tei, K.1
  • 41
    • 78649408990 scopus 로고    scopus 로고
    • LNA incorporated siRNAs exhibit lower off-target effects compared to 2′-O-methoxy in cell phenotypic assays and microarray analysis
    • Puri N., et al. LNA incorporated siRNAs exhibit lower off-target effects compared to 2′-O-methoxy in cell phenotypic assays and microarray analysis. Nucleic Acids Symp. Ser. (Oxf.) 52 (2008) 25-26
    • (2008) Nucleic Acids Symp. Ser. (Oxf.) , vol.52 , pp. 25-26
    • Puri, N.1
  • 42
    • 13744250159 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
    • Elmen J., et al. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res. 33 (2005) 439-447
    • (2005) Nucleic Acids Res. , vol.33 , pp. 439-447
    • Elmen, J.1
  • 43
    • 0034625010 scopus 로고    scopus 로고
    • Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
    • Wahlestedt C., et al. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 5633-5638
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 5633-5638
    • Wahlestedt, C.1
  • 44
    • 0042972933 scopus 로고    scopus 로고
    • Activation of the interferon system by short-interfering RNAs
    • Sledz C.A., et al. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. 5 (2003) 834-839
    • (2003) Nat. Cell Biol. , vol.5 , pp. 834-839
    • Sledz, C.A.1
  • 45
    • 2442705429 scopus 로고    scopus 로고
    • Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
    • Kariko K., et al. Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol. 172 (2004) 6545-6549
    • (2004) J. Immunol. , vol.172 , pp. 6545-6549
    • Kariko, K.1
  • 46
    • 18044365415 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
    • Sioud M. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J. Mol. Biol. 348 (2005) 1079-1090
    • (2005) J. Mol. Biol. , vol.348 , pp. 1079-1090
    • Sioud, M.1
  • 47
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung V., et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11 (2005) 263-270
    • (2005) Nat. Med. , vol.11 , pp. 263-270
    • Hornung, V.1
  • 48
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge A.D., et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23 (2005) 457-462
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1
  • 49
    • 33646544416 scopus 로고    scopus 로고
    • Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2′-hydroxyl uridines in immune responses
    • Sioud M. Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2′-hydroxyl uridines in immune responses. Eur. J. Immunol. 36 (2006) 1222-1230
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1222-1230
    • Sioud, M.1
  • 50
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song E., et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat. Biotechnol. 23 (2005) 709-717
    • (2005) Nat. Biotechnol. , vol.23 , pp. 709-717
    • Song, E.1
  • 51
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge A.D., et al. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 13 (2006) 494-505
    • (2006) Mol. Ther. , vol.13 , pp. 494-505
    • Judge, A.D.1
  • 52
    • 33646561864 scopus 로고    scopus 로고
    • A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
    • Marques J.T., et al. A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat. Biotechnol. 24 (2006) 559-565
    • (2006) Nat. Biotechnol. , vol.24 , pp. 559-565
    • Marques, J.T.1
  • 53
    • 33750976374 scopus 로고    scopus 로고
    • 5′-Triphosphate RNA is the ligand for RIG-I
    • Hornung V., et al. 5′-Triphosphate RNA is the ligand for RIG-I. Science 314 (2006) 994-997
    • (2006) Science , vol.314 , pp. 994-997
    • Hornung, V.1
  • 54
    • 19644378907 scopus 로고    scopus 로고
    • Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart
    • Wang Z., et al. Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat. Biotechnol. 23 (2005) 321-328
    • (2005) Nat. Biotechnol. , vol.23 , pp. 321-328
    • Wang, Z.1
  • 55
    • 1542306855 scopus 로고    scopus 로고
    • Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
    • Kim D.H., et al. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol. 22 (2004) 321-325
    • (2004) Nat. Biotechnol. , vol.22 , pp. 321-325
    • Kim, D.H.1
  • 56
    • 39449128863 scopus 로고    scopus 로고
    • Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon
    • Gondai T., et al. Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon. Nucleic Acids Res. 36 (2008) e18
    • (2008) Nucleic Acids Res. , vol.36
    • Gondai, T.1
  • 57
    • 36949010787 scopus 로고    scopus 로고
    • Lack of interferon (IFN) response to T7 Transcribed pppG (n)(n = 2, 3)-shRNA
    • Gondai T., et al. Lack of interferon (IFN) response to T7 Transcribed pppG (n)(n = 2, 3)-shRNA. Nucleosides Nucleotides Nucleic Acids 26 (2007) 805-808
    • (2007) Nucleosides Nucleotides Nucleic Acids , vol.26 , pp. 805-808
    • Gondai, T.1
  • 58
    • 33646588689 scopus 로고    scopus 로고
    • Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro
    • Robbins M.A., et al. Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro. Nat. Biotechnol. 24 (2006) 566-571
    • (2006) Nat. Biotechnol. , vol.24 , pp. 566-571
    • Robbins, M.A.1
  • 59
    • 0036801463 scopus 로고    scopus 로고
    • Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination
    • Wang L., et al. Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination. J. Clin. Invest. 110 (2002) 1175-1184
    • (2002) J. Clin. Invest. , vol.110 , pp. 1175-1184
    • Wang, L.1
  • 60
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil F., et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303 (2004) 1526-1529
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1
  • 61
    • 0036238993 scopus 로고    scopus 로고
    • Efficient delivery of dsRNA into zona-enclosed mouse oocytes and preimplantation embryos by electroporation
    • Grabarek J.B., et al. Efficient delivery of dsRNA into zona-enclosed mouse oocytes and preimplantation embryos by electroporation. Genesis 32 (2002) 269-276
    • (2002) Genesis , vol.32 , pp. 269-276
    • Grabarek, J.B.1
  • 62
    • 0034775750 scopus 로고    scopus 로고
    • Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells
    • Yang S., et al. Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells. Mol. Cell Biol. 21 (2001) 7807-7816
    • (2001) Mol. Cell Biol. , vol.21 , pp. 7807-7816
    • Yang, S.1
  • 63
    • 0035807818 scopus 로고    scopus 로고
    • Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines
    • Billy E., et al. Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 14428-14433
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 14428-14433
    • Billy, E.1
  • 64
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • Grimm D., et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441 (2006) 537-541
    • (2006) Nature , vol.441 , pp. 537-541
    • Grimm, D.1
  • 65
    • 33845399708 scopus 로고    scopus 로고
    • Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing
    • Narvaiza I., et al. Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing. J. Virol. 80 (2006) 12236-12247
    • (2006) J. Virol. , vol.80 , pp. 12236-12247
    • Narvaiza, I.1
  • 66
    • 54549084606 scopus 로고    scopus 로고
    • Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
    • Sano M., et al. Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection. Nucleic Acids Res. 36 18 (2008) 5812-5821
    • (2008) Nucleic Acids Res. , vol.36 , Issue.18 , pp. 5812-5821
    • Sano, M.1
  • 67
    • 0038132996 scopus 로고    scopus 로고
    • Allele-specific silencing of dominant disease genes
    • Miller V.M., et al. Allele-specific silencing of dominant disease genes. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7195-7200
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 7195-7200
    • Miller, V.M.1
  • 68
    • 1342306385 scopus 로고    scopus 로고
    • Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles
    • Miller V.M., et al. Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. Nucleic Acids Res. 32 (2004) 661-668
    • (2004) Nucleic Acids Res. , vol.32 , pp. 661-668
    • Miller, V.M.1
  • 69
    • 33645160450 scopus 로고    scopus 로고
    • Allele-specific RNA interference for neurological disease
    • Rodriguez-Lebron E., and Paulson H.L. Allele-specific RNA interference for neurological disease. Gene Ther. 13 (2006) 576-581
    • (2006) Gene Ther. , vol.13 , pp. 576-581
    • Rodriguez-Lebron, E.1    Paulson, H.L.2
  • 70
    • 48249098892 scopus 로고    scopus 로고
    • Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi
    • Ohnishi Y., et al. Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi. PLoS ONE 3 (2008) e2248
    • (2008) PLoS ONE , vol.3
    • Ohnishi, Y.1
  • 71
    • 14644421585 scopus 로고    scopus 로고
    • Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3′- or 5′-end of the sense-stranded siRNA element
    • Ohnishi Y., et al. Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3′- or 5′-end of the sense-stranded siRNA element. Biochem. Biophys. Res. Commun. 329 (2005) 516-521
    • (2005) Biochem. Biophys. Res. Commun. , vol.329 , pp. 516-521
    • Ohnishi, Y.1
  • 72
    • 33749438388 scopus 로고    scopus 로고
    • Designing siRNA that distinguish between genes that differ by a single nucleotide
    • Schwarz D.S., et al. Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet. 2 (2006) e140
    • (2006) PLoS Genet. , vol.2
    • Schwarz, D.S.1
  • 73
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann T.S., et al. RNAi-mediated gene silencing in non-human primates. Nature 441 (2006) 111-114
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1
  • 74
    • 36849094017 scopus 로고    scopus 로고
    • Chemical modification: the key to clinical application of RNA interference?
    • Corey D.R. Chemical modification: the key to clinical application of RNA interference?. J. Clin. Invest. 117 (2007) 3615-3622
    • (2007) J. Clin. Invest. , vol.117 , pp. 3615-3622
    • Corey, D.R.1
  • 75
    • 24344500241 scopus 로고    scopus 로고
    • Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
    • Harborth J., et al. Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev 13 (2003) 83-105
    • (2003) Antisense Nucleic Acid Drug Dev , vol.13 , pp. 83-105
    • Harborth, J.1
  • 76
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek J., et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432 (2004) 173-178
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1
  • 77
    • 29844452007 scopus 로고    scopus 로고
    • Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity
    • Kraynack B.A., and Baker B.F. Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity. RNA 12 (2006) 163-176
    • (2006) RNA , vol.12 , pp. 163-176
    • Kraynack, B.A.1    Baker, B.F.2
  • 78
    • 11344257391 scopus 로고    scopus 로고
    • RNA interference using boranophosphate siRNAs: structure-activity relationships
    • Hall A.H., et al. RNA interference using boranophosphate siRNAs: structure-activity relationships. Nucleic Acids Res. 32 (2004) 5991-6000
    • (2004) Nucleic Acids Res. , vol.32 , pp. 5991-6000
    • Hall, A.H.1
  • 79
    • 55249097026 scopus 로고    scopus 로고
    • siRNA stabilization prolongs gene knockdown in primary T lymphocytes
    • Mantei A., et al. siRNA stabilization prolongs gene knockdown in primary T lymphocytes. Eur. J. Immunol. 38 (2008) 2616-2625
    • (2008) Eur. J. Immunol. , vol.38 , pp. 2616-2625
    • Mantei, A.1
  • 80
    • 0038385504 scopus 로고    scopus 로고
    • RNA interference in mammalian cells by chemically-modified RNA
    • Braasch D.A., et al. RNA interference in mammalian cells by chemically-modified RNA. Biochemistry 42 (2003) 7967-7975
    • (2003) Biochemistry , vol.42 , pp. 7967-7975
    • Braasch, D.A.1
  • 81
    • 33846902312 scopus 로고    scopus 로고
    • Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
    • Swayze E.E., et al. Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals. Nucleic Acids Res. 35 (2007) 687-700
    • (2007) Nucleic Acids Res. , vol.35 , pp. 687-700
    • Swayze, E.E.1
  • 82
    • 33645533269 scopus 로고    scopus 로고
    • Improvements in siRNA properties mediated by 2′-deoxy-2′-fluoro-beta-d-arabinonucleic acid (FANA)
    • Dowler T., et al. Improvements in siRNA properties mediated by 2′-deoxy-2′-fluoro-beta-d-arabinonucleic acid (FANA). Nucleic Acids Res. 34 (2006) 1669-1675
    • (2006) Nucleic Acids Res. , vol.34 , pp. 1669-1675
    • Dowler, T.1
  • 83
    • 34247172025 scopus 로고    scopus 로고
    • 2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity
    • Watts J.K., et al. 2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Res. 35 (2007) 1441-1451
    • (2007) Nucleic Acids Res. , vol.35 , pp. 1441-1451
    • Watts, J.K.1
  • 84
    • 69549124745 scopus 로고    scopus 로고
    • Suppression of bcr-abl mRNA by chemically modified siRNA
    • Murao S., et al. Suppression of bcr-abl mRNA by chemically modified siRNA. Nucleic Acids Symp. Ser. (Oxf.) 52 (2008) 499-500
    • (2008) Nucleic Acids Symp. Ser. (Oxf.) , vol.52 , pp. 499-500
    • Murao, S.1
  • 86
    • 33845631509 scopus 로고    scopus 로고
    • Integrated siRNA design based on surveying of features associated with high RNAi effectiveness
    • Gong W., et al. Integrated siRNA design based on surveying of features associated with high RNAi effectiveness. BMC Bioinformatics 7 (2006) 516
    • (2006) BMC Bioinformatics , vol.7 , pp. 516
    • Gong, W.1
  • 87
    • 13444280430 scopus 로고    scopus 로고
    • HuSiDa - the human siRNA database: an open-access database for published functional siRNA sequences and technical details of efficient transfer into recipient cells
    • Truss M., et al. HuSiDa - the human siRNA database: an open-access database for published functional siRNA sequences and technical details of efficient transfer into recipient cells. Nucleic Acids Res. 33 Database issue (2005) D108-111
    • (2005) Nucleic Acids Res. , vol.33 , Issue.Database issue
    • Truss, M.1
  • 88
    • 13444266431 scopus 로고    scopus 로고
    • siRNAdb: a database of siRNA sequences
    • Chalk A.M., et al. siRNAdb: a database of siRNA sequences. Nucleic Acids Res. 33 Database issue (2005) D131-134
    • (2005) Nucleic Acids Res. , vol.33 , Issue.Database issue
    • Chalk, A.M.1
  • 89
    • 33645822531 scopus 로고    scopus 로고
    • siRecords: an extensive database of mammalian siRNAs with efficacy ratings
    • Ren Y., et al. siRecords: an extensive database of mammalian siRNAs with efficacy ratings. Bioinformatics 22 (2006) 1027-1028
    • (2006) Bioinformatics , vol.22 , pp. 1027-1028
    • Ren, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.