-
1
-
-
33845202133
-
A pathogen-inducible endogenous siRNA in plant immunity
-
Katiyar-Agarwal S., et al. A pathogen-inducible endogenous siRNA in plant immunity. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 18002-18007
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 18002-18007
-
-
Katiyar-Agarwal, S.1
-
2
-
-
33645967758
-
A plant miRNA contributes to antibacterial resistance by repressing auxin signaling
-
Navarro L., et al. A plant miRNA contributes to antibacterial resistance by repressing auxin signaling. Science 312 (2006) 436-439
-
(2006)
Science
, vol.312
, pp. 436-439
-
-
Navarro, L.1
-
3
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A., et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
-
4
-
-
0347361541
-
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
-
Yi R., et al. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17 (2003) 3011-3016
-
(2003)
Genes Dev.
, vol.17
, pp. 3011-3016
-
-
Yi, R.1
-
5
-
-
52449115141
-
MicroRNAs - micro in size but macro in function
-
Singh S.K., et al. MicroRNAs - micro in size but macro in function. FEBS J. 275 20 (2008) 4929-4944
-
(2008)
FEBS J.
, vol.275
, Issue.20
, pp. 4929-4944
-
-
Singh, S.K.1
-
6
-
-
34547944309
-
MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
-
Mathonnet G., et al. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science 317 (2007) 1764-1767
-
(2007)
Science
, vol.317
, pp. 1764-1767
-
-
Mathonnet, G.1
-
7
-
-
33644768174
-
Control of translation and mRNA degradation by miRNAs and siRNAs
-
Valencia-Sanchez M.A., et al. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20 (2006) 515-524
-
(2006)
Genes Dev.
, vol.20
, pp. 515-524
-
-
Valencia-Sanchez, M.A.1
-
8
-
-
55949134303
-
DNA methylomes, histone codes and miRNAs: tying it all together
-
Guil S., and Esteller M. DNA methylomes, histone codes and miRNAs: tying it all together. Int. J. Biochem. Cell Biol. 41 1 (2009) 87-95
-
(2009)
Int. J. Biochem. Cell Biol.
, vol.41
, Issue.1
, pp. 87-95
-
-
Guil, S.1
Esteller, M.2
-
9
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir S.M., et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
-
10
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir S.M., et al. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15 (2001) 188-200
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
-
11
-
-
34547650779
-
RFRCDB-siRNA: improved design of siRNAs by random forest regression model coupled with database searching
-
Jiang P., et al. RFRCDB-siRNA: improved design of siRNAs by random forest regression model coupled with database searching. Comput. Methods Progr. Biomed. 87 (2007) 230-238
-
(2007)
Comput. Methods Progr. Biomed.
, vol.87
, pp. 230-238
-
-
Jiang, P.1
-
12
-
-
23444437819
-
Design of a genome-wide siRNA library using an artificial neural network
-
Huesken D., et al. Design of a genome-wide siRNA library using an artificial neural network. Nat. Biotechnol. 23 (2005) 995-1001
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 995-1001
-
-
Huesken, D.1
-
13
-
-
3242889236
-
siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference
-
Naito Y., et al. siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference. Nucleic Acids Res. 32 Web Server issue (2004) W124-W129
-
(2004)
Nucleic Acids Res.
, vol.32
, Issue.Web Server issue
-
-
Naito, Y.1
-
14
-
-
3242882171
-
TROD: T7 RNAi oligo designer
-
Dudek P., and Picard D. TROD: T7 RNAi oligo designer. Nucleic Acids Res. 32 Web Server issue (2004) W121-W123
-
(2004)
Nucleic Acids Res.
, vol.32
, Issue.Web Server issue
-
-
Dudek, P.1
Picard, D.2
-
15
-
-
33747869038
-
siVirus: web-based antiviral siRNA design software for highly divergent viral sequences
-
Naito Y., et al. siVirus: web-based antiviral siRNA design software for highly divergent viral sequences. Nucleic Acids Res. 34 Web Server issue (2006) W448-450
-
(2006)
Nucleic Acids Res.
, vol.34
, Issue.Web Server issue
-
-
Naito, Y.1
-
16
-
-
48449098277
-
OligoWalk: an online siRNA design tool utilizing hybridization thermodynamics
-
Lu Z.J., and Mathews D.H. OligoWalk: an online siRNA design tool utilizing hybridization thermodynamics. Nucleic Acids Res. 36 Web Server issue (2008) W104-108
-
(2008)
Nucleic Acids Res.
, vol.36
, Issue.Web Server issue
-
-
Lu, Z.J.1
Mathews, D.H.2
-
17
-
-
34347229441
-
sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database
-
Shah J.K., et al. sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database. BMC Bioinformatics 8 (2007) 178
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 178
-
-
Shah, J.K.1
-
18
-
-
3242890471
-
siRNA Selection Server: an automated siRNA oligonucleotide prediction server
-
Yuan B., et al. siRNA Selection Server: an automated siRNA oligonucleotide prediction server. Nucleic Acids Res. 32 Web Server issue (2004) W130-134
-
(2004)
Nucleic Acids Res.
, vol.32
, Issue.Web Server issue
-
-
Yuan, B.1
-
19
-
-
0035803583
-
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
-
Elbashir S.M., et al. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20 (2001) 6877-6888
-
(2001)
EMBO J.
, vol.20
, pp. 6877-6888
-
-
Elbashir, S.M.1
-
20
-
-
15044354554
-
RNAi-induced gene silencing by local electroporation in targeting brain region
-
Akaneya Y., et al. RNAi-induced gene silencing by local electroporation in targeting brain region. J. Neurophysiol. 93 (2005) 594-602
-
(2005)
J. Neurophysiol.
, vol.93
, pp. 594-602
-
-
Akaneya, Y.1
-
21
-
-
0344394958
-
Free energy lights the path toward more effective RNAi
-
Silva J.M., et al. Free energy lights the path toward more effective RNAi. Nat. Genet. 35 (2003) 303-305
-
(2003)
Nat. Genet.
, vol.35
, pp. 303-305
-
-
Silva, J.M.1
-
22
-
-
2342564353
-
A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens
-
Hsieh A.C., et al. A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Res. 32 (2004) 893-901
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 893-901
-
-
Hsieh, A.C.1
-
23
-
-
1642346273
-
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference
-
Ui-Tei K., et al. Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. 32 (2004) 936-948
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 936-948
-
-
Ui-Tei, K.1
-
24
-
-
13844281898
-
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
-
Kim D.H., et al. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat. Biotechnol. 23 (2005) 222-226
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 222-226
-
-
Kim, D.H.1
-
25
-
-
13844280638
-
Synthetic shRNAs as potent RNAi triggers
-
Siolas D., et al. Synthetic shRNAs as potent RNAi triggers. Nat. Biotechnol. 23 (2005) 227-231
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 227-231
-
-
Siolas, D.1
-
26
-
-
1542336952
-
Rational siRNA design for RNA interference
-
Reynolds A., et al. Rational siRNA design for RNA interference. Nat. Biotechnol. 22 (2004) 326-330
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 326-330
-
-
Reynolds, A.1
-
27
-
-
21844471799
-
Sequence characteristics of functional siRNAs
-
Jagla B., et al. Sequence characteristics of functional siRNAs. RNA 11 (2005) 864-872
-
(2005)
RNA
, vol.11
, pp. 864-872
-
-
Jagla, B.1
-
28
-
-
33748701701
-
Computational models with thermodynamic and composition features improve siRNA design
-
Shabalina S.A., et al. Computational models with thermodynamic and composition features improve siRNA design. BMC Bioinformatics 7 (2006) 65
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 65
-
-
Shabalina, S.A.1
-
29
-
-
34250805982
-
MicroRNA targeting specificity in mammals: determinants beyond seed pairing
-
Grimson A., et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell 27 (2007) 91-105
-
(2007)
Mol. Cell
, vol.27
, pp. 91-105
-
-
Grimson, A.1
-
30
-
-
52949095730
-
Effects of local mRNA structure on posttranscriptional gene silencing
-
Rudnick S.I., et al. Effects of local mRNA structure on posttranscriptional gene silencing. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 13787-13792
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 13787-13792
-
-
Rudnick, S.I.1
-
31
-
-
39149106448
-
Efficient siRNA selection using hybridization thermodynamics
-
Lu Z.J., and Mathews D.H. Efficient siRNA selection using hybridization thermodynamics. Nucleic Acids Res. 36 (2008) 640-647
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 640-647
-
-
Lu, Z.J.1
Mathews, D.H.2
-
32
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson A.L., et al. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 21 (2003) 635-637
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
-
33
-
-
33646188259
-
3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets
-
Birmingham A., et al. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat. Methods 3 (2006) 199-204
-
(2006)
Nat. Methods
, vol.3
, pp. 199-204
-
-
Birmingham, A.1
-
34
-
-
33646063801
-
EsiRNAs inhibit Hepatitis B virus replication in mice model more efficiently than synthesized siRNAs
-
Xuan B., et al. EsiRNAs inhibit Hepatitis B virus replication in mice model more efficiently than synthesized siRNAs. Virus Res. 118 (2006) 150-155
-
(2006)
Virus Res.
, vol.118
, pp. 150-155
-
-
Xuan, B.1
-
35
-
-
25444482662
-
Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs
-
Kittler R., and Buchholz F. Functional genomic analysis of cell division by endoribonuclease-prepared siRNAs. Cell Cycle 4 (2005) 564-567
-
(2005)
Cell Cycle
, vol.4
, pp. 564-567
-
-
Kittler, R.1
Buchholz, F.2
-
36
-
-
33745614074
-
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
-
Jackson A.L., et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 12 (2006) 1197-1205
-
(2006)
RNA
, vol.12
, pp. 1197-1205
-
-
Jackson, A.L.1
-
37
-
-
38649099969
-
Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
-
Chen P.Y., et al. Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA 14 (2008) 263-274
-
(2008)
RNA
, vol.14
, pp. 263-274
-
-
Chen, P.Y.1
-
38
-
-
33745608078
-
Off-target effects by siRNA can induce toxic phenotype
-
Fedorov Y., et al. Off-target effects by siRNA can induce toxic phenotype. RNA 12 (2006) 1188-1196
-
(2006)
RNA
, vol.12
, pp. 1188-1196
-
-
Fedorov, Y.1
-
39
-
-
44649124293
-
Small RNAs tell big stories in Whistler
-
Seila A.C., and Sharp P.A. Small RNAs tell big stories in Whistler. Nat. Cell Biol. 10 (2008) 630-633
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 630-633
-
-
Seila, A.C.1
Sharp, P.A.2
-
40
-
-
42449091989
-
Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
-
Ui-Tei K., et al. Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res. 36 (2008) 2136-2151
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 2136-2151
-
-
Ui-Tei, K.1
-
41
-
-
78649408990
-
LNA incorporated siRNAs exhibit lower off-target effects compared to 2′-O-methoxy in cell phenotypic assays and microarray analysis
-
Puri N., et al. LNA incorporated siRNAs exhibit lower off-target effects compared to 2′-O-methoxy in cell phenotypic assays and microarray analysis. Nucleic Acids Symp. Ser. (Oxf.) 52 (2008) 25-26
-
(2008)
Nucleic Acids Symp. Ser. (Oxf.)
, vol.52
, pp. 25-26
-
-
Puri, N.1
-
42
-
-
13744250159
-
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
-
Elmen J., et al. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res. 33 (2005) 439-447
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 439-447
-
-
Elmen, J.1
-
43
-
-
0034625010
-
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
-
Wahlestedt C., et al. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 5633-5638
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 5633-5638
-
-
Wahlestedt, C.1
-
44
-
-
0042972933
-
Activation of the interferon system by short-interfering RNAs
-
Sledz C.A., et al. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. 5 (2003) 834-839
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 834-839
-
-
Sledz, C.A.1
-
45
-
-
2442705429
-
Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
-
Kariko K., et al. Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol. 172 (2004) 6545-6549
-
(2004)
J. Immunol.
, vol.172
, pp. 6545-6549
-
-
Kariko, K.1
-
46
-
-
18044365415
-
Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
-
Sioud M. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J. Mol. Biol. 348 (2005) 1079-1090
-
(2005)
J. Mol. Biol.
, vol.348
, pp. 1079-1090
-
-
Sioud, M.1
-
47
-
-
20144389695
-
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
Hornung V., et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11 (2005) 263-270
-
(2005)
Nat. Med.
, vol.11
, pp. 263-270
-
-
Hornung, V.1
-
48
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge A.D., et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23 (2005) 457-462
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
-
49
-
-
33646544416
-
Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2′-hydroxyl uridines in immune responses
-
Sioud M. Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2′-hydroxyl uridines in immune responses. Eur. J. Immunol. 36 (2006) 1222-1230
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 1222-1230
-
-
Sioud, M.1
-
50
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song E., et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat. Biotechnol. 23 (2005) 709-717
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 709-717
-
-
Song, E.1
-
51
-
-
32944454941
-
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
-
Judge A.D., et al. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 13 (2006) 494-505
-
(2006)
Mol. Ther.
, vol.13
, pp. 494-505
-
-
Judge, A.D.1
-
52
-
-
33646561864
-
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
-
Marques J.T., et al. A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat. Biotechnol. 24 (2006) 559-565
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 559-565
-
-
Marques, J.T.1
-
53
-
-
33750976374
-
5′-Triphosphate RNA is the ligand for RIG-I
-
Hornung V., et al. 5′-Triphosphate RNA is the ligand for RIG-I. Science 314 (2006) 994-997
-
(2006)
Science
, vol.314
, pp. 994-997
-
-
Hornung, V.1
-
54
-
-
19644378907
-
Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart
-
Wang Z., et al. Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat. Biotechnol. 23 (2005) 321-328
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 321-328
-
-
Wang, Z.1
-
55
-
-
1542306855
-
Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
-
Kim D.H., et al. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol. 22 (2004) 321-325
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 321-325
-
-
Kim, D.H.1
-
56
-
-
39449128863
-
Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon
-
Gondai T., et al. Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon. Nucleic Acids Res. 36 (2008) e18
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Gondai, T.1
-
57
-
-
36949010787
-
Lack of interferon (IFN) response to T7 Transcribed pppG (n)(n = 2, 3)-shRNA
-
Gondai T., et al. Lack of interferon (IFN) response to T7 Transcribed pppG (n)(n = 2, 3)-shRNA. Nucleosides Nucleotides Nucleic Acids 26 (2007) 805-808
-
(2007)
Nucleosides Nucleotides Nucleic Acids
, vol.26
, pp. 805-808
-
-
Gondai, T.1
-
58
-
-
33646588689
-
Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro
-
Robbins M.A., et al. Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro. Nat. Biotechnol. 24 (2006) 566-571
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 566-571
-
-
Robbins, M.A.1
-
59
-
-
0036801463
-
Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination
-
Wang L., et al. Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination. J. Clin. Invest. 110 (2002) 1175-1184
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1175-1184
-
-
Wang, L.1
-
60
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
-
Heil F., et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303 (2004) 1526-1529
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
-
61
-
-
0036238993
-
Efficient delivery of dsRNA into zona-enclosed mouse oocytes and preimplantation embryos by electroporation
-
Grabarek J.B., et al. Efficient delivery of dsRNA into zona-enclosed mouse oocytes and preimplantation embryos by electroporation. Genesis 32 (2002) 269-276
-
(2002)
Genesis
, vol.32
, pp. 269-276
-
-
Grabarek, J.B.1
-
62
-
-
0034775750
-
Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells
-
Yang S., et al. Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells. Mol. Cell Biol. 21 (2001) 7807-7816
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 7807-7816
-
-
Yang, S.1
-
63
-
-
0035807818
-
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines
-
Billy E., et al. Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 14428-14433
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 14428-14433
-
-
Billy, E.1
-
64
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm D., et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441 (2006) 537-541
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
-
65
-
-
33845399708
-
Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing
-
Narvaiza I., et al. Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing. J. Virol. 80 (2006) 12236-12247
-
(2006)
J. Virol.
, vol.80
, pp. 12236-12247
-
-
Narvaiza, I.1
-
66
-
-
54549084606
-
Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
-
Sano M., et al. Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection. Nucleic Acids Res. 36 18 (2008) 5812-5821
-
(2008)
Nucleic Acids Res.
, vol.36
, Issue.18
, pp. 5812-5821
-
-
Sano, M.1
-
67
-
-
0038132996
-
Allele-specific silencing of dominant disease genes
-
Miller V.M., et al. Allele-specific silencing of dominant disease genes. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7195-7200
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 7195-7200
-
-
Miller, V.M.1
-
68
-
-
1342306385
-
Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles
-
Miller V.M., et al. Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. Nucleic Acids Res. 32 (2004) 661-668
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 661-668
-
-
Miller, V.M.1
-
69
-
-
33645160450
-
Allele-specific RNA interference for neurological disease
-
Rodriguez-Lebron E., and Paulson H.L. Allele-specific RNA interference for neurological disease. Gene Ther. 13 (2006) 576-581
-
(2006)
Gene Ther.
, vol.13
, pp. 576-581
-
-
Rodriguez-Lebron, E.1
Paulson, H.L.2
-
70
-
-
48249098892
-
Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi
-
Ohnishi Y., et al. Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi. PLoS ONE 3 (2008) e2248
-
(2008)
PLoS ONE
, vol.3
-
-
Ohnishi, Y.1
-
71
-
-
14644421585
-
Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3′- or 5′-end of the sense-stranded siRNA element
-
Ohnishi Y., et al. Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3′- or 5′-end of the sense-stranded siRNA element. Biochem. Biophys. Res. Commun. 329 (2005) 516-521
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.329
, pp. 516-521
-
-
Ohnishi, Y.1
-
72
-
-
33749438388
-
Designing siRNA that distinguish between genes that differ by a single nucleotide
-
Schwarz D.S., et al. Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet. 2 (2006) e140
-
(2006)
PLoS Genet.
, vol.2
-
-
Schwarz, D.S.1
-
73
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann T.S., et al. RNAi-mediated gene silencing in non-human primates. Nature 441 (2006) 111-114
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
-
74
-
-
36849094017
-
Chemical modification: the key to clinical application of RNA interference?
-
Corey D.R. Chemical modification: the key to clinical application of RNA interference?. J. Clin. Invest. 117 (2007) 3615-3622
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3615-3622
-
-
Corey, D.R.1
-
75
-
-
24344500241
-
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
-
Harborth J., et al. Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev 13 (2003) 83-105
-
(2003)
Antisense Nucleic Acid Drug Dev
, vol.13
, pp. 83-105
-
-
Harborth, J.1
-
76
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek J., et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432 (2004) 173-178
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
-
77
-
-
29844452007
-
Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity
-
Kraynack B.A., and Baker B.F. Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity. RNA 12 (2006) 163-176
-
(2006)
RNA
, vol.12
, pp. 163-176
-
-
Kraynack, B.A.1
Baker, B.F.2
-
78
-
-
11344257391
-
RNA interference using boranophosphate siRNAs: structure-activity relationships
-
Hall A.H., et al. RNA interference using boranophosphate siRNAs: structure-activity relationships. Nucleic Acids Res. 32 (2004) 5991-6000
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 5991-6000
-
-
Hall, A.H.1
-
79
-
-
55249097026
-
siRNA stabilization prolongs gene knockdown in primary T lymphocytes
-
Mantei A., et al. siRNA stabilization prolongs gene knockdown in primary T lymphocytes. Eur. J. Immunol. 38 (2008) 2616-2625
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 2616-2625
-
-
Mantei, A.1
-
80
-
-
0038385504
-
RNA interference in mammalian cells by chemically-modified RNA
-
Braasch D.A., et al. RNA interference in mammalian cells by chemically-modified RNA. Biochemistry 42 (2003) 7967-7975
-
(2003)
Biochemistry
, vol.42
, pp. 7967-7975
-
-
Braasch, D.A.1
-
81
-
-
33846902312
-
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
-
Swayze E.E., et al. Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals. Nucleic Acids Res. 35 (2007) 687-700
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 687-700
-
-
Swayze, E.E.1
-
82
-
-
33645533269
-
Improvements in siRNA properties mediated by 2′-deoxy-2′-fluoro-beta-d-arabinonucleic acid (FANA)
-
Dowler T., et al. Improvements in siRNA properties mediated by 2′-deoxy-2′-fluoro-beta-d-arabinonucleic acid (FANA). Nucleic Acids Res. 34 (2006) 1669-1675
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 1669-1675
-
-
Dowler, T.1
-
83
-
-
34247172025
-
2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity
-
Watts J.K., et al. 2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Res. 35 (2007) 1441-1451
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 1441-1451
-
-
Watts, J.K.1
-
84
-
-
69549124745
-
Suppression of bcr-abl mRNA by chemically modified siRNA
-
Murao S., et al. Suppression of bcr-abl mRNA by chemically modified siRNA. Nucleic Acids Symp. Ser. (Oxf.) 52 (2008) 499-500
-
(2008)
Nucleic Acids Symp. Ser. (Oxf.)
, vol.52
, pp. 499-500
-
-
Murao, S.1
-
86
-
-
33845631509
-
Integrated siRNA design based on surveying of features associated with high RNAi effectiveness
-
Gong W., et al. Integrated siRNA design based on surveying of features associated with high RNAi effectiveness. BMC Bioinformatics 7 (2006) 516
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 516
-
-
Gong, W.1
-
87
-
-
13444280430
-
HuSiDa - the human siRNA database: an open-access database for published functional siRNA sequences and technical details of efficient transfer into recipient cells
-
Truss M., et al. HuSiDa - the human siRNA database: an open-access database for published functional siRNA sequences and technical details of efficient transfer into recipient cells. Nucleic Acids Res. 33 Database issue (2005) D108-111
-
(2005)
Nucleic Acids Res.
, vol.33
, Issue.Database issue
-
-
Truss, M.1
-
88
-
-
13444266431
-
siRNAdb: a database of siRNA sequences
-
Chalk A.M., et al. siRNAdb: a database of siRNA sequences. Nucleic Acids Res. 33 Database issue (2005) D131-134
-
(2005)
Nucleic Acids Res.
, vol.33
, Issue.Database issue
-
-
Chalk, A.M.1
-
89
-
-
33645822531
-
siRecords: an extensive database of mammalian siRNAs with efficacy ratings
-
Ren Y., et al. siRecords: an extensive database of mammalian siRNAs with efficacy ratings. Bioinformatics 22 (2006) 1027-1028
-
(2006)
Bioinformatics
, vol.22
, pp. 1027-1028
-
-
Ren, Y.1
|