Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

Nature Biotechnology

Volumn 24, Issue 5, 2006, Pages 566-571

  Robbins, Marjorie A ^a,d   Li, Mingjie ^a   Leung, Irene ^b   Li, Haitang ^a   Boyer, Doris V ^b   Song, Yong ^b   Behlke, Mark A ^c   Rossi, John J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b BECKMAN COULTER INC   (United States)

^c Integrated DNA Technologiesm   (United States)

^d Protiva Biotherapeutics   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENETIC ENGINEERING; IMMUNOLOGY; INTERFERONS; LIPIDS; MOLECULAR STRUCTURE;

DENDRITIC CELLS; PROGENITOR-DERIVED HEMATOPOIETIC CELLS; RNA INTERFERENCE; SILENCING COMPLEX;

RNA;

ALPHA INTERFERON; CD34 ANTIGEN; DNA DIRECTED RNA POLYMERASE III; INTERFERON; LIPID; RNA INDUCED SILENCING COMPLEX; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; EMBRYO; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE INDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; IN VITRO STUDY; INTERFERON PRODUCTION; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; RNA CLEAVAGE; RNA INTERFERENCE; RNA STRUCTURE; RNA SYNTHESIS;

ANTIGENS, CD34; CELL SEPARATION; DENDRITIC CELLS; FLOW CYTOMETRY; GENETIC TECHNIQUES; HUMANS; INTERFERONS; LIPIDS; PROMOTER REGIONS (GENETICS); RNA, SMALL INTERFERING; STEM CELLS; TRANSFECTION;

ANIMALIA;

EID: 33646588689     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1206     Document Type: Article

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