HCN pacemaker channels and pain: A drug discovery perspective

Current Pharmaceutical Design

Volumn 15, Issue 18, 2009, Pages 2149-2168

  Wickenden, A D ^a   Maher, M P ^a   Chaplan, S R ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Assays; Drug discovery; Hyperpolarization activated cation nonselective (HCN) channels; Nerve injury; Neuropathic; Pacemaker channels; Pain

Indexed keywords

1 BENZYL 1,4 DIHYDRO 4 PENTYLIMINOQUINOLINE; 4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; ALINIDINE; CATION CHANNEL; CESIUM; CLONIDINE; CYCLIC AMP; FALIPAMIL; G PROTEIN COUPLED RECEPTOR; HALOTHANE; HYPERPOLARIZATION ACTIVATED CATION NONSELECTIVE; HYPERPOLARIZATION ACTIVATED CATION NONSELECTIVE 1; HYPERPOLARIZATION ACTIVATED CATION NONSELECTIVE 2; HYPERPOLARIZATION ACTIVATED CATION NONSELECTIVE 4; HYPERPOLARIZATION ACTIVATED CATION NONSELECTIVE ANTAGONIST; ION TRANSPORT AFFECTING AGENT; LAMOTRIGINE; LOPERAMIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEOTIDE BINDING PROTEIN; POTASSIUM CHANNEL BLOCKING AGENT; PROPOFOL; UNCLASSIFIED DRUG; ZATEBRADINE;

ALLODYNIA; ANGINA PECTORIS; CELL MEMBRANE POTENTIAL; CELLULAR DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG STRUCTURE; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; HIGH THROUGHPUT SCREENING; HUMAN; HYPERPOLARIZATION; HYPOTENSION; INFLAMMATORY PAIN; NERVE INJURY; NEUROPATHIC PAIN; NEUROTRANSMISSION; NONHUMAN; PAIN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINA; REVIEW; SEDATION; SENSORY NERVE; SENSORY NERVE CELL; SIDE EFFECT; SIGNAL TRANSDUCTION; SINUS NODE; SPINAL CORD; XEROSTOMIA;

ANALGESICS; ANIMALS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DRUG DISCOVERY; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PAIN; POTASSIUM CHANNELS; SENSORY RECEPTOR CELLS;

EID: 68449083932     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161209788489122     Document Type: Review

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