Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy

Journal of Neuroscience

Volumn 25, Issue 43, 2005, Pages 9871-9882

  Budde, Thomas ^a   Caputi, Luigi ^b   Kanyshkova, Tatyana ^b   Staak, Rainer ^b   Abrahamczik, Christian ^b   Munsch, Thomas ^b   Pape, Hans Christian ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Absence epilepsy; cAMP; h current; HCN channels; Spike and wave; Thalamic dysfunction

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; 8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; CYCLIC AMP; MESSENGER RNA; PHOSPHODIESTERASE INHIBITOR;

ABSENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERPOLARIZATION; ION CURRENT; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SEIZURE; THALAMOCORTICAL TRACT;

1-METHYL-3-ISOBUTYLXANTHINE; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ACTION POTENTIALS; ADENINE; ANIMALS; BLOTTING, NORTHERN; CEREBRAL CORTEX; CESIUM; CHLORIDES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG INTERACTIONS; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; ENZYME INHIBITORS; EPILEPSY, ABSENCE; FEMALE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ION CHANNELS; MALE; MEMBRANE POTENTIALS; MICROINJECTIONS; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN ISOFORMS; PYRIMIDINES; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THALAMUS;

EID: 27344447273     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2590-05.2005     Document Type: Article

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