A Single Histidine Residue Determines the pH Sensitivity of the Pacemaker Channel HCN2

Journal of Biological Chemistry

Volumn 276, Issue 9, 2001, Pages 6313-6319

  Zong, Xiangang ^a,b   Stieber, Juliane ^a   Ludwig, Andreas ^a   Hofmann, Franz ^a   Biel, Martin ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; HORMONES; MUTAGENESIS; NEUROLOGY; ORGANIC COMPOUNDS; PH EFFECTS; POSITIVE IONS; PROTONS;

MUTANT CHANNELS;

PACEMAKERS;

ARGININE; CATION CHANNEL; CYCLIC NUCLEOTIDE; GLUTAMINE; HISTIDINE; HCN2 POTASSIUM CHANNEL; ION CHANNEL; MUSCLE PROTEIN;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CHRONOTROPISM; HYPERPOLARIZATION; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MOUSE; NERVE CELL NETWORK; NEUROTRANSMITTER RELEASE; NONHUMAN; PACEMAKER; PERIPHERAL NERVE; PH MEASUREMENT; PRIORITY JOURNAL; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS; SYNAPTIC TRANSMISSION; CELL LINE; CHEMISTRY; HUMAN; MUTATION; PH; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

CELL LINE; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNELS; MUSCLE PROTEINS; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035794116     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010326200     Document Type: Article

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