Selective Hcn1 channels inhibition by ivabradine in mouse rod photoreceptors

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 4, 2009, Pages 1948-1955

  Demontis, Gian Carlo ^a   Gargini, Claudia ^a   Paoli, Timoteo Giacomo ^a   Cervetto, Luigi ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.4; ION CHANNEL; IVABRADINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNJ14; UNCLASSIFIED DRUG; BENZAZEPINE DERIVATIVE; CESIUM; CESIUM CHLORIDE; CHLORIDE; CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CATION CHANNEL; HYPERPOLARIZATION-ACTIVATED CATION CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL; KIR2.4 CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ION CURRENT; ION PERMEABILITY; LUMINANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINA ROD; STIMULUS RESPONSE; ACTION POTENTIAL; ANIMAL; C57BL MOUSE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHYSIOLOGY; METABOLISM; PATCH CLAMP; PHYSIOLOGY; TIME;

ACTION POTENTIALS; ANIMALS; BENZAZEPINES; CESIUM; CHLORIDES; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; MALE; MICE; MICE, INBRED C57BL; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RETINAL ROD PHOTORECEPTOR CELLS; TIME FACTORS;

EID: 64049101368     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2659     Document Type: Article

References (37)

1. Brown H, DiFrancesco D. Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sinoatrial node. J Physiol. 1980;308:331-351.
2. DiFrancesco D, Camm JA. Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs. 2004;64:1757-1765.
3. Van Bogaert PP, Pittoors F. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003;478:161-171.
4. DiFrancesco D. Some properties of the UL-FS 49 block of the hyperpolarization-activated current (i(f)) in sino-atrial node myocytes. Pflugers Arch. 1994;427:64-70.
5. Bois P, Bescond J, Renaudon B, Lenfant J. Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br J Pharmacol. 1996;118:1051-1057.
6. Van Bogaert PP, Goethals M, Simoens C. Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres. Eur J Pharmacol. 1990;187:241-256.
7. Glasser SP, Michie DD, Thadani U, Baiker WM. Effects of zatebradine (ULFS 49 CL), a sinus node inhibitor, on heart rate and exercise duration in chronic stable angina pectoris: Zatebradine Investigators. Am J Cardiol. 1997;79:1401-1405.
8. Borer JS, Fox K, Jaillon P, Lerebours G; Ivabradine Investigators Group. Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial. Circulation. 2003;107:817-823.
9. Moosmang S, Stieber J, Zong X, Biel M, Hofmann F, Ludwig A. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem. 2001;2681646-1652.
10. Seifert R, Scholten A, Gauss R, Mincheva A, Lichter P, Kaupp UB. Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A. 1999;96:9391-9396.
11. Altomare C, Terragni B, Brioschi C, et al. Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node. J Physiol. 2003;549(pt 2):347-359.
12. Demontis GC, Moroni A, Gravante B, et al. Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors. J Physiol. 2002;542(pt 1):89-97.
13. Müller F, Scholten A, Ivanova E, Haverkamp S, Kremmer E, Kaupp UB. HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. Eur J Neurosci. 2003; 17:2084-2096.
14. Cangiano L, Gargini C, Della Santina L, Demontis GC, Cervetto L. High-pass filtering of input signals by the I(h) Current in a non-spiking neuron, the retinal rod bipolar cell. PLoS One. 2007;19: e1327.
15. Cheng L, Kinard K, Rajamani R, Sanguinetti MC. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Phar-macol Exp Ther. 2007;322:931-939.
16. Satoh TO, Yamada M. Multiple inhibitory effects of zatebradine (UL-FS 49) on the electrophysiological properties of retinal rod photoreceptors. Pflugers Arch. 2002;443:532-540.
17. Bader CR, Bertrand D, Schwartz EA. Voltage-activated and calcium-activated currents studied in solitary rod inner segments from the salamander retina. J Physiol. 1982;331:253-284.
18. Beech DJ, Barnes S. Characterization of a voltage-gated K channel that accelerates the rod response to dim light. Neuron. 1989; 3:573-581.
19. Wollmuth LP, Hille B. Ionic selectivity of Ih channels of rod photoreceptors in tiger salamanders. J Gen Physiol. 1992;100: 749-765.
20. Cheng H, Aleman TS, Cideciyan AV, Khanna R, Jacobson SG, Swaroop A. In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development. Hum Mol Genet. 2006;15:2588-2602.
21. Demontis GC, Longoni B, Barcaro U, Cervetto L. Properties and functional roles of hyperpolarization-gated currents in guinea-pig retinal rods. J Physiol. 1999;515(pt 3):813-828.
22. Bucchi A, Tognati A, Milanesi R, Baruscotti M, DiFrancesco D. Properties of ivabradine-induced block of HCN1 and HCN4 chan-nels. J Physiol. 2006;572(pt 2):335-346.
23. Bucchi A, Baruscotti M, DiFrancesco D. Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. J Gen Physiol. 2002;120:1-13.
24. Valenzuela C, Delpón E, Franqueza L, et al. Class III antiarrhythmic effects of zatebradine: time-, state-, use-, and voltage-dependent block of hKv1.5 channels. Circulation. 1996;94:562-570.
25. Santoro B, Liu DT, Yao H, et al. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998;93:717-729.
26. Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M. A family of hyperpolarization-activated mammalian cation channels. Nature. 1998;393:587-591.
27. Santoro B, Chen S, Luthi A, et al. Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS. J Neurosci. 2000;20:5264-5275.
28. Franz O, Liss B, Neu A, Roeper J. Single-cell mRNA expression of HCN1 correlates with a fast gating phenotype of hyperpolarization-activated cyclic nucleotide-gated channels (Ih) in central neurons. Eur J Neurosci. 2000;12:2685-2693.
29. DiFrancesco D. Block and activation of the pace-maker channel in calf Purkinje fibres: effects of potassium, caesium and rubidium. J Physiol. 1982;329:485-507.
30. Hughes BA, Kumar G, Yuan Y, et al. Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel. Am J Physiol Cell Physiol. 2000;279:C771-C784.
31. Zolles G, Klöcker N, Wenzel D, et al. Pacemaking by HCN channels requires interaction with phosphoinositides. Neuron. 2006 52: 1027-1036.
32. Gargini C, Demontis GC, Bisti S, Cervetto L. Effects of blocking the hyperpolarization-activated current (Ih) on the cat electroretinogram. Vision Res. 1999;39:1767-1774.
33. Cervetto L, Demontis GC, Gargini C. Cellular mechanisms underlying the pharmacological induction of phosphenes. Br J Pharmacol. 2007;150:383-390.
34. Sampath AP, Rieke F. Selective transmission of single photon responses by saturation at the rod-to-rod bipolar synapse. Neuron. 2004;41:431-443.
35. Schneeweis DM, Schnapf JL. Photovoltage of rods and cones in the macaque retina. Science. 1995 268:1053-1056.
36. Catacuzzeno L, Fioretti B, Perin P, Franciolini F. Spontaneous low-frequency voltage oscillations in frog saccular hair cells. J Physiol. 2004;561(pt 3):685-701.
37. Hutcheon B, Yarom Y. Resonance, oscillation and the intrinsic frequency preferences of neurons. Trends Neurosci. 2000;23:216-222.