Cardiovascular characterisation of UL-FS 49,1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylimino]propyl]-2H-3-benzazepin- 2-on hydrochloride, a new "specific bradycardic agent"

European Journal of Pharmacology

Volumn 104, Issue 1-2, 1984, Pages 9-18

  Kobinger, Walter ^a   Lillie, Christian ^a  

^a BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

AQ A 39; Isolated atria; Sinus bradycardia; Specific bradycardic agent; UL FS 49

Indexed keywords

ATROPINE; CARBACHOL; DILTIAZEM; FALIPAMIL; HYDRALAZINE; MEXILETINE; NEW DRUG; NIFEDIPINE; NORADRENALIN; SOTALOL; VERAPAMIL; VERAPAMIL DERIVATIVE; ZATEBRADINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTICHOLINERGIC EFFECT; CARDIOVASCULAR SYSTEM; CAT; DOG; DRUG EFFICACY; DRUG INTERACTION; GUINEA PIG; HEART; HEART VENTRICLE REPOLARIZATION; NONHUMAN; RABBIT; RAT; SINUS BRADYCARDIA;

ANIMAL; AORTA, THORACIC; BENZAZEPINES; BLOOD PRESSURE; CARDIOVASCULAR AGENTS; CATS; DOGS; ELECTRIC STIMULATION; ELECTROCARDIOGRAPHY; FEMALE; GUINEA PIGS; HEART RATE; HEMODYNAMICS; IN VITRO; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL CONTRACTION; PARASYMPATHOLYTICS; PHTHALIMIDES; POTASSIUM; RABBITS;

EID: 0021175617     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(84)90363-7     Document Type: Article

References (21)

1. Influence of heart rate and inhibition of autonomic tone on the QT interval
2. Drugs with a class III antiarrhythmic action
3. Cardiovascular actions of 5,6-dimethoxy-2-[3-[(α-(3,4-dimethoxy)phenylethyl)-methylamino]propyl]phthalimidine (AQ-A 39), a specific bradycardic a agent
4. Synthetic substitutes for quinidine
5. Calcium-Antagonismus, ein Grundprinzip der Vasodilation
6. Electrophysiological studies on effects of AQ-A 39 in the isolated guinea pig heart and myocardial preparations
7. AQ-A 39 (5,6-dimethoxy-2-[3[[α-(3,4-dimethoxy)-phenylethyl]methylamino]propyl]-phtalimidine), a specific bradycardic agent with direct action on the heart
8. Alinidine, a specific bradycardic agent
9. N-allyl-derivative of clonidine, a substance with specific bradycardic action at a cardiac site
10. Cardiovascular actions of N-allyl-clonidine (St 567), a substance with specific bradycardic action
11. Electrophysiological studies of the effects of 5,6-dimethoxy-2-[3-[[α-(3,4-dimethoxy)-phenethyl]methylamino]propyl]phtallimidine (AQ-A 39) in isolated cardiac muscle
12. 2+ and NaCl solutions
13. Cardiovascular actions of UL-FS 49, 1,3,4,5-tetrahydro-7,8-dimethoxy-3[3-[[-(3,4-dimethoxyphenyl)ethyl]methlimino]propyl-2H-3-benzazepin-2-on- -hydrochlorid, a new “specific bradycardiac agent”
14. Chronotropic, inotropic and vasodilator actions of diltiazem, nifedipine, and verapamil; a comparative study of physiological responses and membrane receptor activity
15. Electrophysiological effects of sotalol - just another beta blocker?
16. The electrophysiological basis of the bradycardic action of AQ-A 39 on the sinoatrial anode
17. Calcium channel block and recovery from block in mammalian ventricular muscle treated with organic channel inhibitors
18. A third class of anti-arrhythmic action; effects on atrial and ventricular intracellular potentials and other pharmacological actions on cardiac muscle of MJ 1999 and AM 3474
19. AQ-A 39, a new bradycardic agent which blocks myocardial calcium (Ca) channels in a frequency- and voltage-dependent manner
20. Mexiletine in isolated tissue models