Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 4, 2005, Pages 1211-1220

  Novella Romanelli, Maria ^a   Cerbai, Elisabetta ^a   Dei, Silvia ^a   Guandalini, Luca ^a   Martelli, Cecilia ^a   Martini, Elisabetta ^a   Scapecchi, Serena ^a   Teodori, Elisabetta ^a   Mugelli, Alessandro ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Bradycardic agents; f Current blockers; Zatebradine analogues

Indexed keywords

CARBENE; ZATEBRADINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GUINEA PIG; HEART ATRIUM; HEART MUSCLE CELL; HEART VENTRICLE; HUMAN; HYPERPOLARIZATION; MALE; MOUSE; NONHUMAN; PATCH CLAMP; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; BENZAZEPINES; GUINEA PIGS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PATCH-CLAMP TECHNIQUES; RATS; RATS, INBRED SHR;

CAVIA PORCELLUS; SUS SCROFA;

EID: 12844288999     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.11.017     Document Type: Article

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