Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat

Neuroscience

Volumn 144, Issue 4, 2007, Pages 1477-1485

  Luo, L ^a   Chang, L ^a   Brown, S M ^a   Ao, H ^a   Lee, D H ^a   Higuera, E S ^a   Dubin, A E ^a   Chaplan, S R ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

allodynia; HCN pacemaker channel; mild thermal injury; neuropathic pain; peripheral; spinal nerve ligation

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CYCLIC NUCLEOTIDE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE MODULATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE MODULATED CHANNEL 1; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE MODULATED CHANNEL 4; ION CHANNEL; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; DRUG MECHANISM; EPIDERMIS CELL; HEART CONTRACTION; HEART RHYTHM; HUMAN; HUMAN CELL; HYPERALGESIA; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; MALE; MECHANOTRANSDUCTION; MEISSNER CORPUSCLE; MERKEL CELL; NERVE CONDUCTION; NERVE LIGATION; NONHUMAN; PAIN; PERIPHERAL NERVE INJURY; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SKIN; SPINAL GANGLION; TACTILE ALLODYNIA; THERMAL INJURY; TOUCH;

ACUTE DISEASE; ANIMALS; CARDIOVASCULAR AGENTS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; HYPERALGESIA; MALE; MECHANORECEPTORS; MERKEL CELLS; NOCICEPTORS; PAIN; PERIPHERAL NERVES; POTASSIUM CHANNELS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SENSORY; SKIN;

EID: 33846314359     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.10.048     Document Type: Article

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