Blocker state dependence and trapping in hyperpolarization-activated cation channels: Evidence for an intracellular activation gate

Journal of General Physiology

Volumn 117, Issue 2, 2001, Pages 91-101

  Ki Soon Shin, ^a   Rothberg, B S ^a   Yellen, G ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

mHCN1; Pore; SPIH; ZD7288

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CATION CHANNEL;

ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CHIMERA; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPERPOLARIZATION; ION CURRENT; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; CARDIOVASCULAR AGENTS; CELLS, CULTURED; HUMANS; ION CHANNEL GATING; ION CHANNELS; KIDNEY; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES;

EID: 0035025069     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.117.2.91     Document Type: Article

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